On March 5, 2024 BioVaxys Technology Corp. (CSE: BIOV) (FRA: 5LB) (OTCQB: BVAXF) ("BioVaxys" or "Company") reported that it has received a Notice of Allowance from the Japanese Patent Office for a Patent ("Patent") for inducing an antibody immune response from a low dose volume delivery of a B-cell epitope formulated with DPX (Press release, BioVaxys Technology, MAR 5, 2024, View Source [SID1234640829]). This Patent was part of the extensive Intellectual Property portfolio recently acquired by BioVaxys from the former IMV, Inc. This Patent has already been issued in the US, and is currently pending in the EU.

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DPX is a proprietary lipid-based delivery platform with no aqueous component that can be formulated with a range of packaged antigens, proteins, peptides, mRNA, or small molecules. Its unique "no release" mechanism of action allows antigen presenting cells (APCs) to be attracted to the injection site, facilitating a robust and sustained immune response.

The smallest dose of a currently approved vaccine is 0.1ml for Sanofi-Pasteur’s Fluzone Intradermal Quadrivalent vaccine. Low dose volume delivery of DPX formulated B-cell epitope is designed to be delivered in single dose as low as 50µL to 90 µL.

An epitope is the part of an antigen that the host’s immune system recognizes, eliciting the immune response to an invading pathogen. It specifically binds to the corresponding antigen receptor on the immune cell (such as a B-cell). Whereas T-cells protect people from getting infected by destroying cancerous and infected cells, B-cells produce antibodies to fight infection.

BioVaxys President and Chief Operating Officer Kenneth Kovan says "Expanding patent protection into major biopharma markets such as Japan further increases the value of the DPX platform for our Company. Having an ability to create low dose DPX+B cell epitope formulations is an attractive approach for packaging antigens for cancer immunotherapeutics and therapeutic vaccines such as for influenza, Zika virus, RSV, HSV, and many other viral or bacterial pathogens.

BioVaxys also is pleased to announce it filed an international patent application through the Patent Cooperation Treaty ("PCT") from two pending patent applications in the US related to methods of formulating DPX compositions that comprise both a lipid-based adjuvant (i.e. PAM) and a polyI:C polynucleotide adjuvant.

The PCT is a patent treaty with more than 150 member countries, makes it possible to seek patent protection for an invention simultaneously in a large number of countries by filing a single "international" patent application instead of filing several separate national or regional patent applications.

On March 5, 2024 Shasqi, Inc. ("Shasqi") a biotech company whose mission is to make cancer drugs more effective with click chemistry, reported that Founder & Chief Executive Officer José M. Mejía Oneto, MD, PhD, will present at the 14th Annual World ADC Conference in London, United Kingdom on Tuesday March 12th at 11:00am GMT (Press release, Shasqi, MAR 5, 2024, View Source [SID1234640828]).

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The session titled "CAPAC: A Modular Platform for Tumor-Targeted Drug Activation Using Click Chemistry In Vivo" will be part of the "Supercharging ADC Efficacy & Conquering Toxicity Through Transformative Emerging Conjugation Technologies" track as part of the 2nd Generation Conjugates Day.

"We are honored to be an invited speaker at the 2nd Next-Generation Conjugation Day during World ADC Europe—an event synonymous with innovation." said Dr. Mejía Oneto. "We’re excited to share more about our technology and present new data demonstrating how our unique approach has the potential to meaningfully increase the therapeutic index of cancer drugs."

As part of the session, Shasqi will share background on its novel Click Activated Protodrugs Against Cancer (CAPAC) platform, which leverages click chemistry for tumor-targeted drug activation. Shasqi will also share clinical proof-of-concept data and unveil preclinical data from the pipeline, showcasing the ability to use antibody fragments to activate high potency payloads at the tumor.

Shasqi has developed a novel approach to activating drugs at the tumor. First, an antigen targeting activator is infused, which binds to the tumor. Then, an inert version of a cancer therapeutic, called a protodrug, is infused. The protodrug finds the activator at the tumor and the active drug is released via a click chemistry reaction. Separation of payload from tumor targeting confers several advantages over antibody-drug conjugates (ADCs) including selective activation at the tumor and the ability to optimize the ratio of each component throughout development, including in the clinic. Together, this allows the therapeutic index of cancer drugs to be maximized.

On March 5, 2024 Sapience Therapeutics, Inc., a clinical-stage biotechnology company focused on the discovery and development of peptide therapeutics to address oncogenic and immune dysregulation that drive cancer, reported three poster presentations at the 2024 American Association for Cancer Research (AACR) (Free AACR Whitepaper), taking place April 5-10, 2024, in San Diego, CA (Press release, Sapience Therapeutics, MAR 5, 2024, View Source [SID1234640827]).

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Sapience will present non-clinical immunotherapy results at AACR (Free AACR Whitepaper) from both of its clinical programs, ST316, a first-in-class antagonist of β-catenin, and ST101, a first-in-class antagonist of C/EBPβ. Sapience will also present first disclosure of pre-clinical data describing its first-in-class AP-1 complex antagonist targeting the interaction of cJun with Fra1.

Poster Presentation Details:

Title: "ST316, a clinical peptide antagonist of beta-catenin, induces anti-tumor immune responses by multiple mechanisms of action"
Session Title: Inflammation in Tumor Initiation and Progression
Location: Poster Section 4
Abstract Number: 5332
Date and Time: Tuesday, April 9, 2024, 1:30 PM to 5:00 PM

Title: "ST101, a clinical CEBPβ antagonist peptide, promotes an immune-active tumor microenvironment by multiple cellular mechanisms"
Session Title: The Tumor Microenvironment as a Drug Target
Location: Poster Section 13
Abstract Number: 2909
Date and Time: Monday, April 8, 2024, 1:30 PM to 5:00 PM

Title: "JunAP, a peptide antagonist against the activator protein 1 transcription factor complex, demonstrates cancer cell cytotoxicity and reduced invasion in vitro and tumor regression in vivo in TNBC models"
Session Title: Oncogenic Transcription Factors
Location: Poster Section 18
Abstract Number: 3051
Date and Time: Monday, April 8, 2024, 1:30 PM to 5:00 PM

More information can be found on the 2024 AACR (Free AACR Whitepaper) website.

About ST316

ST316 is a first-in-class peptide antagonist of the interaction between β-catenin and its co-activator, BCL9, a complex that drives oncogene expression in multiple cancers where aberrant Wnt/β-catenin pathway signaling is observed. ST316-101 (NCT05848739) is a first-in-human, open-label, Phase 1-2 dose-escalation and expansion study designed to determine the safety, tolerability, PK, PD and early efficacy of ST316. The Phase 1 dose-escalation portion of the Phase 1-2 study is enrolling and dosing patients with select advanced solid tumors that are known to harbor abnormalities of the Wnt/β-catenin signaling pathway. The Company expects to complete the Phase 1 portion of the study in the first half of 2024. Following completion of the study’s Phase 1 portion, the recommended dose will advance to the Phase 2 dose expansion portion of the study in colorectal cancer patients.

About ST101

ST101, a first-in-class antagonist of C/EBPβ, is currently being evaluated in the Phase 2 portion of an ongoing Phase 1-2 clinical study in patients with recurrent GBM (rGBM) (NCT04478279). In an ongoing window-of-opportunity sub-study, ST101 is being evaluated as a monotherapy in rGBM and in combination with radiation and temozolomide in newly diagnosed GBM, with patients receiving ST101 before and after surgical resection. ST101 has been granted Fast Track designation for rGBM from the U.S. FDA and orphan designations for glioma from the U.S. FDA and the European Commission.

On March 5, 2024 Myeloid Therapeutics, Inc. ("Myeloid"), a clinical stage immunology company, reported it will be providing updates on its RNA immunotherapies at multiple presentations at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting taking place April 5-10, 2024, at the San Diego Convention Center (Press release, Myeloid Therapeutics, MAR 5, 2024, View Source [SID1234640826]).

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Details follow:

Title: In vivo programming of natural killer cells and T cells using mRNA delivered cytotoxic chimeric antigen receptors
Date & Time: Monday Apr 8, 2024, 9:00 AM – 12:30 PM
Location: Poster Section 2
Session Category: Immunology
Session Title: CAR-NK, NK Engagers, and NK Modulators
Poster Board Number: 2
Published Abstract Number: 1319

Title: In vivo Immune Cell Programming Using mRNA-LNP Chimeric Antigen Receptors
Date & Time: Monday Apr 8, 2024, 9:00 AM – 12:30 PM
Location: Poster Section 2
Session Category: Immunology
Session Title: CAR-NK, NK Engagers, and NK Modulators
Poster Board Number: 4
Published Abstract Number: 1321

Title: Preclinical & clinical activity of autologous mRNA engineered chimeric antigen receptor monocytes for targeted cancer immunotherapy
Date & Time: Monday Apr 8, 2024, 1:30 PM – 5:00 PM
Location: Poster Section 39
Session Category: Clinical Research
Session Title: Adoptive Cellular Therapy 1
Poster Board Number: 18
Published Abstract Number: 3612

On March 5, 2024 GV20 Therapeutics, a clinical-stage biotechnology company integrating AI, genomics, and disease biology to create next-generation antibody therapeutics for cancer, reported that its abstract was selected for an oral presentation at the American Association of Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2024, taking place April 5-10, 2024, in San Diego, CA (Press release, GV20 Therapeutics, MAR 5, 2024, View Source [SID1234640825]).

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Details of the oral presentation are below:

Title: "IGSF8 is a novel innate immune checkpoint and cancer immunotherapy target"
Session Type: Minisymposium
Session Category: Immunology
Session Title: Immune Targets and Therapies
Session Date/Time: Monday Apr 8, 2024, 2:30 PM – 4:30 PM
Abstract Presentation Number: 3914

More information can be found on the 2024 AACR (Free AACR Whitepaper) website.