On January 9, 2024 SkylineDx, an innovative diagnostics company focused on the research and development of molecular diagnostics, reported that the European Patent Office (EPO) has granted European Patent No. 3827101, marking a groundbreaking advancement in the field of cancer diagnostics and personalized treatment (Press release, SkylineDx, JAN 9, 2024, View Source [SID1234639173]).

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This patent introduces innovative approaches to classify and treat individuals afflicted with primary cutaneous melanoma based on the expression levels of gene expression signature , providing the foundation for highly precise diagnosis and personalized treatment plans.

Dharminder Chahal, CEO of SkylineDx, expressed his pride in this achievement, stating, "Obtaining the European Patent is a testament to SkylineDx’s commitment to advancing the field of melanoma diagnosis and treatment. It is a recognition of the important work that our team is doing in collaboration with Mayo Clinic. Our innovative methods for classifying and treating primary cutaneous melanoma represent a significant leap forward in providing personalized care for patients. We are proud to contribute to the improvement of patient outcomes and the advancement of medical research."

The significance of this patent lies not only in its scientific innovations but in its potential to improve the lives of individuals faces with primary cutaneous melanoma. SkylineDx’s dedication to pushing the boundaries of melanoma research and patient care shines through in this remarkable achievement.

On January 9, 2024 ConcertAI and Caris Life Sciences (Caris) reported a multi-year partnership to support AbbVie’s precision medicine-driven research and development efforts, and clinical trial optimization in oncology (Press release, Caris Life Sciences, JAN 9, 2024, View Source [SID1234639172]).

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The agreement will allow AbbVie to leverage Caris’ expansive real-world, multi-modal database in oncology and ConcertAI’s collection of research-grade clinical data across a wide range of cancers, to guide the development of novel therapies for patients most likely to benefit. The agreement will also allow AbbVie to utilize ConcertAI and Caris’ clinical network and laboratory capabilities combined with AI/ ML learning to optimize oncology clinical trials and patient enrollment.

"We are continuing to expand our drug discovery and development efforts in oncology, with the ultimate goal to deliver transformative treatments to cancer patients," said Tom Hudson, SVP, Chief Scientific Officer, Global Research at AbbVie. "This agreement marks a key step in that direction, as it represents a union of cutting-edge technology and pioneering science, leveraging the power of big data, artificial intelligence and machine learning to propel our efforts in the fight against cancer."

"This partnership furthers our goals of enabling causal biological inferences, where multi-modal data can be integrated with AI/ML-based approaches in drug discovery, translation and development, to accelerate oncology pipelines, and allow our biopharma partners to discover and deliver better medicines faster," said Jeff Elton, Ph.D., CEO of ConcertAI.

"We are thrilled to work with AbbVie, a leader in driving innovation in drug development, to support their work in oncology," said Dr. George W. Sledge, Jr., Chief Medical Officer of Caris. "This work may help identify novel targets and mechanisms, and key levers to drive clinical trial excellence to support AbbVie’s oncology portfolio."

On January 9, Y-mabs presented its corporate presentation (Presentation, Y-mAbs Therapeutics, JAN 9, 2024, View Source [SID1234639171]).

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On January 9, 2024 Shorla Oncology (‘Shorla’), a U.S.-Ireland specialty pharmaceutical company, reported that the US Food and Drug Administration (FDA) has accepted for review the company’s New Drug Application (NDA) for a novel formulation to treat breast and ovarian cancer (Press release, Shorla Oncology, JAN 9, 2024, View Source;utm_medium=rss&utm_campaign=shorla-oncology-announces-fda-filing-acceptance-of-new-drug-application-for-novel-formulation-to-treat-breast-and-ovarian-cancer [SID1234639170]). The Agency assigned a Prescription Drug User Fee Act ("PDUFA") action date of June 29th, 2024.

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"This innovative drug (‘SH-105’) will offer hospital pharmacists and patients access to a differentiated, ready to administer, injectable product with unique characteristics that’s expected to facilitate rapid adoption once approved" said Orlaith Ryan, Chief Technical Officer and Co-Founder of Shorla Oncology."

SH-105 is a ready-to-dilute form of a well-established drug that has been used as a freeze-dried powder since the 1950s and has seen supply shortages. SH-105’s liquid form eliminates the need for powder to be reconstituted, improving efficiency, and reducing the risks associated with the complexity of preparation.

"This is an important step in improving access to and administration of a drug that will help women suffering from breast and ovarian cancer," said Sharon Cunningham, Chief Executive Officer and Co-Founder of Shorla Oncology. "It also marks a significant milestone regarding Shorla’s efforts to bring innovative oncology products to market."

More than 350,000 women will be diagnosed with breast cancer in the U.S in 2023, according to the American Cancer Society.[1] About 19,710 women will be diagnosed with ovarian cancer in the United States.

SH-105 is one of several oncology drugs in Shorla’s advanced pipeline. The company recently raised $35 million in Series B funding that will allow Shorla to accelerate the growth of its oncology portfolio. Last year, the company launched Nelarabine for the treatment of T-cell Leukemia and JYLAMVO, the first and only oral methotrexate solution approved in the United States for use in adults for the treatment of acute lymphoblastic leukemia and other indications.

On January 9, 2024 Seres Therapeutics presented its corporate presentation (Presentation, Seres Therapeutics, JAN 9, 2024, View Source [SID1234639169]).

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