On June 1, 2023 Decibel Therapeutics (Nasdaq: DBTX), a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, reported that it will present at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, being held in Chicago, Illinois, June 2-6, 2023 (Press release, Decibel Therapeutics, JUN 1, 2023, View Source [SID1234632337]). The Company will present a poster summarizing data from the interim analysis of the Phase 1b clinical trial of DB-020, a novel, proprietary formulation of sodium thiosulfate (STS) designed to protect against hearing loss in cancer patients receiving cisplatin chemotherapy.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"Hearing loss and tinnitus are significant, often debilitating sequelae of cisplatin-induced ototoxicity, for which there are currently no approved therapies. Cisplatin remains an important chemotherapy for the treatment of multiple cancer types, and DB-020 is designed to protect the patient against cisplatin-induced ototoxicity," said John Lee, Chief Development Officer of Decibel. "Data from the Phase 1b clinical trial demonstrate that treatment with DB-020 may result in a meaningful reduction in cisplatin-associated ototoxicity and support its continued development to potentially provide a therapy for an irreversible condition."

The Phase 1b clinical trial was a randomized, blinded study in which patients were dosed with DB-020 in one ear and placebo in the contralateral ear in conjunction with their prescribed infusion of cisplatin chemotherapy. Additional information about the clinical trial can be found at clinicaltrials.gov.

Decibel’s ASCO (Free ASCO Whitepaper) presentation includes additional ototoxicity measures, which are consistent with the previously reported topline interim analysis data showing that 87% of patients who experienced cisplatin-induced ototoxicity in their placebo-treated ear were protected from ototoxicity in their DB-020-treated ear. Treatment with DB-020 prior to cisplatin administration had no apparent effect on systemic cisplatin levels. DB-020 was generally well tolerated, with no serious adverse effects and no tympanic perforations.

Poster presentation details:

Title: A Phase 1 clinical trial of DB-020 tympanic injections administered prior to high dose cisplatin chemotherapy to reduce ototoxicity
Session and track: Head and Neck Cancer – Advanced/Metastatic Disease
Abstract number: 6043
Poster board number: 35
Date and time: Monday, June 5th, 1:15 p.m. CDT

On June 1, 2023 CytomX Therapeutics, Inc. (Nasdaq: CTMX), a leader in the field of conditionally activated, localized biologics, reported that Sean McCarthy, D.Phil., chief executive officer and chairman, will present at the Jefferies Healthcare Conference on Thursday, June 8 at 4:00 p.m. ET (Press release, CytomX Therapeutics, JUN 1, 2023, View Source [SID1234632336]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

A live webcast of the fireside chat will be available on the Events and Presentations page of CytomX’s website at www.cytomx.com. In addition, management will be available for one-on-one meetings with investors who are registered to attend the conferences.

On June 1, 2023 Abeona Therapeutics Inc. (Nasdaq: ABEO) reported that Vish Seshadri, Chief Executive Officer, will participate in a fireside chat at the Jefferies Healthcare Conference on Friday, June 9, 2023 at 9:00 a.m. Eastern time (Press release, Abeona Therapeutics, JUN 1, 2023, View Source [SID1234632335]). The Company will also participate in one-on-one investor meetings at the conference.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

A live webcast of the fireside chat will be available on the Investors section of the Abeona website under "Events" at View Source The webcast will be archived for 30 days. Those interested in attending the fireside chat or requesting a one-on-one meeting with Abeona are encouraged to contact their Jefferies representative.

On June 1, 2023 Bristol Myers Squibb (NYSE: BMY) reported that the company will participate in the following investor conferences in June 2023 (Press release, Bristol-Myers Squibb, JUN 1, 2023, View Source [SID1234632332]):

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Company executives will take part in a fireside chat at the 2023 Jefferies Healthcare Conference in New York, New York on June 8, 2023. They will answer questions about the company at 9:00 a.m. ET.

Bristol Myers Squibb executives will also participate in a fireside chat at the Goldman Sachs 44th Annual Global Healthcare Conference on June 13, 2023, in Dana Point, California. They will answer questions about the company at 8:40 a.m. PT/11:40 a.m. ET.

Investors and the general public are invited to listen to a live webcast of both sessions during their respective times at View Source An archived edition of each session will be available later the same day it occurs.

On June 1, 2023 Biodesix, Inc. (Nasdaq: BDSX), a leading data-driven diagnostic solutions company with a focus in lung disease, reported that three new scientific abstracts will be presented as part of the 2023 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting including a poster presented by Friends of Cancer Research (FoCR) featuring genomic data contributed by Biodesix and other organizations (Press release, Biodesix, JUN 1, 2023, View Source [SID1234632331]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

This poster highlights long term patient outcomes from the ctMoniTR Project, a study evaluating the prognostic value of changes in circulating tumor DNA (ctDNA) in patients treated with targeted therapies. The new data release indicates that ctDNA shows promise as an early endpoint to support drug development and regulatory decision-making.

"We are thrilled to partner with our colleagues in industry, academia, government and Friends of Cancer Research in contributing to the new data analysis on ctDNA and outcomes that will be released at the ASCO (Free ASCO Whitepaper) 2023 Annual Meeting," said Gary Pestano, Chief Development Officer of Biodesix. "ctDNA continues to show promise, in a range of clinical indications and we are proud to support the efforts to generate evidence on how it can positively impact patient lives."

The other two abstracts showcase new health economic and outcomes data on the VeriStrat host immune classifier, part of IQLung personalized lung cancer treatment guidance testing. These analyses evaluated healthcare resource utilization (HCRU) and healthcare costs in patients with non-small cell lung cancer (NSCLC) classified by the test. The VeriStrat test is a novel predictive and prognostic blood-based host immune classifier that stratifies immune checkpoint inhibition (ICI) treatment response in patients with advanced NSCLC. Prior studies have shown that patients classified by the test as host immune classifier hot (HIC-Hot), also known as VeriStrat Good, had better outcomes, on average living 2-3 times longer when compared to patients classified as host immune classifier cold (HIC-Cold), also known as VeriStrat Poor.

The first poster, titled "Real-world healthcare resource utilization amongst non-small cell lung cancer (NSCLC) patients tested with a host immune classifier (HIC)," shows that patients with HIC-C classifications have higher HCRU during their lung cancer diagnosis. However, patients with an HIC-H classification had higher HCRU with respect to prescriptions and emergency room visits. The second poster, titled "Real-world healthcare costs amongst non-small cell lung cancer (NSCLC) patients tested with a host immune classifier (HIC)," shows that patients with HIC-C classifications had significantly higher total medical costs through the course of lung cancer diagnosis and treatment than those with an HIC-H classification.

These data reinforce the utility of the VeriStrat test in guiding treatment decisions and suggest that earlier identification of the VeriStrat classification may help identify patients with NSCLC most likely to benefit from additional health system navigation support.