On February 8, 2023 Tailor Bio, an innovative techbio company, reported that it has secured £2 million in funding to advance its pan-cancer precision medicine platform (Press release, Tailor Bio, FEB 8, 2023, View Source [SID1234641527]). The funding round was led by London-based Ascension Life Fund, with support from Time-Boost Capital, Acequia Capital, First-In Ventures, Illumina Accelerator, Cambridgeshire & Peterborough Combined Authority and prominent genomics angel investor Graham Snudden (Founder of BlueGnome, acquired by Illumina).

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Tailor Bio’s platform aims to make precision medicine a reality for the deadliest cancers by providing new insight into chromosomal instability (CIN). CIN is a genomic phenomenon present in 80% of all cancers and extreme CIN is typically found in more aggressive, difficult to treat cancers1. Tailor Bio’s platform provides unique understanding of CIN to help identify new therapeutic targets and improve patient stratification for more targeted and effective treatments.

Tailor was founded to translate cutting edge cancer research from academia to patient benefit. The company’s scientific co-founders include group leaders Dr Geoff Macintyre from the Spanish National Cancer Institute, Professor James Brenton, Professor Florian Markowetz and Dr Anna Piskorz from Cancer Research UK Cambridge Institute, University of Cambridge.

The company is also proud to announce that Professor Steve Jackson has joined the team as an advisor. Professor Jackson is a renowned cancer researcher and was instrumental in the development of the PARP inhibitor olaparib, which is currently used to treat certain types of ovarian, breast, prostate and pancreatic cancers. He has also founded several successful biotech startups, which together with his expertise in cancer research and drug development will be invaluable as Tailor Bio continues to develop its platform.

Tailor Bio CEO, Jason Yip, said: "We are thrilled to have secured this funding, which will enable us to further develop and deploy our platform in order to provide new and more effective treatments for cancer patients by using precision medicine. We are excited to accelerate our work with the guidance of Professor Steve Jackson and the support of our investors."

Dr. Ala Alenazi, Principal at Ascension Life Fund said: "The healthcare impact, scientific validation and team vision won our early conviction in Tailor Bio. The team published a ground-breaking study on the cover of Nature showing that CIN tumours display signatures that can inform a personalised therapeutic approach. The momentum has not stopped since and we’re excited to join them on their journey to supercharge their platform and strategy. We’re also lucky to be joined by a syndicate of brilliant investors and angels."

The funds will be used to further develop the platform, grow the team and expand the company’s operations.

For further information please contact [email protected].

On February 8, 2023 – Asieris Pharmaceuticals, a global biopharma company specializing in discovering, developing, and commercializing innovative drugs for the treatment of genitourinary tumors and other related diseases, reported a research collaboration and option-to-license agreement with ReviR Therapeutics, a privately held developer of a suite of small molecule RNA-targeting technologies for cancer and other genetically-defined diseases (Press release, Asieris Pharmaceuticals, FEB 8, 2023, View Source [SID1234632107]). This collaboration aims to discover and develop innovative treatments for genitourinary (GU) tumors and other related serious diseases, leveraging ReviR’s proprietary RNA-targeting technologies.

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The collaboration will include multiple oncology targets, with the goal of improving patient outcomes. According to the agreement, Asieris will utilize ReviR’s innovative RNA modulation technologies, named BindeR and SpliceR, to identify and develop new therapeutics that target RNA to treat GU and related cancers.

ReviR combines computational and high throughput drug discovery technologies with the goal of delivering next-generation medicines to patients. Its VoyageR AI platform integrates computational approaches to discover traditionally undruggable RNA targets. Initially, ReviR’s focus is in CNS, oncology, and genetically defined disease indications. Asieris will be able to use ReviR’s VoyageR AI platform to accelerate its discovery and development process in treating GU tumors and other related serious diseases.

"Asieris is a global biopharma company specializing in the development of GU oncology therapies, and we are excited to be working with them to discover new treatments for indications of interest," stated Paul August, Ph.D., Chief Scientific Officer of ReviR Therapeutics. "Our BindeR and SpliceR platform technologies have the potential to advance therapeutics for undruggable cancer targets, and we believe this collaboration will accelerate the discovery of new treatments for patients."

"The cooperation with Asieris will provide ReviR with access to specialized knowledge and resources to validate the effectiveness of our RNA targeted small molecule platforms" said Peng Yue, Ph.D., CEO of ReviR Therapeutics. "Such collaboration will enable us to partake in synergistic endeavors with a highly proficient team of seasoned experts at Asieris, which would undoubtedly lead to novel discoveries and breakthroughs in the small molecule, RNA targeting field. As the first of many partnerships to come for ReviR, we believe that this collaboration will greatly augment our efforts to enhance patient outcomes and further the field of cancer research."

"We are pleased to be collaborating with ReviR, an innovative biopharmaceutical company focused on the development of RNA-targeting small molecule therapies," said Alice Chen, Ph.D., Vice President of Discovery Biology and Head of Translational Research at Asieris. "We believe that our in-house R&D expertise on small molecule oncology drug discovery, combined with ReviR’s proprietary RNA-targeting technologies, will speed up our delivery of treatment benefits to patients. We will continue to adhere to our differentiated R&D strategy, focus on genitourinary tumors and related diseases, and continue to expand the global reach of our innovation to deliver novel drug products for patients in China and globally."

On February 8, 2023 Akiram Therapeutics, spin-out from SciLifeLab, reported that raised 68 MSEK and is heading for clinical trials in 2024 (Press release, Akiram Therapeutics, FEB 8, 2023, View Source [SID1234628975]).

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With the goal to enable personalized medicine, the idea was to evaluate the use of tailored molecular radiotherapy as treatment for advanced thyroid cancer, for which there is currently no effective treatment available. Since the exit, Marika Nestor and colleagues from Uppsala University have started a company – Akiram Therapeutics – to further develop the candidate drug for clinical use. The drug is a novel antibody-based radiopharmaceutical, which has potential to be broadly used in several other cancer indications.

"Marika’s project represented an ideal case for the SciLifeLab DDD model. In short, that means that we get innovative ideas from academic researchers around Sweden and use our technical infrastructure and drug discovery knowledge to develop prototype drugs, while the academic research group continues to develop the biological understanding", says Per Arvidsson, Director Drug Discovery & Development Platform, SciLifeLab.

In January 2023, Akiram Therapeutics secured investments of 68 MSEK from Sciety Venture Partners and Linc AB, in a venture capital round led by Sciety.

"The support and knowhow from SciLifeLab’s Drug Discovery and Development Platform has been instrumental for the development of the drug that is the basis for the company. The focus on bringing basic research from academia into applied science for the benefit of society, combined with the idea that the researchers behind an innovation continue to own their intellectual property rights, is a motivational force to take the step from lab to business, says Marika Nestor, Department of Immunology, Genetics and Pathology, Uppsala University.

Based on 20 years of work in the target protein, Marika realized that a subgroup of thyroid cancer patients, that does not respond to current treatment, has a specific protein expressed on the cancer cells. She approached the SciLifeLab DDD platform for help in developing an antibody that could carry a radioactive payload to the tumor to selectively expose it to cell killing radiation while sparing normal tissue.

"We used our expertise at the Drug Discovery and Development Platform in production of a suitable antigen and selected for human antibody binders in our in-house developed phage-display libraries. We characterized several lead antibodies at DDD, while Marika’s team, operated by co-Principal Investigator Anja Mortensen, was working on labeling the best leads and could demonstrate that they did indeed bind selectively to the target – both on cells and later in animal models. The lead antibodies were further engineered for optimal properties, such as isoform selection, binding affinity, biophysical properties, etc. Marika was able to demonstrate a good efficacy in killing cancer cells, while sparing normal cells and tissue. DDD also supported with bioanalysis and calculations of pharmacokinetic and pharmacodynamic response", says Per Arvidsson.

Until the financing round, the research behind Akiram Therapeutics has been carried out at Uppsala University with funding from among others from SciLifeLab, VINNOVA and the Swedish Cancer Society.

"Akiram Therapeutics is a great example of a company that bring together the best of academia and industry to advance breakthrough innovations. The collaboration between Akiram Therapeutics and SciLifeLab, coupled with the promising preclinical data and experienced team, made it a compelling investment opportunity for us. The DDD model is a critical component in the life science ecosystem, and we are proud to support projects like Akiram that are working towards finding solutions for unmet medical needs", says Andreas Lindblom, Managing Parter at Sciety.

"For us, the collaborative environment where we alternated work in the lab with the preclinical models that SciLifeLab have, were very successful. Without the support from SciLifeLab for pre-clinical proof of concept, and Testa Center, where we could optimize the production of the antibody, we would not have started the company. Now, with the financing, our mission to contribute to meet the therapeutic need of a group of cancer patients is about to be realized", finishes Marika Nestor.

On February 9, 2023 Moleculin presented its corporate presentation (Presentation, Moleculin, FEB 8, 2023, View Source [SID1234626999]).

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On February 9, 2023 Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809; NASDAQ: EVO) reported that the Company has extended and expanded its integrated multi-target drug discovery agreement with data-driven biotech creation firm, Related Sciences ("RS"), to continue to grow their joint portfolio of drug development candidates through 2030, leveraging Evotec’s industry-leading capabilities across the full R&D continuum (Press release, Evotec, FEB 8, 2023, View Source [SID1234626991]).

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Launched in early 2021, the Evotec-RS partnership brings together a unique set of complementary capabilities to efficiently select, discover, and develop new, precisely targeted medicines for unmet patient needs. By combining RS’ unique FacetsTM opportunity selection engine and decentralised team science model, with Evotec’s comprehensive platform of integrated drug discovery services and advanced A.I./M.L. capabilities, the parties jointly progress large portfolios of related programmes from target to clinic and then share the economic value created.

To bolster the growing portfolio of more than 15 discovery-stage assets, the partners are expanding the collaboration to include Evotec’s leading-edge capabilities in covalent inhibitor discovery, leveraging and building upon Evotec’s custom covalent libraries and novel screening approaches to discover an exciting new class of highly potent and selective covalent medicines for eligible targets.

In addition to substantial investment from RS and its companies to finance all Evotec-led research and discovery efforts across the portfolio of promising new drug programmes, Evotec is eligible to receive milestones, royalties, and a founding equity stake in all RS assets developed under the partnership.

Dr Craig Johnstone, Chief Operating Officer of Evotec, said: "We are delighted to expand and extend this unique and transformative partnership with Related Sciences. Through best-in-class, fully integrated interdisciplinary science, A.I./M.L.-enabled target selection and drug design, and joint project leadership and portfolio management, Evotec and Related Sciences are well positioned to generate novel, high quality treatments for patients with significant unmet medical needs."

Adam Kolom, Cofounder and CEO at Related Sciences, said: "Our unique data science, technology, and risk-optimization platforms at Related Sciences combine beautifully with Evotec’s best-in-class integrated drug discovery capabilities to create a powerful new model for hyper-efficient, scalable discovery of important new medicines for patients. We are excited to continue our collaborative work in this partnership, including adding new world-class capabilities for the discovery of covalent inhibitors to our growing, multi-modality portfolios."

No financial details of the collaboration were disclosed.