On March 13, 2023 On March 7th, 2023, Suzhou Porton Advanced Solutions Ltd. (Porton Advanced) and Bennu Biotherapeutics (Bennubio) reported a strategic partnership to advance cell and gene therapy R&D pipelines (Press release, Porton Advanced Solutions, MAR 13, 2023, View Source [SID1234628602]). The partnership aims to accelerate the development of T-cell therapies for tumors and autoimmune diseases.

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As an end-to-end gene and cell therapy service CDMO, Porton Advanced provides comprehensive solutions covering plasmids, cell therapy, gene therapy, oncolytic virus, mRNA therapy, and bacterial therapy. Bennu Biotherapeutics is focused on developing T-cell therapies to address T-cell exhaustion, offering TIL, TCR-T, and Treg therapy for solid tumors and autoimmune diseases. Under this strategic agreement, Porton Advanced will provide CDMO services for multiple pipelines for gene and cell therapy, including plasmids, virus, TIL, TCR-T, and Treg, to Bennu Biotherapeutics.

"We are pleased to collaborate with Bennu Biotherapeutics, which focuses on the development of innovative therapies for tumors and autoimmune diseases. Through our end-to-end Cell and Gene Therapy CDMO, Porton Advanced aims to help Bennu Biotherapeutics develop multiple pipelines for cell therapy products, accelerate the development of innovative drugs such as TIL, and bring these beneficial drugs to market as soon as possible," said Dr. Yangzhou Wang, CEO of Proton Advanced.

Ms. Zhao Ping, Co-founder and CEO of Bennu Biotherapeutics, said, "We can advance our process development and production by utilizing the advanced process development technologies provided by Porton Advanced. Through this strategic cooperation, we can accelerate the development of our process development platforms, enhancing our strength and market competitiveness. Both companies will continue to explore and innovate, giving full play to their advantages and making the biotechnology industry prosper in rapid development."

On March 13, 2023 Combined Therapeutics Inc. (CTx), a privately held biotechnology company developing the next generation of mRNA therapeutics with a novel modified-mRNA platform to prevent infectious diseases and treat cancer, reported its intellectual property position reinforcement in mRNA vaccine technology with the issue of U.S. Patent 11,596,685 by the United States Patent and Trademark Office (USPTO) on March 7, 2023 (Press release, Combined Therapeutics, MAR 13, 2023, View Source [SID1234628601]).

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This patent recognizes significant innovative research and development advances by Combined Therapeutics in the mRNA vaccine field and covers its vaccine compositions which include its proprietary mRNA MOPCTx (Multi-Organ Protection) technology to deliver viral or bacterial antigens in combination with a panel of molecular adjuvants. These mRNA-expressed antigens and adjuvants together are formulated in a delivery vehicle and can be used to develop both preventive as well as therapeutic vaccines against serious infectious diseases and cancer.

"We are still only at the beginning of where our mRNA platform can take us in our efforts to further optimize global mRNA vaccine safety and efficacy," said Romain Micol, M.D., MPH, Ph.D., the company’s president, chief executive officer and co-founder. "This recognition of our scientific advancements supports our development of next-generation mRNA medicines and strengthens our position as a leading innovator in vaccine technology."

As made evident by the recent pandemic, the world is increasingly in need of affordable, safe, and effective vaccines. CTx’s MOP technology offers a flexible mRNA platform that can be engineered to meet specific vaccine needs and demands. This platform allows vaccine antigen expression at the site of injection, where it is needed, while restricting expression in key organs such as the heart, liver, and kidney. Additionally, when combined with a molecular adjuvant, the CTx mRNA platform enhances several critical vaccine immunogenicity parameters including extending the duration of immunity, decreasing the needed vaccine dose and improving the protection of vulnerable populations.

On March 13, 2023 Liminal BioSciences Inc. (Nasdaq: LMNL) ("Liminal BioSciences" or the "Company"), reported that it plans to report its fourth quarter and year ended 2022 financial results after market close on Wednesday March 15, 2023 (Press release, Liminal BioSciences, MAR 13, 2023, View Source,-2023 [SID1234628599]). Liminal will host a conference call and webcast to discuss financial results at 8:30 am (ET) on Thursday March 16, 2023.

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To join the conference call without operator assistance, you may register and enter your phone number at https://bit.ly/3FeNJBk to receive an instant automated call back. You can also dial direct to be entered to the call by an Operator by dialing 416-764-8609 and 888-390-0605, using the following passcode: 77593817. An audio replay of the call will be available as of Thursday March 16, 2023 at 11:30 am (ET). The numbers to access the audio replay are 416-764-8677 and 1-888-390-0541 using the following password (593817 #). A live audio webcast of the conference call will be available by clicking here.

On March 13, 2023 ProMIS Neurosciences Inc. (TSX: PMN) (Nasdaq: PMN), a biotechnology company focused on the generation and development of antibody therapeutics targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA), reported an oral presentation and two onsite poster presentations at the upcoming American Academy of Neurology (AAN) Annual Meeting, which will be held on April 22-27, 2023 in Boston, MA (Press release, ProMIS Neurosciences, MAR 13, 2023, View Source [SID1234628598]). The presentations highlight ProMIS’ broad pipeline of next-generation neurodegenerative disease therapeutics, including data that further characterize lead drug AD candidate, PMN310, as well as preclinical optimization studies of an Alzheimer’s vaccine and data supporting RACK1 as a potential target in amyotrophic lateral sclerosis (ALS).

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Oral Presentation:

Title: Rational Design of a Vaccine for Alzheimer’s Disease Using Computationally-Derived Conformational B Cell Epitopes to Selectively Target Toxic Amyloid-Beta Oligomers
Session: S26: Experimental Therapeutics in Dementia (abstract #4532)
Presenter: Dr. Johanne Kaplan
Date & Time: April 25, 2023 at 1:36 p.m. ET

Poster Presentations:

Title: Protection Against Toxic Amyloid-Beta Oligomers by PMN310, a Monoclonal Antibody Rationally Designed for Greater Therapeutic Potency in Alzheimer’s Disease
Session: P1: Aging and Dementia: Basic Science (abstract #4597)
Presenter: Dr. Johanne Kaplan
Date & Time: April 23, 2023 from 8:00 – 9:00 a.m. ET

Title: RACK1 Knockdown Is a Potential Therapeutic Target in ALS and FTLD-TDP
Session: P1: Aging and Dementia: Basic Science (abstract #3494)
Presenter: Dr. Neil Cashman
Date & Time: April 23, 2023 from 8:00 – 9:00 a.m. ET

On March 13, 2023 DiaMedica Therapeutics Inc. (Nasdaq: DMAC), a clinical-stage biopharmaceutical company focused on developing novel treatments for neurological disorders and kidney diseases, reported that Rick Pauls, its President and CEO will present a corporate overview at the virtual Oppenheimer 33rd Annual Healthcare Conference, which will take place March 13th – 15th, 2023 (Press release, DiaMedica, MAR 13, 2023, View Source [SID1234628597]).

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Mr. Pauls is scheduled to present at 2:40 p.m. Eastern Time on Wednesday, March 15, 2023. In addition to the presentation, Mr. Pauls will be available for one-on-one investor meetings throughout the conference. Investors that are interested in arranging a meeting should contact their Oppenheimer representative.