On September 13, 2023 Devyser and Thermo Fisher Scientific reported to have entered into a collaboration agreement to promote laboratory services (Press release, Thermo Fisher Scientific, SEP 13, 2023, View Source [SID1234635145]). The goal is to partner with pharmaceutical companies to support their development projects utilising Devyser’s unique assays in its CLIA-certified laboratory.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The companies will work together to promote the Devyser laboratory services to support and advance research and development for pharmaceutical companies.

"We are very excited to enter into this agreement. Being able to support pharmaceutical companies’ development projects to enable new and improved therapies is a part of our vision for Devyser. We are convinced that Thermo Fisher, with its global network and outstanding reach, will provide a strong platform for partnering with global pharmaceutical companies in addition to Devyser’s own discussions," says Fredrik Alpsten, CEO at Devyser. "This collaboration is in line with our strategy to expand our presence in the US."

Devyser established the US CLIA-certified laboratory during the spring of 2023 and received CLIA certification from the Centers for Medicare and Medicaid Services (CMS) in May 2023. The laboratory is based in Atlanta, Georgia.

On September 13, 2023 Zentalis pharmaceuticals presented its corporate presentation (Presentation, Zentalis Pharmaceuticals, SEP 13, 2023, View Source [SID1234635144]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

On September 13, 2023 Synaffix B.V., a Lonza company (SIX:LONN) focused on commercializing its clinical-stage platform technology for the development of antibodydrug conjugates (ADCs) with best-in-class therapeutic index, reported a licensing agreement to develop bispecific ADCs with ABL Bio, Inc. (KOSDAQ: 298380), a clinical-stage biotech developing bispecific antibody technology for immuno-oncology and neurodegenerative diseases (Press release, Synaffix, SEP 13, 2023, View Source [SID1234635143]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Synaffix will receive an upfront payment, milestone payments and tiered royalties on net sales of resulting products and will be responsible for manufacturing components specifically related to its proprietary technologies. ABL Bio will be responsible for the research, development, and commercialization of any bispecific ADCs developed under the agreement. Following the recent acquisition of Synaffix by Lonza, ABL Bio considers Lonza as a potential partner for clinical production of the antibody to be used in the first program, underscoring the strong and immediate post-merger synergies. The first program will commence upon deal signature with options exercisable for up to two additional programs over time.

ADCs prepared from bispecific antibodies are designed to overcome the limitations of conventional therapeutic ADCs that target only a single antigen on the targeted cancer cell. By designing ADCs that must bind to two different targets in order to produce a therapeutic effect, it is possible to target cancerous cells more specifically and further improve the therapeutic safety profile.

On September 13, 2023 Sensei Biotherapeutics, Inc. (Nasdaq: SNSE), a clinical stage immuno-oncology company focused on the discovery and development of next-generation therapeutics for cancer patients, reported it will present additional preclinical data on SNS-101, a conditionally active, human monoclonal antibody targeting the immune checkpoint VISTA (V-domain Ig suppressor of T cell activation), at the Seventh Annual CRI-ENCI-AACR International Cancer Immunotherapy Conference (CIMT) (Free CIMT Whitepaper): Translating Science into Survival, being held September 20 – 23, 2023 in Milan, Italy (Press release, Sensei Biotherapeutics, SEP 13, 2023, View Source [SID1234635142]). The new data build on SNS-101’s preclinical safety and efficacy profile and provide additional insights into its conditionally active mechanism of action. SNS-101 is currently in a Phase 1/2 clinical study.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Presentation Details:

Title: SNS-101, a clinical-stage pH-dependent and TME-selective anti-VISTA antibody with favorable pharmacokinetic and safety characteristics, promotes anti-tumoral M1 macrophage polarization in PD-1 refractory settings
Presentation Type: Poster
Date and Time: Thursday, September 21, 2023, from 12:30 pm to 2:00 pm CET
Session: Poster Session A

The poster will be made available on the Sensei Bio website following the presentation.

On September 13, 2023 Sana Biotechnology presented tis corporate presentation (Presentation, Sana Biotechnology, SEP 13, 2023, View Source [SID1234635141]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!