On October 9, 2023 Coeptis Therapeutics Holdings, Inc. (NASDAQ: COEP) ("Coeptis" or "the Company"), a biopharmaceutical company developing innovative cell therapy platforms for cancer, reported that Dan Yerace, Director and Vice President of Operations, will participate in a panel titled, "Ambitious Innovation: Emerging Cell and Gene Therapies," at the BioFlorida Conference on Thursday October 12th from 11:50 AM-12:50 PM (Press release, Coeptis Therapeutics, OCT 9, 2023, View Source [SID1234635727]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Details of the panel discussion are as follows:

Event:

BioFlorida Conference

Date & Time:

October 12, 2023, at 11:50 AM, EDT

Panel Title

Ambitious Innovation: Emerging Cell and Gene Therapies

Location:

Sawgrass Marriott Golf Resort & Spa, Ponte Vedra Beach, FL

On October 9, 2023 TransThera Sciences (Nanjing) Inc., a clinical-stage biopharmaceutical company focused on inventing differentiated drugs for global patients, reported to deliver two oral presentations of tinengotinib clinical data in cholangiocarcinoma (CCA) at 2023 European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress, and in breast cancer at 2023 San Antonio Breast Cancer Symposium (SABCS) annual meeting respectively (Press release, TransThera Biosciences, OCT 9, 2023, View Source [SID1234635725]). TransThera will also give a poster presentation of tinengotinib phase 1b/2 clinical data in Chinese patients at 2023 ESMO (Free ESMO Whitepaper).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

2023 ESMO (Free ESMO Whitepaper), October 22-24, Madrid, Spain

Mini-Oral Presentation, Abstract #95MO
Title: Tinengotinib in Patients with Advanced, Fibroblast Growth Factor Receptor (FGFR) inhibitor Refractory/Relapsed Cholangiocarcinoma
Presenter: Meredith S Pelster, MD

Poster presentation, Abstract #670P
Title: Preliminary Efficacy and Safety of Tinengotinib (TT-00420) Monotherapy in Chinese Patients (pts) with Advanced Solid Tumors: Results from a Phase Ib/II Study
Presenter: Jean Fan, MD

2023 SABCS, December 5-9, San Antonio, TX, US.

Rapid-Fire Mini-Oral Presentation, Abstract #1572754
Title: The efficacy and safety of tinengotinib in patients with advanced or metastatic HR+/HER2- breast cancer or TNBC

"We are thrilled that tinengotinib clinical data has been selected for multiple oral and poster presentations in these impactful global scientific meetings. " Commented Dr. Frank Wu, chairman and CEO of TransThera, "It is a strong recognition from the community to tinengotinib as a very novel compound in global phase 3 development, capable of demonstrating efficacy in a variety of solid tumors with significant unmet medical needs. The upcoming presentations mark the potential of tinengotinib in CCA and breast cancer. We look forward to more discussions next year in other indications!"

About tinengotinib

Tinengotinib is a global innovative clinical-stage spectrum-selective kinase inhibitor that exerts antitumor effects by targeting tumor cells and improving the tumor microenvironment. Ongoing clinical trials in the US and China have revealed the potential of Tinengotinib to be efficacious in various solid tumors. It was granted the Orphan-Drug Designation and Fast Track Designation by the FDA for the treatment of CCA. In July 2023, tinengotinib was granted the Breakthrough Therapy Designation (BTD) by NMPA in China.

On October 9, 2023 Hansa Biopharma, "Hansa" (Nasdaq Stockholm: HNSA), a pioneer in enzyme technology for rare immunological conditions, reported high-level results from NICE-01, the first-in-human trial for HNSA-5487 (Press release, Hansa Biopharma, OCT 9, 2023, View Source [SID1234635724]). Results showed the molecule was safe and well tolerated. Fast and complete depletion of immunoglobulin G (IgG) antibodies was observed at increasing doses in all subjects. Pharmacokinetics (PK) was in line with expectations and pharmacodynamics (PD) (efficacy on IgG cleavage) showed a fast and complete cleavage of IgG to F(ab’)2- and Fc-fragments with increasing doses.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

NICE-01 is a double blind, randomized, placebo-controlled trial evaluating safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending doses of HNSA-5487 administered as a single intravenous (IV) infusion. The trial included a total of 36 healthy male and female adult participants.

HNSA-5487 is the company’s lead candidate in the Novel Immunoglobulin Cleaving Enzymes for Repeat Dosing (NiceR) program. The NiceR program aims to develop next-generation enzymes with lower immunogenicity that would potentially allow for repeat dosing in a range of indications including IgG-driven autoimmune diseases where patients experience flares, transplantation where repeat dosing would be beneficial, gene therapy and oncology.

Søren Tulstrup, President and CEO, Hansa Biopharma said, "This is encouraging data as we continue to explore the potential for HNSA-5487 and better understand how this powerful, new enzyme could benefit patients and clinicians. An enzyme with lower immunogenicity would potentially enable repeat dosing, allowing a prolonged effect by flexibly extending the IgG-free window depending on the number of repeated infusions. This could enable innovative treatment approaches in a broad range of indications, and benefit patients with diseases where a prolonged IgG-free window is needed".

Analysis of additional exploratory endpoints on IgG recovery and immunogenicity is now being conducted, with follow up on all subjects for 12 months. This analysis will serve as key input in determining the further clinical development program, including selection of indications.

On October 9, 2023 Harpoon Therapeutics, Inc. (Nasdaq: HARP), a clinical-stage immunotherapy company developing novel T cell engagers, reported that it will present interim monotherapy data from its Phase 1/2 clinical trial evaluating HPN328 in small cell lung cancer (SCLC) and other neuroendocrine neoplasms (NEN) in a poster presentation at the European Society of Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress (ESMO) (Free ESMO Whitepaper) 2023 taking place in Madrid, Spain from October 20-24, 2023 (Press release, Harpoon Therapeutics, OCT 9, 2023, View Source [SID1234635722]). HPN328 targets delta-like ligand 3 (DLL3) and is derived from Harpoon’s proprietary Tri-specific T cell Activating Construct (TriTAC) platform designed to recruit a patient’s own immune cells to kill tumor cells.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"We are excited to present data from over 70 patients with multiple tumor types in HPN328 monotherapy cohorts, with an emphasis on our ongoing 1 mg priming cohorts with target doses up to 24 mg. Full enrollment of these 1 mg priming dose cohorts will be the basis for selecting our recommended Phase 2 dose(s) by the end of this year. In our poster, we will share tolerability data from all enrolled patients and preliminary response data in patients at doses above the efficacy threshold of 1.215 mg," said Luke Walker, M.D., Chief Medical Officer for Harpoon Therapeutics. "In addition to nearing completion of monotherapy dose optimization, we have recently initiated enrollment in our combination cohorts evaluating HPN328 plus atezolizumab to enable future development in early lines of therapy."

Details of the ESMO (Free ESMO Whitepaper) poster presentation are as follows:

Abstract Title: Interim Results from a Phase 1/2 Study of HPN328, a Tri-Specific, Half-Life (T1/2) Extended DLL3-targeting T-Cell Engager in Patients (pts) with Small Cell Lung Cancer (SCLC) and other Neuroendocrine Neoplasms (NEN)
Presentation Number: 698P
Session Number/Title: Developmental Therapeutics
Session Date, Time: Monday, October 23, 2023, 12:00 – 13:00 CEST
Presenter: Noura Choudhury, M.D.
Location: Hall 8

The poster will also be available on Harpoon’s website following the presentation.

For more details about the ESMO (Free ESMO Whitepaper) Annual Meeting, please visit:
View Source

On October 9, 2023 Kineta, Inc. (Nasdaq: KA), a clinical-stage biotechnology company focused on the development of novel immunotherapies in oncology that address cancer immune resistance, reported that it will present at the Oxford Global Immuno US 2023, to be held on October 12-13, 2023 in San Diego, CA (Press release, Kineta, OCT 9, 2023, View Source;utm_medium=rss&utm_campaign=kineta-to-present-preclinical-data-on-vista-blocking-kva12123-at-immuno-us-2023 [SID1234635721]). Thierry Guillaudeux, Ph.D., Chief Scientific Officer of Kineta, will present a preclinical overview of KVA12123, the company’s novel VISTA blocking immunotherapy, currently being evaluated in a Phase 1/2 clinical trial in patients with advanced solid tumors.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Presentation Details:
Presentation Title: Anti-VISTA Monoclonal Antibody Program
Session: Discovery & Development: Cell Therapies & Antibody Approaches
Session location: Conference Room 3
Presenter: Thierry Guillaudeux, Ph.D.
Date / Time: Thursday, October 12 at 9:50-10:15 A.M. Pacific Time