On August 9, 2022 Helix BioPharma Corp. (TSX: "HBP") ("Helix" or the "Company"), a clinical-stage biopharmaceutical company that is developing unique therapies in the field of immuno-oncology based on its proprietary technology platform DOS47, reported that it has entered into a two-year scientific collaboration agreement ("Agreement") with University Hospital Tuebingen (Germany) to assess the therapeutic response of L-DOS47 in several cancer models expressing CEACAM6, with advanced preclinical metabolic imaging (Press release, Helix BioPharma, AUG 9, 2022, View Source [SID1234619306]).

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We aim to explore the potential synergistic effects of L-DOS47 in combination with checkpoint inhibitors on relevant cancer models. To accomplish this overarching aim, Helix established a two-year collaborative partnership with a unique team from the University Hospital Tuebingen to gain further insights into the effects of L-DOS47 on the tumor microenvironment and pH modulation in vivo. In addition, the collaboration also explores the potential for designing novel LDOS47-based radiotracers with application in translational immune-oncology and molecular imaging.

Mr. Artur Gabor, CEO of Helix, commented, "We are excited to collaborate with the University Hospital of Tuebingen and especially the Medical Faculty, which have relevant experience and knowledge in molecular imaging, particularly the method of AcidoCEST, which makes pH changes in the tumor microenvironment visible through a color change. We expect this collaboration to result in new and additional insight into the therapeutic response of L-DOS47 in several not yet explored preclinical cancer models expressing CEACAM6."

Prof. André F. Martins (Ph.D., Department of Preclinical Imaging and Radiopharmacy) and Manfred Kneilling (MD, Department of Preclinical Imaging and Radiopharmacy & Department of Dermatology) of the University of Tuebingen said, "We are pleased to work with Helix on this exciting project. Our technological advances combined with Helix’ L-DOS47, which has already shown promising preclinical and clinical safety data, will allow us to gain further insights into its unique mechanism of action. L-DOS47 might be in combination with immune check point inhibitor-based immunotherapies and other targeted therapies applicable to promote tumors regression and thus to improve the treatment efficacy and hopefully long-term survival." Prof. Martins and Kneilling are members of the "Image-Guided and Functionally Instructed Tumor Therapies" (iFIT) Cluster of Excellence at the University of Tuebingen. iFIT is the only oncology-based cluster in Germany, a research consortium aiming to develop innovative and sustainable cancer therapies.

Eagle Pharmaceuticals has filed a 10-Q – Quarterly report [Sections 13 or 15(d)] with the U.S. Securities and Exchange Commission .

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Exelixis has filed a 10-Q – Quarterly report [Sections 13 or 15(d)] with the U.S. Securities and Exchange Commission .

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Heron Therapeutics has filed a 10-Q – Quarterly report [Sections 13 or 15(d)] with the U.S. Securities and Exchange Commission .

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On August 9, 2022, Caribou Biosciences, Inc., a Delaware corporation (the "Company"), reported that entered into an Open Market Sale AgreementSM (the "Sales Agreement") with Jefferies LLC ("Jefferies") with respect to an "at the market offering" program, under which the Company may, from time to time, in its sole discretion, issue and sell through Jefferies, acting as sales agent, up to $100.0 million of the Company’s shares of common stock, par value $0.0001 per share (the "Shares") (Filing, 8-K, Caribou Biosciences, AUG 9, 2022, View Source [SID1234618252]).

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The issuance and sale, if any, of the Shares by the Company under the Sales Agreement is subject to the effectiveness of the Company’s registration statement on Form S-3 (File No. 333-266712) (the "Registration Statement"), filed with the Securities and Exchange Commission on August 9, 2022.

Pursuant to the Sales Agreement, Jefferies may sell the Shares by any method permitted by law deemed to be an "at the market offering" as defined in Rule 415(a)(4) of the Securities Act of 1933, as amended (the "Securities Act"). Jefferies will use commercially reasonable efforts consistent with its normal sales and trading practices to sell the Shares from time to time, based upon instructions from the Company (including any price or size limits or other customary parameters or conditions the Company may impose).

The Company will pay Jefferies a commission equal to 3.0% of the aggregate gross proceeds of any Shares sold through Jefferies pursuant to the Sales Agreement.

The Company is not obligated to sell any Shares under the Sales Agreement. The offering of the Shares pursuant to the Sales Agreement will terminate upon the earlier to occur of (i) the sale of all Shares subject to the Sales Agreement and (ii) the termination of the Sales Agreement as permitted therein.

The Sales Agreement contains representations, warranties, and covenants that are customary for transactions of this type. In addition, the Company has agreed to indemnify Jefferies against certain civil liabilities, including liabilities under the Securities Act.

The foregoing description of the Sales Agreement is not complete and is qualified in its entirety by reference to the full text of the Sales Agreement, a copy of which is filed as Exhibit 10.1 to this Current Report on Form 8-K and is incorporated herein by reference.

This Current Report on Form 8-K shall not constitute an offer to sell or the solicitation of an offer to buy the securities discussed herein, nor shall there be any offer, solicitation, or sale of the securities in any jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction.