On January 11, 2024 Curis presented its corporate presentation (Presentation, Curis, JAN 11, 2024, View Source [SID1234639204]).

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On January 11, 2024 Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX), a clinical stage pharmaceutical company focused on the discovery, development and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors, reported that on January 10, 2024, the Compensation Committee of Crinetics’ Board of Directors granted non-qualified stock option awards to purchase an aggregate of 112,500 shares of its common stock to eight new non-executive employees under the Crinetics Pharmaceuticals, Inc. 2021 Employment Inducement Incentive Award Plan (the "2021 Inducement Plan") (Press release, Crinetics Pharmaceuticals, JAN 11, 2024, View Source [SID1234639203]). The stock options were granted as inducements material to the employees entering into employment with Crinetics in accordance with Nasdaq Listing Rule 5635(c)(4).

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The 2021 Inducement Plan is used exclusively for the grant of equity awards to individuals who were not previously employees of Crinetics, or following a bona fide period of non-employment, as an inducement material to such individuals’ entering into employment with Crinetics, pursuant to Nasdaq Listing Rule 5635(c)(4).

The options have an exercise price of $37.60 per share, which is equal to the closing price of Crinetics’ common stock on The Nasdaq Global Select Market on January 10, 2024. The shares subject to the stock options will vest over four years, with 25% of the shares vesting on the one-year anniversary of the applicable vesting commencement date and the balance of the shares vesting in a series of 36 successive equal monthly installments thereafter, subject to each employee’s continued employment with Crinetics on such vesting dates. The options are subject to the terms and conditions of the 2021 Inducement Plan and the terms and conditions of a stock option agreement covering the grant.

On January 11, 2024 Checkpoint Therapeutics, Inc. ("Checkpoint") (Nasdaq: CKPT), a clinical-stage immunotherapy and targeted oncology company, reported that James Oliviero, President and Chief Executive Officer, will participate in a fireside chat at the B. Riley Securities 4th Annual Oncology Conference, taking place on Thursday, January 18, 2024, at 4:00 p.m. EST (Press release, Checkpoint Therapeutics, JAN 11, 2024, View Source [SID1234639202]).

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To access this event, please RSVP to your B. Riley Securities sales representative. A replay of Checkpoint’s fireside chat will be available on this link after the meeting.

On January 10, 2024, Coherus BioSciences, Inc. (the "Company") reported that it had delivered a notice of termination of the TIGIT Program (as defined in the Collaboration Agreement) to Shanghai Junshi Biosciences, Co., Ltd ("Junshi Biosciences") pursuant to the Exclusive License and Commercialization Agreement (the "Collaboration Agreement") dated February 1, 2021, between the Company and Junshi Biosciences (Press release, Coherus Biosciences, JAN 10, 2024, View Source [SID1234651090]). The Company had previously notified Junshi Biosciences on January 9, 2022 of its election to exercise the license option for the TIGIT program CHS-006 described in the Collaboration Agreement (the "TIGIT Program").

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After its acquisition of Surface Oncology, Inc. in September 2023, the Company disclosed that it would conduct a portfolio prioritization process to allocate resources towards the most promising and/or competitively positioned product candidates in its pipeline. The Company believes it is in its best interests to terminate future work with Junshi Biosciences on the TIGIT Program. The Company plans to wind down work with Junshi Biosciences on the TIGIT Program over the coming months pursuant to the termination. Despite the termination of the work with Junshi BioSciences on the TIGIT Program, the Company will continue to support patients in its current studies involving CHS-006 (clinicaltrials.gov identifier# NCT05061628 and clinicaltrials.gov identifier# NCT05757492).

The Collaboration Agreement remains effective and active for all other purposes as the Company continues to work together with Junshi Biosciences on the development of LOQTORZI (toripalimab-tpzi).

On January 10, 2024 Shorla Oncology reported that FDA has accepted it’s New Drug Application (NDA) for SH-105 to treat patients with breast and ovarian cancers (Press release, Shorla Oncology, JAN 10, 2024, View Source [SID1234639217]). The NDA was given a Prescription Drug User Fee Act action date of June 29, 2024.

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"This innovative drug will offer hospital pharmacists and patients access to a differentiated, ready to administer, injectable product with unique characteristics that’s expected to facilitate rapid adoption once approved," said Orlaith Ryan, Shorla Oncology chief technical officer and cofounder, in a press release.1

The novel therapy is a formulation of a well-established freeze-dried powder medication that has been in use dating back to the 1950s. The ready-to-dilute liquid formulation eliminates the need for powder reconstitution, which Shorla stated will bolster the product’s efficiency and lower the risks associated with drug preparation.

Shorla Oncology, a United States-Ireland specialty pharmaceutical company, develops oncology treatments for rare, orphan, and pediatric cancers, for which there are limited current treatment options. Shorla closed an $8.3 million round of Series A funding in June 2020 and in October 2023, the company announced $35 million raised in Series B funding.2,3

On March 13, 2023, the FDA approved Shorla’s nelarabine injection (SH-111) to treat patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma.4

In December 2023, the company launched the first oral solution for methotrexate in the United States to treat adults with acute lymphoblastic leukemia as part of a combination maintenance regimen; cutaneous T-cell lymphoma as a single agent or in combination with chemotherapy; relapsed/refractory non-Hodgkin lymphoma in combination with chemotherapy; rheumatoid arthritis; and severe psoriasis.5

The more recent filing of the NDA for SH-105 may add to the company’s current oncology product offerings and provide hope to patients with these diseases, according to Shorla.

"This is an important step in improving access to and administration of a drug that will help women suffering from breast and ovarian cancer," Sharon Cunningham, chief executive officer and cofounder of Shorla Oncology, said in the release. "It also marks a significant milestone regarding Shorla’s efforts to bring innovative oncology products to market."