On January 26, 2023 IceCure Medical Ltd. (NASDAQ: ICCM) (TASE: ICCM) ("IceCure" or the "Company"), developer of minimally-invasive cryoablation technology, the ProSense System that destroys tumors by freezing, reported its participation in the Society of Interventional Oncology’s Annual Scientific Meeting ("SIO2023") in Washington, D.C. on January 19 – 23, 2023 (Press release, IceCure Medical, JAN 26, 2023, View Source [SID1234626603]). ProSense was demonstrated throughout the duration of the conference at IceCure’s booth. Separately, in a breast session organized by SIO2023, ProSense was featured in a panel discussion on January 21st led by Dr. Kenneth Tomkovich and included Dr. Robert Ward, both ProSense users. The discussion included cryoablation as a treatment option as well as a mention of ICE3 interim trial results.

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Dr. Tomkovich, Diagnostic and Interventional Radiologist with Princeton Radiology and Director of Breast Imaging and Interventions at CentraState Medical Center, is Co-lead Investigator of IceCure’s landmark ICE3 study for the treatment of small, low-risk, early-stage malignant breast tumors. Dr. Ward, Assistant Professor of Diagnostic Imaging at the Warren Alpert Medical School of Brown University, Program Director for the Breast Imaging Fellowship, Associate Chief of Diagnostic Imaging at Women & Infants Hospital, specializes in women’s imaging and breast tumor cryoablation.

Commenting on the growing interest in ProSense, Dr. Tomkovich stated, "we are seeing increasing interest from interventional radiologists and interventional oncologists, many of whom are practitioners who previously were not treating breast cancer patients. Their interest appears to be driven by the encouraging ICE3 interim results, which can drive the development of new patient markets for practitioners while making the minimally invasive procedure more accessible to patients."

On January 26, 2023 Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH), a discovery and development stage specialty pharmaceutical company focused on improving the outcomes of cancer patients treated with radiation therapy (RT), reported Anatoly Dritschilo, M.D., CEO, will present and host one-on-one meetings with investors at the Lytham Partners Investor Select Conference, taking place virtually on January 31, 2023 (Press release, Shuttle Pharmaceuticals, JAN 26, 2023, https://www.prnewswire.com/news-releases/shuttle-pharmaceuticals-to-present-at-lytham-partners-investor-select-conference-on-january-31-301731807.html [SID1234626602]).

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Company Webcast

The Company’s webcast presentation will be available for viewing at 9:00am ET on Tuesday, January 31, 2023, on the Company’s website at View Source or View Source The webcast will also be archived and available for replay.

1×1 Meetings

Management will be participating in virtual one-on-one meetings throughout the event. To arrange a meeting with management, please contact Lytham Partners at 1×[email protected] or register at View Source

On January 26, 2023 Agenus (NASDAQ: AGEN), an immuno-oncology company with a pipeline of immunological agents targeting cancer and infectious disease, reported that Dr. Garo Armen, Chairman and CEO, and Dr. Steven O’Day, Chief Medical Officer, will participate in the following upcoming investor conferences (Press release, Agenus, JAN 26, 2023, View Source [SID1234626601]).

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Guggenheim 5th Annual Oncology Day – Fireside chat presentation will be held in-person on Thursday, February 9th, 2023 at 9:35 AM ET
SVB Securities Global Biopharma Conference – Fireside chat presentation will be held virtually on Thursday, February 16th, 2023 at 10:00 AM ET
A live webcast of the presentations from Guggenheim and SVB Securities conferences can be accessed on the company’s website at View Source A replay will be posted following the event.

On January 26, 2023 Sapience Therapeutics, Inc., a clinical-stage biotechnology company focused on the discovery and development of peptide therapeutics to address oncogenic and immune dysregulation that drive cancer, announced today that management will present at the Guggenheim Healthcare Talks 2023 Oncology Day, being held February 8-9, 2023, in New York, NY (Press release, Sapience Therapeutics, JAN 26, 2023, View Source [SID1234626600]).

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Sapience CEO and President, Dr. Barry Kappel, will participate in a fireside chat with Guggenheim research analyst Michael Schmidt on Wednesday, February 8, 2023, at 11:20 am ET. Company management will also participate in one-on-one meetings with investors during the conference.

On January 26, 2023 Sana Biotechnology, Inc. (NASDAQ: SANA), a company focused on creating and delivering engineered cells as medicines, reported the U.S. Food and Drug Administration (FDA) has cleared the company’s Investigational New Drug (IND) application to initiate a first-in-human study of SC291 in patients with various B-cell malignancies (Press release, Sana Biotechnology, JAN 26, 2023, View Source [SID1234626599]).

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SC291 is a CD19-targeted allogeneic CAR T cell therapy developed using Sana’s hypoimmune platform. The goal of the hypoimmune platform is to overcome the immunologic rejection of allogeneic cells, which if true for SC291 may result in longer CAR T cell persistence and a higher rate of durable complete responses for patients with B-cell lymphomas or leukemias. The hypoimmune platform includes disruption of major histocompatibility (MHC) class I and MHC class II expression to hide cells from the adaptive immune system, which includes antibody and T cell responses, as well as overexpression of CD47 to inhibit activation of the innate immune cell system, in particular macrophages and natural killer (NK) cells. The company has presented data across multiple preclinical models highlighting the potential of this platform to cloak cells from immune recognition and the potential of SC291 as a therapeutic for patients with B-cell malignancies.

"The clearance of our SC291 IND is an important milestone, putting us closer to our goal of making an important medicine for patients with B-cell lymphomas and leukemias," said Steve Harr, Sana’s President and CEO. "We look forward to understanding the safety, potency, and persistence of these cells in patients, and we are optimistic that SC291 can become an important medicine for patients with these difficult cancers. Furthermore, this platform forms the backbone for additional development of CAR T cells targeting CD22, BCMA, and beyond. We expect initial clinical data from the SC291 study later this year and believe insights from this study will better inform our opportunities across the broader platform, both for CAR T cells and for programs outside of cancer such as our pancreatic islet cell therapy for patients with type 1 diabetes."

About Hypoimmune Platform

Sana’s hypoimmune platform is designed to create cells ex vivo that can "hide" from the patient’s immune system to enable the transplant of allogeneic cells without the need for immunosuppression. We are applying the hypoimmune technology to both donor-derived allogeneic T cells, with the goal of making potent and persistent CAR T cells at scale, and pluripotent stem cells, which can then be differentiated into multiple cell types at scale. Preclinical data demonstrate across a variety of cell types that these transplanted allogeneic cells are able to evade both the innate and adaptive arms of the immune system while retaining their activity. Our most advanced programs utilizing this platform include an allogeneic CAR T program targeting CD19+ cancers, an allogeneic CAR T program targeting CD22+ cancers, an allogeneic CAR T program targeting BCMA+ cancers, and stem-cell derived beta islet cells for patients with type 1 diabetes.