IN8bio to Present at the H.C. Wainwright 3rd Annual Cell Therapy Virtual Conference

On February 24, 2025 IN8bio, Inc. (Nasdaq: INAB), a leading clinical-stage biopharmaceutical company focused on innovative gamma-delta T cell therapies, reported that William Ho, CEO and co-founder, will be presenting at the (Press release, In8bio, FEB 24, 2025, View Source [SID1234650475]):

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H.C. Wainwright 3rd Annual Cell Therapy Virtual Conference
Date/Time Tuesday, February 25, 2025, at 11:00 a.m. ET.
Webcast Link View Source

A live webcast and replay will be available under "Events and Presentations" in the News & Presentations section of the IN8bio website at View Source

GSK completes acquisition of IDRx, Inc.

On February 24, 2025 GSK plc (LSE/NYSE: GSK) reported that it has completed the acquisition of IDRx, Inc. (IDRx), a Boston-based, clinical-stage biopharmaceutical company dedicated to developing precision therapeutics for the treatment of gastrointestinal stromal tumours (GIST) (Press release, GlaxoSmithKline, FEB 24, 2025, View Source [SID1234650474]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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As announced previously1, the acquisition includes lead molecule IDRX-42, an investigational, highly selective tyrosine kinase inhibitor (TKI) that is designed to improve outcomes for patients with GIST. IDRX-42 has demonstrated activity against all clinically relevant primary and secondary KIT mutations, a key medical need in current GIST treatment. GIST typically presents in the gastrointestinal (GI) tract with 80% of cases driven by mutations in the KIT gene that lead to the growth, proliferation, and survival of tumour cells (primary or activating mutations).2 90% of patients treated in the first line develop new KIT mutations (secondary or resistance mutations) that typically lead to relapse with limited therapeutic options.3

Hesham Abdullah, Senior Vice President, Global Head Oncology R&D, GSK, said: "This acquisition adds to GSK’s growing pipeline of targeted therapeutics for cancers originating in the gastrointestinal tract. We plan to advance IDRX-42 for second line treatment of gastrointestinal stromal tumours, where there are no approved treatments to effectively address all resistance mutations, and accelerate development in an earlier setting."

Financial Considerations
The total cash consideration for this acquisition amounts to up to $1.15 billion. This includes an upfront payment of $1 billion, with the possibility of an additional $150 million milestone payment contingent upon success-based regulatory approval. GSK will also be responsible for success-based milestone payments as well as tiered royalties for IDRX-42 owed to Merck KGaA, Darmstadt, Germany.

About GIST
GIST represent the most prevalent form of soft tissue sarcoma, with an estimated annual global diagnosis of 80,000 to 120,000 patients.4 GIST commonly manifests in the GI tract, with approximately 80% of cases being attributed to mutations in the KIT gene.5 These mutations, known as primary or activating mutations in exons 9 and 11, drive the growth, proliferation, and survival of tumour cells. In the first line of treatment, around 90% of patients develop secondary or resistance mutations in exons 13 and 17 of the KIT gene, leading to relapse with limited therapeutic alternatives.6 Notably, there are currently no approved TKIs capable of effectively targeting the full range of clinically significant primary and secondary mutations in KIT.

About IDRX-42
IDRX-42 is a highly selective, investigational small molecule TKI designed to target all key KIT mutations in GIST. The U.S. Food and Drug Administration (FDA) has granted IDRX-42 Fast Track designation for the treatment of patients with GIST after disease progression on or intolerance to imatinib, and Orphan Drug designations for the treatment of GIST.

Galapagos to Present at Upcoming Investor Conferences

On February 24, 2025 Galapagos NV (Euronext & NASDAQ: GLPG), a global biotechnology company dedicated to transforming patient outcomes through life-changing science and innovation, reported that its management will present at the following investor conferences in March (Press release, Galapagos, FEB 24, 2025, View Source [SID1234650473]):

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TD Cowen 45th Annual Healthcare Conference
Date: Tuesday, March 4, 2025
Location: Boston, MA
Corporate Presentation: 1:50 – 2:20 PM ET / 7:50 – 8:20 PM CET
Live Webcast Link: Here

Barclays 27th Annual Global Healthcare Conference
Date: Wednesday, March 12, 2025
Location: Miami, FL
Corporate Presentation: 11:00 – 11:25 AM ET / 5:00 – 5:25 PM CET
Live Webcast Link: Here

A live webcast of the presentations can also be accessed on the Investors page of the Company’s website at www.glpg.com/investors. Replays of the webcasts will be available following the completion of the event and will be archived for up to 90 days.

Exact Sciences to Participate in March Investor Conferences

On February 24, 2025 Exact Sciences Corp. (Nasdaq: EXAS), a leading provider of cancer screening and diagnostic tests, reported that company management will participate in the following conferences and invited investors to participate by webcast (Press release, Exact Sciences, FEB 24, 2025, View Source [SID1234650471]).

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TD Cowen Health Care Conference, Boston
Fireside chat on Monday, March 3, 2025 at 10:30 a.m. ET
Raymond James Institutional Investors Conference, Orlando
Presentation on Tuesday, March 4, 2025 at 1:05 p.m. ET
The webcasts can be accessed in the investor relations section of Exact Sciences’ website at www.exactsciences.com.

CytoDyn Announces Promising Survival Observations in mTNBC Patients Treated with Leronlimab

On February 24, 2025 CytoDyn Inc. (OTCQB: CYDY) ("CytoDyn" or the "Company"), a biotechnology company developing leronlimab, a CCR5 antagonist with the potential for multiple therapeutic indications, reported encouraging survival outcomes among a group of patients with metastatic triple-negative breast cancer ("mTNBC") treated with leronlimab (Press release, CytoDyn, FEB 24, 2025, View Source [SID1234650470]). Although mTNBC typically has a poor prognosis, observed survival rates at 12, 24, and 36 months after treatment with leronlimab compare favorably with reported life expectancy after treatment with currently approved therapies. In addition, the Company confirmed that a small group of patients who failed treatment after developing metastatic disease survived more than 36 months after receiving leronlimab, are alive today, and currently identify as having no evidence of ongoing disease.

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Following the resolution of the Company’s dispute with its former CRO, CytoDyn obtained follow-up records from patients treated with leronlimab during the Company’s prior clinical trials in oncology. After confirming these patient outcomes, CytoDyn worked with consultants and key opinion leaders to summarize the findings and submit an abstract to the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Breast Cancer meeting taking place in Munich, Germany, from May 14 to 17, 2025.

"We are encouraged by the longer-term survival data to pursue this potentially paradigm-shifting therapeutic pathway for patients suffering from metastatic triple-negative breast cancer," said Richard Pestell, MD, PhD, AO, the Company’s Lead Consultant in Preclinical and Clinical Oncology. "As a cancer therapeutic, leronlimab was well tolerated with remarkably infrequent treatment-related adverse events. These promising results suggest further studies with leronlimab are warranted to expand oncology treatment options and improve patient care."

Dr. Jacob Lalezari, CEO of CytoDyn, added: "These provocative observations of improved survival in patients with mTNBC and prior treatment failure in the metastatic setting, including reported clearance of disease in a group of long-term survivors, provides early clinical evidence of leronlimab’s potential impact in the treatment of TNBC and other solid tumors. I expect the Company’s oncology efforts to accelerate in the coming months, with further announcements in both mTNBC and colorectal cancer."

Based on these survival observations, the Company has initiated two pre-clinical studies in mTNBC that will evaluate possible treatment synergies between leronlimab, an antibody-drug complex treatment (sacituzumab govitecan), and an immune checkpoint inhibitor (pembrolizumab). The Company will also continue to perform follow-up testing on the group of mTNBC survivors who currently identify as having no evidence of ongoing disease.