On January 23, 2024 HEPHAISTOS-Pharma, a biotechnology company developing next generation immunotherapies against cancer, reported that it has raised a €2 million seed round to finance GMP transfer and advance its lead candidate towards the clinic (Press release, HEPHAISTOS-Pharma, JAN 23, 2024, View Source [SID1234639429]). The round was co-led by xista science ventures and the Foundation Fournier-Majoie, with the participation of Noshaq.

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« The Foundation is very pleased to be part of HEPHAISTOS-Pharma thanks to this financing round. The valuable and dedicated team developed a promising TLR4 compound that will be used systemically which will bring to the oncologists a best-in-class product for their cancer patients. We are eager to help the company bring to the clinic this innovative program. » said Jerome Majoie, CEO and Chairman at Fournier- Majoie Foundation.

"We are very proud to be joined by institutional investors" said Frederic CAROFF, CEO, and co-founder of HEPHAISTOS-Pharma. "They bring the necessary funds to match our non-dilutive financing, but also the expertise and network that will help structure the company. They will play a critical role in the success of HEPHAISTOS as we move our platform to the clinic. We are also thankful to our historical investors and new business angels from Angels Santé, who joined the round."

The proceeds from this financing round will enable HEPHAISTOS to industrialize its manufacturing process and prepare for the clinical phases, with the goal of advancing its lead candidate, ONCO-Boost, into clinical development for the treatment of solid tumors with high unmet medical needs, in particular sarcoma. Ingrid Kelly, Partner at xista science ventures, commented that « HEPHAISTOS has an impressive set of preclinical data, showing the high potential of their TLR4 agonist ONCO-Boost to tackle solid tumors, particularly in combination with immunotherapies such as checkpoint inhibitors.

The proceeds will also be used to open a new subsidiary in Liège, Wallonia. The objective will be to leverage local state-of -the-art facilities and expertise to explore additional applications and strengthen HEPHAISTOS’ pipeline. "We are delighted to attract HEPHAISTOS to develop part of its activities in our vibrant local ecosystem. In the midst of a challenging market landscape, Noshaq remains a magnet for innovative companies with a disruptive approach and high-level management" said Eric Brandt, Investment Manager at NOSHAQ.

On January 23, 2024 Genmab A/S (Nasdaq: GMAB) reported that worldwide net trade sales of DARZALEX (daratumumab), including sales of the subcutaneous (SC) product (daratumumab and hyaluronidase-fihj, sold under the tradename DARZALEX FASPRO in the U.S.), as reported by Johnson & Johnson were USD 9,744 million in 2023 (Press release, Genmab, JAN 23, 2024, View Source [SID1234639428]). Net trade sales were USD 5,277 million in the U.S. and USD 4,467 million in the rest of the world. Genmab receives royalties on the worldwide net sales of DARZALEX, both the intravenous and SC products, under the exclusive worldwide license to Janssen to develop, manufacture and commercialize daratumumab.

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On January 23, 2024 Delcath Systems, Inc. (Nasdaq: DCTH), an interventional oncology company focused on the treatment of primary and metastatic cancers of the liver, reported that Gerard Michel, CEO, will participate in a fireside chat moderated by Bill Maughan Ph.D., Senior Analyst at Canaccord Genuity, at the Lytham Partners 2024 Investor Select Conference. Management will also host virtual one-on-one meetings with investors (Press release, Delcath Systems, JAN 23, 2024, View Source [SID1234639427]).

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Company Webcast

The webcasted fireside chat will take place at 8:45 AM ET on Thursday, February 1, 2024. The webcast can be accessed at View Source or on the Company’s website at delcath.com. The webcast will also be available for replay following the event.

1×1 Meetings

Management will be participating in virtual one-on-one meetings throughout the event. To arrange a meeting with management, please contact Lytham Partners at 1×[email protected] or register for the event at View Source

Further information on the conference is available at View Source

On January 23, 2024 Bristol Myers Squibb (NYSE: BMY) reported that it has successfully completed its acquisition of Mirati Therapeutics, Inc. ("Mirati"). With the completion of the acquisition, Mirati shares have ceased trading on the NASDAQ Global Select Market and Mirati is now a wholly owned subsidiary of Bristol Myers Squibb (Press release, Bristol-Myers Squibb, JAN 23, 2024, View Source [SID1234639426]).

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"The closing of the Mirati transaction is a significant milestone in our efforts to further diversify our oncology portfolio and strengthen our pipeline in the latter half of the decade and beyond," said Chris Boerner, Ph.D., Chief Executive Officer, Bristol Myers Squibb. "Mirati’s incredibly talented employees have built a strong portfolio of assets and capabilities that are highly complementary with BMS’. We welcome them and look forward to working together to leverage BMS’ global scale and resources to deliver more treatments for cancer patients, faster."

Through this transaction, BMS has added commercialized lung cancer medicine KRAZATI (adagrasib) to its oncology portfolio as well as several promising clinical assets, including a potential first-in-class MTA-cooperative PRMT5 inhibitor in Phase 1 development, and a leading KRAS and KRAS enabling program with two candidates in Phase 1 development.

The transaction is expected to be treated as a business combination and to be dilutive to Bristol Myers Squibb’s non-GAAP earnings per share by approximately $0.35 per share in 2024.

Advisors

Evercore Inc. and Morgan Stanley & Co. LLC are serving as financial advisors to Bristol Myers Squibb, and Kirkland & Ellis LLP is serving as legal counsel. Centerview Partners LLC is serving as financial advisor to Mirati, and Skadden, Arps, Slate, Meagher & Flom LLP is serving as legal counsel.

On January 23, 2024 Anixa Biosciences, Inc. ("Anixa" or the "Company") (NASDAQ: ANIX), a clinical-stage biotechnology company focused on the treatment and prevention of cancer, reported that its collaborator, Cleveland Clinic, has received a "Decision to Grant" notice from the Japan Patent Office (JPO) for the patent application titled "Ovarian Cancer Vaccines (Press release, Anixa Biosciences, JAN 23, 2024, View Source [SID1234639425])."

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Anixa Chairman and CEO Dr. Amit Kumar commented, "This new Japanese patent extends the expanded claims for this novel ovarian cancer vaccine technology to another geographic region, joining the European and U.S. patents awarded last year. As the exclusive worldwide licensee of the technology, we highly value the broad protection this patent provides as our research and development continues. If our vaccine is approved, one of the most aggressive gynecological cancers could be prevented from ever developing in women globally."

The Ovarian Cancer Vaccines patent was invented by the late Dr. Vincent Tuohy, Dr. Suparna Mazumder, and Dr. Justin Johnson of Cleveland Clinic. The researchers demonstrated in pre-clinical studies that vaccination against the extracellular domain of anti-Müllerian hormone receptor II (AMHR2-ED) significantly inhibits tumor growth and enhances overall survival. The results indicate that vaccinating women against AMHR2-ED could provide safe and effective preemptive immunity against epithelial ovarian carcinoma, the most common form of ovarian cancer.

Anixa is the exclusive worldwide licensee for the vaccine technology from Cleveland Clinic, a nonprofit, multispecialty academic medical center. Preclinical work on the vaccine is supported by the National Cancer Institute’s PREVENT Program, a peer-reviewed program designed to support development of the best ideas in cancer prevention.