On February 16, 2023 Cue Biopharma, Inc. (Nasdaq: CUE), a clinical-stage biopharmaceutical company developing a novel class of injectable biologics to selectively engage and modulate disease-specific T cells directly within the patient’s body, reported that the company’s therapeutic Immuno-STAT (Selective Targeting and Alteration of T cells) platform and biologics will be featured in a poster at the 67th Biophysical Society Annual Meeting, taking place February 18-22, 2023 in San Diego, CA (Press release, Cue Biopharma, FEB 16, 2023, View Source [SID1234627339]). The research is part of a strategic research collaboration that Cue Biopharma initiated with Dr. Michael Dustin’s laboratory at the University of Oxford in May 2020 to determine the molecular mechanisms underlying the activity of the company’s interleukin 2 (IL-2) based CUE-100 series of biologics.
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"The data continue to support the differentiated mechanism of action of Cue Biopharma’s Immuno-STAT CUE-100 series of biologics, by uniquely mimicking the natural process of immune synapse formation," said Jesusa Capera-Aragones, Ph.D., post-doctoral researcher, Dustin laboratory of the Kennedy Institute at the University of Oxford. "By simultaneously presenting a targeted antigen and the immunostimulatory molecule IL-2, Cue Biopharma’s biologics enable the specific and simultaneous engagement of IL-2 and T cell receptors, as it would occur in nature. This promotes the selective activation of disease-specific "killer" T cells, while maximizing T cell activation and minimizing off-target binding, potentially translating in a larger therapeutic window reducing toxicities seen with other IL-2-based therapies.
Dr. Anish Suri, Ph.D., president and chief scientific officer of Cue Biopharma, added "We are very pleased with the research and collaboration with Dr. Dustin’s laboratory of the Kennedy Institute at the University of Oxford. The data continue to validate the platform design and support the results we are seeing as part of our Phase 1 clinical study of our lead CUE-100 candidate, CUE-101, in human papilloma virus (HPV)+ head and neck cancer, that shows activation of HPV+ specific "killer" T cells in patients. We look forward to sharing clinical progress and continue to provide clinical validation of the platform, with potential to treat a large number of cancers."
Presentation Details
Abstract title: Understanding the Spatial and Functional Link Between the IL-2R and TCR at the Immunological Synapse
Presenter: Jesusa Capera-Aragones, Ph.D., from the Kennedy Institute at the University of Oxford
Poster Session: Membrane Receptors and Signal Transduction Track A: Novel Engineered Cell Therapies and Concepts
Poster Board Number: B231
Date and Time: February 22, 2023, 10:30 a.m. PST
Location: Exhibit Hall BC
Program Number: 2481-Pos
About the CUE-100 Series
The CUE-100 series consists of Fc-fusion biologics that incorporate peptide-MHC (pMHC) molecules along with rationally engineered IL-2 molecules. This singular biologic is anticipated to selectively target, activate and expand a robust repertoire of tumor-specific T cells directly in the patient’s body. The binding affinity of IL-2 for its receptor has been deliberately attenuated to achieve preferential selective activation of tumor-specific effector T cells while reducing the potential for effects on regulatory T cells (Tregs) or broad systemic activation, potentially mitigating the dose-limiting toxicities associated with current IL-2-based therapies.
About Immuno-STAT
The company’s Immuno-STAT (Selective Targeting and Alteration of T cells) platform biologics are designed for targeted modulation of disease-associated T cells in the areas of immuno-oncology and autoimmune disease. Each of our biologic drugs is designed using our proprietary scaffold comprising: 1) a peptide-major histocompatibility complex (pMHC) to provide selectivity through interaction with the T cell receptor (TCR), and 2) a unique co-stimulatory signaling molecule to modulate the activity of the target T cells. The simultaneous engagement of co-regulatory molecules and pMHC binding mimics the signals delivered by antigen presenting cells (APCs) to T cells during a natural immune response. This design enables Immuno-STAT biologics to engage with the T cell population of interest, resulting in selective T cell modulation. Because our drug candidates are delivered directly in the patient’s body (in vivo), they are fundamentally different from other T cell therapeutic approaches that require the patients’ T cells to be extracted, modified outside the body (ex vivo) and reinfused.