On May 24, 2024 Pacylex Pharmaceuticals Inc. (Pacylex) is a clinical-stage pharmaceutical company developing N-myristoyltransferase (NMT) inhibitors as targeted therapies for the treatment of hematologic cancers and solid tumors, reported that complete Phase 1 clinical study results for zelenirstat, a proprietary, potent, NMTi, will be presented at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting from May 31 to June 4, 2024, at McCormick Place in Chicago, Illinois (Press release, Pacylex Pharmaceuticals, MAY 24, 2024, View Source [SID1234645048]).

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The Phase 1 dose escalation safety and tolerability study was conducted in 29 patients with refractory/relapsed (r/r) lymphoma and refractory solid tumors who averaged 4 lines of prior therapy. Zelenirstat, administered as a once daily oral medication, was well-tolerated in Phase 1 patients up to the recommended Phase 2 dose (RP2D) with no dose limiting toxicities observed in 6 dose levels. The most common treatment related adverse events were mild to moderate gastrointestinal side effects which were self-limiting and occurred in a minority of patients.

The 7 patients receiving the recommended Phase 2 dose had significantly better progression free and overall survival than the 17 treated at lower doses; 57% had stable disease or better for six months or longer, despite having 5 different types of cancer. Prolonged Stable Disease was observed in a person with colorectal cancer that had only short-term benefit from any of the 6 prior lines of therapy; this participant continues to receive the RP2D more than a year after starting therapy and had reductions of approximately 50% in CEA (carcinoembryonic antigen) and tumor volumes.

Zelenirstat appears to work in different cancers by inhibiting the myristoylation required for assembly, translocation, and/or function of validated targets like B-cell receptor, EGFR, and VEGFR. Zelenirstat also blocks Complex I formation in mitochondria of cancer cells which shuts down oxidative phosphorylation, especially critical for metastasis and cancer stem cells.

A poster will present the complete safety results and efficacy signals from the Company’s Phase 1 study of zelenirstat, as well as evidence for mechanisms of action relevant to anticancer activity in different cancer types. The Company’s CMO, Dr. John Mackey, and CEO, Dr. Michael Weickert, will be available during the poster session and for one-on-one meetings.

On May 24, 2024 Allogene Therapeutics, Inc. (the "Company"), Overland Pharmaceuticals (CY) Inc. ("Overland") and Allogene Overland Biopharm (CY) Limited (the "JV Company") reported to have entered into a Share Exchange Agreement pursuant to which Overland’s cell therapy business merged into the JV Company (the "Organizational Restructuring").

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As background, the JV Company was originally formed on December 14, 2020 by Overland and the Company. Upon formation of the JV Company, the Company contributed an exclusive license to develop, manufacture and commercialize specific Company product candidates targeting BCMA, CD70, FLT3 and DLL3 (the "Licensed Products") in China, Taiwan, South Korea and Singapore (the "Territory"), with the Company retaining exclusive rights to the Licensed Products outside the Territory (the "Exclusive License Agreement"), and Overland contributed $117 million in upfront and certain quarterly cash payments. In return, the Company received a $40 million upfront payment and Seed Preferred Shares representing 49% of the JV Company’s outstanding stock and Overland received Seed Preferred Shares representing 51% of the JV Company’s outstanding stock.

Under the Share Exchange Agreement, the JV Company acquired from Overland a 100% equity interest in Overland Pharmaceuticals (US) Inc. ("Overland US"). Overland US includes certain research and development, clinical, and general and administrative staff, as well as select cell therapy assets, including its lead program, OL-101, an autologous GPRC5D-BCMA bispecific dual targeting CAR-T for refractory multiple myeloma. Upon completion of the closing of the share exchange, Overland US became a wholly owned subsidiary of the JV Company, Overland’s ownership increased to 81.54%, the Company’s ownership decreased to 18%, and the Ordinary Shares issuable under the share incentive plan of the JV Company equaled 0.46% of the capitalization of the JV Company on an as-converted and fully-diluted basis. In addition, the JV Company increased the total number of Ordinary Shares issuable under its share incentive plan, which resulted in diluting Overland’s and the Company’s ownership to 69.63% and 15.37%, respectively, and the Ordinary Shares issuable under the share incentive plan of the JV Company were increased to 15% of the capitalization of the JV Company on an as-converted and fully-diluted basis.

Under a separate agreement between Overland and HH BioPharma Holdings Ltd. ("HBP") executed on May 24, 2024, Overland distributed all Series Seed Preferred Shares of the JV Company held by Overland to HBP and HBP has assumed all rights and obligations attached to such Shares and all rights and obligations of Overland under the Share Exchange Agreement.

In connection with the Organizational Restructuring, on May 24, 2024, the Company and Allogene Overland BioPharm (PRC) Co., Limited (the "Licensee"), an indirect wholly owned subsidiary of the JV Company, entered into a First Amendment to Exclusive License Agreement (the "Amendment") to amend and supplement certain provisions of the Exclusive License Agreement dated December 14, 2020 between the Company and the JV Company which has since assigned all of its rights and obligations under the Exclusive License Agreement to the Licensee. Under the Amendment, the Company continues to grant the JV Company an exclusive license to develop, manufacture, and commercialize the Licensed Products in the Territory, with the Company retaining exclusive rights to the Licensed Products outside the Territory, and the royalty obligations to the Company were amended to a flat mid single-digit royalty on net sales in the Territory that are no longer subject to reductions as previously provided. The Amendment also provides the Company with additional rights to terminate the Exclusive License Agreement in its entirety or with respect to the relevant Licensed Product(s) if the Licensee fails to initiate manufacturing technology transfer with respect to a Licensed Product as agreed in the Amendment, or if HBP commits a funding default or a material breach of its representations, warranties, or covenants under the Share Exchange Agreement. The Amendment also provides that the Exclusive License Agreement will terminate automatically if the Company’s ownership in the JV Company falls below 7.5% (other than due to the Company’s sale of the Shares of the JV Company), unless at that time the JV Company and the Company have mutually agreed on the manufacturing technology transfer plan for the Licensed Product(s) and the JV Company elects to continue the license for such Licensed Product(s) with increased milestones and royalties. Under the Amendment terms such increased milestones and royalties consist of up to $115 million in milestone payments for each Licensed Product and tiered mid single-digit to low double-digit royalties on net sales in the Territory.

In connection with the Organizational Restructuring, on May 24, 2024, the Company, HBP, and the JV Company also entered into an Amended and Restated Shareholders’ Agreement which amends and restates the prior Shareholders’ Agreement dated December 14, 2020 among the Company, Overland, and the JV Company in its entirety. Pursuant to the Amended and Restated Shareholders’ Agreement, the board of directors of the JV Company will be comprised of five directors, with three directors designated by HBP, one director designated by the Company, and one director serving as the chief executive officer of the JV Company. The Amended and Restated Shareholders’ Agreement provides each of the Company and HBP certain shareholder-level consent rights, certain director-level consent rights, registration rights, information rights, and pre-emptive rights for future equity issuances. The Amended and Restated Shareholders’ Agreement shall terminate upon the consent of the parties, provided that its provisions with respect to director designation rights, shareholder-level consent rights, director-level consent rights, information rights, and pre-emptive rights shall terminate upon a qualified IPO or sale of the JV Company or its assets.

The foregoing description of the material terms of the Share Exchange Agreement, the Amended and Restated Shareholders’ Agreement and the Amendment is qualified in its entirety by reference to the complete text of such agreements, which the Company intends to file with the Securities and Exchange Commission as exhibits to the Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2024.

On May 24, 2024 Bio-Path Holdings, Inc., (NASDAQ:BPTH), a biotechnology company leveraging its proprietary DNAbilize liposomal delivery and antisense technology to develop a portfolio of targeted nucleic acid cancer drugs, reported an upcoming poster presentation at the 2024 European Hematology Association (EHA) (Free EHA Whitepaper) Congress, taking place June 13-16, 2024 in Madrid, Spain (Press release, Bio-Path Holdings, MAY 24, 2024, View Source [SID1234643777]).

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Jorge Cortes, M.D., Director of the Georgia Cancer Center, will present interim results from the Company’s Phase 2 study of prexigebersen (BP1001) in combination with decitabine and venetoclax for the treatment of acute myeloid leukemia (AML). The data show prexigebersen continues to be well-tolerated and has now demonstrated compelling efficacy results in two reporting cohorts including evaluable newly diagnosed AML patients and evaluable refractory/relapsed AML patients, both of which exceeded outcomes with frontline therapy.

"We look forward to Dr. Cortes’ presentation of these very compelling data, which continue to demonstrate prexigebersen’s potential as a safe and effective treatment for AML," said Peter Nielsen, Chief Executive Officer of Bio-Path. "We are particularly enthusiastic with its improvement over frontline therapy and are eager to have these data presented before an audience of the world’s leading hematologists at EHA (Free EHA Whitepaper)."

Details for the poster presentation are as follows:

Title: Interim Safety and Efficacy of BP1001 in a Phase II Acute Myeloid Leukemia
Study Date and Time: Friday, June 14, 2024 at 6:00 PM CEST
Location: IFEMA Madrid Recinto Ferial, Hall 7
Abstract Number: P536

On May 24, 2024 Innate Pharma SA (Euronext Paris: IPH; Nasdaq: IPHA) ("Innate" or the "Company") reported that five abstracts with Innate’s drug candidates have been accepted for the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) 2024 Annual Meeting, taking place May 31-June 4, 2024 in Chicago, Illinois (Press release, Innate Pharma, MAY 24, 2024, View Source [SID1234643704]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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ASCO abstract details:

Lacutamab

Abstract: 7082
Abstract Title: Lacutamab in patients with relapsed and/or refractory mycosis fungoides: results from the TELLOMAK Phase 2 trial
First Author: Pierluigi Porcu
Session Type: Poster Session
Session Title: Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia
Session Date and Time: Monday June 3, 2024 – 9:00 AM – 12:00 PM

IPH6501

Abstract: TPS7095
Abstract Title: A Phase 1/2, Open-Label, Multicenter Trial Investigating the Safety, Tolerability, and Preliminary Antineoplastic Activity of IPH6501 in Patients With Relapsed and/or Refractory CD20-expressing Non-Hodgkin Lymphoma
First Author: Lorenzo Falchi
Session Type: Poster Session
Session Title: Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia
Session Date and Time: Monday June 3, 2024 – 9:00 AM – 12:00 PM

Abstract: 7030
Abstract Title: Preclinical assessment of IPH6501, a first-in-class IL2v-armed tetraspecific NK Cell Engager directed against CD20 for R/R B-NHL, in comparison to a CD20-targeting T Cell Engager
First Author: Olivier Demaria
Session Type: Poster Session
Session Title: Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia
Session Date and Time: Monday June 3, 2024 – 9:00 AM – 12:00 PM

Monalizumab (partnered with AstraZeneca)

Abstract: 8046
Abstract Title: Updated results from COAST, a phase 2 study of durvalumab (D) ± oleclumab (O) or monalizumab (M) in patients (pts) with stage III unresectable non-small cell lung cancer (uNSCLC)
First Author: Charu Aggarwal
Session Type: Poster Session
Session Title: Lung Cancer—Non-Small Cell Local-Regional/Small Cell/Other Thoracic Cancers
Session Date and Time: Monday June 3, 2024 – 1:30 PM – 4:30 PM

Abstract: TPS8129
Abstract Title: A phase II trial of monalizumab in combination with durvalumab (MEDI4736) plus platinum-based chemotherapy for first-line treatment of extensive stage small cell lung cancer (MOZART): Hoosier Cancer Research Network LUN21-530 study.
First Author: Hirva Mamdani
Session Type: Poster Session
Session Title: Lung Cancer—Non-Small Cell Local-Regional/Small Cell/Other Thoracic Cancers
Session Date and Time: Monday June 3, 2024 – 1:30 PM – 4:30 PM

On May 24, 2024 Foundation Medicine, Inc., reported that 22 new pieces of research from its robust oncology diagnostics portfolio will be presented at the 2024 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting from May 31 to June 4 in Chicago (Press release, Foundation Medicine, MAY 24, 2024, View Source [SID1234643703]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Emerging Applications of Liquid Biopsy Using FoundationOneLiquid CDx and FoundationOneTracker

Utility of circulating tumor DNA (ctDNA) to inform treatment of patients with metastatic breast cancer (Abstract #1042)
Use of circulating tumor DNA (ctDNA) to affect the adjuvant or post-adjuvant treatment of patients with stage III and high-risk stage II resected colon cancer: The ERASE-CRC project by GONO (Abstract #TPS3644)
Utility of ctDNA burden as a prognostic biomarker for efficacy in TALAPRO-2: A phase 3 study of talazoparib (TALA) + enzalutamide (ENZA) vs placebo (PBO) + ENZA as first-line (1L) treatment in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) (Abstract #5020)
Prognostic value of baseline circulating tumor DNA (ctDNA) tumor fraction (TF) in metastatic hormone-sensitive prostate cancer (mHSPC) (Abstract #5085)
BRCA1/2 reversion mutations (BRCArev) in advanced prostate cancer in the absence of prior PARP inhibitor (PARPi) therapy (Abstract #5056)
Utility of CGP in Earlier Stages of Disease, Rare Cancers, and Using RNA Sequencing

Preliminary results of the Lung Cancer Mutation Consortium LCMC4 evaluation of actionable drivers in early-stage lung cancer (LEADER) screening trial (Abstract #8068)
Impact of alterations in tumor suppressor genes (TSG-alt) on survival outcomes in patients (pts) with de novo metastatic castration-sensitive prostate cancer (dn-mCSPC) receiving androgen deprivation therapy (ADT) with androgen receptor pathway inhibition (ARPI) or docetaxel (Abstract #5091)
On the right TRACK: Providing comprehensive genomic profiling (CGP) and molecular tumor board (MTB) for patients (pts) with rare cancers (Abstract #3127)
New soft tissue sarcoma (STS) transcriptomic clusters to unveil STS subsets with unique biological characteristics and refine the accuracy of overall survival (OS) prediction (Abstract #11545)
New CGP Biomarkers, Including Homologous Recombination Deficiency (HRD) Signature and Methyl Thioadenosine Phosphorylase (MTAP) Genomic Loss

Pathological complete response (pCR) association with a novel homologous recombination deficiency HRD signature (HRDsig) in patients with triple-negative breast cancer (TNBC) receiving neoadjuvant therapy (Tx) (Abstract #591)
Characterization of diverse targetable ERBB2 alterations in 512,993 patients with solid tumors (Abstract #3129)
Nature and distribution of methyl thioadenosine phosphorylase (MTAP) genomic loss in human tumors (Abstract #3067)
Genomic alterations (GA) in ESR1, PIK3CA, AKT1, and PTEN in HR(+)HER2(-) patients (pts) with metastatic breast cancer (MBC): Co-occurrence and prevalence along treatment course (Abstract #1060)
Impact of Ancestry on the Genomic Alteration Landscape

Genetic ancestry-associated differences in genomic profiling and treatment patterns in pancreatic ductal adenocarcinoma (PDAC) (Abstract #4138)
Endometrial cancer (EC) by ERBB2 amplification (ERBB2amp) status: Differences in molecular subtypes, ancestry, and real-world outcomes (Abstract #5614)
"Our data at this year’s ASCO (Free ASCO Whitepaper) annual meeting reflects Foundation Medicine’s progress in making genomic profiling indispensable to cancer care and research, particularly in lung, breast and prostate cancers where there is an increasing number of targeted therapies for health care providers to consider for these patients," says Mia Levy, MD, PhD, Chief Medical Officer at Foundation Medicine. "We are also excited to demonstrate our new RNA sequencing capabilities and spotlight the expanding utility of ctDNA to inform treatment decision making through a simple blood sample."

The following is a complete list of Foundation Medicine abstracts that will be presented. To access the abstracts being presented at ASCO (Free ASCO Whitepaper), please visit ASCO (Free ASCO Whitepaper).org/abstracts.

Follow Foundation Medicine on LinkedIn, X and Instagram for more updates from #ASCO24 and visit us in person at Booth #22031.

Abstract #

Title

Collaborator

Products

Posters

Abstract #3127
6/1/2024 9:00 AM-
12:00 PM

On the right TRACK: Providing comprehensive genomic profiling (CGP) and molecular tumor board (MTB) for patients (pts) with rare cancers

TargetCancer Foundation, UC San Diego Moores Cancer Center, University of California, San Diego, Medical College of Wisconsin (MCW) Cancer Center, The Sidney Kimmel Comprehensive Cancer Center at The Johns Hopkins Hospital, The University of Texas MD Anderson Cancer Center, Department of Pharmacy, Rutgers New Jersey Medical School, Medication Acquisition, Inc., Sarah Cannon Research Institute, University of Nebraska, WIN Consortium for Precision Medicine

FoundationOneCDx
FoundationOneLiquid CDx

Abstract #3129
6/1/2024 9:00 AM-
12:00 PM CDT

Characterization of diverse targetable ERBB2 alterations in 512,993 patients with solid tumors

Memorial Sloan Kettering Cancer Center

FoundationOneCDx
FoundationOneLiquid CDx

Abstract #4138
6/1/2024 1:30 PM-
4:30 PM CDT

Genetic ancestry-associated differences in genomic profiling and treatment patterns in pancreatic ductal adenocarcinoma (PDAC)

Yale Cancer Center, New York University Perlmutter Cancer Center

FoundationOneCDx
Flatiron Health-Foundation
Medicine Clinico-Genomic
Database (CGDB)

Abstract #TPS3644
6/1/2024 1:30 PM-
4:30 PM CDT

Use of circulating tumor DNA (ctDNA) to affect the adjuvant or post-adjuvant treatment of patients with stage III and high-risk stage II resected colon cancer: The ERASE-CRC project by GONO

University of Pisa, Italy

FoundationOneTracker

Abstract #11545
6/1/2024 1:30 PM-
4:30 PM CDT

New soft tissue sarcoma (STS) transcriptomic clusters to unveil STS subsets with unique biological characteristics and refine the accuracy of overall survival (OS) prediction

Universitario Lisboa Norte, Institute Portugues de Oncologia de Lisboa Francisco Gentil, Institute Superior Tecnico, Universidade de Lisboa, Institute de Medicina Molecular Joao Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, F. Hoffmann-La Roche AG, Institute Superior Tecnico (1ST), Universidade de Lisboa, Hospital CUF Descobertas

FoundationOneRNA for
research use

Abstract #3067

6/1/2024 9:00 AM-
12:00 PM CDT

Nature and distribution of methyl thioadenosine phosphorylase (MTAP) genomic loss in human tumors

San Raffaele Hospital and Scientific Institute, Italy

FoundationOne
FoundationOneCDx

Abstract #1060
6/2/2024 9:00 AM-
12:00 PM CDT

Genomic alterations (GA) in ESR1, PIK3CA, AKT1, and PTEN in HR(+)HER2(-) patients (pts) with metastatic breast cancer (MBC): co-occurrence and prevalence along treatment course

Emory University

FoundationOneCDx
FoundationOneLiquid CDx
Flatiron Health-Foundation
Medicine Clinico-Genomic
Database (CGDB)

Abstract #591
6/2/2024 9:00 AM-
12:00 PM CDT

Pathological complete response (pCR) association with a novel homologous recombination deficiency HRD signature (HRDsig) in patients with triple-negative breast cancer (TNBC) receiving neoadjuvant therapy (Tx)

Stanford University

FoundationOneCDx
Flatiron Health-Foundation
Medicine Clinico-Genomic
Database (CGDB)

Abstract #5056
6/2/2024 9:00 AM-
12:00 PM CDT

BRCA1/2 reversion mutations in advanced prostate cancer in the absence of prior PARP inhibitor (PARPi) therapy

Cedars-Sinai Medical Center, Upstate University Medical Center, University of California – San Diego

FoundationOneLiquid CDx

Abstract #1042
6/2/2024 9:00 AM-
12:00 PM CDT

Utility of circulating tumor DNA (ctDNA) to inform treatment of patients with metastatic breast cancer

Johns Hopkins University School of Medicine, Vanderbilt University Medical Center, Allegheny Health Network, Weill Cornell Medicine and New York-Presbyterian Hospital

FoundationOneLiquid CDx

Abstract #5091
6/2/2024 9:00 AM-
12:00 PM CDT

Impact of alterations in tumor suppressor genes (TSG-alt) on survival outcomes in patients (pts) with de novo metastatic castration-sensitive prostate cancer (dn-mCSPC) receiving androgen deprivation therapy (ADT) with androgen receptor pathway inhibition (ARPI) or docetaxel

Huntsman Cancer Institute, Masonic Cancer Center

Flatiron Health-Foundation
Medicine Clinico-Genomic
Database (CGDB)

Abstract #5085
6/2/2024 9:00 AM-
12:00 PM CDT

Prognostic value of baseline circulating tumor DNA (ctDNA) tumor fraction (TF) in metastatic hormone-sensitive prostate cancer (mHSPC)

Rogel Comprehensive Cancer Center, University of Michigan, Karmanos Cancer Institute, Wayne State University

FoundationOneLiquid CDx

Abstract #5020
6/2/2024 9:00 AM-
12:00 PM CDT

Utility of ctDNA burden as a prognostic biomarker for efficacy in TALAPRO-2: A phase 3 study of talazoparib (TALA) + enzalutamide (ENZA) vs placebo (PBO) + ENZA as first-line (1L) treatment in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)

Peter MacCallum Cancer Centre, Department of Medical Oncology, Institut Gustave Roussy, University of Paris-Saclay, Pfizer Inc., National Cancer Center Hospital East, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Orbassano, The Urology Center of Colorado, National Cancer Center, Tom Baker Cancer Centre, University of Calgary, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Huntsman Cancer Institute (NCI-CCC), University of Utah

FoundationOneLiquid CDx
FoundationOneMonitor for
Research Use

Abstract #3626
6/2/2024 9:00 AM-
12:00 PM CDT

Contrasting comprehensive genomic profiles of adenocarcinomas of the appendix in younger versus older patients

Upstate Medical University

FoundationOne
FoundationOneCDx

Abstract #4588
6/2/2024 9:00 AM-
12:00 PM CDT

FGFR3-mutated urothelial carcinoma of bladder and upper tract including ureter and renal pelvis: A comparative genomic profiling study

Upstate Medical University, University of California – Los Angeles, University of Washington, Huntsman Cancer Center, Moffitt Cancer Center, MD Anderson Cancer Center, Cleveland Clinic, San Rafael University

FoundationOne
FoundationOneCDx

Abstract #8032
6/2/2024 9:00 AM-
12:00 PM CDT

Retrospective analysis of change in frequency of STK11 mutation in lung adenocarcinomas over a 10-year period

Upstate Medical University

FoundationOne
FoundationOneCDx

Abstract #1092
6/2/2024 9:00 AM-
12:00 PM CDT

Impact of HER2 low status on genomic signatures in triple negative breast cancer (TNBC)

Yale University

FoundationOne
FoundationOneCDx

Abstract #11575
6/2/2024 9:00 AM-
12:00 PM CDT

Intimal sarcomas (ISarc) of the cardiac chambers (CC) of the heart and great vessels (GV): A comprehensive genomic profiling (CGP) study

Upstate Medical University

FoundationOne
FoundationOneCDx

Abstract #6036
6/2/2024 9:00 AM-
12:00 PM CDT

Clinical, molecular, and immunologic profiling of brain metastases (BM) in head and neck squamous cell carcinoma (HNSCC)

Dana-Farber Cancer Institute, University of California – San Diego, Phase Genomics

Abstract #5614
6/3/2024 9:00 AM-
12:00 PM CDT

Endometrial cancer (EC) by ERBB2 amplification (ERBB2amp) status: Differences in molecular subtypes, ancestry, and real-world outcomes

University of Colorado Health, Mount Sinai

FoundationOneCDx

Abstract #8068
6/3/2024 1:30 PM-
4:30 PM CDT

Preliminary results of the Lung Cancer Mutation Consortium LCMC4 evaluation of actionable drivers in early-stage lung cancer (LEADER) screening trial

Baylor College of Medicine, Harvard University, University of Michigan, University of Missouri, University of Washington, University of California – Los Angeles, University of Colorado, Memorial Sloan Kettering

FoundationOneCDx
FoundationOneLiquid CDx

Abstract #8532
6/3/2024 1:30 PM-
4:30 PM CDT

Molecular profiling across histologies in lung cancer: Time to change WHO nomenclature?

Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Papardo Hospital, Roche Sequencing Solutions

FoundationOneCDx