On June 13, 2023 Bicycle Therapeutics plc (NASDAQ:BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle) technology, reported that management will participate in a fireside chat at the TD Cowen Radiopharmaceutical Innovation Summit on June 20th, 2023 at 12:30 p.m. ET (Press release, Bicycle Therapeutics, JUN 13, 2023, View Source [SID1234632647]). The conference will be held in a virtual meeting format.

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A live webcast of the fireside chat will be accessible in the Investors & Media section of Bicycle’s website at www.bicycletherapeutics.com. An archived replay of the webcast will be available for 90 days following the fireside chat date.

On June 13, 2023 Aravive, Inc. (Nasdaq: ARAV, "the Company"), a late clinical-stage oncology company developing targeted therapeutics to treat metastatic disease, reported that in accordance with Nasdaq rules regarding employment inducement awards, the Company has granted an equity compensation award to a new employee (Press release, Aravive, JUN 13, 2023, View Source [SID1234632646]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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The Compensation Committee of ARAV’s Board of Directors approved the award of options to purchase an aggregate of 40,000 shares of common stock, with a grant date of June 8, 2023 (the "Grant Date"), to the newly hired employee in accordance with Nasdaq Listing Rule 5635(c)(4).

The stock option has an exercise price of $1.71, the closing price of ARAV’s common stock on the Grant Date. The stock option will vest and become exercisable with 25% of the shares underlying the stock option award vesting on the first anniversary of the date of hire and the remaining 75% of the shares subject to the Option will vest in equal monthly installments over the next 36 months of continuous service.

On June 13, 2023 Alligator Bioscience (Nasdaq Stockholm: ATORX) reported that it will host a virtual Key Opinion Leader (KOL) event on the interim efficacy data from the OPTIMIZE-1 Phase 2 study evaluating mitazalimab as first-line treatment for pancreatic cancer patients (Press release, Alligator Bioscience, JUN 13, 2023, View Source [SID1234632645]). The webinar will take place on Tuesday, June 27, 2023 at 9:00 AM ET / 3:00 PM CET. To register for the event, please click here.

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The event will feature Dr. Zev Wainberg, Professor of Medicine at University of California, Los Angeles (UCLA) and co-director of the UCLA Gastrointestinal (GI) Oncology Program, who will present the unmet medical need and current treatment landscape for patients suffering from metastatic pancreatic cancer, along with the potential for mitazalimab to provide an effective and safe first-line treatment solution.

Additionally, in a discussion moderated by Alligator Chief Medical Officer Dr. Sumeet Ambarkhane, we will provide insights into the latest interim efficacy readout and survival data from the OPTIMIZE-1 Phase 2 study evaluating CD40 agonist mitazalimab in combination with chemotherapy (mFOLFIRINOX) in 1st line metastatic pancreatic cancer.

As a reminder, the latest interim data analysis published on January 2nd showed encouraging outcomes for pancreatic cancer patients treated with mitazalimab combined with chemotherapy, achieving 52% Objective Response Rate (ORR) and Disease Control Rate (DCR) of >90%.

A live question and answer session will follow the formal presentations.

On June 12, 2023 Alpha Fusion reported the company has completed a third-party allotment of new shares to Toshiba Energy Systems & Solutions Corporation (hereinafter referred to as Toshiba ESS) as the second close of Series A (Press release, Alpha Fusion, JUN 12, 2023, View Source [SID1234647191]). This brings the total amount of funding raised to date to 590 million yen. Alpha Fusion will work with Toshiba ESS, which has strengths in fields such as nuclear power-related technology and heavy ion cancer therapy, to bring Japan’s world-leading innovative cancer treatment to the world as soon as possible. Building

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an astatine supply system both domestically and internationallyAlpha
Fusion is a startup that was established to deliver "targeted alpha nuclear medicine therapy using astatine (At-211)" to cancer patients around the world. Targeted alpha therapy (TAT) physically attacks cancer cells using alpha rays that emit high energy over a short distance of about a few cells. By binding alpha-particle-emitting nuclides to compounds (ligands) that accumulate in cancer cells, it is expected that cancer cells can be killed more safely and powerfully than the beta and gamma rays that are already in clinical use.

Astatine is a radioisotope that emits alpha rays and can be produced in an accelerator. Japanese research institutes such as Osaka University and the RIKEN Institute have led the world in astatine research. In order to build a stable supply system for astatine in Japan, which is expected to see an increase in demand in the future, Osaka University is leading the astatine manufacturing base construction project (J Innopla, a subsidy project for the Ministry of Economy, Trade and Industry’s "Development of an industry-academia fusion base at a regional core university"). In addition to Alpha Fusion, existing shareholder Sumitomo Heavy Industries, Ltd. and new shareholder Toshiba ESS are also participating in the construction of this astatine manufacturing base.

On June 12, 2023 Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, reported new data demonstrating the ability of the DecisionDx-SCC test to identify cutaneous squamous cell carcinoma (cSCC) tumors at a biologically high risk of metastasis in a subset of patients considered to be at a low risk of metastasis by traditional staging (i.e., patients with T1 tumors under the American Joint Committee on Cancer Eighth Edition (AJCC8) and Brigham and Women’s Hospital (BWH) staging systems) (Press release, Castle Biosciences, JUN 12, 2023, View Source [SID1234632690]). The data was shared in a poster, titled "The 40-gene expression profile (40-GEP) test allows for an improved prognostication of the likelihood of metastasis in patients with T1 cutaneous squamous cell carcinoma (cSCC) with high-risk factors," during the recent 2023 Fall Clinical Dermatology Conference for PAs & NPs.

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"The 40-gene expression profile (40-GEP) test allows for an improved prognostication of the likelihood of metastasis in patients with T1 cutaneous squamous cell carcinoma (cSCC) with high-risk factors"

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"Traditional staging, which includes solely tumor characteristics, only tells part of the story and leaves out a very critical piece of the plot, the biology of an individual patient’s tumor, which can provide greater insight into each patient’s unique metastatic propensity," said Ally-Khan Somani, M.D., Ph.D., board-certified dermatologist, Mohs micrographic surgeon and director of Dermatologic Surgery & Cutaneous Oncology Division at the Indiana University School of Medicine in Indianapolis. "By estimating a cSCC patient’s personal risk of metastasis, the DecisionDx-SCC test has proven to elevate the narrative, which can lead to more informed, pertinent risk-aligned treatment decisions that can help improve outcomes."

In the study, the DecisionDx-SCC test was able to significantly stratify three-year metastasis free survival rates within the AJCC8 and BWH T1 populations of the cSCC cohort. Approximately 70% of the AJCC8- and BWH-staged T1 tumors that metastasized were identified as being biologically high-risk by the DecisionDx-SCC test. This data supports the ability of the test to improve risk assessments based on staging alone, enabling clinicians and patients to make more risk-appropriate surveillance and treatment decisions.

Castle’s poster will be published in SKIN, The Journal of Cutaneous Medicine (www.jofskin.org), and may also be viewed here.

About DecisionDx-SCC

DecisionDx-SCC is a 40-gene expression profile test that uses an individual patient’s tumor biology to predict individual risk of cutaneous squamous cell carcinoma metastasis for patients with one or more risk factors. The test result, in which patients are stratified into a Class 1 (low), Class 2A (moderate) or Class 2B (high) risk category, predicts individual metastatic risk to inform risk-appropriate management.

Peer-reviewed publications have demonstrated that DecisionDx-SCC is an independent predictor of metastatic risk and that integrating DecisionDx-SCC with current prognostic methods can add positive predictive value to clinician decisions regarding staging and management. More information about the disease and test can be found at www.CastleTestInfo.com.