Exact Sciences Announces Preliminary Fourth Quarter 2022 Results

On January 08, 2023 Exact Sciences Corp. (Nasdaq: EXAS), a leading provider of cancer screening and diagnostic tests, reported that the company expects to report revenue between $550.7 million and $552.7 million for the fourth quarter ended Dec. 31, 2022 (Press release, Exact Sciences, JAN 9, 2023, View Source [SID1234626057]).

"Exact Sciences’ fourth quarter results show the strength of our business and the momentum building behind the best brands in cancer diagnostics, Cologuard and Oncotype DX," said Kevin Conroy, chairman and CEO. "The foundation supporting Cologuard and Oncotype DX will fuel consistent revenue growth and profitability, putting Exact Sciences in a leading position to deliver the next wave of innovation in cancer diagnostics to patients, health systems, and health care providers globally."

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Preliminary, Unaudited Fourth Quarter 2022 Financial Results

For the three-month period ended Dec. 31, 2022, as compared to the same period of 2021:

•Total revenue between $550.7 million and $552.7 million, an increase of 16 percent, or 28 percent excluding COVID-19 testing
•Screening revenue between $401.8 million and $402.8 million, an increase of 45 percent, or 41 percent excluding the PreventionGenetics acquisition
•Precision Oncology revenue between $142.9 million and $143.9 million, a decrease of 4 percent, or an increase of 1 percent excluding the divested Oncotype DX Genomic Prostate Score test and the impact of foreign currency exchange rates
•COVID-19 testing revenue of approximately $5.9 million, a decrease of 87 percent

Preliminary, Unaudited 2022 Financial Results

For the twelve-month period ended Dec. 31, 2022, as compared to the same period of 2021:

•Total revenue between $2,082.0 million and $2,084.0 million, an increase of 18 percent, or 25 percent excluding COVID-19 testing
•Screening revenue between $1,423.0 million and $1,424.0 million, an increase of 34 percent, or 30 percent excluding the PreventionGenetics acquisition
•Precision Oncology revenue between $601.0 million and $602.0 million, an increase of 7 percent, or 11 percent excluding the divested Oncotype DX Genomic Prostate Score test and the impact of foreign currency exchange rates
•COVID-19 testing revenue of approximately $58.0 million, a decrease of 59 percent

Screening includes laboratory service revenue from Cologuard tests, PreventionGenetics, and immaterial revenue from Biomatrica and Oncoguard Liver products. Precision Oncology includes laboratory service revenue from global Oncotype DX products and therapy selection products.

Exact Sciences has not completed preparation of its financial statements for the fourth quarter or full year of 2022. The revenue ranges presented in this news release for the fourth quarter of 2022 and for the year ended Dec. 31, 2022 are preliminary and unaudited and are thus inherently uncertain and subject to change as we complete our financial results for the fourth quarter of 2022. Exact Sciences is in the process of completing its customary year-end close and review procedures as of and for the year ended Dec. 31, 2022, and there can be no assurance that final results for this period will not differ from these estimates. During the course of the preparation of Exact Sciences’ consolidated financial statements and related notes as of and for the year ended Dec. 31, 2022, the company’s independent registered public accountants may identify items that could cause final reported results to be materially different from the preliminary financial estimates presented herein.

Exact Sciences plans to report 2022 financial results during its February 2023 earnings call.

Target a better now

On January 9, 2023 Immunogen presented its corporate presentation (Presentation, ImmunoGen, JAN 9, 2023, View Source [SID1234626068]).

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Transformative medicines for patients

On January 9, 2023 Immunocore presented its corporate presentation (Presentation, Immunocore, JAN 9, 2023, View Source [SID1234626067]).

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EpiAxis Therapeutics to present at Biotech Showcase 2023

On January 09, 2023 EpiAxis Therapeutics, a leading LSD1 company with a focus on the treatment, diagnosis and monitoring of cancer and the prevention of its recurrence, reported it is is presenting at Biotech Showcase 2023 (Press release, EpiAxis Therapeutics, JAN 9, 2023, View Source;utm_medium=rss&utm_campaign=epiaxis-therapeutics-to-present-at-biotech-showcase-2023 [SID1234626054]).

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EpiAxis CEO Dr Jeremy Chrisp will discuss the company’s focus on developing novel cancer treatments and the prevention of cancer recurrence.

EpiAxis’ lead therapeutic program targets the epigenetic eraser enzyme lysine-specific demethylase 1 (LSD1) using a novel dual mechanism that targets the dormant cancer cells that seed cancer recurrence and, concurrently reinvigorates exhausted immune cells for improved cancer clearance.

"Our Phase 1 proof of concept study has validated LSD1 as a target and confirms inhibition of LSD1 reprograms cancer cells," Dr Chrisp said.

"We have dominant intellectual property across our first-in-class assets covering targeting of LSD1 in combination with surgery, other drugs including chemotherapy, immuno-therapy, radiotherapy across the metastatic setting."

In 2022, EpiAxis signed a material transfer agreement with Seattle Children’s Research Institute that will help researchers study a new approach to treating paediatric brain cancer. It also entered a collaboration with University Health Network (UHN) – Canada’s largest and leading research hospital – to study a new approach to prostate cancer treatment.

EpiAxis is also collaborating with Peptilogics to leverage AI for drug discovery to inhibit epigenetic oncology targets, aiming to reprogram cancer cells and drive immune reinvigoration.

Biotech Showcase, produced by Demy-Colton and EBD Group, is an investor conference focused on driving advances in therapeutic development by providing a sophisticated networking platform for executives and investors that fosters investment and partnership opportunities. The conference takes place each year during the course of one of the industry’s largest gatherings and busiest weeks.

"We are delighted that EpiAxis Therapeutics will be joining us in San Francisco and presenting at Biotech Showcase this year," said Sara Demy, CEO of Demy-Colton.

"Biotech Showcase is a prime occasion for life science entrepreneurs and investors to come together to discover the potential of innovative technologies that will drive the future of drug discovery."

Immatics corporate presentation

On January 9, 2023 Immatics presented its corporate presentation (Presentation, Immatics, JAN 9, 2023, View Source [SID1234626065]).

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