Lilly commits $92.5 million to Purdue to establish an innovative pharmaceutical manufacturing scholarship program and to extend research collaboration

On October 27, 2022 Purdue University and Eli Lilly and Company (NYSE: LLY) are establishing an innovative new pharmaceutical manufacturing scholarship program and have renewed their strategic research collaboration in a series of moves reported that that will expand their impact in Indiana and improve lives on a global scale (Press release, Eli Lilly, OCT 27, 2022, View Source [SID1234622471]). Lilly has committed $92.5 million to the West Lafayette campus through these two programs.

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Lilly’s commitment includes $42.5 million over 10 years to fund pharmaceutical manufacturing scholarships for incoming Purdue undergraduate students, offering 75-100 talented students each year full tuition with a guaranteed internship or co-op at Lilly and a promise of coordinated interaction with company leaders. Priority access to the new Lilly Scholars program will be given to undergraduate students who are underrepresented in Purdue’s student population, have overcome socioeconomic or educational disadvantages or are among the first generation in their family to attend college.

"Lilly is among Purdue’s most important partners, and this latest commitment reaffirms our longtime collaboration. Through these collaborations, Lilly and Purdue are helping to build a critical pharmaceutical ecosystem in the heartland," said Purdue President Mitch Daniels. "We have a company that is committed to advancing research and fostering talent. Lilly is investing in students very early in their education rather than waiting until late in their college careers – connecting to students before they even arrive on campus."

The Lilly Scholars program will provide participating students with preferred access and opportunities to compete for a role at the company following graduation. The first scholarships will be offered for fall 2023.

Purdue and Lilly have a historic relationship, dating back to the organizations’ founding years. The organizations entered into a new strategic research collaboration in 2017, funded by an initial $50 million commitment from Lilly. Those collaborative research efforts have helped advance understanding of the physiology of drug delivery and develop technologies to improve delivery of pharmaceuticals for better patient outcomes and experiences. Lilly and Purdue are now expanding that research collaboration, signing a new $50 million master agreement that extends the work for another five years, with a research focus on genetic medicine, intrathecal delivery and nanoparticle drug delivery.

"As the number of people who may benefit from our innovative medicines continues to increase, we are investing to advance critical research and build a more diverse pipeline of talent in Indiana. Together with Purdue, we can help to keep our state’s best and brightest in Indiana, furthering Lilly’s ability to make life better for millions of people," said David A. Ricks, Lilly’s chair and CEO. "As a Purdue graduate, I am proud of the success the university has built and even more proud to see Lilly and Purdue team up to make both institutions better and better."

The basic research by Purdue faculty helps Lilly expedite the development of technologies and pharmaceuticals, improving the pace of getting therapies to patients who need them. Over the last eight years, Lilly has introduced 18 new medicines to make life better for people living with diseases like diabetes and cancer. The company aims to introduce four additional potential new medicines in the next 18 months.

"Purdue’s approach to interdisciplinary research with Lilly is driven by an impact-focused mindset aimed at improving the lives of patients. Our collaboration spans training and development all the way to cutting-edge research and facilities," said Theresa Mayer, Purdue University executive vice president for research and collaboration. "The extension of our agreement will continue to provide exceptional opportunities for faculty members and hundreds of graduate students from across the country to work side-by-side with colleagues from this leading pharmaceutical company."

Both Lilly and Purdue have made strategic commitments in recent years to strengthen expertise and programs in bioscience areas, including pharmaceutical manufacturing.

Earlier this year, Purdue established the William D. Young Institute for Advanced Manufacturing of Pharmaceuticals, an interdisciplinary organization focused on furthering pharmaceutical manufacturing to reduce costs and expand access to new drugs emerging from biotech research. That institute follows a $250 million investment in life sciences as part of the Purdue Moves strategic plan, which resulted in three university-wide interdisciplinary institutes: the Purdue Institutes of Drug Discovery; Inflammation, Immunology and Infectious Disease; and Integrative Neuroscience, which have helped to attract leading faculty researchers in critical research areas. Purdue has also invested in state-of the-art facilities, including the Bindley Bioscience Center, which provides a unique infrastructure to support interdisciplinary research.

Over the last five years, Lilly has committed over $6 billion in pharmaceutical manufacturing globally. This includes $2.1 billion and up to 500 new jobs in the LEAP Technology Park in Boone County, Indiana, announced in May 2022, and up to 1,500 more jobs during construction of the site.

"Collaborations between academia and industry are essential to innovation to bring therapies to patients as quickly as possible," said Edgardo Hernandez, executive vice president and president of manufacturing operations at Lilly. "With the expansion of our footprint in Indiana, these initiatives with Purdue will help bring a highly skilled pipeline of diverse talent and enhance our manufacturing capacity to deliver medicines to patients around the world."

As Lilly and Purdue work together on new curricula, experiential learning, and certificate and degree programs in pharmaceutical manufacturing, they will help continue to grow pharmaceutical manufacturing in Indiana and expand Purdue’s talent pipeline to the company with students supported by the new scholarship program. Every year, Lilly hires Purdue graduates in areas such as engineering, sales, finance, human resources, marketing, procurement, supply chain and more. In fact, Lilly employs nearly 2,500 Purdue graduates – more than from any other university.

"These commitments will better position Purdue to recruit the best, brightest and most diverse students we can," said Kristina Wong Davis, vice provost for enrollment management at Purdue.

Triumvira Immunologics to Present Clinical and Preclinical Updates at Society for Immunotherapy of Cancer (SITC) 37th Annual Meeting

On October 27, 2022 Triumvira Immunologics ("Triumvira"), a clinical-stage company developing novel, targeted autologous and allogeneic T cell therapeutics that co-opt the natural biology of T cells to treat patients with cancer, reported that it will present data from its ongoing clinical and preclinical programs at the upcoming Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 37th Annual Meeting, being held Nov. 10-12, 2022, in Boston and virtually (Press release, Triumvira Immunologics, OCT 27, 2022, View Source [SID1234622470]). The presentations will include updated clinical data from its Phase 1/2 trial of TAC01-HER2 in patients with solid tumors and preclinical data on T cell therapy candidates TAC01-CLDN18.2 and GUCY2C-TAC T.

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Details of presentations:

Title: A Phase I/II Trial Investigating Safety and Efficacy of Autologous TAC T Cells Targeting HER2 in Relapsed or Refractory Solid Tumors
Abstract #: 760

Title: Development of GUCY2C-TAC T cells for the treatment of colorectal cancer
Abstract #: 201

Title: Evidence for durable anti-tumor responses by TAC-T cells in preclinical models of solid tumors
Abstract #: 261

Title: Preclinical studies of TAC01-CLDN18.2, an autologous Claudin 18.2-directed TAC T cell therapy, in the treatment of gastric cancer
Abstract #: 294

Q3 and first 9 months 2022 results

On October 27, 2022 ArcticZymes Technologies (OSE: AZT) reported sales of NOK 29.3 million (25.2) and an EBITDA of NOK 2.8 million (9.9) for the third quarter of 2022 (Press release, Biotec Pharmacon, OCT 27, 2022, View Source [SID1234622469]).

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Highlights from Q3 and first 9 months 2022

ArcticZymes Technologies (AZT) had Q3 sales of NOK 29.3 million growing by 16% (Q3 2021: NOK 25.2 million) and sales for the first 9 months of NOK 108.8 million growing by 24% (9M 2021: NOK 87.5 million)
AZT had a positive EBITDA for Q3 of NOK 2.8 million, a reduction of NOK 6.2 million (Q3 2021: NOK 9.9 million) and a positive EBITDA for the first nine months of NOK 40.2 million, a reduction of 0.6 million (9M 2021: NOK 40.8 million)
Increased expenses correspond to investing in growth initiatives such as talent acquisition, expansion in Oslo, the Drug Master File (DMF) and external M&A support
Cash flow for Q3 was positive NOK 7.6 million (Q3 2021: NOK 9.9 million) giving a cash balance of NOK 238.6 million (Q3 2021: NOK 186.9 million)
Expression studies have yielded several promising R&D prototypes of RNA enzymes
ArcticZymes intensifies the M&A process, entering discussions with a select group of international companies
CEO Jethro Holter comments:

"Sales continue to grow despite headwinds related to seasonal effects with customer vacations and the foreseen void created following the pandemic where demand for enzymes for Coronavirus-related applications has vastly reduced.

The main growth driver for the quarter was the Biomanufacturing business. Molecular tools achieved flat performance for the quarter but growth for the first nine months.

Inorganic growth initiatives advance to discussions with a select group of international companies."

Syndax to Announce Third Quarter 2022 Financial Results and Host Conference Call and Webcast on November 3, 2022

On October 27, 2022 Syndax Pharmaceuticals, Inc. (Nasdaq: SNDX), a clinical-stage biopharmaceutical company developing an innovative pipeline of cancer therapies, reported that it will report its third quarter 2022 financial results and provide a business update on Thursday, November 3, after the close of the U.S. financial markets (Press release, Syndax, OCT 27, 2022, View Source [SID1234622461]).

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In connection with the earnings release, Syndax’s management will host a conference call and live audio webcast at 4:30 p.m. ET on Thursday, November 3, 2022 to discuss the Company’s financial results and provide a business update.

The live audio webcast and accompanying slides may be accessed through the Events & Presentations page in the Investors section of the Company’s website. Alternatively, the conference call may be accessed through the following:

For those unable to participate in the conference call or webcast, a replay will be available on the Investors section of the Company’s website at www.syndax.com approximately 24 hours after the conference call and will be available for 90 days following the call.

Oncolytics Biotech® to Host Conference Call to Discuss Third Quarter Financial Results and Recent Operational Highlights

On October 27, 2022 Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC) reported that it will host a conference call and webcast on Monday, November 7, 2022, at 8:30 a.m. ET to discuss a corporate update and financial results for the third quarter of 2022 (Press release, Oncolytics Biotech, OCT 27, 2022, https://ir.oncolyticsbiotech.com/news/detail/583/oncolytics-biotech-to-host-conference-call-to-discuss-third-quarter-financial-results-and-recent-operational-highlights [SID1234622460]).

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A webcast of the call will also be available on the Investor Relations page of Oncolytics’ website, available by clicking here, and will be archived for three months. A dial in replay will be available for one week and can be accessed by dialing (888) 390-0541 (North America) or (416) 764-8677 (International) and using replay code: 406-541#.