Medidata Announces Multi-Year Partnership Expansion with Catalyst for Oncology Trial Delivery

On October 26, 2023 Medidata, a Dassault Systèmes company and leading provider of clinical trial solutions to the life sciences industry, reported a multi-year partnership expansion with Catalyst Clinical Research to support their global oncology brand, Catalyst Oncology (Press release, Catalyst Clinical Research, OCT 26, 2023, View Source [SID1234638823]). This renewal builds upon Catalyst’s existing success with the Medidata Platform and incorporates wider offerings, including Medidata Grants Manager and Medidata AI Intelligent Trials, as Catalyst has grown into a robust and global full-service clinical research organization.

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This continued commitment for Medidata Rave EDC, Medidata Rave CTMS, and Medidata Rave eTMF enables Catalyst to run complex clinical trials while simplifying its operations and management. By using these integrated capabilities, and incorporating the expansive elements of Grants Manager and Intelligent Trials, Catalyst can streamline workflows, automate document management, and improve visibility to critical trial metrics.

"Medidata remains our preferred partner because of their scalability and skill in managing complex trials," said Nik Morton, president and COO, Catalyst. "Their advanced technology will further support our growth and expansion."

Catalyst has supported over 150 oncology studies and is currently managing more than 80 next-generation cancer clinical trials today across Phases I-III. With 90% of all oncology approvals last year in the U.S. developed using Medidata software, Catalyst’s use of the Medidata Platform will be critical to their continued expansion. In addition, Catalyst is excited to leverage Medidata AI, which accesses a dataset spanning more than 20 years to engage a more diverse patient population and accelerate enrollment.

"Medidata is thrilled to serve as Catalyst’s partner since their first trial in 2019 and be part of their continued success," said Joan Shaiman, senior vice president, Partners, Medidata. "Their decision to recommit to the core elements of our Platform and adopt broader solutions demonstrates that we have the expertise and capabilities needed to support faster decision-making and accelerate trials to advance cancer research."

Interim Report January to September 2023

On October 26, 2023 Orion reported its Interim Report January to September 2023 (Presentation, Orion, OCT 26, 2023, View Source [SID1234638623]).

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Boston Scientific Announces Results for Third Quarter 2023

On October 26, 2023 Boston Scientific Corporation (NYSE: BSX) reported net sales of $3.527 billion during the third quarter of 2023, growing 11.2 percent on a reported basis, 11.1 percent on an operational1 basis and 10.2 percent on an organic2 basis, all compared to the prior year period (Press release, Boston Scientific, OCT 26, 2023, View Source;_gl=1*1muje07*_ga*MTgxMjY3ODM0OS4xNzAyMzU3ODg1*_ga_759NN7RMMK*MTcwMjM1Nzg4NC4xLjEuMTcwMjM1NzkxNS4wLjAuMA.. [SID1234638411]). The company reported GAAP net income attributable to Boston Scientific common stockholders of $505 million or $0.34 per share (EPS), compared to $174 million or $0.12 per share a year ago, and achieved adjusted3 EPS of $0.50 for the period, compared to $0.43 a year ago.

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"We achieved another quarter of strong performance, thanks to the hard work of our talented global team and our differentiated medical technologies that improve the lives of patients across the globe," said Mike Mahoney, chairman and chief executive officer, Boston Scientific. "As we shared at our recent Investor Day meeting, we are well-positioned for the long term, backed by our category leadership strategy, strong pipeline of innovation and track record of strong commercial execution."

Third quarter financial results and recent developments:

Reported net sales of $3.527 billion, representing an increase of 11.2 percent on a reported basis, compared to the company’s guidance range of 8.5 to 10.5 percent; 11.1 percent on an operational basis; and 10.2 percent on an organic basis, compared to the company’s guidance range of 7 to 9 percent, all compared to the prior year period.
Reported GAAP net income attributable to Boston Scientific common stockholders of $0.34 per share, compared to the company’s guidance range of $0.21 to $0.25 per share, and achieved adjusted EPS of $0.50 per share, compared to the guidance range of $0.46 to $0.48 per share.
Achieved the following net sales growth in each reportable segment, compared to the prior year period:
MedSurg: 10.6 percent reported, 10.0 percent operational and 9.4 percent organic
Cardiovascular: 11.6 percent reported, 11.7 percent operational and 10.6 percent organic
Achieved the following net sales growth in each region, compared to the prior year period:
United States (U.S.): 8.5 percent reported and operational
Europe, Middle East and Africa (EMEA): 14.7 percent reported and 10.9 percent operational
Asia-Pacific (APAC): 14.8 percent reported and 19.5 percent operational
Latin America and Canada (LACA): 22.0 percent reported and 16.1 percent operational
Emerging Markets4: 14.4 percent reported and 19.0 percent operational
Announced positive 12-month results from the ADVENT pivotal clinical trial of the FARAPULSE Pulsed Field Ablation (PFA) System,5 which met the primary safety and efficacy endpoints, and demonstrated the FARAPULSE PFA System is noninferior to standard-of-care therapies.
Completed enrollment in the first phase of the ADVANTAGE AF clinical trial studying the FARAPULSE PFA System for the treatment of patients with persistent atrial fibrillation (AF) and commenced enrollment in an extension arm of the study to evaluate the safety and effectiveness of adjunctive use of the FARAPOINT PFA Catheter for cavotricuspid isthmus (CTI) ablations, a procedure used to treat atrial flutter.
Received U.S. Food and Drug Administration (FDA) approval for the POLARx Cryoablation System, which includes the POLARx FIT Cryoablation Balloon Catheter and is used to treat patients with paroxysmal AF.
Announced the U.S. FDA approval of the latest-generation WATCHMAN FLX Pro Left Atrial Appendage Closure (LAAC) Device, which is designed to improve visualization during device placement, reduce device-related thrombus post-implant and treat a broader range of patient anatomies.
Received U.S. FDA 510(k) clearance and launched the next-generation LUX-Dx II/II+ Insertable Cardiac Monitor (ICM) System for long-term monitoring of arrhythmias.
Received CE Mark, U.S. FDA clearance and Japanese Pharmaceuticals and Medical Devices Agency (PMDA) approval for the AVVIGO+ Multi-Modality Guidance System, a next-generation technology that provides high-quality intravascular ultrasound (IVUS) imaging and physiologic assessment of coronary vessels and lesions.
Announced positive data at the Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium demonstrating statistical superiority of the AGENT Drug Coated Balloon5 versus uncoated balloon angioplasty for the treatment of patients with in-stent restenosis, meeting the primary endpoint of target lesion failure (TLF) at 12 months (17.9% vs. 28.7%, P=0.006) for the AGENT IDE clinical trial.
Presented at TCT were study results demonstrating statistically significant lower major bleeding rates in patients with pulmonary embolism (PE) who were treated with the EKOS Endovascular System compared to the Inari FlowTriever System as analyzed in the REAL-PE study.
Received U.S. FDA De Novo classification grant and marketing authorization for an expanded indication for the AXIOS Stent and Electrocautery-Enhanced Delivery System. The new indication allows for use of the device to facilitate endoscopic drainage of the gallbladder for patients with acute cholecystitis who are at high risk for surgery.
Announced U.S. FDA approval for an expanded indication of the WaveWriter Alpha Spinal Cord Stimulator (SCS) Systems for the treatment of painful diabetic peripheral neuropathy (DPN).
Announced agreement to acquire Relievant Medsystems, Inc., a privately held medical technology company that has developed and commercialized the only U.S. FDA-cleared system, the Intracept Intraosseous Nerve Ablation System, for vertebrogenic pain, subject to customary closing conditions.
1. Operational net sales growth excludes the impact of foreign currency fluctuations.

2. Organic net sales growth excludes the impact of foreign currency fluctuations and net sales attributable to acquisitions and divestitures for which there are less than a full period of comparable net sales.

3. Adjusted EPS excludes the impacts of certain charges (credits) which may include amortization expense, goodwill and intangible asset impairment charges, acquisition/divestiture-related net charges (credits), investment portfolio gains and losses, restructuring and restructuring-related net charges (credits), certain litigation-related net charges (credits), EU MDR implementation costs, debt extinguishment charges, deferred tax expenses (benefits) and discrete tax items.

4. Periodically, we assess our list of Emerging Markets countries, and effective January 1, 2023, modified our list to include all countries except the United States, Western and Central Europe, Japan, Australia, New Zealand and Canada. We have revised prior year amounts to conform to the current year’s presentation.

5. The FARAPULSE PFA System and the AGENT DCB are investigational devices. Restricted by Federal law to investigational use only. Not available for sale in the U.S.

Net sales for the third quarter by business and region:


Increase/(Decrease)


Three Months Ended
September 30,


Reported
Basis


Impact of
Foreign
Currency
Fluctuations


Operational
Basis


Impact of
Recent
Acquisitions /
Divestitures


Organic
Basis

(in millions)

2023

2022



Endoscopy

$ 629

$ 559


12.6 %


(0.7) %


11.9 %


(1.4) %


10.6 %


Urology

483

433


11.5 %


(0.5) %


11.1 %


— %


11.1 %


Neuromodulation

229

221


3.7 %


(0.4) %


3.2 %


— %


3.2 %


MedSurg

1,341

1,213


10.6 %


(0.5) %


10.0 %


(0.6) %


9.4 %


Cardiology

1,647

1,479


11.4 %


(0.1) %


11.4 %


— %


11.4 %


Peripheral Interventions

538

479


12.3 %


0.6 %


12.9 %


(4.5) %


8.4 %


Cardiovascular

2,185

1,958


11.6 %


0.1 %


11.7 %


(1.1) %


10.6 %

Net Sales

$ 3,527

$ 3,170


11.2 %


(0.1) %


11.1 %


(0.9) %


10.2 %



Increase/(Decrease)



Three Months Ended
September 30,


Reported
Basis


Impact of
Foreign
Currency
Fluctuations


Operational
Basis


(in millions)

2023

2022



U.S.

$ 2,099

$ 1,934


8.5 %


— %


8.5 %



EMEA

671

585


14.7 %


(3.8) %


10.9 %



APAC

611

532


14.8 %


4.7 %


19.5 %



LACA

146

119


22.0 %


(5.9) %


16.1 %



Net Sales

$ 3,527

$ 3,170


11.2 %


(0.1) %


11.1 %




Emerging Markets4

$ 594

$ 519


14.4 %


4.6 %


19.0 %


Amounts may not add due to the use of rounded numbers. Growth rates are based on actual, unrounded amounts and may not recalculate precisely.

Growth rates that exclude the impact of foreign currency fluctuations and/or the impact of acquisitions/divestitures are not prepared in accordance with U.S. GAAP.

Guidance for Full Year and Fourth Quarter 2023

The company now estimates net sales growth for the full year 2023, versus the prior year period, to be approximately 11 percent on both a reported basis and organic basis. Full year organic net sales guidance excludes the impact of foreign currency fluctuations and net sales attributable to acquisitions and divestitures for which there are less than a full period of comparable net sales. The company now estimates EPS on a GAAP basis in a range of $1.00 to $1.04 and estimates adjusted EPS, excluding certain charges (credits), of $1.99 to $2.02.

The company estimates net sales growth for the fourth quarter of 2023, versus the prior year period, to be in a range of approximately 9 to 11 percent on a reported basis, and approximately 8 to 10 percent on an organic basis. Fourth quarter organic net sales guidance excludes the impact of foreign currency fluctuations and net sales attributable to acquisitions and divestitures for which there are less than a full period of comparable net sales. The company estimates EPS on a GAAP basis in a range of $0.26 to $0.30 and adjusted EPS, excluding certain charges (credits), of $0.49 to $0.52.

Conference Call Information
Boston Scientific management will be discussing these results with analysts on a conference call today at 8:00 a.m. ET. The company will webcast the call to interested parties through its website: investors.bostonscientific.com. Please see the website for details on how to access the webcast. The webcast will be available for approximately one year on the Boston Scientific website.

BioInvent International AB: Interim report January–September 2023

On October 26, 2023 BioInvent reported Interim report January–September 2023 (Presentation, BioInvent, OCT 26, 2023, https://www.bioinvent.com/sites/bioinvent/files/pr/20231026-7e7c641f-ae2a-4798-b82c-755644c71a5a-1.pdf?ts=1698300010 [SID1234638115]).

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MaaT Pharma to Present Preclinical Data at SITC on MaaT034, an Artificial Intelligence-Generated Product Aimed at Improving Patients’ Responses to Immunotherapies

On October 26, 2023 MaaT Pharma (EURONEXT: MAAT – the "Company"), a clinical-stage biotech company and a leader in the development of Microbiome Ecosystem TherapiesTM (MET) dedicated to improving survival outcomes for patients with cancer, reported the details of two poster presentations at the 38th Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) Annual Meeting, the world-leading event in immunotherapy, scheduled to be held from November 1-5, 2023, in San Diego, California, U.S.A (Press release, MaaT Pharma, OCT 26, 2023, View Source [SID1234636538]). Presentations will include in vitro results for its new Artificial Intelligence (AI)-generated lead product, MaaT034, designed to improve responses to immunotherapy for patients with solid tumors. MaaT034 is the first member of the MET-C platform that can co-cultivate a healthy microbiota ecosystem. The first-in-human testing is planned for 2025, with the first clinical batches to be produced in 2024.

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Nathalie Corvaia, Chief Scientific Officer, states "we are very excited to present our first pre-clinical data at SITC (Free SITC Whitepaper) showing biological activity for MaaT034, our new generation of co-cultured products and the robustness of our proprietary AI-engine, gutPrint. MaaT034 is active in restoring the integrity of the gut barrier and stimulating immune cells leading to an improvement in the immune cell response to ICI therapy. This bolsters our confidence in our immuno-oncology approach driven by our AI engine. We are looking forward to moving to clinical evaluation in 2025."

Poster Presentation Details:

Poster 1 Title: Evaluation of a new co-cultured microbiome ecosystem therapy candidate (MaaT03X) for clinical testing as adjuvant/neoadjuvant to immune checkpoint inhibitors in solid tumors
Poster Number: 1321
Date & Location: November 3, 2023 – Exhibit Halls A & B1
Key findings for MaaT034:

replicates, at large industrial scale, the richness and diversity of healthy native-based microbiome ecosystems
restores the integrity of a damaged gut barrier
activates AhR[1] pathway involved in gut homeostasis
stimulates both myeloid and lymphoid immune cells
improves immune cell response to ICI therapy
Poster 2 Title: Robust Machine Learning (ML) approach for screening Microbiome Ecosystem Therapies (MET) drug candidates in combination with Immune Checkpoint Inhibitors
Poster Number: 1304
Date & Location: November 3, 2023 – Exhibit Halls A & B1
Key findings for gutPrint AI engine:

selection and training of models to grade samples as "Responder-like" according to the baseline stool metagenomics of ICI treated cancer patients
improvement of predictive performance compared to literature with more patient data, cross studies and indication
application of the best performing model (mean LODO AUC = 0.65) to MaaT Pharma’s healthy donor cohort or pooled samples (mixes of stools from 4 to 8 healthy donors) classified a large majority of those as "Responder-like" microbiota (especially pooled samples)