On April 13, 2023 Veracyte, Inc. (Nasdaq: VCYT) reported that it will release financial results for the first quarter of 2023 after the close of market on Thursday, May 4, 2023 (Press release, Veracyte, APR 13, 2023, View Source [SID1234630048]). Company management will host a conference call and webcast to discuss financial results and provide a general business update at 4:30 p.m. Eastern Time on the same day.

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The conference call will be webcast live from the company’s website and will be available via the following link: View Source A webcast replay will be available following the conclusion of the live broadcast and will be accessible on the company’s website at View Source

The conference call dial-ins can be accessed by registering at: https://register.vevent.com/register/BI87218b059133453fb9c7e07391fd40e3

On April 13, 2023 Sysmex Inostics Inc., a subsidiary of Japan’s Sysmex Corporation and Baltimore-based biotechnology firm, and Genomic Testing Cooperative (GTC), based in Irvine, California, reported to have formed a strategic partnership for Sysmex Inostics to commercialize GTC’s tissue and liquid biopsy solid tumors and hematology assay services to biopharma customers (Press release, Sysmex Inostics, APR 13, 2023, View Source [SID1234630047]). This includes GTC’s Solid Tumor Profile Plus, Liquid Trace Solid Tumor Profile, Liquid Trace Hematology Profile, and Hematology Profile Plus assay services.

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The partnership synergizes GTC’s proprietary genomic databases, technology in artificial intelligence (AI), and DNA and RNA next generation sequencing (NGS) profiling, with Sysmex Inostics’ global commercial capabilities in biopharma therapeutic development and ultra-sensitive Plasma-Safe-SeqS technology.

Shinichi Sato, president, and Chief Executive Officer of Sysmex Inostics, stated, "Our new relationship with GTC extends our commitment to our biopharma partners. We understand not one testing solution fits all stages of therapeutic development and it was imperative to offer our biopharma partners GTC’s broader panels for their discovery work." And added, "It’s truly a special day for Sysmex Inostics."

"The alliance with Sysmex Inostics is fundamental to our mission of democratizing genomic testing and making it available and affordable to every patient dealing with cancer. It represents another step forward in our efforts to expand our cooperative model," stated Maher Albitar, MD, Founder, Chief Executive Officer, and Chief Medical Officer of GTC.

The collaboration provides biopharma a full suite of assay services from both companies for each phase in the clinical trial process. The companies will also work jointly on improvements and new indications of the tests for use by biopharma researchers.

GTC’s cooperative state-of the-art and cost-effective offerings are distinctive and cover various modalities including chromosomal abnormalities, RNA expression and immunophenotyping, tumor cell of origin, homologous recombination deficiency (HRD), tumor mutation burden (TMB), exon skipping, and levels of EBV and HPV viral RNA if present. GTC testing uses proprietary AI analysis of DNA and RNA data from blood and tissue samples. Further setting them apart, various GTC’s tests have CE IVDR and New York State (NYS) approval with Medicare Reimbursement, the lab has CAP, CLIA and NYS licensure.

Sysmex Inostics adds its long-standing biopharma relationships and commercial capabilities to the partnership. The company will also continue to serve the market with CLIA-validated Plasma-Safe-SeqS testing, expertly curated and ultra-sensitive liquid biopsy panel to detect known cancer driving mutations. The technology allows biopharma to expedite clinical trial patient enrollment with the peace of mind their patients are being monitored with one of the most sensitive liquid biopsy tests on the market.

Sysmex Inostics & GTC will exhibit at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2023 in Orlando, FL from April 16, through April 19, 2023. Both companies will take meetings with the over 20,000 global cancer research professionals in attendance.

On April 13, 2023 Sensei Biotherapeutics, Inc. (Nasdaq: SNSE), an immuno-oncology company focused on the discovery and development of next-generation therapeutics for cancer patients, reported that Company management will participate in a panel titled ‘Overcoming Resistance & Immunosuppression in Solid Tumors’ at Canaccord Genuity’s Horizons in Oncology Virtual Conference on Thursday, April 20th at 3:00 p.m. ET (Press release, Sensei Biotherapeutics, APR 13, 2023, View Source [SID1234630046]).

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On April 13, 2023 Sana Biotechnology, Inc. (NASDAQ: SANA), a company focused on changing the possible for patients through engineered cells, reported that Nature Communications has published a paper titled "Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice (Press release, Sana Biotechnology, APR 13, 2023, View Source [SID1234630045]). The preclinical studies published in this paper evaluated the performance of Sana’s hypoimmune (HIP) allogeneic chimeric antigen receptor (CAR) T cells versus unmodified allogeneic (allo) CAR T cells. The key findings demonstrate that HIP CAR T cells significantly outperformed unmodified allo CAR T cells in tumor studies using fully immunocompetent, humanized mice in both durability of tumor clearance as well as CAR T cell expansion and persistence. In additional in vitro assays and in vivo assays, the data demonstrate that HIP engineering does not impact CAR T cell specificity, impair cytotoxic function, accelerate T cell exhaustion, or weaken anti-tumor efficacy. The HIP CAR T cell persistence observed in allogeneic, fully immunocompetent, humanized mice resulted in durable tumor clearance as shown by the rapid clearance of a second tumor challenge at ninety days after HIP CAR T cell administration, highlighting the potential long-term persistence and efficacy in clearing any hidden or remaining tumor cells in a patient with cancer.

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"We designed our hypoimmune allogeneic CAR T platform to overcome immune rejection challenges that have limited efficacy to date for allogeneic CAR T cell therapies and the access and product variability of autologous CAR T cells," said Steve Harr, Sana’s President and CEO. "These preclinical data highlight that our hypoimmune CAR T cells can evade immune detection, persist, and clear tumor cells both acutely and over time. SC291, our hypoimmune CD19-targeted allogeneic CAR T therapy, has transformative potential for patients with B-cell malignancies if these results translate to our clinical studies, and we look forward to presenting initial clinical data later this year."

HIP CAR T Cells Provide Lasting Tumor Killing Efficacy in Fully Immunocompetent Allogeneic Humanized Mice and Prevent Tumor Regrowth After Subsequent Reinjection of Tumor Cells
The ability to effectively kill tumors was assessed in immunocompetent humanized mice. Longitudinal bioluminescence imaging (BLI) showed that HIP CAR T cells provided lasting removal of tumor throughout the study period. In contrast, unmodified allogeneic CAR T cells only temporarily slowed the progression of tumor growth in this immunocompetent model and eventually failed to control cancer progression. In these same mice, CAR T cell efficacy was assessed after reinjection of tumor cells eighty-three days following the administration of the CAR T cells. HIP CAR T cell-treated mice rapidly cleared the tumor cells, demonstrating the persistence and effectiveness of the HIP CAR T cells even after three months. These findings demonstrate that HIP modified allogeneic CAR T cells persist and result in the effective suppression of CD19 expressing tumors. Consistent with the experience in patients to date, unmodified allogeneic CAR T cells show greatly reduced persistence and a high rate of tumor recurrence in this model.

HIP CAR T Cells are Equally Effective at Clearing Tumors in In Vivo Immunodeficient Models
The efficacy of HIP CAR T cells in clearing tumors was assessed in immunodeficient mice that received low, middle, and high doses of either HIP CAR T cells or unmodified allogeneic CAR T cells intravenously. HIP CAR T cells and unmodified allogeneic CAR T cells similarly reduced bone marrow cancer burden.

HIP Modifications Do Not Impair CAR T Function and HIP CAR T Cells Are Not Prone to Exhaustion
In vitro studies demonstrate that HIP engineering does not impact CAR T cell specificity, impair cytotoxic function, accelerate T cell exhaustion, or weaken anti-tumor efficacy across a number of parameters including TIM3, TIGIT, LAG3, CLTA-4, CD39, or PD-1.

Using an immunodeficient model to eliminate the contribution of allogeneic rejection, the longer-term function of HIP CAR T cells and unmodified allogeneic CAR T cells were evaluated in NSG mice receiving multiple injections of tumor cells at 15 and 27 days following CAR T cell administration. On day 63, mice treated with HIP CAR T cells showed significantly higher CAR+ cell numbers in the bone marrow and spleen and more effectively reduced CD19+ cancer cells in the bone marrow as compared to mice receiving unmodified allogeneic CAR T cells. No differences in CAR T cell exhaustion were observed between the groups.

HIP CAR T Cells can be Cleared Rapidly by Targeting CD47
Given the reliance of HIP CAR T cells on CD47 overexpression to protect these MHC class I- and II-disrupted cells against an innate immune response, another study was conducted to evaluate the use of CD47-targeting fusion proteins to "hide" CD47 overexpression, enable innate immune cell killing, and serve as a safety switch to eliminate HIP CAR T cells. The administration of CD47-targeting fusion proteins resulted in a near-complete ablation of HIP CAR T cells. The effect was highly specific and did not target other tissue cell types that express HLA. Only HLA-deficient HIP CAR T cells were susceptible to innate immune clearance.

On April 13, 2023 Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage oncology company developing targeted therapies for RAS-addicted cancers, reported that Mark A. Goldsmith, M.D., Ph.D., the company’s chief executive officer and chairman, will be the featured speaker in a fireside chat at the 22nd Annual Needham Healthcare Conference (Press release, Revolution Medicines, APR 13, 2023, View Source [SID1234630044]). The conference will take place April 17-20, 2023.

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Details of the company’s participation are as follows:

22nd Annual Needham Healthcare Conference
Conference Dates: April 17-20, 2023
Fireside Chat Time/Date: 3:00 p.m. Eastern on Thursday, April 20, 2023
Format: Virtual conference; webcast available
To access the live webcast of the presentation, please visit the "Events & Presentations" page of Revolution Medicines’ website at View Source Additionally, a replay of the webcast will be available on the "Events & Presentations" page of the Revolution Medicines website for at least 14 days following the conference.