BIOGEN TO REPORT FIRST QUARTER 2023 FINANCIAL RESULTS APRIL 25, 2023

On April 11, 2023 Biogen Inc. (Nasdaq:BIIB) reported it will announce first quarter 2023 financial results Tuesday, April 25, 2023, before the financial markets open (Press release, Biogen, APR 11, 2023, View Source [SID1234629960]).

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Following the release of the financials, the Company will host a live webcast with Biogen management at 8:00 a.m. ET. To access the live webcast, please go to the investors section of Biogen’s website at investors.biogen.com. An archived version of the webcast will be available for at least 90 days following the presentation.

OncoSec Announces Closing of $2 Million Registered Direct Offering Priced At-The-Market Under Nasdaq Rules

On April 11, 2023 OncoSec Medical Incorporated (NASDAQ: ONCS) (the "Company" or "OncoSec"), a clinical-stage biotechnology company developing intratumoral immunotherapies to stimulate the patient’s immune system to target cancer cells and eradicate disease, reported the closing of its previously announced registered direct offering of 1,582,932 shares of its common stock, at a purchase price of $1.25 per share, priced at-the-market under Nasdaq rules (Press release, OncoSec Medical, APR 11, 2023, View Source [SID1234629959]). The Company also issued in a concurrent private placement unregistered warrants to purchase up to an aggregate of 1,582,932 shares of common stock. The warrants have an exercise price of $1.12 per share, are immediately exercisable upon issuance, and will expire five and one-half years from the date of issuance.

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H.C. Wainwright & Co. acted as the exclusive placement agent for the offering.

The gross proceeds to the Company from the offering were approximately $2 million, before deducting the placement agent’s fees and other offering expenses payable by the Company. The Company intends to use the net proceeds from this offering as working capital for general corporate purposes.

The securities described above (excluding the warrants and the shares of common stock underlying the warrants) were offered and sold by the Company in a registered direct offering pursuant to a "shelf" registration statement on Form S-3 (File No. 333-260850) that was originally filed with the Securities and Exchange Commission (the "SEC") on November 8, 2021, and declared effective on November 15, 2021. The offering of such securities in the registered direct offering was made only by means of a prospectus supplement that forms a part of the effective registration statement. A final prospectus supplement and the accompanying base prospectus relating to the registered direct offering were filed with the SEC and are available on the SEC’s website at www.sec.gov. Electronic copies of the final prospectus supplement and the accompanying base prospectus may also be obtained from H.C. Wainwright & Co., LLC at 430 Park Avenue, 3rd Floor, New York, NY 10022, by phone at (212) 856-5711 or e-mail at [email protected].

The warrants described above were offered in a private placement under Section 4(a)(2) of the Securities Act of 1933, as amended (the "Act"), and Regulation D promulgated thereunder and, along with the shares of common stock underlying such warrants, have not been registered under the Act, or applicable state securities laws. Accordingly, the warrants and the underlying shares of common stock may not be offered or sold in the United States except pursuant to an effective registration statement or an applicable exemption from the registration requirements of the Act and such applicable state securities laws.

This press release shall not constitute an offer to sell or a solicitation of an offer to buy any of the securities described herein, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

Medigene to present Phase I clinical data for MDG1011 with poster presentation at EBMT 2023 Annual Meeting

On April 11, 2023 Medigene AG (Medigene, FSE: MDG1, Prime Standard), an immuno-oncology platform company focusing on the discovery and development of T cell immunotherapies for solid tumors, reported that it will present a poster at the European Society for Blood and Marrow Transplantation (EBMT) 2023 annual meeting being held on April 23-26, 2023 in Paris (Press release, MediGene, APR 11, 2023, View Source [SID1234629958]).

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The data to be presented show the full results from the CD-TCR-001 dose escalation study with MDG1011, a T cell receptor engineered T cell (TCR-T) therapy directed against the tumor antigen PRAME (PReferentially expressed Antigen in MElanoma) with HLA-A*02:01, in heavily pre-treated patients suffering from different hematological malignancies. MDG1011 was well-tolerated, with efficacy most evident at the highest dose level tested. Data also showed that MDG1011 cells were still detectable after several months while PRAME levels decreased and remained low.

The abstract for this clinical study has been published online View Source and the accompanying presentation in the form of an ePoster will be available online on April 23, 2023.

ePoster details

AS-EBMT-2023-00737:

First-in-Human Study of MDG1011, a TCR-T Cell Therapy directed against HLA-A*02:01-Restricted PRAME, for High-Risk Myeloid and Lymphoid Neoplasms (CD-TCR-001)

Simone Thomas, Martin Wermke, Vladan Vucinic, Eva Wagner-Drouet, Andreas Mackensen, Robert Zeiser, Gesine Bug, Michael Schmitt, Petra Prinz, Dolores Schendel, Kai Pinkernell, René Goedkoop

Blueprint Medicines to Present at Upcoming Investor Conferences

On April 11, 2023 Blueprint Medicines Corporation (Nasdaq: BPMC) reported its participation in the following upcoming investor conferences (Press release, Blueprint Medicines, APR 11, 2023, View Source [SID1234629957]):

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22nd Annual Needham Healthcare Conference, held virtually, on Tuesday, April 18, 2023 at 2:15 p.m. ET.

Stifel 2023 Targeted Oncology Days, held virtually, on Tuesday, April 25, 2023 at 11:30 a.m. ET.

A live webcast of each presentation will be available by visiting the "Events and Presentations" section of Blueprint Medicines’ website at View Source A replay of the webcasts will be archived on Blueprint Medicines’ website for 30 days following each presentation.

Abstract Evaluating Allarity’s DRP® Companion Diagnostic for Cisplatin Accepted at 2023 ASCO Annual Meeting

On April 11, 2023 Allarity Therapeutics, Inc. ("Allarity" or the "Company"), a clinical-stage pharmaceutical company developing novel oncology therapeutics together with drug-specific DRP companion diagnostics for personalized cancer care, reported that an abstract on the Company’s proprietary DRP technology has been accepted for a poster presentation at the 2023 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting (Press release, Allarity Therapeutics, APR 11, 2023, View Source [SID1234629956]).

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Researchers will present the data at the ASCO (Free ASCO Whitepaper) meeting taking place June 2-6 online and in person at the McCormick Place in Chicago. The poster shows the final data from a phase 2 study evaluating the ability of the DRP companion diagnostic for cisplatin to prospectively identify patients with metastatic breast cancer that are likely to respond to treatment with LiPlaCis, a targeted liposomal formulation of cisplatin. Allarity conducted the study in collaboration with investigators at hospitals in Denmark, as well as its CRO Smerud Medical Research International AS. The LiPlaCis program is currently licensed to Chosa Oncology AB for further clinical development.

The poster presentation details are as follows:

Poster Title: "Predictive biomarker for cisplatin in prospective phase 2 of liposomal cisplatin in metastatic breast cancer."
Authors: Nielsen, D., Jakobsen, E,H., Langkjer, S.T., Danoe, H., Balslev, E., Knoop, A., … Lassen, U.N.
Abstract Number: 3130
Session Title: Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Date and Time: 6/3/2023, 8:00 AM-11:00 AM local time

ASCO will publish the official abstracts on its meeting website in advance of the ASCO (Free ASCO Whitepaper) Annual Meeting at 5:00 p.m. ET on Thursday, May 25, 2023.