EDAP Announces Pricing of Public Offering of American Depositary Shares

On September 22, 2022 EDAP TMS S.A. (NASDAQ: EDAP) (the "Company"), a global leader in robotic energy-based therapies, reported that the price of its public offering of its American Depositary Shares ("ADSs"), which commenced on September 22, 2022, has been set today at $7.50 per ADS, before underwriting discounts and commissions, and that the number of offered ADSs is 2,666,667 (Press release, EDAP TMS, SEP 22, 2022, View Source(NASDAQ%3A%20EDAP)%20(the,and%20that%20the%20number%20of [SID1234621392]). In addition, Jefferies LLC has been granted a 30-day over-allotment option to purchase up to an additional 400,000 ADSs on the same terms and conditions. The gross proceeds from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by the Company, are expected to be approximately $20,000,003. The closing of the offering is expected to occur on September 27, 2022, subject to customary closing conditions.

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Jefferies LLC is acting as the sole book-running manager for the offering.

A shelf registration statement on Form F-3 (including a prospectus) relating to the Company’s American Depositary Shares was filed with the Securities and Exchange Commission (the "SEC") on April 7, 2021 and is effective. The Company has also filed a base prospectus dated April 16, 2021 and a preliminary prospectus supplement dated September 22, 2022 with respect to the offering. A final prospectus supplement and the accompanying prospectus will be filed with the SEC. You may obtain these documents for free by visiting EDGAR on the SEC’s website at www.sec.gov. Alternatively, when available, a copy of the prospectus supplement (and accompanying prospectus) relating to the offering may be obtained from Jefferies LLC, Attn: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, New York 10022, by telephone at +1 (877) 821-7388 or by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. In particular, no public offering of the ADSs will be made in Europe.

Mirati Therapeutics to Participate in Two Upcoming Healthcare Conferences

On September 22, 2022 Mirati Therapeutics, Inc. (NASDAQ: MRTX), a clinical-stage targeted oncology company, reported that it will participate in two upcoming healthcare conferences (Press release, Mirati, SEP 22, 2022, View Source [SID1234621391]).

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Thursday, September 29 at 10:00 a.m. ET / 7:00 a.m. PT at the Guggenheim Nantucket Therapeutics Conference. David Meek, chief executive officer, will represent the company in a fireside chat.
Monday, October 3 at 1:10 p.m. ET / 10:10 a.m. PT at the Bank of America Precision Oncology Conference. David Meek, chief executive officer, will represent the company in a fireside chat.
Investors and the general public are invited to listen to a live webcast of the sessions through the "Investors and Media" section on Mirati.com. A replay of the webcast will be made available following the event.

NeuBase to Participate at Chardan’s 6th Annual Genetic Medicines Conference

On September 22, 2022 NeuBase Therapeutics, Inc. (Nasdaq: NBSE) ("NeuBase" or the "Company"), a biotechnology platform company Drugging the Genome to address disease at the base level using a new class of precision genetic medicines, reported that company management will participate in-person for a fireside chat at Chardan’s 6th Annual Genetic Medicines Conference being held in New York City on October 3-4, 2022 (Press release, NeuBase Therapeutics, SEP 22, 2022, View Source [SID1234621375]).

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An audio replay of the webcast will be available following the presentation for 90 days. To access the replay, please click here. Please contact your representative at Chardan to schedule a one-on-one meeting with NeuBase management during the conference.

Aprea Therapeutics Announces Poster Presentation at the 2022 Rivkin Center and American Association for Cancer (AACR) Virtual Ovarian Cancer Research Seminar Series

On September 22, 2022 Aprea Therapeutics, Inc. (Nasdaq: APRE), a biopharmaceutical company focused on developing novel synthetic lethality-based cancer therapeutics targeting DNA damage response (DDR) pathways, reported that the abstract titled "ATRN-W1051, a novel and potent WEE1 inhibitor for the treatment of CCNE1-overexpressing ovarian cancer" will be presented at the 14th Biennial Virtual Ovarian Cancer Research Seminar Series presented by the Rivkin Center and the American Association for Cancer Research (AACR) (Free AACR Whitepaper) (Press release, Aprea, SEP 22, 2022, View Source [SID1234621374]). The series will take place on September 21, 22, 28, and 29, 2022, with each day scheduled to run from 12:00-2:00pm U.S. Pacific Time.

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"A growing body of scientific evidence provides exciting development opportunities for our WEE1 inhibitor, ATRN-W1051," said Oren Gilad, Ph.D., President and Chief Executive Officer of Aprea. "ATRN-W1051 is designed to be a potent and selective WEE1 inhibitor with a differentiated structure and potentially preferable pharmacokinetic properties. The presented data demonstrate anti-proliferative activity against a variety of cancer cell lines and tumor growth inhibition in a genetically-defined ovarian cancer xenograft model. We look forward to completing the IND-enabling studies and plan to initiate the clinical program shortly thereafter."

A copy of the poster will be accessible from the "Events Calendar" in the News and Events section of the Aprea website.

China CDE Grants CMG901 Breakthrough Therapy Designation for Claudin 18.2-Positive Advanced Gastric & Gastroesophageal Junction Cancer

On September 22, 2022 Keymed Biosciences (HKEX:02162) reported that the Center for Drug Evaluation (CDE) of the China National Medical Products Administration (NMPA) has granted CMG901 the Breakthrough Therapy Designation for the treatment of advanced gastric and gastroesophageal junction(GEJ) cancer which have relapsed and/or are intolerant to prior therapies (Press release, Keymed Biosciences, SEP 22, 2022, View Source;gastroesophageal-junction-cancer-301630843.html [SID1234621373]).

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About CMG901

CMG901 is a Claudin 18.2-targeted antibody-drug conjugate (ADC) developed for the treatment of Claudin 18.2-expressing solid tumors. In April 2022, the U.S. Food and Drug Administration (FDA) granted CMG901 Fast Track Designation[i] and Orphan Drug Designation[ii] as monotherapy for the treatment of unresectable or metastatic gastric and gastroesophageal junction (GEJ) cancer which are resistant/refractory to prior therapies.

About CDE’s Breakthrough Therapy Designation

CDE’s Breakthrough Therapy Designation is designed to expedite the clinical development of innovative drugs presenting significant clinical advantages. A breakthrough therapy must provide effective treatment for a seriously debilitating or life-threatening condition that has no effective therapy or demonstrate substantial improvement over available therapies. According to the CDE, BTD provides opportunities for more intensive CDE guidance and discussion with respect to clinical trials and development strategy, and for priority review later.