On October 6, 2023 Defence Therapeutics Inc. ("Defence" or the "Company"), a Canadian biopharmaceutical company specialized in the development of immune-oncology vaccines and drug delivery technologies, reported its participation to the upcoming Festival of Biologics to be held in Basel, Switzerland, October 10-12, 2023 (Press release, Defence Therapeutics, OCT 6, 2023, View Source;utm_medium=rss&utm_campaign=defence-to-present-three-of-its-leading-products-at-the-upcoming-festival-of-biologics-in-basel-switzerland [SID1234635851]).

The Festival of Biologics is a hub for the life science community to bridge the gap between academia and industry, covering the start to finish of biologics from discovery, through development, to manufacturing, clinical trials and commercialisation. Biologics have completely transformed the way that patients are treated. Biologics are central as they increase the range of options for treatments, giving new opportunities for patients and their clinicians.

With five events in one, the Festival of Biologics encourages conversation across the entire industry to inspire changes, bring forward innovations, and address complex challenges that the biologics industry is facing. In addition, this meeting offers an unparalleled opportunity to hear from stakeholders representing both the science and business communities who report on the latest data impacting cancer therapeutics to fight a wider range of cancers. The Festival of Biologics emphasizes the future needs of the oncology industry and highlights the importance for novel modalities related to cell therapies, vaccines and more effective antibody-drug conjugates (ADCs).

Defence is pleased to present its latest data during the Festival of Biologics on three of its leading products: i) its ARMTM anti-cancer vaccine technology, ii) its anti-cervical protein-based AccuVAC-PT007 vaccine and iii) its advanced AccuTOXTM program as an injectable for solid tumors.

"The three presentations given by our Chief Scientific Officer, Dr. Moutih Rafei, are aimed at two main objectives: i) to share with the scientific community how our innovative Accum platform technology can uplift many weak or moderate biomedical treatments as a means to significantly enhance their therapeutic window of action, and ii) to establish strategic partnerships with major players in the field to accelerate our therapeutics to patients faster", says Mr. Plouffe, CEO and president of Defence.

In addition, Defence has granted incentive stock options to its directors and management to purchase a total of 2,400,000 common shares of Defence pursuant to and in accordance with the terms and conditions of Defence’s stock option plan, subject to any regulatory approval. Each stock option vests immediately and is exercisable at a price of $2.50 per share for a period of ten years from the granted date.

On October 11, 2023 Cytovation ASA, a clinical stage immune-oncology company focused on the development of CyPep-1, its first-in-class, dual-acting targeted tumor immunotherapy, reported positive initial data from Part 2 of its Phase 1/2a CICILIA basket trial with all trial endpoints met (Press release, Cytovation, OCT 11, 2023, View Source;utm_medium=rss&utm_campaign=cytovation-reports-promising-interim-results-from-phase-1-2a-cicilia-study-with-cypep-1-in-solid-tumors [SID1234635850]). In this heavily pretreated, advanced and metastatic patient group CyPep-1 exhibits an excellent safety profile with no dose-limiting toxicities and has shown strong early signs of efficacy across solid tumor types.

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Lars Prestegarden, MD, PhD, CEO of Cytovation, commented: "The initial efficacy data from our CICILIA basket trial are highly encouraging and important to informing our view of the future development pathway for CyPep-1. They confirm our pre-clinical findings suggesting that CyPep-1’s unique, dual mechanism of action could offer an important treatment option for patients whose tumors are driven by an aberrant Wnt/β-catenin signaling pathway, which is estimated to drive up to 20% of all solid tumors and can be as high as 90% in certain types. Our fast-to-market strategy in Adrenocortical Carcinoma is intended to provide us with a bridgehead from which to rapidly expand development of CyPep-1 into other beta-catenin-driven indications, like Colorectal and Liver Cancer, bringing a potentially important new treatment option to significant numbers of patients." The early signals of efficacy from CICILIA confirm the importance of CyPep-1’s unique dual mechanism of action with the most promising responses seen in patients with tumor types characterized by aberrant Wnt/β-catenin pathway signaling and with liver metastases. This is consistent with pre-clinical findings, further details of which will be presented at the upcoming European Society of Medical Oncology (ESMO) (Free ESMO Whitepaper) congress (October 20th – 23rd). Furthermore, these pre-clinical and early clinical findings support the Company’s decision to rapidly advance development of CyPep-1 with an initial focus on metastatic Adrenocortical Carcinoma (ACC), a rare and highly aggressive tumor type driven by Wnt/ β-catenin and with no approved treatment options after first line. Cytovation is planning to start a Phase 2 trial in ACC in 2024 with registrational intent. This strategy provides a fast and cost-effective route to market, while validating the broader potential of the CyPep-1 platform for future development indications in β-catenin-driven solid tumors.

About CyPep-1
CyPep-1 is a unique and highly differentiated synthetic peptide therapy that has the potential to change the outlook for large cancer patient populations where there remains an urgent need for new treatment options. CyPep-1 has a unique dual mechanism of action, combining inhibition of the Wnt/β-catenin oncogenic pathway with tumor-specific cell destruction and immune activation through neoantigen release and in situ vaccination. Preclinical and early clinical findings have demonstrated that CyPep-1 is safe and well tolerated with no dose-limiting toxicities and strong signs of biological activity and clinically relevant responses.

On October 11, 2023 C4 Therapeutics, Inc. (C4T) (Nasdaq: CCCC), a clinical-stage biopharmaceutical company dedicated to advancing targeted protein degradation science to develop a new generation of small-molecule medicines and transform how disease is treated, reported plans to share data from the Phase 1 dose escalation portions of the ongoing Phase 1/2 trials of CFT7455 and CFT8634 (Press release, C4 Therapeutics, OCT 11, 2023, View Source [SID1234635849]). The CFT8634 Phase 1 dose escalation data has been accepted as a poster presentation at the Connective Tissue Oncology Society (CTOS) Annual Meeting taking place from November 1 – 4, 2023 in Dublin, Ireland. C4T will host a company-sponsored event on December 12, 2023, to share the CFT7455 dose escalation data in relapsed/refractory multiple myeloma (R/R MM).

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Upcoming CFT8634 Clinical Data

The Phase 1/2 trial is designed to characterize safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and evidence of anti-tumor activity of CFT8634 based on RECIST 1.1 criteria. As of August 29, 2023, 32 patients were enrolled across six dose escalation cohorts using a daily dosing schedule.

CTOS Presentation Details

Title: Initial results from a Phase 1 study of CFT8634, a novel bifunctional degradation activating compound (BiDAC) degrader of BRD9, in synovial sarcoma and SMARCB1-null tumors
Format: Poster Presentation
Time: Thursday, November 2, 2023; 5:30 PM – 6:30 PM IST (9:00 AM EST)
Presenter: Mark Agulnik, M.D., sarcoma section chief, department of medical oncology and therapeutics research, City of Hope

Data included in the poster presentation will be PK, PD, safety and RECIST criteria efficacy measures.

Upcoming CFT7455 Clinical Data

The Phase 1/2 trial is designed to characterize the safety, tolerability, PK, PD and anti-tumor activity of CFT7455 in patients with R/R MM or relapsed/refractory non-Hodgkin’s lymphoma (R/R NHL). The Phase 1 dose escalation portion of the ongoing Phase 1/2 trial has utilized a 14 days on/14 days off dosing schedule within which both daily dosing and Monday/Wednesday/Friday dosing were explored. C4T has completed the Phase 1 dose escalation for CFT7455 as a monotherapy in R/R MM using a 14 days on/14 days off dosing schedule; 22 patients were enrolled across five dose escalation cohorts for this portion of the study. Enrollment continues for the Phase 1 dose escalation evaluating CFT7455 with dexamethasone in R/R MM and as a monotherapy in R/R NHL.

At a company-sponsored event on December 12, 2023, C4T plans to present Phase 1 dose escalation data that focuses on the CFT7455 monotherapy regimen in R/R MM.

Upcoming Investor Conferences

The company is planning to participate in the following upcoming investor conferences:

November 8, 2023: Management will participate in the UBS Biopharma Conference taking place in Miami, FL.
November 14, 2023: Management will participate in the Stifel 2023 Conference taking place in New York, NY.

On October 11, 2023 Be Biopharma, Inc. ("Be Bio"), a company pioneering the discovery and development of Engineered B Cell Medicines (BeCMs), reported that Chief Executive Officer Joanne Smith-Farrell, Ph.D., will present at the annual Cell & Gene Meeting on the Mesa to be held October 10-12 in Carlsbad, California, and livestreamed globally (Press release, Be Biopharma, OCT 11, 2023, View Source [SID1234635847]).

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Details regarding the Be Biopharma presentation at the conference are as follows:

Event: 2023 Cell & Gene Meeting on the Mesa

Presentation: About B Cells: A New Class of Cellular Medicines

Date: October 11, 2023

Time:4:15-6:00pm PT

Location: Park Hyatt Aviara Resort, 7100 Aviara Resort Dr., Carlsbad, California 92011

Dr. Smith-Farrell will also participate on October 12 in an interactive discussion about resourcing strategies to support advancing innovation while meeting the practical and economic considerations of R&D.

Organized by the Alliance for Regenerative Medicine, the Cell & Gene Meeting on the Mesa is a three-day conference featuring more than 120 dedicated company presentations by leading public and private companies, highlighting technical and clinical achievements over the past 12 months in the areas of cell therapy, gene therapy, gene editing, tissue engineering, and broader regenerative medicine technologies, as well as over 100 panelists and featured speakers.

Virtual attendance is available, which includes a livestream of the Be Biopharma presentation and the ability to view all conference sessions on-demand. Please visit View Source for full information including registration. Complimentary attendance at this event is available for credentialed investors and members of the media only. Investors should contact Savannah Bryant at sbryant@alliancerm.org and interested media should contact Stephen Majors at smajors@alliancerm.org.

About B Cells – A New Class of Cellular Medicines

Imagine what could "Be?" In nature, a single B cell engrafts in the bone marrow and can produce thousands of proteins per second at constant levels over decades. B cells are nature’s exquisite medicine factories, manufacturing proteins to fight disease and maintain health. Unleashing the power of B cells is driving a new class of cellular medicines – Engineered B Cell Medicines (BeCMs). BeCMs have the potential to be durable, allogeneic, redosable and administered without toxic conditioning. The promise of BeCMs could transform therapeutic biologics with broad application — across protein classes, patient populations and therapeutic areas.

On October 11, 2023 Akoya Biosciences, Inc. (Nasdaq: AKYA) ("Akoya"), The Spatial Biology Company, reported that it will release financial results for the third quarter of 2023 after the market close on November 8th, 2023 (Press release, Akoya Biosciences, OCT 11, 2023, View Source [SID1234635846]). Company management will host a conference call to discuss financial results at 5:00 p.m. ET.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Investors interested in listening to the conference call are required to register online. It is recommended to register at least a day in advance. A live and archived webcast of the event will be available on the "Investors" section of the Akoya website at View Source