On March 7, 2023 Nuvo Pharmaceuticals Inc. d/b/a Miravo Healthcare (TSX:MRV; OTCQX:MRVFF) ("Miravo" or the "Company") reported that, at today’s special meeting of shareholders (the "Meeting"), its shareholders ("Shareholders") voted in favour of a special resolution to approve the previously announced plan of arrangement (the "Arrangement") pursuant to which, among other things, Searchlight Pharma Inc. (the "Purchaser") will acquire all of the issued and outstanding shares of the Company (the "Company Shares") in exchange for cash consideration of $1.35 per Company Share, subject to the terms and conditions of an arrangement agreement dated December 22, 2022 (Press release, Nuvo Pharmaceuticals, MAR 7, 2023, View Source [SID1234628267]).

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The Arrangement required approval by: (i) at least two-thirds of the votes cast by Shareholders present in person (virtually) or represented by proxy at the Meeting; and (ii) a simple majority of the votes cast by Shareholders present in person (virtually) or represented by proxy at the Meeting, excluding the votes cast by persons described in items (a) through (d) of Section 8.1(2) of Multilateral Instrument 61-101 – Protection of Minority Security Holders in Special Transactions ("MI 61-101").

Of the votes cast with respect to the Arrangement, an aggregate of 4,160,856 Company Shares were voted in favour of the Arrangement, representing approximately 89.23% of the votes cast on the resolution. In addition, an aggregate of 3,547,374 Company Shares, representing approximately 87.60% of the votes cast on the resolution excluding votes attached to Company Shares held by persons described in items (a) through (d) of Section 8.1(2) of MI 61-101, were voted in favour of the Arrangement.

Completion of the Arrangement remains subject to court approval as well as other customary closing conditions. It is expected that the Company will apply for a final order of the Ontario Superior Court of Justice (Commercial List) approving the Arrangement on March 10, 2023. Assuming that the conditions to closing are satisfied or waived, it is expected that the Arrangement will be completed on or around March 14, 2023. Following completion of the Arrangement, The Company will be de-listed from the TSX and applications will be made for the Company to cease to be a reporting issuer.

Further information about the Arrangement is set forth in the materials prepared by the Company in respect of the Meeting, which were mailed to Shareholders and filed under the Company’s profile on SEDAR at www.sedar.com.

On March 7, 2023 2seventy bio reported presenting its corporate presentation (Presentation, 2seventy bio, MAR 7, 2023, View Source [SID1234628266]).

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On March 7, 2023 Tasly Pharmaceuticals, Inc. (Tasly U.S.), "dedicated to a healthier world," reported that it will participate in the Trade Winds ASEAN Mission and Business Forum March 13-15 in Bangkok, Thailand (Press release, Tasly Pharmaceuticals, MAR 7, 2023, View Source [SID1234628263]).

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The Trade Winds event, organized by the U.S. Commercial Service (part of the U.S. Department of Commerce), is the largest U.S. government-led trade mission and business development forum. It will feature meetings with U.S. commercial diplomats and business representatives from more than 20 Asian countries, as well as opportunities for networking and dialogue.

Tasly U.S., whose vision is "to change the way the world takes and understands medicine," will discuss its development of T89 (Dantonic), which has become the first herbal medicine-derived compound to complete a U.S. Food and Drug Administration Phase III global clinical trial, with promising data.

"Tasly U.S. is positioned to become a world-renowned innovator in pharmaceuticals, biologics, and nutraceuticals," said Dr. He Sun, President and CEO of Tasly Pharmaceuticals, Inc. "We see the upcoming Trade Winds ASEAN Mission and Business Forum in Bangkok as an opportunity to introduce our capabilities, our products in development, and our unique perspective, to leading companies in the ASEAN region."

In addition to presenting and discussing its products, used in the treatment of cardiovascular disease, non-alcoholic fatty liver disease (NAFLD), Tourette Syndrome, and others, Dr. Sun said Tasly U.S. looks forward to discussing business collaboration and drug co-development with other Trade Winds exhibitors and participants.

Trade Winds ASEAN Mission and Business Forum will take place at the Anatara and Avani Riverside Hotel in Bangkok March 13-15 from approximately 8:00 a.m. until 8:30 p.m. each day.

On March 7, 2023 Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage oncology company developing targeted therapies for RAS-addicted cancers, reported the closing of its underwritten public offering of 15,681,818 shares of common stock at a public offering price of $22.00 per share, before underwriting discounts and commissions (Press release, Revolution Medicines, MAR 7, 2023, View Source [SID1234628262]). The shares of common stock issued and sold in the offering include 2,045,454 shares issued upon exercise in full by the underwriters of their option to purchase additional shares of common stock at the public offering price, less underwriting discounts and commissions. The gross proceeds from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by Revolution Medicines, were $345.0 million. All shares in the offering were offered by Revolution Medicines.

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J.P. Morgan, TD Cowen, SVB Securities and Guggenheim Securities acted as the joint book-running managers for the offering. UBS Investment Bank acted as lead manager.

A shelf registration statement relating to these securities was filed with the U.S. Securities and Exchange Commission (SEC) on March 2, 2021, and automatically became effective upon filing. This offering was made solely by means of a prospectus. A copy of the final prospectus supplement and the accompanying prospectus relating to this offering may be obtained for free by visiting EDGAR on the SEC’s website at www.sec.gov. Alternatively, a copy of the final prospectus supplement and the accompanying prospectus relating to this offering may be obtained by contacting: J.P. Morgan Securities LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, by telephone at (866) 803-9204 or by email at [email protected]; Cowen and Company, LLC, 599 Lexington Avenue, New York, NY 10022, by email at [email protected] or by telephone at (833) 297-2926; SVB Securities LLC, 53 State Street, 40th Floor, Boston, MA 02109, Attention: Syndicate Department, by telephone at (800) 808-7525, ext. 6105, or by email at [email protected]; or: Guggenheim Securities, LLC Attention: Equity Syndicate Department, 330 Madison Avenue, New York, NY 10017 or by telephone at (212) 518-9544, or by email at [email protected]

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

On March 7, 2023 NanOlogy LLC, a clinical-stage oncology company, reported issuance of a US patent titled: Local Delivery of Antineoplastic Particles in Combination with Systemic Delivery of Immunotherapeutic Agents for the Treatment of Cancer (Press release, NanOlogy, MAR 7, 2023, View Source;utm_medium=rss&utm_campaign=nanology-granted-a-us-patent-for-its-investigational-drugs-in-combination-with-immune-checkpoint-inhibitors-in-the-treatment-of-cancer [SID1234628261]). The patent (11,583,499) is valid in the US until November 25, 2038, and has corresponding filings globally. It adds to an extensive global intellectual property portfolio of more than 250 issued or filed patents covering composition, formulation, use, and technology.

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The new patent covers a method of treating cancer by intratumoral administration of large surface area microparticle (LSAM) taxanes in combination with systemic administration of immune checkpoint inhibitors (ICIs).

ICIs are often used in combination with other systemic cancer therapies particularly in the treatment of solid tumors to prime the immune system to increase response. A growing body of preclinical and clinical data demonstrate local and systemic immunomodulation following local delivery of NanOlogy’s LSAM investigational drugs together with outside research pointing to the value of treating the primary tumor in neoadjuvant, locally advanced, and metastatic settings to improve clinical outcomes.

"The Cancer Research Institute estimates more than 5000 clinical trials are underway worldwide with immune checkpoint inhibitors; many are combination trials with other systemic cancer agents in solid tumors." said Gere DiZerega, MD, NanOlogy Chief Medical Officer. "The goal is to identify which combinations can increase the immune response thereby increasing the overall solid tumor response to treatment. Unfortunately, a key challenge is the stacking of severe toxicities that can occur when multiple systemic therapies are used in combination."

"With this patent added to our portfolio, NanOlogy is in a strong position to further investigate clinically whether the combination of its local LSAM investigational drugs with systemic ICIs increases response without adding toxicity as suggested in our preclinical and early clinical research", added Marc Iacobucci, a Managing Director for NanOlogy. "Our goal is to improve cancer treatment and potentially offer a strategy for product lifecycle extension for ICIs when used in combination with our drugs."

In all, NanOlogy clinical programs have advanced tumor directed LSAM investigational drugs in multiple solid tumors including pancreas, lung, bladder, peritoneal, ovarian, prostate, and dermal cancers. More than 170 patients have been treated to date across its clinical trials with signals of tumor and immune response and no confirmed drug-related serious adverse events.