On October 24, 2022 Transcenta Holding Limited ("Transcenta") (HKEX: 06628), a clinical stage biopharmaceutical company with fully-integrated capabilities in discovery, research, development and manufacturing of antibody-based therapeutics, reported that Transcenta is invited to participate the 10th TEMTIA meeting in Paris, France, November 7 to 10 and present preclinical data of TST003, Transcenta’s first-in-class, high affinity humanized monoclonal antibody targeting Gremlin1 (Press release, Transcenta, OCT 24, 2022, View Source [SID1234622326]).

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Details of the speech are as follows:

Topic：TST003, a first-in-class anti-Gremlin1 monoclonal antibody, blocks EMT and displays potent single agent anti-tumor activities in PDX models of multiple difficult-to-treat solid tumors
Date & Time: 9 November 2022, 3:30 pm-3:45 pm (Paris time)
Speaker: Dr. Xueming Qian, CEO, Transcenta

TEMTIA is an international meeting dedicated to the study of epithelial to mesenchymal transition (EMT). EMT process is triggered when epithelial cells loosen cohesiveness and adopt an individualized motile phenotype in link with the progressive loss of epithelial features. EMT was originally defined in the context of developmental stages and contributes to cancer progression and metastasis. EMT has shown to be an important mechanism for resistance to cancer therapies including checkpoint inhibitor immunotherapy.

About TST003

TST003 is a high affinity monoclonal antibody targeting Gremlin1, a member of TGFb superfamily. Gremlin1 protein is a highly conserved secreted protein and has shown to play important roles during development. Gremlin1 is highly upregulated in multiple solid tumors. Gremlin1 protein promotes epithelial mesenchymal transition. TST003 has shown promising single agent activities in patient-derived xenograft tumor models of multiple difficult-to-treat solid tumors resistant to checkpoint inhibitor including castration resistant prostate cancer and microsatellite stable colorectal cancer. TST003 also enhanced the anti-tumor activity of checkpoint inhibitor in syngeneic tumor model. TST003 has received FDA clearance for entering clinical testing in September, 2022.

On October 24, 2022 ViewRay, Inc. (NASDAQ: VRAY) reported that the findings from the first Phase II prospective international multi-institutional study to deliver ablative doses of radiation to pancreatic cancer patients will be presented at the 64th Annual Meeting of the American Society for Radiation Oncology (ASTRO), being held October 23-26, 2022, at the Henry B. Gonzalez Convention Center in San Antonio (Press release, ViewRay, OCT 24, 2022, View Source [SID1234622325]). The results will be featured as part of the Special Session of Late-Breaking Abstracts and will take place on Tuesday, October 25, at 3:00 p.m. Central Time. The data will be presented by Parag Parikh, M.D., study’s principal investigator and Director of GI Radiation Oncology and MR-Guided Radiation Therapy at the Henry Ford Cancer Institute in Detroit.

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The trial, titled "Stereotactic MRI-Guided On-table Adaptive Radiation Therapy (SMART) for Locally Advanced Pancreatic Cancer" – and known as SMART Pancreas (NCT 03621644) – was launched in 2019 in response to compelling retrospective data that suggested the potential for ablative dose radiation to improve overall survival relative to patients receiving lower radiation doses without increasing the rate of severe gastrointestinal toxicity.

In the SMART Pancreas study, 136 patients were treated at 13 international centers with ablative MRIdian SMART, 50Gy over 5 fractions. The study’s primary outcome measured grade 3 or higher gastrointestinal toxicity in the first 90 days after treatment. The study’s primary safety objective was met, with zero incidences of acute grade 3+ GI toxicity definitely-related to SMART treatment.

Secondary measures of the study include overall survival, local control, distant progression-free survival, and changes in patient-reported quality of life. While study patients are still early in the follow-up period, 16.4 months from diagnosis and 8.8 months from SMART treatment, the ASTRO presentation will highlight preliminary clinical outcomes data of 1-year local control and distant progression-free survival were 82.9% and 50.6% respectively. One-year overall survival from diagnosis was 93.9%.

"We are pleased to see this prospective study confirmed our experience using MRIdian for pancreas cancer. Ablative SMART for locally advanced and borderline resectable pancreatic cancer is safe; and is promising to improve patient outcomes in this devastating disease," said Dr. Parikh. This study supports further studies looking at overall survival, such as the LAP-ABLATE randomized study that was recently opened."

The MRIdian system provides oncologists outstanding anatomical visualization through diagnostic-quality MR images and the ability to adapt a radiation therapy plan to the targeted cancer with the patient on the table. This combination allows physicians to define tight treatment margins to avoid unnecessary radiation exposure of vulnerable organs-at-risk and healthy tissue and allows the delivery of ablative radiation doses in five or fewer treatment sessions, without relying on implanted markers. By providing real-time continuous tracking of the target and organs-at-risk, MRIdian enables automatic gating of the radiation beam if the target moves outside the user-defined margins. This allows for delivery of the prescribed dose to the target while sparing surrounding healthy tissue and critical structures, which results in minimizing toxicities typically associated with conventional radiation therapy.

To date, nearly 27,000 patients have been treated with MRIdian. Currently, 54 MRIdian systems are installed at hospitals around the world where they are used to treat a wide variety of solid tumors and are the focus of numerous ongoing research efforts. MRIdian has been the subject of hundreds of peer-reviewed publications, scientific meeting abstracts, and presentations. For a list of treatment centers, please visit: View Source

Conflicts of interest: Parag Parikh, M.D. discloses research funding and consulting from ViewRay, Inc, and research funding from Galera Therapeutics, Inc. He also discloses stock ownership from Nuvaira, Inc.

On October 24, 2022 Biotheryx, Inc., a clinical stage company discovering and developing a portfolio of innovative small molecule targeted protein degraders (TPDs) in areas of high unmet medical need, reported that it will present preclinical data from its targeted protein degrader programs at the 5th Annual Targeted Protein Degradation Summit, being held October 25-28, 2022, in Boston, Massachusetts (Press release, BioTheryX, OCT 24, 2022, View Source [SID1234622324]).

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Leah Fung, Ph.D., Chief Scientific Officer of Biotheryx, will present as a Keynote Plenary Speaker in a session, "Highlighting Key Discoveries of Bifunctional Degraders to New Targets," to highlight novel small molecule bifunctional degraders of son of sevenless homolog 1 (SOS1), potent inhibitors of Kirsten rat sarcoma (KRAS) mutant cancers. Aparajita Chourasia, Ph.D., Vice President of Biology of Biotheryx will also present the latest preclinical data in support of the Company’s BTX-1188 molecular glue program targeting GSPT1 and IKZF1/3.

"We are looking forward to sharing findings at the TPD Summit that highlight the potential of our innovative PRODEGY platform to develop new and exciting cancer therapies," said Dr. Fung. "The data Biotheryx are presenting are evidence of our team’s commitment to the discovery and design of first-in-class protein degraders."

On October 24, 2022 KaliVir Immunotherapeutics, Inc., a biotech company developing cutting-edge, multi-mechanistic oncolytic viral immunotherapy programs, reported that Dr. Stephen Thorne, Co-Founder and CSO, will present data on its product candidate VET3-TGI at the 14th International Oncolytic Virotherapy Conference (IOVC), taking place October 23-26, 2022, in Karuizawa, Nagano, Japan (Press release, KaliVir Immunotherapeutics, OCT 24, 2022, View Source [SID1234622323]).

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VET3-TGI is based on KaliVir’s unique Vaccinia Enhanced Template (VET) platform, capable of generating potent novel oncolytic vaccinia viruses with modifications to maximize viral replication and enhance intravenous delivery and spread. VET3-TGI incorporates modifications granting the expression of CXCR3, IL-12 and a TGF-β inhibitor, allowing for efficient trafficking to the tumor, activation of anti-tumor immune responses and inhibition of immunosuppressive activity.

On October 24, 2022 PharmAbcine Inc. (KOSDAQ: 208340ks), a clinical-stage biotech company focusing on the development of next-generation antibody therapeutics, reported that the Company is invited at upcoming Jefferies 2022 London Healthcare Conference. Jefferies is scheduled to be held in London from November 15-17, 2022 (Press release, PharmAbcine, OCT 24, 2022, View Source [SID1234622322]).

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Details of the events are as follows:

Event: Jefferies 2022 London Healthcare Conference
Date: November 15-17, 2022
Event Calendar: View Source

Jefferies London Healthcare Conference is one of the largest healthcare-dedicated conference in Europe. In the past conference, over 550 companies and 3,000 attendees from Americas, Europe, Middle East, Africa, and Asia have joined the event.

At Jefferies, Dr. Jin-San Yoo, Chairman and Chief Executive Officer of PharmAbcine, will hold meetings with registered members of the investor community to look for investment opportunities and discuss the current trends in drug development and healthcare sector. The registered members will include leading global executives, institutional investors, and private equity investors.

To schedule a one-on-one meeting with PharmAbcine, contact the assigned Jefferies representative.