On March 6, 2024 Medigene AG (Medigene or the "Company", FSE: MDG1, Prime Standard), an immuno-oncology platform company focusing on the discovery and development of T cell immunotherapies for solid tumors, reported that it will present a poster at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting (AACR) (Free AACR Whitepaper) 2024 taking place from April 5-10, 2024 in San Diego, USA as well as an oral presentation at the ELRIG-Forum 2024 to be held in Darmstadt, Germany on March 7, 2024 (Press release, MediGene, MAR 6, 2024, View Source [SID1234640873]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Poster presentation:

AACR 2024
View Source
Location: San Diego Convention Center, San Diego
Date: April 5-10, 2024

Details on the poster presentation are as follows:
Abstract title: TCR-gated control of costimulatory switch protein (CSP) activation in rTCR-T cells expressing PD1-41BB
Maja Buerdek, Petra U. Prinz, Kathrin Mutze, Andrea Coluccio, Stefanie Tippmer, Miriam Bosch, Giulia Longinotti, Mario Catarinella, Kathrin Davari, Christiane Geiger, Barbara Loesch, Kristy Crame, Dolores J. Schendel.
Session details: PO.IM01.13 – Adoptive Cell Therapies 1: Tumor Antigen-Specific T-cells and TCR-T, Sunday, April 7, 1:30 PM – 5:00 PM local time

The work to be presented shows that recombinant T cell receptor engineered T cells (rTCR-T cells), when armored and enhanced by the PD1-41BB CSP, exhibit superior TCR-T cell functionality and safety as well as a favorable safety profile, revealing the strong potential for improving treatment of cancer patients suffering from advanced solid tumor malignancies.

The abstract for this research has been published online at View Source!/20272/presentation/6084 and the poster will be available online after the conference at View Source." target="_blank" title="View Source." rel="nofollow">View Source

The Company is planning a first-in-human trial for MDG1015, a TCR-T therapy incorporating the CSP in gastric cancer, ovarian cancer, myxoid/round cell liposarcoma and synovial sarcoma with IND/CTA filing targeted for 2H 2024. MDG1015 is a first-in-class, third generation TCR-T therapy targeting NY-ESO-1/ LAGE-1a, armored and enhanced by the PD1-41BB CSP.

Oral presentation:

ELRIG-Forum 2024
View Source
Location: Darmstadtium Convention Centre, Darmstadt
Date and time: March 7, 2024, 11:10 – 11:30am local time
Presenter: Dr. Barbara Lösch, Head, Technology & Innovation
Title: Evolution by Innovation: Connecting the Dots of TCR-T Therapies

Dr. Lösch will provide an overview on the Company’s proprietary End-to-End (E2E) Platform and highlight various tools within the E2E Platform that can enhance TCR-T cell functionality, safety and efficacy for generation of best-in-class, differentiated TCR-T therapies.

This presentation will available on Medigene’s website on March 7, 2024: View Source

On March 6, 2024 BeiGene, Ltd. (NASDAQ: BGNE; HKEX: 06160; SSE: 688235), a global oncology company, reported the presentation of emerging oncology pipeline data at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting April 5-10 in San Diego (Press release, BeiGene, MAR 6, 2024, View Source [SID1234640871]). BeiGene has nine abstracts scheduled for poster presentations at AACR (Free AACR Whitepaper).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"Our presentations at this year’s AACR (Free AACR Whitepaper) showcase our ongoing development of tislelizumab combinations in solid tumors as we assess the clinical potential of multiple novel immuno-oncology candidates and make data-driven decisions for further development," said Lai Wang, Ph.D., Global Head of Research & Development at BeiGene. "More broadly, they reflect our deep commitment to discovering innovative new medicines for cancer patients, including by pioneering novel mechanisms like targeted degradation."

BeiGene will present results from the AdvanTIG-204 Phase 2 study of tislelizumab (anti-PD1) plus ociperlimab (anti-TIGIT) in first-line limited-stage small cell lung cancer (SCLC) as well as results of a biomarker study of the same doublet in the setting of first-line non-small cell lung cancer (NSCLC). An ongoing, global Phase 3 trial of ociperlimab plus tislelizumab in stage IV, PD-L1 high NSCLC, AdvanTIG-302, will complete enrollment this month (NCT04746924). An additional clinical presentation includes the first data from a Phase 1a dose escalation study of BGB-10188, a phosphatidylinositol 3 kinase delta (PI3Kδ) inhibitor, plus tislelizumab in patients with solid tumors.

BeiGene will also be presenting preclinical characterizations of several novel molecules from its internal discovery engine, including a CEA x 4-1BB bispecific antibody and a chimeric degradation activation compound (CDAC) targeting BTK, BGB-16673. Clinical data from an ongoing Phase 1 study of BGB-16673 in relapsed/refractory B-cell malignancies were presented at ASH (Free ASH Whitepaper) 2023, demonstrating clinical responses and a tolerable safety profile in heavily pre-treated patients with B-cell malignancies, including those with BTK inhibitor-resistant disease (NCT05006716).​

An additional preclinical presentation highlights the therapeutic potential of the triple-combination of tislelizumab with anti-LAG-3 (LBL-007) and anti-TIM-3 (surzebiclimab); this combination is being evaluated in an ongoing Phase 2 study in head and neck squamous cell carcinoma (NCT05909904).

BeiGene Presentations During AACR (Free AACR Whitepaper) 2024

Abstract Title

Abstract #

Presentation

Time (PDT)

Lead Author

Preclinical

Characterization of the correlation between BTK

degradation and tumor growth inhibition of the

BTK target protein degraders using PK/PD

modeling

2110

Monday, April 8

9 a.m. – 12:30 p.m.

Section 30

Board #1

Y. Wu

BGB-B167, a first-in-class 4-1BB/CEACAM5

bispecific antibody, exhibits potent in vitro and in

vivo anti-tumor activity and superior safety profile

in preclinical models

2371

Monday, April 8

9 a.m. – 12:30 p.m.

Section 38

Board #17

Z. Li

Translational assessment of triple combination

with tislelizumab (anti-PD-1), LBL-007 (anti-LAG-

3) and surzebiclimab (anti-TIM-3) highlights its

strong anti-tumor activity and clinical potential in

solid tumors such as HNSCC

4041

Tuesday, April 9

9 a.m. – 12:30 p.m.

Section 3

Board #17

H. Zhu

Clinical

Exploration of potential biomarkers correlated

with efficacy of ociperlimab (anti-TIGIT) plus

tislelizumab (anti-PD1) in 1L PD-L1+ non-small

cell lung cancer (NSCLC)

CT053

Monday, April 8

9 a.m. – 12:30 p.m.

Section 48

Board #3

S. Kim

A first in human, phase 1a, dose escalation study

of BGB 10188, a phosphatidylinositol 3 kinase

delta (PI3Kδ) inhibitor, + tislelizumab (anti-PD-1)

in patients with solid tumors

CT189

Tuesday, April 9

9 a.m. – 12:30 p.m.

Section 48

Board #17

R. Cosman

AdvanTIG-204: A phase 2, multicenter,

randomized, 3-arm, open-label study investigating

the preliminary efficacy and safety of ociperlimab

(anti-TIGIT) + tislelizumab (anti-PD-1) +

concurrent chemoradiotherapy (cCRT) in patients

with untreated limited-stage small cell lung cancer

(SCLC)

CT255

Tuesday, April 9

1:30 p.m. – 5 p.m. Section 48

Board #14

Y. Gong

BGB-A317-LBL-007-202 (NCT06010303): A

phase 2, randomized, active-controlled, open-

label study to evaluate the efficacy and safety of

LBL 007 (anti-LAG-3) in combination with

tislelizumab (TIS; anti-PD-1) plus chemotherapy

(chemo) as first-line (1L) treatment in patients

with unresectable locally advanced/metastatic

esophageal squamous cell carcinoma (ESCC)

CT274

Tuesday, April 9

1:30 p.m. – 5 p.m. Section 50

Board #4

S. Park

Liberty-201 (NCT05609370): Maintenance

fluoropyrimidine and bevacizumab with or without

anti-lymphocyte activation gene-3 (LAG-3)

antibody LBL-007 plus anti-programmed cell

death protein-1 (PD-1) antibody tislelizumab (TIS)

for patients (pts) with metastatic or unresectable

microsatellite stable (MSS)/mismatch repair

proficient (pMMR)colorectal cancer (CRC)

CT276

Tuesday, April 9 1:30 p.m. – 5 p.m.

Section 50

Board #6

H.-J. Lenz

BGB-LC-201 (NCT05635708): A phase 2, open-

label, multi-arm study of tislelizumab (TIS; anti-

PD-1) in combination with investigational agents

+/- chemotherapy as first-line treatment for

patients with locally advanced, unresectable, or

metastatic non-small cell lung cancer (NSCLC)

CT277

Tuesday, April 9

1:30 p.m. – 5 p.m. Section 50

Board #7

G. Blumenschein

About Tislelizumab

Tislelizumab is a uniquely designed humanized immunoglobulin G4 (IgG4) anti-programmed cell death protein 1 (PD‑1) monoclonal antibody with high affinity and binding specificity against PD‑1. It is designed to minimize binding to Fc-gamma (Fcγ) receptors on macrophages, helping to aid the body’s immune cells to detect and fight tumors.

On March 6, 2024 Vedanta Biosciences, a clinical-stage company that is developing a potential new category of oral therapies based on defined bacterial consortia, reported that management will host investor meetings at the Leerink Partners 2024 Global Biopharma Conference being held in Miami, FL from Monday, March 11 through Wednesday, March 13, 2024 (Press release, Vedanta Biosciences, MAR 6, 2024, View Source [SID1234640869]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

On March 6, 2024 Syncromune, Inc., a clinical-stage biopharmaceutical company dedicated to the development of SYNC-T, an in situ platform combination therapy optimized for solid tumor cancers, reported that it will present late-breaking Phase 1 clinical data at this year’s American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2024, being held in San Diego, California from April 5 to 10, 2024 (Press release, Syncromune, MAR 6, 2024, View Source [SID1234640868]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The presentation, titled, "Systemic responses to SYNC-T therapy: in situ personalized cancer vaccination with intratumoral infusion of multitarget immunotherapy in patients with metastatic castrate-resistant prostate cancer (mCRPC)," will include results from the SV-102 Phase 1 trial, and the therapy’s potential impact on the treatment landscape for metastatic castrate-resistant prostate cancer. This late-breaking presentation marks the first time that the Company will have publicly shared data from its clinical trials of the SYNC-T therapy platform.

Presentation Details are:

Title: Systemic responses to SYNC-T therapy: in situ personalized cancer vaccination with intratumoral infusion of multitarget immunotherapy in patients with metastatic castrate-resistant prostate cancer (mCRPC)

Presenter: Charles J. Link, M.D.

Date: April 7, 2024

Time: 3:00 – 5:00pm PT

Session Title: Cancer Vaccines: Ready for Prime Time?

Location: San Diego Convention Center, San Diego, California

On March 6, 2024 Sensei Biotherapeutics, Inc. (Nasdaq: SNSE), a clinical stage immuno-oncology company focused on the discovery and development of next generation therapeutics for cancer patients, reported that the company will present preclinical data on its conditionally active immuno-oncology programs at upcoming scientific conferences (Press release, Sensei Biotherapeutics, MAR 6, 2024, View Source [SID1234640867]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Details of the company’s presentations are as follows:

Keystone Symposia’s Cancer Immunotherapy: Beyond Immune Checkpoint Blockade and Overcoming Resistance

Title: VISTA checkpoint targeting by SNS-101, a pH-selective antibody with enhanced safety and pharmacokinetic profiles, alters the tumor microenvironment and overcomes immune checkpoint inhibitor resistance
Presenter: Edward van der Horst, Ph.D., Chief Scientific Officer
Session: Progress in Drugging the TIGIT and VISTA Pathways
Date and time: Tuesday, March 19, 2024, 3 – 4:30 p.m. PT

Material from the presentation will also be presented in a poster at the conference, as detailed:
Poster Number: 3021
Session: Poster Session 3
Date and time: Wednesday, March 20, 2024, at 7:30 p.m. PT

American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2024

Title: Conditionally active CD28xVISTA bispecific antibodies induce myeloid-driven tumor-specific T-cell co-stimulation for improved cancer immunotherapy
Presentation Type: Poster Presentation
Session Category: Immunology
Session Title: Immune Modulation Employing Agonist or Co-Stimulatory Approaches
Date and Time: Tuesday, April 9, 2024, 1:30 p.m. – 5:00 p.m. PT
Location: Poster Section 3
Abstract Number: 5294