On January 25, 2023 Zymeworks Inc. (Nasdaq: ZYME), a clinical-stage biotechnology company developing novel, multifunctional biotherapeutics, reported that management will participate in the following upcoming investor conferences (Press release, Zymeworks, JAN 25, 2023, View Source [SID1234626564]).

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Guggenheim Oncology Conference 2023. Zymeworks’ management will participate in one-on-one meetings on February 8th – 9th and a fireside chat on February 9th at 2:10 pm Eastern Time (ET) in New York, NY.
SVB Securities Global Biopharma Conference. Zymeworks’ management will participate virtually in one-on-one meetings on February 14th – 15th and present on February 14th at 10:40 am ET.
All presentations and webcasts will be available on Zymeworks’ website at View Source

On January 25, 2023 RenovoRx, Inc. (Nasdaq: RNXT), a biopharmaceutical company focused on the localized treatment of solid tumors, reported that Shaun Bagai, Chief Executive Officer, is scheduled to present virtually at the Sequire Biotechnology Conference on Thursday, February 2, 2023 at 4 p.m. (ET) (Press release, Renovorx, JAN 25, 2023, View Source [SID1234626563]). To register for the event, visit the Sequire Biotechnology Conference website.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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During the webinar, Mr. Bagai will discuss the company’s mission to become a leading provider in oncology therapy by disrupting standard of care (intravenous systemic chemotherapy) treatment of difficult-to-treat cancers, and how its proprietary RenovoTAMP therapy platform offers an innovative approach to delivering local, targeted chemotherapy to solid tumors. The goals of the RenovoTAMP therapy platform are to improve quality of life for patients living with cancer by reducing the debilitating side effects typical of standard of care chemotherapy treatment and to extend patient survival. Additionally, Mr. Bagai will review the Company’s pivotal Phase III TIGeR-PaC clinical trial which has its first interim analysis targeted for reporting early this year.

The webinar is open to the public and participants will have an opportunity to ask questions during the Q&A portion of the webinar. Management will also be available during the conference for 1-on-1 meetings with the investment community. To schedule a meeting please reach out to KCSA Strategic Communications by emailing [email protected].

A webcast of the event will be available for a limited time on the Events page in the Investors section of the Company’s website.

On January 25, 2023 VieCure reported a new collaboration with Labcorp to provide clinicians greater access to precision oncology decision support (Press release, VieCure, JAN 25, 2023, View Source [SID1234626562]). This strategic collaboration will support patient-specific treatment plans by integrating Labcorp’s precision medicine testing solutions with VieCure’s clinical decision support tool, helping community cancer care providers advance health equity and increase precision diagnostic test utilization for cancer patients, including those living in rural and remote areas who may lack access to larger oncology centers. Together, the two companies will be positioned to improve clinical outcomes for patients, creating a streamlined experience for biomarker-informed, personalized cancer care through an integrated clinic-genomic workflow of Labcorp’s precision medicine testing solutions.

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"We have an opportunity to help further democratize precision oncology and make it easier for community oncologists to offer the right care for the right patient every time."

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"Nearly 75% of cancer patients in the United States are treated in the community and private practice settings," said Dr. Fred Ashbury, chief scientific officer at VieCure. "We have an opportunity to help further democratize precision oncology and make it easier for community oncologists to offer the right care for the right patient every time."

Next-generation sequencing (NGS) has become foundational for precision oncology, with rapidly expanding diagnostic, prognostic, and therapeutic implications, but a there are a number of challenges for data standards and interoperability that make it difficult for clinicians to effectively manage and stay up-to-date on potential treatments. Labcorp’s comprehensive precision oncology test menu includes centralized solutions – including NGS-based tests spanning solid tumors, hematologic malignancies, and hereditary cancers – and kitted solutions (through the Feb. 2022 acquisition of Personal Genome Diagnostics Inc.), allowing institutions to internalize NGS and provide testing in house and integrate comprehensive molecular data into patient records.

"Labcorp’s leadership and scale in precision medicine diagnostic testing and drug development will accelerate access to personalized treatments for cancer patients treated in community oncology practices," said Prasanth Reddy, MD, MPH, FACP, senior vice president and global head of oncology at Labcorp. "Labcorp’s comprehensive portfolio of cancer diagnostic and next-generation sequencing products will be fully integrated into the VieCure platform, improving the clinical workflow experience for community oncologists to aid in precision medicine selection for oncology patients and drive better outcomes."

On January 25, 2023 InnoCare Pharma (HKEX: 09969; SSE: 688428), a leading biopharmaceutical company focusing on the development of therapies for cancer and autoimmune diseases, reported that the latest clinical result of FGFR inhibitor gunagratinib (ICP-192) for the treatment of cholangiocarcinoma was presented at 2023 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Gastrointestinal (ASCO GI) Cancers Symposium (Press release, InnoCare Pharma, JAN 25, 2023, View Source [SID1234626561]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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The study was presented in a poster entitled "Gunagratinib, a highly selective irreversible FGFR inhibitor, in patients with previously treated locally advanced or metastatic cholangiocarcinoma harboring FGFR pathway alterations: A phase IIa dose-expansion study". Abstract number is 572.

As of September 5, 2022, 18 cholangiocarcinoma patients were treated orally with gunagratinib 20 mg QD. The median age of the patients was 52 with 44.4% male. Among 17 patients who have completed at least one tumor assessment, the overall response rate (ORR) was 52.9%, the disease control rate (DCR) was 94.1% and median progression free survival (mPFS) was 6.93 months (not reached at cutoff). Gunagratinib showed a well-tolerated safety profile.

Professor Ye Guo from Shanghai East Hospital of Tongji University said, "The study data demonstrated that gunagratinib is safe and well-tolerated in previously treated patients with locally advanced or metastatic cholangiocarcinoma harboring FGFR2 gene fusions or rearrangements. The response rate in such a patient group is high comparing to other approved FGFR inhibitors. Gunagratinib is a promising second-generation FGFR inhibitor with potential for the treatment of multiple indications with FGF/FGFR pathway abnormalities."

More information can be found at ASCO (Free ASCO Whitepaper) official website.

On January 25, 2023 Hoth Therapeutics, Inc. (NASDAQ: HOTH), a patient-focused biopharmaceutical company, reported that it has selected 3 of its clinical sites for its Phase 2a clinical trial for the treatment for rash and skin disorders associated with epidermal growth factor receptor (EGFR) inhibitor therapy (Press release, Hoth Therapeutics, JAN 25, 2023, View Source [SID1234626560]). EGFR inhibitors are critical therapeutic agents for the treatment of non-small cell lung cancer (NSCLC), pancreatic cancer, colorectal cancer, squamous-cell carcinoma of the head and neck, and breast cancer. The phase 2a dose ranging study as well as a proposed follow-up phase 2b safety and efficacy dose extension study; both studies will be conducted in cancer patients receiving EGFR inhibitor therapy.).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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The initial 3 clinical sites for the Phase 2a are located across the United States in the following cities:
St Louis, MO
Miami, FL
Houston, TX

"We are pleased to have selected our initial clinical sites," said Robb Knie, the Company’s CEO. "The caliber of the clinics selected represents some of the best cancer treatment facilities in the country. This selection process represents a major milestone for Hoth and we look forward to initiating patient enrollment."