On November 21, 2023 Curium, a global leader in nuclear medicine, reported the successful completion of patient enrollment in the pivotal Phase 3 ECLIPSE trial (Press release, Curium, NOV 21, 2023, View Source [SID1234637900]).

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ECLIPSE is a Phase 3, multi-center, open-label, randomized clinical trial comparing the safety and efficacy of 177Lu-PSMA I&T versus hormone therapy in patients with metastatic castration-resistant prostate cancer. The ECLIPSE trial enrolled over 400 patients, ahead of schedule, across 51 trial sites in the United States and Europe.

Sakir Mutevelic, MD, MSc, Chief Medical Officer at Curium said: "We are proud to announce the completion of enrollment in the ECLIPSE trial, and would like to thank the patients, trial investigators, clinical research partners, and our Curium cross-functional teams for their dedication and commitment. We are looking forward to delivering the study results once the data matures."

Michael Patterson, CEO, North America commented: "Curium is committed to advancing radioligand treatment options for patients with prostate cancer. Our proven ability to reliably manufacture and distribute nuclear medicine products across the globe is at the core of our business. We are excited to continue to build on our trusted relationships with nuclear medicine physicians and their staffs while advancing the scientific knowledge leveraged by oncologists, radiation oncologists, and urologists to treat patients with metastatic castration-resistant prostate cancer."

For more information about the ECLIPSE trial (NCT05204927): www.eclipseclinicaltrial.org.

On November 21, 2023 Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX) reported that company management will participate in fireside chats at the 6th Annual Evercore ISI HealthCONx Conference in Miami, Florida and the Piper Sandler 35th Annual Healthcare Conference in New York City (Press release, Crinetics Pharmaceuticals, NOV 21, 2023, View Source [SID1234637899]).

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Details of the fireside chat are as follows:

6th Annual Evercore ISI HealthCONx Conference:
Date: Tuesday, November 28, 2023
Time: 3:50 p.m. Eastern Time

Piper Sandler 35th Annual Healthcare Conference:
Date: Thursday, November 30, 2023
Time: 8:00 a.m. Eastern Time

The live and archived webcast will be accessible on the Events & Presentations page in the Investors section on the Crinetics’ website on our events page.

If you are interested in arranging a 1×1 meeting with management, please contact your Cantor representative.

On November 21, 2023 BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) reported that the company will present at the 6th Annual Evercore ISI HealthCONx Conference on Tuesday, November 28th in Miami at 9:35 a.m. ET and the 35th Annual Piper Sandler Healthcare Conference on Wednesday, November 29th in New York at 12:30 p.m. ET (Press release, BioCryst Pharmaceuticals, NOV 21, 2023, View Source [SID1234637897]).

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Links to the live audio webcasts and replays of the presentations may be accessed in the Investors & Media section of BioCryst’s website at http://www.biocryst.com.

On November 21, 2023 BeiGene, Ltd. (NASDAQ: BGNE; HKEX: 06160; SSE: 688235), a global biotechnology company, and Ensem Therapeutics, Inc. (ENSEM), a biotechnology company focusing on high-value and difficult-to-drug oncology targets, reported an agreement for BeiGene to acquire an exclusive global license to an Investigational New Drug (IND) application-ready oral cyclin-dependent kinase 2 (CDK2) inhibitor (Press release, BeiGene, NOV 21, 2023, View Source [SID1234637896]).

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"We are committed to developing novel molecules with the potential to transform the therapeutic landscape for cancer patients, and this partnership fits well with our strategic focus on breast cancer as an area with tremendous unmet need for innovative treatment options," said Lai Wang, Ph.D., Global Head of R&D at BeiGene. "This CDK2 inhibitor from ENSEM complements our internally discovered Phase 1 CDK4 inhibitor, which has the potential to improve upon current CDK4/6 inhibitors in some breast cancer patients, and strengthens our early development pipeline in breast cancer and other solid tumors. We are excited to work with ENSEM to bring this molecule into the clinic in the near future."

Under the terms of the agreement, ENSEM will receive an upfront payment, and will be eligible for additional payments upon the achievement of certain development, regulatory, and commercial milestones, totaling up to $1.33 billion, in addition to tiered royalties.

"We are pleased to partner with BeiGene on the development of this differentiated CDK2 inhibitor," said Shengfang Jin, Ph.D., President and Chief Executive Officer at ENSEM. "We believe BeiGene is the right partner to advance our first IND-ready asset due to their wealth of expertise in bringing innovative cancer therapies to patients globally. This partnership validates the capabilities of ENSEM’s drug discovery and development team and the ability to rapidly advance potential best-in-class or first-in-class molecules utilizing our Kinetic Ensemble platform. We look forward to progressing our additional pipeline programs to help patients in need and supporting BeiGene’s important work to take this therapy into clinical trials."

On November 21, 2023 Alkermes plc (Nasdaq: ALKS) reported that management will participate in fireside chat presentations at two upcoming investor conferences (Press release, Alkermes, NOV 21, 2023, View Source [SID1234637895]).

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Piper Sandler 35th Annual Healthcare Conference
Date/Time: Tuesday, Nov. 28, 2023 at 11:00 a.m. ET (4:00 p.m. GMT)

6th Annual Evercore ISI HealthCONx Conference
Date/Time: Wednesday, Nov. 29, 2023 at 10:00 a.m. ET (3:00 p.m. GMT)

The live webcasts may be accessed under the Investors tab on www.alkermes.com and will be archived for 14 days.