Natera to Present New Data at the 2024 SGO Annual Meeting on Women’s Cancer, Following Recent Medicare Coverage Decisions in Ovarian and Breast Cancers

On March 12, 2024 Natera, Inc. (NASDAQ: NTRA), a global leader in cell-free DNA testing, reported new data being presented on its personalized and tumor-informed molecular residual disease (MRD) test, Signatera, and hereditary cancer test, Empower, at the 2024 Society of Gynecologic Oncology (SGO) Annual Meeting on Women’s Cancer taking place March 16-18, 2024 (Press release, Natera, MAR 12, 2024, View Source [SID1234641088]).

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A total of seven abstracts will be presented, including two oral presentations and five poster presentations. The presentations will feature new data highlighting Signatera’s predictive and prognostic utility in ovarian cancer and other gynecologic malignancies.

"On the heels of receiving Medicare coverage for Signatera in ovarian cancer and for breast cancer in the neoadjuvant setting, we are thrilled to share new Signatera and Empower data with the gynecologic oncology community," said Adam ElNaggar, MD, medical director of oncology at Natera. "We believe this momentum is indicative of the growing clinical value our tests provide for patients across the continuum of gynecologic cancer care, and demonstrate our continued leadership in MRD."

Below is the full list of Signatera and Empower data presentations at the SGO Annual Meeting.

Oral Presentations:

Focused Plenary I: The Science to Drive Purpose | March 16, 2:15 – 3:30 PM | Presenter: Anne Knisely, MD | Ovarian Cancer
Prognostic implications of minimal residual disease detection by second look laparoscopy and circulating tumor DNA (ctDNA) in patients with ovarian cancer after frontline therapy
Focused Plenary IV: ctDNA: Molecular Mirrors & Markers | March 17, 1:45 – 2:45 PM | Presenter: Mike Shalamov | Gynecologic Cancers
Utility of ctDNA as an early predictive biomarker of response to radiation in gynecologic malignancies
Poster Presentations:

Poster #1241 | Session 1 | March 17, 1:15 – 2:45 PM | Presenter: Michael Toboni, MD | Ovarian Cancer
PARPi response monitoring using personalized ctDNA testing in patients with ovarian cancer
Poster #1242 | Session 1 | March 17, 1:15 – 2:45 PM | Presenter: Peter W. Ketch, MD | Uterine Cancer
Treatment Monitoring Utilizing ctDNA-based MRD Detection in Early Stage Uterine Cancer
Poster #1243 | Session 1 | March 17, 1:15 – 2:45 PM | Presenter: Michael Toboni, MD | Uterine Cancer
Personalized ctDNA analysis used for ctDNA detection and response monitoring in patients with advanced or recurrent uterine cancer
Poster #1274 | Session 1 | March 17, 1:15 – 2:45 PM | Presenter: Floortje Backes, MD | Endometrial and Ovarian Cancer
Utility of ctDNA in assessment of treatment response in patients with Recurrent/Metastatic Endometrial Cancer and Recurrent/Platinum-Resistant Ovarian Cancer
Poster #1181 | Session 1 | March 17, 1:15 – 2:45 PM | Presenter: Sarah Lee, MD | Pan-cancer
Diagnostic yield and characteristics of germline-positive genetic testing ordered by obstetricians and gynecologists in female patients with a personal history of cancer
About Signatera

Signatera is a personalized, tumor-informed, molecular residual disease test for patients previously diagnosed with cancer. Custom-built for each individual, Signatera uses circulating tumor DNA to detect and quantify cancer left in the body, identify recurrence earlier than standard of care tools, and help optimize treatment decisions. The test is available for clinical and research use and is covered by Medicare for patients with colorectal cancer, breast cancer, ovarian cancer and muscle invasive bladder cancer, as well as for immunotherapy monitoring of any solid tumor. Signatera has been clinically validated across multiple cancer types and indications, with published evidence in more than 50 peer-reviewed papers.

SOTIO Presents New Preclinical Data on Enhanced CAR T-Cell Therapies at AACR Annual Meeting

On March 12, 2024 SOTIO Biotech, a clinical-stage immuno-oncology company owned by PPF Group, reported it will present new preclinical data at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting taking place April 5-10, 2024, in San Diego, California (Press release, SOTIO, MAR 12, 2024, View Source [SID1234641087]).

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In a poster at the conference, SOTIO will present data from the company’s BOXR platform of enhanced T cell therapies. SOTIO leveraged the BOXR technology to design CAR T cells enhanced with transgenes encoding GOT2 (glutamine oxaloacetate transaminase) and TIGAR (TP53-induced glycolysis and apoptosis regulator), both of which are believed to play a role in T cell fitness in the hostile solid tumor microenvironment. Compared to unmodified CAR T cells and CAR T cells enhanced with GOT2 solely, CAR T cells enhanced with GOT2 and TIGAR showed better tumor infiltration, lower levels of exhaustion, and superior anti-tumor activity in a mouse model of solid tumors.

SOTIO’s lead candidate from the BOXR platform, BOXR1030 — a GOT2-enhanced CAR T-cell therapy — is currently being evaluated in a Phase 1/2 study for patients with solid tumors.

A second study to be presented at the meeting investigated the immunostimulatory effects of PARP inhibitors in models of epithelial ovarian cancer, determining their activity on molecular and cellular pathways to inform better combination therapy strategies with cancer immunotherapies.

Poster details are as follows:

Title: "Dual expression of exogenous glutamine oxaloacetate transaminase (GOT2) and TP53-induced glycolysis and apoptosis regulator (TIGAR) enhance CAR T cell activity in preclinical solid tumor models"
Presenting Author: Amy Jensen-Smith
Abstract Number: 4012
Date & Time: April 9, 2024, 9:00 a.m. – 12:30 p.m. PT

Title: "Immunological control by PARP inhibitors for successful immunotherapy in metastatic ovarian carcinoma"
Presenting Author: Peter Holicek
Abstract Number: 5278
Date & Time: April 9, 2024, 1:30 p.m. – 5:00 p.m. PT

Presentation materials will be available after presentations conclude here.

Nutcracker Therapeutics to Present Data on mRNA Drug Candidate and Immunomodulatory Cytokine at AACR 2024

On March 12, 2024 Nutcracker Therapeutics, Inc., a biotechnology company dedicated to developing transformative RNA therapies through its proprietary technology platform, reported that two poster presentations highlighting the company’s RNA therapeutics pipeline will be introduced at the 2024 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting (Press release, Nutcracker Therapeutics, MAR 12, 2024, View Source [SID1234641086]).

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The first presentation entails LIGHT, an immunomodulatory cytokine that is one of the components of NTX-250, the company’s lead candidate for cervical intraepithelial neoplasia. The second presentation is on preclinical data for Nutcracker’s mRNA drug candidate for prostate cancer, NTX-470. This therapy is designed to target prostate cancer antigens with mRNA-encoded, multi-specific T cell engagers with a strong anti-tumor effect and low toxicity.

Poster Presentations at AACR (Free AACR Whitepaper) 2024

Title: NTX-470, a novel multispecific T cell engager expressed from mRNA targets PSMA and STEAP1 prostate cancer antigens to generate enhanced functional activity
Abstract Number: 6725
Session Title: Targeted Immune Cell Engagers
Session Date and Time: April 10, 2024, 9:00 a.m. to 12:30 p.m.
Lead Author: Chris Rae

Title: Enhanced membrane stability of mRNA nanoparticle derived TNFSF14 results in superior T- cell and NK cell stimulation
Abstract Number: 6536
Session Title: Tumor Microenvironment and Cancer Immunity
Session Date and Time: April 9, 2024, 1:30 p.m. to 5:00 p.m.
Lead Author: Adrienne Sallets

The 2024 AACR (Free AACR Whitepaper) Annual Meeting takes place in San Diego from April 5-10. Full abstracts are available on the AACR (Free AACR Whitepaper) Online Program Planner. More information about the conference can be found on AACR (Free AACR Whitepaper)’s website.

RenovoRx to Present at the 36th Annual ROTH Conference on March 19, 2024

On March 12, 2024 RenovoRx, Inc. ("RenovoRx" or the "Company") (Nasdaq: RNXT), a clinical-stage biopharmaceutical company developing novel precision oncology therapies based on a local drug-delivery platform, reported that Shaun Bagai, RenovoRx’s Chief Executive Officer, will present at the 36th Annual ROTH Conference to be held March 17-19, 2024 in Dana Point, CA (Press release, Renovorx, MAR 12, 2024, View Source [SID1234641085]).

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Mr. Bagai will meet with investors and participate in a fireside chat hosted by Jonathan Aschoff, Senior Research Analyst at Roth MKM on Tuesday, March 19, 2024 at 10:00 am PT.

Mr. Bagai will discuss recent Company milestones, including an initial positive interim analysis on the Company’s pivotal Phase III TIGeR-PaC clinical trial. The study is evaluating the Company’s lead product candidate, RenovoGem, and proprietary Trans-Arterial Micro-Perfusion (TAMP) therapy platform for the treatment of locally advanced pancreatic cancer.

He will also discuss other significant milestones achieved and the Company’s plans for 2024 and beyond, including recent completion of a $6.1 million private placement that has extended cash runway, allowing the Company to drive towards its key goal of a second interim analysis for TIGeR-PaC that will be triggered by the 52nd event (death), which is estimated to occur in late 2024.

ROTH MKM Healthcare Opportunities Conference
Date: March 19, 2024
Time: 10:00 AM PT
Speaker: Shaun Bagai, CEO
Location: The Ritz Carlton, Dana Point, CA
Webcast: Registration Link

To schedule a one-on-one investor meeting with RenovoRx’s management team, please contact your ROTH MKM representative or KCSA Strategic Communications at [email protected].

City of Hope to Present New Research at the American Association of Cancer Research (AACR) Annual Meeting 2024, Highlighting Promising Data on Prostate, Colorectal and Pancreatic Cancer

On March 12, 2024 City of Hope, one of the largest cancer research and treatment organizations in the United States, reported that it will present new findings at the AACR (Free AACR Whitepaper) Annual Meeting, which will take place April 5 to 10 in San Diego (Press release, City of Hope, MAR 12, 2024, View Source [SID1234641084]).

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"CTX130 allogeneic CRISPR-Cas9-engineered chimeric antigen receptor (CAR) T cells in patients with advanced clear cell renal cell carcinoma: Long-term follow-up and translational data from the Phase 1 COBALT-RCC study"

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This year, City of Hope doctors and scientists will also present data during AACR (Free AACR Whitepaper)’s Press Program and a clinical trials plenary session:

Monday, April 8, 2024, at 8:30 a.m.
Research by Ajay Goel, Ph.D., M.S., City of Hope professor and chair, Department of Molecular Diagnostics and Experimental Therapeutics, and Caiming Xu, Ph.D., a postdoctoral fellow in Goel’s lab, will be presented at an AACR (Free AACR Whitepaper) press conference. The abstract is titled "An exosome-based liquid biopsy for non-invasive, early detection of patients with pancreatic ductal adenocarcinoma: A multicenter and prospective study."
Sunday, April 7, 2024, at 1 to 3 p.m.
Sumanta Kumar Pal, M.D., City of Hope chair, kidney and bladder cancer disease team, will present on "CTX130 allogeneic CRISPR-Cas9-engineered chimeric antigen receptor (CAR) T cells in patients with advanced clear cell renal cell carcinoma: Long-term follow-up and translational data from the Phase 1 COBALT-RCC study" during a clinical trials plenary session called, Beyond Immune Checkpoint Inhibition: Novel Immunotherapy Strategies.
Additional data presentations include:

"Multi-omics characterization of molecular features and global-local genomic ancestry analysis of colorectal cancer in Hispanic-Latinos"
Minisymposium session 3932: Monday, April 8, 2024, 3:35 to 3:50 p.m.
To investigate why Hispanic/Latino colorectal cancer (CRC) patients in Los Angeles face mortality rates up to 20% higher than their Caucasian counterparts, City of Hope’s Enrique Velazquez Villarreal, M.D., Ph.D., M.P.H., M.S., City of Hope assistant professor, Department of Integrative Translational Sciences, and John D. Carpten, Ph.D., City of Hope’s chief scientific officer, Irell & Manella Cancer Center Director’s Distinguished Chair and Morgan & Helen Chu Director’s Chair of the Beckman Research Institute, along with a team of researchers, searched for mutations in CRC tumors by utilizing molecular profiling technologies. Results yielded important insights into the molecular characterization of CRC tumors and the multifaceted clinical and genomic heterogeneity within Hispanic/Latino populations, as well as crucial information on CRC tumor heterogeneity and the tumor microenvironment.

"Microbiome modification impacts PSCA directed chimeric antigen receptor (CAR) T cell therapy for prostate cancer"
Poster presentation 6676/7: Wednesday, April 10, 2024, 9 a.m. to 12:30 p.m.
John Murad, Ph.D., a staff scientist in the laboratory of Saul J. Priceman, Ph.D., City of Hope associate professor, Department of Hematology & Hematopoietic Cell Transplantation, and colleagues developed methods to evaluate the impact of microbiome manipulation in the team’s established syngeneic PSCA+ prostate cancer mouse model. They found that the model was sensitive to microbiome modulation and that the use of patient-derived human fecal matter transfers can significantly impact PSCA-CAR T cell directed anti-tumor responses.
Late-Breaking Presentation

Wednesday, April 10, 2024, from 9 a.m. to 12:30 p.m.
Stephen Gruber, M.D., Ph.D., M.P.H., vice president, City of Hope National Medical Center, Evan and Ming Hsieh Family Director’s Chair of the Center for Precision Medicine and medical oncologist, will report on findings from an international team of researchers’ work investigating "Artificial intelligence measures of tumor infiltrating lymphocytes predict colorectal cancer-specific and overall survival." His presentation is titled "Late-Breaking Research: Bioinformatics, Computational Biology, Systems Biology, and Convergent Science 3."
Symposiums and Educational Sessions

Marcel van den Brink, M.D., Ph.D., president of City of Hope Los Angeles and City of Hope National Medical Center, and Deana and Steve Campbell Chief Physician Executive Distinguished Chair, will lead a major symposium as chair of The Microbiome and Treatment Response to Cancer Therapy, to be held on Tuesday, April 9, 2024, from 10:15 a.m. to 11:45 a.m. He will also present on "The role of the intestinal microbiome in cancer immunotherapy," discussing clinical and preclinical studies that demonstrate how changes in the gut microbiome can affect outcomes after hematopoietic cell transplantation and CAR T cell therapy.
John D. Carpten, Ph.D., will chair and serve as a featured speaker for the presentation "Molecular Profiling in Breast Cancer and Racial/Ethnic Minorities: Dedicated to the Memory of Edith P. Mitchell."
Michael Caligiuri, M.D., City of Hope professor, Division of Leukemia, Department of Hematology & Hematopoietic Cell Transplantation, is the chair for an educational session on Saturday, April 6, 2024, from 12:30 to 2 p.m. titled, The Road to Entrepreneurship. Industry experts will discuss how to get started, review criteria and find investors.
Michael Caligiuri, M.D., will also chair the inaugural AACR (Free AACR Whitepaper) event called From Cancer Discoveries to Patients on April 4 and 5. The event brings together leaders in clinical research, biotech and the investment community as part of AACR (Free AACR Whitepaper)’s commitment to expediting the advancement of lifesaving cancer discoveries.