On May 18, 2023 Adicet Bio, Inc. (Nasdaq: ACET), a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer, reported preclinical data highlighting ADI-270, an armored allogeneic "off-the-shelf" gamma delta CAR (chimeric antigen receptor) T cell therapy candidate targeting CD70+ cancers, at the 26th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) (Free ASGCT Whitepaper) taking place from May 16-20, 2023, in Los Angeles, CA (Press release, Adicet Bio, MAY 18, 2023, View Source [SID1234631873]).

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"We believe that ADI-270, combined with a third generation CAR and armoring technologies designed to improve persistence and resilience within the TME, may be able to overcome multiple barriers for realizing efficacy for cell therapies in solid tumors. Together with both innate and adaptive immune targeting and tumor infiltration, we believe ADI-270 can potentially improve clinical outcomes for patients," said Dr. Blake Aftab, Ph.D., Chief Scientific Officer of Adicet. "These findings provide critical groundwork to support the continued clinical development of ADI-270 as a potentially meaningful therapeutic option."

In this study, gamma delta T cells modified to express CD70 CAR were successfully generated and expanded without evident hindrances from CD70-mediated fratricide in the process. Data being presented included the following findings:

ADI-270 demonstrated preclinical proof-of-concept as an armored allogeneic gamma delta CAR T cell therapy candidate utilizing the CD27 natural receptor in a third generation CAR format for targeting CD70-positive cancers.
ADI-270 gamma delta 1 CAR T cells expressed a predominant naïve-like memory phenotype with potent in vitro cytotoxicity and production of proinflammatory cytokines against CD70+ tumor cell lines via multiple mechanisms.
ADI-270 showed significant inhibition of tumor growth in CD70+ tumor cell lines, which was maintained in the presence of TGF beta inhibitory factor, and exhibited improved resistance to killing by host T cell rejection.
ADI-270 also demonstrated marked biodistribution and infiltration into solid tumor models of renal cell carcinoma.
Details for the poster presentations are as follows:

Title: ADI-270: An Armored Allogeneic "Off-the-Shelf" CAR gamma delta T Cell therapy Targeting CD70+ Cancers

Abstract Number: 1023
Poster Session: Thursday Poster Session
Date & Time: May 18, 2023 at noon

On May 18, 2023 Oncomatryx reported that it has acquired Tube Pharmaceuticals GmbH, the developer of the Cytolysin toxic payload (Press release, Oncomatryx, MAY 18, 2023, View Source [SID1234631872]).

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The multimillion €uros transaction is a strategic decision by Oncomatryx that will foster its leadership in the field of ADCs targeting the tumor microenvironment. It culminates a decade-long alliance between Oncomatryx and Tube that has already rendered clinical-stage ADCs targeting the Tumor Microenvironment. Oncomatryx’s pioneering drug OMTX705, which incorporates the cytolysin toxic payload developed by Tube, is a first-in-class antibody-drug conjugate targeting cancer-associated fibroblasts. OMTX705 has shown complete tumor regression in many PDx and syngeneic murine models, as well as an unbeatable safety profile in rats and monkeys. A FIH multiple expansion cohort clinical trial targeting metastatic solid tumors is ongoing in seven hospitals in Spain and USA.

Oncomatryx now owns the comprehensive portfolio of cytolysins synthesized by Tube and the cutting-edge technology developed in its laboratories. Led by Dr. Wolfgang Richter, the Austrian company has more than 15 years of experience and has positioned itself as a top-level benchmark in the generation of novel ADC payloads.

This significant step forward in Oncomatryx internationalization strategy will also enhance its chemistry department thanks to the incorporation of Dr. Richter, who will drive the company’s efforts to continue developing novel drugs that attack the tumor microenvironment.

According to Laureano Simon, founder of Oncomatryx, "This strategic agreement is a significant milestone for Oncomatryx. It consolidates our technological portfolio and our commitment to target the microenvironment of the most invasive tumors. In addition, bringing Dr. Richter’s knowledge and experience into our team will open up even more possibilities in the design and development of novel ADCs."

It is worth noting that over the past 10 years, Oncomatryx has been involved in the development of innovative medicines in collaboration with prestigious universities, hospitals, and research centers in Europe and USA, such as the University of Stuttgart, the University of Torino, CIC-Biogune, the National Center for Oncological Research, Onkologikoa, Harvard University and the MD Anderson Cancer Center, among others.

On May 18, 2023 LadRx Corporation (OTCQB: LADX) ("LadRx" or the "Company"), a biopharmaceutical innovator focused on research and development of life-saving cancer therapeutics, reported that its previously announced reverse stock split of its common stock at a ratio of 1 post-split share for every 100 pre-split shares became effective at 5:00 a.m. PDT on Wednesday, May 17, 2023 (Press release, LadRx, MAY 18, 2023, View Source [SID1234631871]). Under FINRA rules, the Company’s common stock will be traded on the OTC Capital Markets under the symbol "LADXD" on a split-adjusted basis for the first 20 trading days, after which the Company’s stock will trade under its symbol "LADX". The new CUSIP number for the common stock following the reverse stock split is 232828707.

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On May 18, 2023 Fulgent Genetics, Inc. (NASDAQ: FLGT) ("Fulgent" or the "Company"), a technology-based company with a well-established clinical diagnostic business and a therapeutic development business, reported that Phase 1/1b clinical data on its lead therapeutic development candidate, FID-007, to treat various solid tumors, will be presented at the American Society for Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting at 8:00 a.m. Central Time on June 3, 2023 in Chicago, Illinois (Press release, Fulgent Genetics, MAY 18, 2023, View Source [SID1234631870]).

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Details of the presentation are as follows:

Abstract Title: A phase 1 dose escalation/expansion study of FID-007, a novel nanoparticle paclitaxel formulation, in patients with solid tumors
Session: Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Presenters: Drs. Jacob Thomas and Anthony El-Khoueiry of University of Southern California
Presentation Date and Time: June 3, 2023, at 8:00 a.m. Central Time
Presentation Type: Poster Session
Abstract #3026, poster board #224

About FID-007

FID-007 consists of paclitaxel encapsulated in a polyethyloxazoline (PEOX) polymer excipient designed to enhance PK, biodistribution, and tolerability. In addition to allowing the drug to remain in solution until it can enter a cancer cell, the PEOX nanoparticle is designed to preferentially deliver paclitaxel to the tumor through the leaky hyperpermeable vasculature.

On May 18, 2023 BridGene Biosciences, Inc., a biotechnology company using a proprietary chemoproteomics technology to discover and develop small molecules for high-value, traditionally undruggable targets, announced that Wolf Wiedemeyer, Ph.D., head of biology at BridGene, reported that it will be giving a presentation, titled "A Covalent TEAD Inhibitor with Exceptional Anti-cancer Activity & Combination Potential," at the 2nd Annual Hippo Pathway Targeted Drug Development Summit on May 24 in Boston (Press release, Bridgene Biosciences, MAY 18, 2023, View Source [SID1234631869]).

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The 2nd Annual Hippo Pathway Targeted Drug Development Summit is an industry-led forum, aimed at accelerating the understanding and opportunity of the Hippo signaling pathway in progressing the discovery, translation, and clinical development of safe and effective therapeutics within oncology, regenerative medicine, fibrosis, and beyond.

Dr. Wiedemeyer’s presentation will provide a preclinical update on a lead covalent TEAD inhibitor, including in vivo efficacy, harnessing TEAD selectivity to expand into TEADi-responsive indications and exploring combination approaches with KRAS inhibitors, which have shown promising results in clinical trials for cancer.

"Our IMTAC live-cell chemoproteomic platform to identify small molecules against challenging targets has successfully identified several potent and drug-like covalent ligands for TEAD and provided the foundation for BridGene to discover its pre-clinical oncology drug candidate BGI-9004," said CEO and Co-founder Ping Cao, Ph.D.

Details regarding the poster presentation are as follows:

Event:

2nd Annual Hippo Pathway Targeted Drug Development Summit

Title:

A Covalent TEAD Inhibitor with Exceptional Anti-cancer Activity &
Combination Potential

Date:

Wednesday, May 24, 2023

Time:

2:15 p.m. ET

Location:

Boston Park Plaza, Boston, Mass.