On April 11, 2023 Prelude Therapeutics Incorporated (Nasdaq: PRLD), a clinical-stage precision oncology company, reported details relating to eight abstracts being presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2023, taking place April 14-19 in Orlando, Florida (Press release, Prelude Therapeutics, APR 11, 2023, View Source [SID1234629955]).
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"Prelude’s six preclinical and two clinical abstracts being presented at the AACR (Free AACR Whitepaper) Annual Meeting highlight the important progress we are making across our pipeline. Initial safety, pharmacokinetic and pharmacodynamic profiles in solid tumors for both PRT2527 and PRT1419 support continued development of both compounds in hematological cancers," said Jane Huang, M.D., President and Chief Medical Officer of Prelude. "Additionally, we will be presenting preclinical data on our orally bioavailable SMARCA2 degrader program for the first time."
"We are also presenting preclinical data for both our next generation CDK4/6 inhibitor, PRT3645, and our SMARCA2 degrader, PRT3789, in combination with other targeted therapies. These studies demonstrate the favorable combinability of our compounds with standard of care medicines and inform potential clinical development," added Peggy Scherle, Ph.D., Chief Scientific Officer of Prelude.
Details of the clinical abstracts upcoming presentations are as follows:
Title: A phase 1, open-label, dose-escalation study of PRT1419, a selective induced myeloid leukemia cell differentiation protein (MCL-1) inhibitor, in patients (pts) with advanced/metastatic solid tumors
Presenter: Gerald Falchook
Session Title: First-in-Human Phase I Clinical Trials 2
Date and Time: Tuesday April 18, 2023, 9:00 AM – 12:30 PM
Location: Poster Section 45
Poster Board Number: 4
Abstract Presentation Number: CT172
Title: A phase 1, open-label, multicenter, dose-escalation study of PRT2527, a cyclin-dependent kinase 9 (CDK9) inhibitor, in adult patients (pts) with advanced solid tumors
Presenter: Jason T. Henry
Session Title: First-in-Human Phase I Clinical Trials 2
Date and Time: Tuesday April 18, 2023 9:00 AM – 12:30 PM
Location: Poster Section 45
Poster Board Number: 5
Abstract Presentation Number: CT173
Details of the preclinical abstracts are as follows:
Title: SMARCA2 (BRM) degraders promote differentiation and inhibit proliferation in AML models
Presenter: Anjana Agarwal
Session Category: Experimental and Molecular Therapeutics
Session Title: New Therapeutic Targeted Agents
Date and Time: Monday April 17, 2023 9:00 AM – 12:30 PM
Location: Section 16
Poster Board Number: 17
Abstract Presentation Number: 1594
Title: Development of pharmacodynamic assays for quantifying SMARCA2 protein degradation and target gene expression in response to a SMARCA2 degrader (PRT3789)
Presenter: Andrew Moore
Session Category: Experimental and Molecular Therapeutics
Session Title: Pharmacokinetics, Pharmacodynamics, and Molecular Pharmacology
Date and Time: Monday April 17, 2023 1:30 PM – 5:00 PM
Location: Section 18
Poster Board Number: 15
Abstract Presentation Number: 2792
Title: Combination therapy with selective SMARCA2 (BRM) degraders for treatment of SMARCA4 (BRG1)-deficient cancers
Presenter: Michael Hulse
Session Category: Experimental and Molecular Therapeutics
Session Title: Epigenetics
Date and Time: Wednesday April 19, 2023 9:00 AM – 12:30 PM
Location: Section 20
Poster Board Number: 8
Abstract Presentation Number: 6270
Title: The brain penetrant CDK4/6 Inhibitor, PRT3645, is highly effective in combination with other targeted therapies in preclinical models of NSCLC and HER2-positive breast cancer
Presenter: Yue Zou
Session Category: Molecular/Cellular Biology and Genetics
Session Title: Cyclin-dependent Kinases and Cyclin-dependent Kinase Inhibitors
Date and Time: Wednesday April 19, 2023 9:00 AM – 12:30 PM
Location: Section 9
Poster Board Number: 2
Abstract Presentation Number: 5973
Title: MCL1 inhibitor PRT1419 demonstrates anti-tumor activity in PBRM1-altered clear cell renal cancer and synergizes with standard of care agents
Presenter: Norman Fultang
Session Category: Experimental and Molecular Therapeutics
Session Title: Cell Death Pathways and Treatment / Molecular Classification of Tumors for Diagnostics, Prognostics, and Therapeutic Outcomes
Date and Time: Wednesday April 19, 2023 9:00 AM – 12:30 PM
Location: Section 16
Poster Board Number: 9
Abstract Presentation Number: 6147
Title: Selective and orally bioavailable SMARCA2 targeted degraders induce synthetic lethality in SMARCA4- deficient solid tumor
Presenter: Koichi Ito
Session Category: Experimental and Molecular Therapeutics
Session Title: Epigenetics
Date and Time: Wednesday April 19, 2023 9:00 AM – 12:30 PM
Location: Section 20
Poster Board Number: 15
Abstract Presentation Number: 6277