Synlogic to Present at the Jefferies Global Healthcare Conference

On May 23, 2023 Synlogic, Inc. (Nasdaq: SYBX), the leading company advancing therapeutics based on synthetic biology, reported that Aoife Brennan, M.B. Ch.B., President and Chief Executive Officer, will present at the Jefferies Global Healthcare Conference being held in New York, NY, June 7-9, 2023 (Press release, Synlogic, MAY 23, 2023, View Source [SID1234631970]).

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Presentation Details:

Wednesday, June 7, 2023
2:00-2:25 PM EDT (Track 2)
To access the webcast of the presentation, please click here
A replay of the presentation will be available for 90 days. Recorded presentations, if available, can be found on the Archived Events section of the Synlogic website.

Entry into a Material Definitive Agreement

On May 23, 2023, Sensei Biotherapeutics, Inc. (the "Company") reported to have entered into a Purchase Agreement (the "Purchase Agreement") with Apeiron Investment Group Ltd., Presight Sensei Co-Invest Fund, L.P., Presight Sensei Co-Invest Management, L.L.C., Christian Angermayer, Apeiron SICAV Ltd. – Presight Capital Fund ONE, and Altarius Asset Management Ltd. (collectively, the "Apeiron Parties") (Filing, Sensei Biotherapeutics, MAY 23, 2023, View Source [SID1234631969]).

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Pursuant to the Purchase Agreement, the Company has agreed to purchase 4,454,248 shares of the Company’s common stock (the "Purchased Shares") from certain of the Apeiron Parties (the "Sellers") for a purchase price of $1.58 per share. The Purchased Shares constitute the Apeiron Parties’ entire beneficial ownership of the Company’s common stock.

Apeiron Investment Group Ltd. has also agreed to withdraw its notice of intent to nominate director candidates for election to the Company’s Board of Directors (the "Board") at the 2023 annual meeting of stockholders, effective upon the closing of the purchase of the Purchased Shares (the "Closing").

This share repurchase does not alter the Company’s previously disclosed realigned cost structure or its estimated cash runway into the second half of 2025. By avoiding a proxy contest, the Company has kept its focus on its multiple anticipated near-term clinical and preclinical milestones as it makes progress towards the development of next-generation cancer therapeutics, including its lead candidate, SNS-101, for which the Company is planning to initiate a Phase 1/2 clinical study in mid-2023.

The Closing is subject to the fulfillment or waiver of certain conditions set forth in the Purchase Agreement, including (i) no injunction or other order, judgment, law, regulation, decree or ruling or other legal restraint or prohibition having been issued, enacted or promulgated by a court or other governmental or regulatory authority of competent jurisdiction that would have the effect of prohibiting or preventing the consummation of the transactions contemplated in the Purchase Agreement; (ii) the representations and warranties of the Company or the Sellers, as applicable, set forth in the Purchase Agreement being true and correct as of the date of the Purchase Agreement and as of the date of Closing; and (iii) the Company or the Sellers, as applicable, having timely performed in all material respects all of its or their obligations under the Purchase Agreement required to be performed by it or them prior to or at the Closing.

The Purchase Agreement further provides, among other things, that:


Each Apeiron Party will vote, and will cause all of its controlling or controlled affiliates and associates to vote, all of its or their shares of the Company’s common stock at all annual and special meetings of stockholders, as well as in any consent solicitations of the Company’s stockholders, in each case to the extent still beneficially owned by such persons as of the applicable record date, in accordance with the Board’s recommendations, subject to certain exceptions relating to the recommendations of Institutional Shareholder Services, Inc. and Glass Lewis & Co., LLC and proposals in respect of any extraordinary transaction.


The Apeiron Parties are subject to customary standstill restrictions including, among other things, with respect to nominating persons for election to the Board, submitting any stockholder proposal for consideration at any stockholder meeting, soliciting any proxies, conducting any "withhold" or similar campaign and acquiring any additional shares of the Company’s voting securities or any of the Company’s indebtedness.


Each party agrees not to make public statements that constitute an ad hominem attack on, or disparage, defame, slander or are reasonably likely to damage the reputation of the other party, subject to certain exceptions.


Each party agrees not to threaten, institute, solicit, join, or knowingly encourage or assist a lawsuit against the other party, subject to certain exceptions.


The Purchase Agreement will remain in effect until the date that is the earlier of (i) four years from the date of the Purchase Agreement and (ii) 30 days prior to the nomination deadline for the nomination of director candidates for election to the Company’s Board at the Company’s 2027 annual meeting of stockholders. In addition, certain obligations of each party will terminate upon an uncured material breach of certain provisions of the Purchase Agreement by the other party.

The foregoing summary of the Purchase Agreement does not purport to be complete and is subject to, and qualified in its entirety by, the full text of the Purchase Agreement, which is attached as Exhibit 10.1 to this Current Report on Form 8-K and is incorporated herein by reference.

Propanc Biopharma’s Intellectual Property Portfolio Achieves Significant Milestones in North America

On May 23, 2023 Propanc Biopharma, Inc. (OTC Pink: PPCB) ("Propanc" or the "Company"), a biopharmaceutical company developing novel cancer treatments for patients suffering from recurring and metastatic cancer, reported that the Company’s intellectual property (IP) portfolio achieved significant milestones in North America (Press release, Propanc, MAY 23, 2023, View Source [SID1234631968]). The foundation patent, covering composition claims for the Company’s lead product candidate, PRP, received a notice of allowance from the Canadian Intellectual Property Office (CIPO). In further news, the Company’s method to treat cancer stem cells (CSCs) using PRP was granted a patent by the United States Patent and Trademark Office (USPTO). This is the third patent granted to the Company in the US, with further applications under examination by the USPTO.

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The Canadian foundation patent is the final application in the Company’s foundation patent family to achieve allowance. This means that allowance or grant status has been secured in every jurisdiction in which the Company filed a foundation patent application. Propanc has an accepted application or achieved grant status for the foundation patent in over 30 different countries across North America, Europe, Asia, the Middle East and Japan.

For the US granted CSCs patent, the claims cover a method to minimize the progression of cancer in a patient who has already received a first line treatment by detecting the presence of CSCs followed by administering PRP. This patent describes the clinical application of PRP when the patient experiences a relapse and the cancer returns after primary standard of care has been applied.

"The milestones achieved for our intellectual property portfolio in North America are highly significant, as we now have patents in force in every jurisdiction selected by the Company for future commercialization of PRP," said James Nathanielsz, BAS, MEI, Propanc’s Chief Executive Officer. "This represents perseverance and 15 years of hard work to reach a stage where we have established our IP portfolio. Our technology is a novel approach for the treatment and prevention of metastatic cancer from solid tumors, which is the leading cause of death for sufferers. Our therapy is free from side effects normally associated with standard treatment approaches, based off our limited clinical experience from treatment. We look forward to advancing PRP to a First-In-Human study in advanced cancer patients to further establish the benefits of this first-in-class treatment."

Dr Julian Kenyon, MD, MB, ChB, Propanc’s Chief Scientific Officer, said, "More than 15 years ago, we determined to find a way to patent this unique treatment approach for cancer sufferers based on an initial investigation at my clinical practice. I believe PRP can become an important treatment approach to control the spread of solid tumors by targeting CSCs. We are very interested in possible clinical applications of PRP, such as treating resistant tumors post standard therapy, or as a chemo-sensitizing agent. We expect to continue to grow and expand our intellectual property portfolio whilst advancing PRP into the clinic to establish proof of concept in a target patient population, and identify a suitable partner for licensing."

PRP is a mixture of two proenzymes, trypsinogen and chymotrypsinogen from bovine pancreas, administered by intravenous injection. A synergistic ratio of 1:6 inhibits growth of most tumor cells. Examples include kidney, ovarian, breast, brain, prostate, colorectal, lung, liver, uterine, and skin cancers.

OnKure Therapeutics Announces $54 Million Series C Financing

On May 23, 2023 OnKure, Inc. a precision oncology company, reported that it has successfully closed a $54 million Series C financing (Press release, OnKure, MAY 23, 2023, View Source;utm_medium=rss&utm_campaign=onkure-therapeutics-announces-54-million-series-c-financing [SID1234631967]). The financing was led by Surveyor Capital (a Citadel company) with participation from new investor Deep Track Capital, as well as existing investors Acorn Bioventures, Cormorant Asset Management, Perceptive Advisors, Samsara BioCapital, funds and accounts managed by BlackRock, and other undisclosed investors.

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Proceeds from the financing will be used to support the continued development of OnKure’s differentiated pipeline of next generation precision medicines, including the advancement of its lead discovery program OKI-219, a selective PI3K alpha H1047R inhibitor, into the clinic.

"We are delighted to be working with our new and existing investors to achieve our vision of developing the next generation of tumor-agnostic, oncology precision medicines," said Tony Piscopio, Ph.D., Co-Founder, President and Chief Executive Officer of OnKure. "Our team of drug discovery veterans are actively exploring a pipeline of novel oncogene-targeted programs designed to achieve optimal tolerability and efficacy. We look forward to filing our second IND in 2023 and advancing OKI-219 into clinical development early next year."

"OnKure is at the forefront of innovation in the oncology space," commented Isaac Manke, Ph.D., a Partner at Acorn Bioventures and Chairman of OnKure. "We are proud to have participated in this Series C financing to enable this team of industry leaders to be able to continue to bring new cancer therapies to patients around the world."

Kura Oncology to Participate in Two Upcoming Investor Conferences

On May 23, 2023 Kura Oncology, Inc. (Nasdaq: KURA), a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer, reported that Troy Wilson, Ph.D., J.D., President and Chief Executive Officer, is scheduled to participate in the following events at upcoming investor conferences (Press release, Kura Oncology, MAY 23, 2023, View Source [SID1234631966]):

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A fireside chat at the virtual TD Cowen 4th Annual Oncology Innovation Summit at 1:30 p.m. ET / 10:30 a.m. PT on May 30, 2023; and

A fireside chat at the Jefferies Healthcare Conference in New York at 3:00 p.m. ET / 12:00 p.m. PT on June 7, 2023.
Live audio webcasts will be available in the Investors section of Kura’s website at www.kuraoncology.com, with archived replays available following the events.