On October 30, 2024 Alloy Therapeutics, a biotechnology ecosystem company dedicated to democratizing access to biologics drug discovery platforms and services, reported that it has entered into an institutional licensing agreement with Scripps Research for its ATX-Gx platform for fully human antibody discovery (Press release, Alloy Therapeutics, OCT 30, 2024, View Source [SID1234647475]). The non-exclusive license enables all Scripps Research scientists to use the ATX-Gx platform for antibody drug and vaccine discovery workstreams. Scripps Research has been at the forefront of biomedical research since its founding in 1924, and its scientists have played pivotal roles in the development of more than 15 medicines approved by the U.S. Food and Drug Administration.
Over the past five years, Alloy’s ATX-Gx platform has become the industry standard for fully human transgenic mouse platforms. The ATX-Gx platform enables therapeutic discovery programs and has been used by over 170 partners. The institutional license with Scripps Research further expands the platform’s reach in vaccine discovery. The ATX-Gx platform, which enables best-in-class in-vivo human antibody discovery, comprises multiple strains of mice that have been engineered to express human antibody genes. These humanized mice produce immune responses that are as robust as wild-type animals but also have immune repertoires similar to those of humans. Antibodies discovered using ATX-Gx mice are highly likely to demonstrate similar activity in humans and require minimal to no optimization before being advanced to preclinical and clinical studies. This platform has the potential to increase the pace and success of vaccine and therapeutic discovery research across a broad array of indications.
"Our ATX-Gx platform has already been validated as a powerful tool for antibody therapeutics discovery, and we are excited that the scientists at Scripps Research are expanding the use of our platform into vaccine development," said Piotr Bobrowicz, Ph.D., President at Alloy. "We look forward to supporting the Scripps Research team as it deploys the ATX-Gx platform and to being part of its success as the institution continues to break scientific boundaries."
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