Philogen to attend 19th EADO Congress on April 20-22, 2023

On March 16, 2023 Philogen reported that it will attend 19th EADO Congress on April 20-22, 2023 (Press release, Philogen, MAR 16, 2023, View Source [SID1234628940]).

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Dr. Covelli (CMO), Dr. Elia, Dr. Ravenni, and Dr. Nadal will participate at the event in Rome.

The dermato-oncology team from St. Gallen will give a presentation entitled "Intralesional administration of L19IL2/L19TNF in difficult-to-treat BCC patients shows favorable safety profile and leads to complete remission of tumor lesions"

Moreover, Prof. Dario Neri, CEO and CSO of Philogen, is giving a presentation on the 21st of April 2023 entitled "Innovative targeted therapies in Oncology and beyond".

Philogen to attend AACR Annual Meeting in Orlando on April 14-18, 2023

On March 16, 2023 Philogen reported that it will attend AACR (Free AACR Whitepaper) Annual Meeting in Orlando on April 14-18, 2023 (Press release, Philogen, MAR 16, 2023, View Source [SID1234628939]).

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Prof. Dr. Dario Neri (CEO and CSO), Dr. Covelli (CMO), Dr. Dakhel, Dr. De Luca, Dr. Cazzamalli, Dr. Galbiati, Dr. Puca, Matilde Bocci, Eleonora Prodi, Sara Puglioli, Giulia Rotta and Aureliano Zana will participate at the event.

Moreover, the following abstracts have been accepted as Poster Presentations:

Dr. Galbiati – Tumor-targeted interleukin-2 enhances the anti-cancer activity of multivalent OncoFAP radioligand therapeutics

Eleonora Prodi – Tripokin: potential best-in-class for tumor targeted interleukin-2 (IL2) potentiated by tumor necrosis factor (TNF)

Matilde Bocci – Delivery of cytotoxic camptothecin derivatives to tumors by OncoFAP-based Small Molecule-Drug Conjugates

Sara Puglioli – DNA-encoded affinity maturation libraries enable the discovery of low picomolar Fibroblast Activation Protein inhibitors suitable for radioligand therapy of solid tumors

Aureliano Zana – FAP-targeted non-internalizing drug conjugates: a comparative evaluation between small molecules, antibodies and peptides

Giulia Rotta – Decreasing toxicity of immunocytokines by transient and selective inhibition of their intracellular signaling activation.

ASX Health Stocks: High fives as Telix gets expanded FDA approval, Prescient’s PTX-100 returns good results

On March 16, 2023 Telix Pharma (ASX:TLX) reported the US FDA has approved a supplementary New Drug Application (sNDA) for Illuccix, a kit for the preparation of gallium Ga 68 gozetotide injection (Press release, Prescient Therapeutics, MAR 16, 2023, View Source;utm_medium=rss&utm_campaign=asx-health-stocks-high-fives-as-telix-gets-expanded-fda-approval-prescients-ptx-100-returns-good-results [SID1234628938]).

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The approval was this time given for the use of Illuccix on patients with metastatic prostate cancer, for whom lutetium-177 (177Lu) PSMA-directed therapy is indicated.

To qualify for radioligand therapy, the FDA said patients must be imaged with an approved gallium-based PSMA-PET agent.

This expansion means Illuccix can now be used in the US to identify and select patients who are candidates for the only FDA-approved prostate-specific membrane antigen (PSMA)-directed radioligand therapy (Pluvicto).

It is estimated that 32,000 patients per year in the US may be considered for PSMA-directed radioligand therapy.

Efficacy for Prescient’s PTX-100
Prescient Therapeutics’ (ASX:PTX) Phase 1b clinical trial of PTX-100 in relapsed and refractory T cell lymphomas (TCL) continues to show encouraging results.

The study has demonstrated several clinical responses, including two patients with relapsed and refractory peripheral TCL (PTCL) that have had complete responses (complete eradication of cancer) since the prior update in November.

These responses are not generally expected in this disease.

Although the primary goal of the study is to evaluate safety, PTX-100 continues to exhibit encouraging clinical activity in the difficult-to-treat patient population, especially when considered against responses expected from current standards of care.

Meanwhile, PTX-100 also continues to exhibit good safety profile at the highest dose of 2000 mg/m2, with very few serious adverse events.

The study is being led by globally renowned haematologist, Professor H. Miles Prince, at Epworth Hospital in Melbourne.

Other notable ASX healthcare news today
Lumos Diagnostics (ASX: LDX) announced that it has entered into three new agreements with US-based women’s healthcare company Hologic that will provide Lumos with up to US$5.9 million in total in non-dilutive funding.

This includes $4.2m from the sale and leaseback agreement for some of Lumos’ capital equipment, and $1.7m from additional work on existing projects.

Incannex (ASX:IHL) says it plans to commercialise its psychedelic clinics business in collaborative partnership with leading psychedelic experts.

The company plans to open multiple psychedelic-assisted psychotherapy clinics in Australia and overseas, with the first clinic opening in Melbourne in 2023.

Propanc Biopharma Confirms PRP Exerts Significant Effects Against Chemoresistant Pancreatic Tumor Cells

On March 16, 2023 Propanc Biopharma, Inc. (OTC Pink: PPCB) ("Propanc" or the "Company"), a biopharmaceutical company developing novel cancer treatments for patients suffering from recurring and metastatic cancer, reported that PRP exerts significant effects against chemoresistant pancreatic tumor cells, as reported by one of the Company’s joint researchers, Mrs. Belén Toledo Cutillas MSc, at the laboratory of Professor Macarena Perán, PhD, University of Jaén, Granada, Spain (Press release, Propanc, MAR 16, 2023, View Source [SID1234628937]).

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Laboratory studies by qPCR (quantitative polymerase chain reaction), along with western and immunofluorescence analyses, confirm downregulation of chemoresistant genes expression in chemoresistant tumor cells treated with PRP, compared with tumor cells and untreated chemoresistant tumor cells as experimental controls. Mrs. Cutillas believes the results are "fantastic" and corroborate her research into the effects of PRP as a chemosensitizing agent against pancreatic cancer, and the influence of PRP on the tumor microenvironment.

Dr Julian Kenyon, MD, MB, ChB, Propanc’s Chief Scientific Officer said, "Resistance to standard chemotherapy is a significant problem for pancreatic cancer sufferers with a poor prognosis. The work undertaken with our joint research partners confirms PRP effects the tumor microenvironment and suppresses chemoresistant genes in pancreatic tumor cells. This means not only can PRP prevent tumor formation, which leads to drug resistance, but also it alters the signaling pathways to eliminate this possibility. PRP is a unique approach because, rather than inhibiting a specific gene target, it re-educates these cells to overcome tumor resistance. This could have tremendous implications for PRP as a chemosensitizer agent with standard treatment approaches to generate better clinical outcomes for pancreatic cancer patients. We look forward to working with our joint research partners to better understand these applications for PRP as we advance towards Phase I and II clinical studies."

PRP is a mixture of two proenzymes, trypsinogen and chymotrypsinogen from bovine pancreas, administered by intravenous injection. A synergistic ratio of 1:6 inhibits growth of most tumor cells. Examples include kidney, ovarian, breast, brain, prostate, colorectal, lung, liver, uterine, and skin cancers.

Quest Diagnostics to Discuss Strategic Priorities to Drive Growth and Create Shareholder Value at 2023 Investor Day

On March 16, 2023 Quest Diagnostics reported at a meeting with analysts and investors at its Investor Day, members of the executive leadership team of Quest Diagnostics Incorporated (NYSE: DGX), the world’s leading provider of diagnostic information services, will discuss the company’s priorities to grow revenues and create shareholder value (Press release, Quest Diagnostics, MAR 16, 2023, View Source [SID1234628936]). The company is also updating its long-term financial outlook to extend from 2023 through 2026.

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Quest Diagnostics Incorporated logo. (PRNewsFoto/Quest Diagnostics Incorporated)

"We have made refinements to our strategy to accelerate growth from our physician and hospital customers, and are building strong platforms to win in the important areas of molecular genomics and oncology as well as consumer health," said Jim Davis, CEO and President. "In addition, we have a range of initiatives underway to continue to drive operational productivity while further improving the customer experience. For the 2023 through 2026 period, we expect to generate revenues at a mid single-digit CAGR and adjusted EPS at a high single-digit CAGR."

At the meeting, members of the company’s executive leadership team will highlight strategic initiatives underway to drive growth, including:

Building on the company’s strong position in physician lab services by partnering with health plans as well as expanding value-based care and retail relationships;
Achieving growth with hospitals by expanding reference capabilities, enhancing Professional Lab Services offerings and acquiring outreach laboratory testing services;
Growing in the consumer health market through direct sales, menu expansion and partnerships;
Increasing share in advanced diagnostics through ongoing investments in molecular genomics and oncology; and
Delivering 3% annual savings and productivity improvements by executing the company’s Invigorate program, which includes leveraging automation and artificial intelligence, reducing denials and write-offs, enhancing the digital experience, and selecting and retaining talent.
The company will also discuss its capital deployment strategy at the meeting.

Mr. Davis continued: "Quest’s nearly 50,000 employees are united by our common purpose, which is: Working together to create a healthier world, one life at a time. They certainly brought our purpose to life during the pandemic and live it every day. Inspired by our employees, we recently introduced this new purpose, which serves as a compass for our business strategy evolution, growth and culture."

Guidance for Full Year 2023

The Company’s guidance for 2023 remains unchanged as follows:

Low

High

Net revenues

$8.83 billion

$9.03 billion

Net revenues decrease

(10.7) %

(8.6) %

Base business revenues (a)

$8.65 billion

$8.75 billion

Base business revenues increase

2.6 %

3.8 %

COVID-19 testing revenues

$175 million

$275 million

COVID-19 testing revenues decrease

(88.0) %

(81.1) %

Reported diluted EPS

$7.61

$8.21

Adjusted diluted EPS

$8.40

$9.00

Cash provided by operations

At least $1.3 billion

Capital expenditures

Approximately $400 million

(a) excludes COVID-19 testing

The additional table attached below includes reconciliations of non-GAAP adjusted measures to GAAP measures.

*Note on Non-GAAP Financial Measures
As used in this press release the term "reported" refers to measures under accounting principles generally accepted in the United States ("GAAP"). The term "adjusted" refers to non-GAAP operating performance measures that exclude special items such as restructuring and integration charges, amortization expense, and excess tax benefits ("ETB") associated with stock-based compensation.

The company has provided a compound annual growth rate projection for 2023 to 2026 of high single-digits for adjusted diluted EPS, which is a non-GAAP measure. The company is unable to present a reconciliation of adjusted diluted EPS to reported diluted EPS, the most comparable GAAP measure due to the inherent uncertainty and variability in the nature and amount of special items referenced above, and the amount of these items could be significant in any of the associated periods.

Non-GAAP adjusted measures are presented because management believes those measures are useful adjuncts to GAAP results. Non-GAAP adjusted measures should not be considered as an alternative to the corresponding measures determined under GAAP. Management may use these non-GAAP measures to evaluate our performance period over period and relative to competitors, to analyze the underlying trends in our business, to establish operational budgets and forecasts and for incentive compensation purposes. We believe that these non-GAAP measures are useful to investors and analysts to evaluate our performance period over period and relative to competitors, as well as to analyze the underlying trends in our business and to assess our performance.

Participating in Investor Day

Advance registration is required. To register for the event, please go to: Quest Diagnostics Investor Day 2023 Registration.

A live webcast of the event will be broadcast on the Quest Diagnostics Investor Relations website.

A copy of the presentation materials discussed at the meeting and an archived copy of the webcast will be available on the Quest Diagnostics Investor Relations website.