Oncoinvent ASA half-yearly report: Strong focus on financial discipline and advancing Phase 2 program in ovarian cancer

On August 27, 2025 Oncoinvent reported continued progress in the ongoing Phase 2 trial in ovarian cancer with a strong focus on advancing the program and maximizing recruitment (Press release, Oncoinvent, AUG 27, 2025, View Source [SID1234655534]).

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Highlights for the first half of 2025:

Radspherin

Positive final data from Phase1/2a trial in colorectal cancer patients
Positive interim 18-months data from Phase1 trial in ovarian cancer patients
Positive read-out of safety lead-in cohort and opening of randomized part of Phase 2 trial in ovarian cancer patients
Regulatory approvals for additional sites for the randomized Phase 2 trial in ovarian cancer, with expected onboarding before end of 2025
Corporate

Operating expenses reduced by 28% versus last year
Merger with BerGenBio
Fully guaranteed rights issue of NOKm 130
CEO Øystein Soug and CFO Tore Kvam will present the results for the first half of 2025 at a webcast available at https://channel.royalcast.com/landingpage/hegnarmedia/20250827_3/, Wednesday 27 August at 08:00 CEST. The presentation and Q&A will be held in English. A recording of the webcast will be made available on our website shortly after the presentation.

Zemcelpro® (UM171 Cell Therapy) receives EC authorization as the first and only cell therapy for blood cancer patients without access to suitable donor cells

On August 27, 2025 ExCellThera Inc. (ExCellThera), a world leader in blood stem cell expansion and metabolic fitness, and its wholly owned subsidiary Cordex Biologics, reported the conditional marketing authorization of Zemcelpro by the European Commission (EC) for the treatment of adults with haematological malignancies requiring an allogeneic haematopoietic stem cell transplantation following myeloablative conditioning for whom no other type of suitable donor cells is available (Press release, ExCellThera, AUG 27, 2025, View Source [SID1234655533]). This EC decision authorizes the marketing of Zemcelpro in all European Union member states, as well as Iceland, Norway and Liechtenstein.

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Zemcelpro, also known as UM171 Cell Therapy, is a novel personalized cryopreserved haematopoietic stem cell transplantation product containing two components, namely UM171-expanded CD34+ cells (dorocubicel) and unexpanded CD34- cells, each derived from the same cord blood unit.

In Europe, over 10,000 patients each year are diagnosed with haematological malignancies—including leukemias and myelodysplastic syndromes—that require stem cell transplant. While access to transplant has improved in recent years, a number of patients still cannot access suitable donor cells. Barriers include the absence or unavailability of a compatible donor or the inability to secure donor cells within the therapeutic window for transplant, which can be especially short in urgent cases. Unlike documented transplant procedures which are well-tracked through national registries, no official statistics exist for patients who miss the opportunity for a potentially curative transplant—a group that includes a disproportionately high number of individuals from ethnic minority backgrounds.

"The curative potential of allogeneic stem cell transplantation is still limited by the access to a suitable donor. The access to stem cell donation according to the stringent disease course is one of the major limiting factors for success," said Dr. Fabio Ciceri, Professor of Hematology, Vita-Salute San Raffaele University, Millan, Italy. "UM171 Cell Therapy offers an option timely available for patients in need."

Patients with blood cancers who do not receive the stem cell transplant they require represent a significant burden to healthcare systems, driven by ongoing medical needs, disease progression, complications, hospitalizations and supportive/palliative care. Beyond this, the societal impact is profound, with premature deaths leading to lost productivity and considerable emotional and economic strain on families and communities.

"Each year, thousands of people across Europe are diagnosed with blood cancers that require potentially life-saving allogeneic stem cell transplantation. Yet some are left without access to suitable donor-derived blood stem cells, facing a critical and unmet medical need," said Dr. J. (Jurjen) Versluis, Internist-Hematologist and Principal Investigator, Erasmus MC, Rotterdam, The Netherlands.

Zemcelpro is an innovative, one-time cell therapy with curative intent, developed to give blood cancer patients without access to suitable donor cells the transplant they urgently need. By enabling more patients to receive a life-saving transplant, Zemcelpro has the potential not only to save lives but also to reduce the healthcare and societal burden associated with these devastating conditions.

The timing of Zemcelpro availability in individual countries will depend on several factors, including the completion of national reimbursement procedures. In the meantime, Cordex Biologics is working closely with national health authorities to enable early access for eligible patients ahead of the reimbursement process, and is engaging with leading stem cell transplantation centers to establish a network of treatment centers for the future administration of Zemcelpro.

"This authorization marks a pivotal milestone in delivering on the therapeutic promise of Zemcelpro for adults battling life-threatening haematological malignancies. As the first and only cell therapy approved for patients without access to suitable donor cells, Zemcelpro offers a vital new stem cell transplant option — and renewed hope — for those who have been left without one," said David Millette, CEO of ExCellThera and Cordex Biologics.

Additional regulatory filings are planned for Zemcelpro with other health authorities, including in the US, Canada, the UK, and Switzerland. Cordex Biologics is also actively seeking strategic partnerships to support and accelerate the commercialization of Zemcelpro in Europe and other international markets.

The safety of Zemcelpro is consistent with the well-characterized safety profile of conventional allogeneic blood stem cell transplantation for haematological malignancies following myeloablative conditioning.

For full details on the Warnings and Precautions for Use and Adverse Reactions (including appropriate management), please refer to the EU Summary of Product Characteristics (SmPC) of Zemcelpro.

About Conditional Marketing Authorizations (CMAs)

CMAs are for medicines that fulfil a significant unmet medical need such as being for serious and life-threatening diseases, where no satisfactory treatment methods are available or where the medicine offers a major therapeutic advantage. A CMA is granted where comprehensive clinical data is not yet complete, but the benefit of the medicine to address a significant unmet need outweighs the need for data that will become available in the future. CMAs are valid for one year and renewable annually with ongoing regulatory review of data.

About Zemcelpro

Zemcelpro, also known as UM171 Cell Therapy, is a novel personalized cryopreserved haematopoietic stem cell transplantation product containing two components, namely UM171-expanded CD34+ cells (dorocubicel) and unexpanded CD34- cells, each derived from the same cord blood unit.

Zemcelpro, developed by Cordex Biologics, a wholly owned subsidiary of ExCellThera, has been evaluated in 120 patients with haematologic malignancies in clinical trials in the United States, Europe and Canada. Zemcelpro has received orphan drug designation and regenerative medicine advanced therapy (RMAT) designations from the FDA as well as orphan medicinal product designation, advanced therapy medicinal product (ATMP) classification and priority medicines (PRIME) designation from the EMA.

Zemcelpro has been tested in Phase 2 trials in patients with high and very high-risk acute leukemias and myelodysplasias who have limited treatment options with low survival outcomes and high incidence of relapse under the current standard of care, including patients with patients with TP53 mutations or other genetic abnormalities, patients requiring a second transplant, and patients with refractory or active disease. A pivotal Phase 3 trial in this patient population will be initiated as soon as possible.

The use of Zemcelpro in other patient populations, including pediatric patients and patients with non-malignant haematological diseases, is also being investigated.

Zemcelpro is a registered trademark of Cordex Biologics.

The product safety and efficacy have not yet been established by other regulatory agencies, such as the FDA, the MHRA and Health Canada.

Antiva Biosciences Announces Positive Top-Line Results from Phase 1b/2 Study of ABI-2280 for Treatment of Cervical High-Risk Human Papillomavirus (hrHPV) Infection

On August 27, 2025 Antiva Biosciences, a biopharmaceutical company developing novel, topical therapeutics for the treatment of high-risk infections and pre-cancerous lesions caused by human papillomavirus (HPV) in women, reported positive top-line results from the company’s Phase 1b/2 clinical trial of ABI-2280, an investigational topical treatment for oncogenic (high-risk) cervical HPV (hrHPV) infection (Press release, Antiva Biosciences, AUG 27, 2025, View Source [SID1234655532]). The study achieved its primary endpoint with patients receiving ABI-2280 demonstrating statistically significant improvements in the rate of hrHPV negativity at Week 12 as compared with placebo. Additionally, the trial showed ABI-2280 treatment to be safe and well tolerated with the most commonly reported adverse events (AEs) categorized as mild and moderate and localized to the treatment area.

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"Women with persistent high-risk HPV have an approximately one-in-five chance of their infection progressing to pre-cancer or worse over four-to-six years, yet they do not have any options to treat the infection in the hopes of halting disease progression before this occurs. This reality highlights the clinical importance of the data generated in this study of ABI-2280, which demonstrated a 30 percent improvement in hrHPV negativity as compared to placebo, combined with a favorable safety and tolerability profile," said Margaret Stanley, OBE, FMedSci, Hon FRCOG, FFPH, Professor Emeritus, University of Cambridge. "Equally encouraging is the durability of the efficacy demonstrated by ABI-2280, which provides optimism that the treatment has the potential to keep HPV undetectable for long periods of time."

Each year in the United States, it is estimated that over six million women become newly infected with cervical hrHPV. When cervical hrHPV infections persist, they can lead to precancerous changes in the cervix and, ultimately, cervical cancer. There are no approved therapeutic options for treatment of hrHPV infections. Instead, these patients are counseled to wait and see if their infection clears or progresses to higher grade disease. During this wait and see period, patients are also at risk of transmitting this oncogenic virus to sexual partners. Approximately 30 percent of women with hrHPV fail to clear the virus within 12 months. These patients are considered to have persistent cervical hrHPV infections.

The Phase 1b/2 trial is a randomized, double-blind, placebo-controlled study designed to evaluate the safety, tolerability and efficacy of ABI-2280 administered intravaginally in women diagnosed with persistent cervical hrHPV infection. The study dosed a total of 139 female patients ranging in age between 25 and 55 years old who have had a documented hrHPV infection for at least one year without evidence of precancerous lesions worse than low grade cervical intraepithelial neoplasia (CIN1). Part A of the trial evaluated multiple placebo-controlled sentinel cohorts enrolled sequentially to determine the safety, tolerability and preliminary efficacy of various dose levels of ABI-2280 in two-week and six-week dosing regimens. Following the completion of the sentinel cohorts, the top cumulative dose from each of the two-week and six-week dosing regimens was advanced into Part B expansion cohorts for further evaluation of efficacy.

Results from Part B of the study demonstrated that both ABI-2280 treatment regimens (1 mg dosed three times over two weeks for a cumulative dose of 3 mg; 1 mg dosed five times over six weeks for a cumulative dose of 5 mg) drove increased hrHPV negativity rates at Week 12 as compared to placebo. For the primary efficacy endpoint, 46% of patients in the more frequently dosed 3mg cohort achieved hrHPV negativity at Week 12 for all hrHPV genotypes present at baseline as compared to only 16% of placebo patients (p=0.0077). The 3mg cohort also achieved statistically significant improvements over placebo for both Week 12 secondary endpoints of complete hrHPV negativity at Week 12 and two or more consecutive hrHPV negative tests by Week 12. While 32% of patients in the less frequently dosed 5mg cohort also achieved hrHPV negativity at Week 12 for all genotypes present at baseline, this result did not achieve statistical significance compared with placebo.

Both ABI-2280 treatment cohorts demonstrated clear separation from placebo in hrHPV negativity at every observed timepoint in the study (Weeks 2, 4, 8 and 12). Notably, interim Week 24 data demonstrated durability of therapeutic activity for ABI-2280. Interim data for all patients in the study who have reached Week 24 showed 87% of patients who were hrHPV negative at Week 12 following ABI-2280 treatment maintained hrHPV negativity at Week 24.

ABI-2280 demonstrated favorable safety and tolerability across all dose levels and regimens in the study. Among patients treated with ABI-2280, the most frequently reported adverse events were deemed to be mild or moderate and were localized to the lower genitourinary tract, consistent with the site of topical administration.

"We are very pleased with the top-line data readout from this trial of ABI-2280 as we believe it provides strong support for moving into a Phase 2b trial in women with high-risk HPV infections," said Elaine Chien, MD, FACOG, chief medical officer of Antiva. "We are thrilled to achieve clinically meaningful and statistically significant hrHPV negativity with the most frequently administered dose which provides a roadmap for potentially achieving even greater efficacy with optimized dosing strategies in Phase 2b."

ABI-2280 is expected to have potent activity across all genotypes of HPV worldwide and works by blocking HPV replication and inducing apoptosis in HPV-infected cells. Antiva has leveraged its development expertise to formulate a vaginal insert of ABI-2280 that enables at home self-administration at diagnosis.

About HPV-Related Diseases and Cervical Cancer

Human Papilloma Virus (HPV) is so common that nearly all sexually active men and women are infected with the virus at some point in their lives. Many of these are transient infections that the body is capable of clearing, but this typically takes months to years. When HPV infections persist, they are known to drive the formation of malignancies, including cervical, anal, vulvar, penile, and head and neck cancers.

The prevalence of cervical high-risk HPV (hrHPV) infection is estimated to be 20% among U.S. females of reproductive age, or approximately 19 million women. Each year in the U.S., it is estimated that over 6 million women become newly infected with hrHPV. There are currently no treatment options for hrHPV and these patients are counseled to wait and see if their infection clears or progresses to higher grade disease. During this wait and see period, patients are also at risk of transmitting this oncogenic virus to sexual partners. Approximately 30 percent of women with hrHPV fail to clear the virus within 12 months. These patients are considered to have persistent hrHPV and have an estimated 20 percent chance of having their infection progress to pre-cancer or cancer over the following four-to-six years. Women diagnosed with hrHPV often experience significant stress due to the social stigma of a sexually transmitted infection and the association with cervical cancer. The lack of available treatments further contributes to increased anxiety and emotional distress.

The introduction of prophylactic vaccines for HPV was a major step forward in the fight against HPV-associated cancers by preventing infection by certain high-risk HPV subtypes. However, due to low adoption rates in major territories such as the US, EU, and Japan, coverage of only 50% of all known oncogenic HPV genotypes with the most broad-spectrum vaccines currently available, and limited access to the vaccines in developing countries, HPV infections and the disease states driven by such infections remain a major unmet clinical need.

Globally, cervical cancer is the fourth most common cancer in women and as such represents a major public health problem. According to the World Health Organization, an estimated 660,000 women were diagnosed with cervical cancer worldwide and approximately 350,000 women died from the disease in 2022.

Innovent Announces 2025 Interim Results and Business Updates

On August 27, 2025 Innovent Biologics, Inc. (Innovent) (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high-quality medicines for the treatment of cancer, cardiovascular and metabolic, autoimmune, ophthalmology and other major diseases, reported its 2025 interim results and major business updates (Press release, Innovent Biologics, AUG 27, 2025, View Source [SID1234655531]).

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Dr. Michael Yu, Founder, Chairman of the Board and CEO of Innovent, stated: "We delivered an outstanding performance in the first half of 2025, driven by the comprehensive acceleration of our dual-engine growth model and global innovation strategy. Supported by our oncology leadership and successful commercial launch across our general biomedicine portfolio, we have expanded our product portfolio to 16 drugs and achieved a notable improvement in revenue and profitability, maintaining strong business momentum.

On the innovation front, several core pipeline candidates with global potential achieved key proof-of-concept data, and are entering global registration trials. This demonstrates the depth of Innovent’s innovation capabilities and lays a solid foundation for globalization.

We firmly believe that a clear strategic vision combined with excellent execution will continue to drive Innovent’s growth. Looking ahead, we will further consolidate our leadership in oncology, continue exploring and implementing diversified commercialization strategies across our general biomedicine product portfolio, and accelerate the global development of our next-generation innovative pipeline. Anchored by our strategic goals of achieving RMB 20 billion in product revenue by 2027 and advancing five pipeline programs into global Phase 3 trials by 2030, Innovent will continue striving to become a world-class biopharmaceutical company."

Dual-driven revenue growth with execution excellence

Robust revenue growth and substantial profit improvement[1]

Total revenue: RMB 5.95 billion, up 50.6% year-on-year
Product revenue: RMB 5.23 billion, up 37.3% year-on-year
Net profit: RMB 1.21 billion; EBITDA: RMB 1.41 billion
Gross margin: 86.8%, up 2.7 percentage points year-on-year
Selling and administrative expenses ratio: 44.2%, down 7.9 percentage points year-on-year
R&D investment: RMB 903 million
Cash on hand: approximately USD 2 billion[2]
Dual-engine growth supported by comprehensive and diversified product portfolio

Expansion of oncology product portfolio with three new launches
Dovbleron (taletrectinib) : Potentially best-in-class ROS1 inhibitor
Limertinib: Third-generation EGFR TKI
Jaypirca(pirtobrutinib) : First non-covalent BTK inhibitor
Strengthening general biomedicine portfolio with innovative pipeline
SINTBILO (tafolecimab injection): First PCSK-9 inhibitor successfully included in the NRDL, received approval by Macau ISAF in May 2025
SYCUME (teprotumumab N01 injection): First approved anti-IGF-1R monoclonal antibody, ending a 70-year drought of no new treatment options for thyroid eye disease (TED) in China
Mazdutide (GCG/GLP-1) : Globally first and only GCG/GLP-1 dual receptor agonist for weight management, with another NDA for glycemic control of T2D adults under NMPA review
Innovative commercial strategy with multi-channel coverage

Actively responding to the national "Year of Weight Management": Participating in the development of the weight-loss industry ecosystem, promoting the concept of scientific weight management, and advancing obesity prevention and chronic disease management
Deepening hospital presence and academic influence: Strengthening academic coverage in public hospitals, with the GLORY-1 study published in The New England Journal of Medicine, significantly enhancing academic influence
Innovative multi-channel coverage: Leveraging a comprehensive sales team of over 1,000 people, integrating public hospitals, retail pharmacies, online medical platforms, and private clinic networks to facilitate convenient access to medications for chronic disease patients
Emphasizing disease education and patient management: Integrating digital tools and professional activities to establish a patient-centric disease management system, enhancing chronic disease education and patient adherence
Enhancing brand strength through the establishment of a lifecycle management system

TYVYT: NDAs for renal and colorectal cancer are under regulatory review; Phase 3 study of neoadjuvant treatment in lung cancer is underway
SYCUME (teprotumumab N01 injection): new Phase 3 studies in plan for inactive TED and head-to-head comparison with steroid therapy in TED
Mazdutide (GCG/GLP-1): second NDA for glycemic control of T2D adults is under regulatory review, alongside with two new Phase 3 studies for obstructive sleep apnea (OSA) and obesity with metabolic dysfunction-associated fatty liver disease (MAFLD, head-to-head with semaglutide 2.4mg). Additional PoC studies are ongoing for adolescent obesity, metabolic dysfunction-associated steatohepatitis (MASH), heart failure with preserved ejection fraction (HFpEF), etc.
Picankibart (IL-23p19): a potent and long-acting IL-23p19 for moderate-to-severe plaque psoriasis pending NMPA approval; Phase 3 studies are ongoing for treatment withdrawal maintenance and psoriasis with prior inadequate response to IL-17 biologics
Emerging value from globalization strategy, prioritizing novel pipeline’s global R&D

Flagship pipeline showcased at top-tier conferences, entering global registration studies

IBI363 (PD-1/IL-2α-bias): Unleashing potential as a next-generation IO therapy with global first-in-class design
Three oral presentations at ASCO (Free ASCO Whitepaper) highlighted breakthrough PoC data across difficult-to-treat tumors such as IO resistant cold tumors and low PD-L1 expression, demonstrating the unique advantages of dual immune activation and long-term survival benefits
Three pivotal studies are underway or in plan: the first global Phase 3 study is initiating in China and the U.S. to address unmet needs in IO-resistant squamous NSCLC; the first pivotal Phase 2 study in melanoma was initiated, challenging Keytruda in first-line setting; and the first Phase 3 study in late-line colorectal cancer is about to initiate
Continuous exploration in first-line settings and more cancer types, including first-line lung cancer, first-line colorectal cancer, neoadjuvant lung cancer, EGFR-mutated lung cancer, platinum-resistant ovarian cancer, and more
BI343 (CLDN18.2 ADC): two registration trials in GC and PDAC; globally the first ADC to enter a Phase 3 trial in PDAC
First MRCT Phase 3 study of GC has been initiated in China and Japan
First Phase 3 study of PDAC has been initiated
Global MRCT of PDAC is in plan
NMPA CDE Breakthrough Therapy Designation (BTD) and FDA Fast-track Designation (FTD) granted
Over 10 next-generation programs advancing into global development
Oncology: IBI3009 (DLL3 ADC), IBI3001 (EGFR/B7H3 ADC), IBI3003 (GPRC5D/BCMA/CD3), IBI3005 (EGFR/HER3 ADC), IBI3014 (PD-L1/TROP2 ADC), IBI3020 (CEACAM5 dual-payload ADC), etc
CVM: IBI3016 (AGT siRNA), IBI3032 (oral GLP-1), etc
Autoimmune: IBI356 (OX40L), IBI3002 (TSLP/ IL-4Rα), etc
Hybrid models to accelerate innovation

IBI3009 (DLL3 ADC): global rights granted to Roche, to benefit SCLC patients worldwide
Enhance global presence with broader market access

Six products (TYVYT, BYVASDA, Pemazyre, Dupert, SINTBILO, SYCUME) have been launched in markets including Hong Kong, Macau, Taiwan, and Southeast Asia
More launches planned Brazil, Mexico, Columbia, India, etc
Research innovation showcased at medical conferences

Oncology pipeline: AACR (Free AACR Whitepaper), ASCO (Free ASCO Whitepaper), Nature Medicine
General biomedicine pipeline: ADA, NEJM
Facilities and manufacturing capacity adhering to high-quality standards

7,500 employees globally
Global R&D centers located in the San Francisco Bay Area, Shanghai, and Suzhou
To date, Innovent has a total of 140,000L of operational capacity, accounting for 20% of China’s total biopharmaceutical production capacity
First manufacturing site: 60,000L antibody and ADC production capacity in operation, ensuring high-quality supply
Second manufacturing site: first phase of 80,000L antibody production capacity in operation, for global supply and CDMO operations
Committed to responsible business practices and enhancing ESG management practices

Over 3,000 new oncology patients begin treatment with Innovent-developed therapeutics each day, and to date, more than 5 million patients have benefited from Innovent’s innovative drugs
Innovent has been graded ‘AAA’ rating in MSCI ESG rankings, positioning us at the forefront of the biotechnology industry
We have supported over 200,000 patients through our dedicated patient assistance programs, with drug donations totaling RMB 3.6 billion
Our commitment to medical philanthropy has been recognized through prestigious awards, including the "Medical Philanthropy Promoter" title and designation as a "China Philanthropic Enterprise"
Provided over 2,200 job opportunities for recent graduates
To date, Innovent Biologics has contributed more than RMB 6 billion in taxes and fees

Fosun International Announces 2025 Interim Results: Steady Growth in Core Businesses with Accelerated Innovation and Globalization

On August 27, 2025 Fosun International Limited (HKEX stock code: 00656, "Fosun International"), together with its subsidiaries ("Fosun" or the "Group"), reported its interim results for the six months ended 30 June 2025 (the "Reporting Period") (Press release, Fosun, AUG 27, 2025, View Source [SID1234655530]).

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In the first half of 2025, Fosun actively captured macroeconomic trends, maintained a clear strategic focus, and leveraged its strong capabilities in innovation and globalization to drive steady business development. Its long-term commitment to innovation led to multiple breakthroughs, with the innovative drug business entering a period of rapid growth. Globalization efforts continued to bear fruit. Overseas revenue contribution rose and expansion into emerging markets progressed steadily. In addition, Fosun fully embraced AI applications to empower its businesses, accelerating innovation and enhancing efficiency, while developing new growth points. Meanwhile, its "business streamlining, and advancements and exits" strategy delivered notable results, with asset structure further optimized and financial position remaining solid. During the Reporting Period, the Group’s total revenue reached RMB87.28 billion, industrial operation profit amounted to RMB3.15 billion, and profit attributable to owners of the parent reached RMB661.2 million.

The four core subsidiaries – Fosun Pharma, Yuyuan, Fosun Insurance Portugal and Fosun Tourism Group ("FTG") – achieved a total revenue of RMB63.61 billion in the first half of 2025, accounting for 73% of the Group’s total revenue. Fosun Pharma’s profit attributable to parent amounted to RMB1.7 billion in the first half of the year, representing a year-on-year increase of 38.96%. Yuyuan’s core businesses stabilized and began to recover, with the jewelry and fashion segment generating RMB12.9 billion in operating revenue during the first half of the year, including RMB7.6 billion in the second quarter, representing a substantial quarter-on-quarter increase. Fosun Insurance Portugal saw steady growth in both domestic and international businesses, achieving a net profit of EUR133 million, representing a year-on-year increase of 27.6%. FTG’s global operational capabilities continued to improve. Its business volume reached a record high of RMB9.53 billion, and adjusted net profit grew 42.0% year-on-year.

Meanwhile, Fosun continued to optimize its asset portfolio, maintaining a solid financial position with ample cash reserves. As at the end of the Reporting Period, the total debt to total capital ratio stood at 53%, with debt ratio remaining at a healthy level. In May 2025, the international credit rating agency S&P affirmed Fosun’s credit metrics and maintained its rating outlook as "Stable". The Group’s Hong Kong-listed companies in the Health segment saw a strong market capitalization performance in the first half of 2025, driving a revaluation of underlying asset values.

Guo Guangchang, Chairman of Fosun International, said: "In the first half of the year, we remained steadfast in implementing our core business-focused strategy. Our core segments—pharmaceuticals and healthcare, cultural tourism and consumption, financial services and insurance—delivered steady growth. In particular, we achieved several industry-leading breakthroughs in innovative drugs, which have not only been well received by the market but will also benefit more patients worldwide. Meanwhile, we continued to strengthen our global operating capabilities, allowing more competitive products and services to accelerate their expansion into international markets to serve a growing number of families."

Innovative drug business ushers in a period of rapid growth, fostering multiple "China’s first" and the "World’s first" innovations

Innovation is a core competence that Fosun has accumulated over a long period of time and has consistently adhered to. During the Reporting Period, Fosun’s investment in technology innovation reached RMB3.6 billion and its global innovation system integrating "independent R&D + investment incubation + ecosystem collaboration" continued to gain momentum, fostering a series of globally competitive innovations.

In terms of therapeutic drugs, a total of 5 indications of 4 innovative drugs independently developed and licensed-in by Fosun Pharma were approved for launch both domestically and internationally, 4 innovative drugs had entered the pre-launch approval stage. Among them, the Class I new drug independently developed by Fosun Pharma, FUMAINING (luvometinib tablets), was approved for marketing in Chinese mainland, filling the treatment gap in the field of rare tumors. In August 2025, the small molecule orally administered DPP-1 inhibitor developed by Fosun Pharma achieved overseas licensing for a potential total of US$645 million.

Henlius’ HLX43 is a PD-L1-targeting antibody-drug conjugate (ADC) currently in global Phase II clinical trials. It is undergoing clinical studies for solid tumors such as non-small cell lung cancer (NSCLC) and thymic carcinoma in countries including China, the United States, Japan, and Australia. HLX43 has demonstrated notable competitiveness in terms of drug safety, efficacy, and R&D progress, and holds strong potential to become a broad-spectrum anti-cancer drug. At the upcoming World Conference on Lung Cancer in September 2025, ten cutting-edge studies featuring Henlius’ innovative products, including HLX43, have been selected for presentation. In addition, HLX22, an innovative anti-HER2 monoclonal antibody, was granted Orphan Drug Designation (ODD) by the European Commission (EC) for the treatment of gastric cancer, marking it as the first anti-HER2-targeted therapy for gastric cancer to receive ODD approval from both the EU and the US. Henlius is continuously expanding its innovation pipeline in disease areas like oncology and autoimmune, advancing a differentiated portfolio of potential best-in-class (BIC) and first-in-class (FIC) candidates.

In addition, breakthrough progress has been made in the fields of medical devices and diagnostics. Leveraging the "licensed medical devices" permission in Hainan, the Da Vinci SP endoscopic single orifice surgical system has completed real-world study reports across multiple specialties, helping accelerate its formal registration and approval process. Meanwhile, the operating entity of the "MRgFUS" (MR guided focused ultrasound) brain therapy system, Fosun Insightec, is steadily advancing the registration of new models and the expansion into new indications.

In the field of cultural and tourism consumption, construction of FTG’s Taicang Alps Resort Phase II project commenced in June 2025, which will feature an indoor ski facility boasting five "world’s firsts". The project is scheduled to begin operations in June 2029.

Combining global resources with China’s capabilities, proportion of overseas revenue exceeds half of total revenue

Leveraging its business presence and profound industry operations in over 40 countries and regions around the world, Fosun’s overseas revenue saw steady growth. In the first half of 2025, overseas revenue reached RMB46.67 billion, accounting for 53% of the Group’s total revenue.

Henlius consistently achieved major breakthroughs in global operations during the Reporting Period. Its core innovative product HANSIZHUANG (serplulimab), the world’s first anti-PD-1 monoclonal antibody (mAb) approved for first-line treatment of small cell lung cancer (SCLC), recorded a global sales revenue of RMB597.7 million. In the first half of 2025, HANSIZHUANG received approvals in the EU, Singapore, Malaysia, the United Kingdom and India for first-line treatment of extensive-stage small cell lung cancer (ES-SCLC). Additionally, it was approved in Indonesia and Thailand for the treatment of squamous non-small cell lung cancer (sqNSCLC). To date, HANSIZHUANG has been successfully approved in nearly 40 countries and regions, covering nearly half of the world’s population. Henlius’ core breast cancer product HANQUYOU (trastuzumab), the "China-developed" mAb biosimilar approved in China, the EU, and the US, recorded a global sales revenue of RMB1.4442 billion in the first half of 2025. During the Reporting Period, HANQUYOU was newly approved in countries including Mexico, bringing its cumulative approvals to over 50 countries and regions worldwide.

During the Reporting Period, Henlius’ overseas products profits surged over 200%. Cash inflows from BD agreements exceeded RMB1 billion, surging 280% year-on-year. As the overseas sales volume of commercialized products continues to rise, the company expects significant growth in overseas revenue and profits for the full year of 2025, with strong momentum likely to continue into 2026.

Fosun rapidly advanced its pace of global expansion across more industries and business segments. Hainan Mining commenced pilot production at Phase 1 of the Bougouni lithium mine in Mali and will strategically initiate the planning of Phase 2 development. Leveraging its established projects such as the Bougouni lithium mine in Mali, Roc Oil oilfield project in Malaysia and the recently acquired oilfield project in Oman, Hainan Mining is accelerating the building of a "Minerals + Energy" network spanning West Africa, the Middle East, and Southeast Asia. Revenue from overseas operations has now increased to 57% of total revenue.

Following its overseas debut in Paris, France in late 2023, the Yuyuan Lantern Festival continued its overseas journey in 2025: In January, the themed lantern installation made a stunning appearance in Hanoi, Vietnam, commemorating the 75th anniversary of the establishment of diplomatic relations between China and Vietnam. In June, the Lantern Festival officially lit up at ICONSIAM, a renowned commercial landmark in Bangkok, Thailand, as part of the celebrations marking the 50th anniversary of the establishment of diplomatic relations between China and Thailand. In April 2025, Songhelou, a time-honored Chinese brand with a 268-year history, opened its first overseas restaurant in London, the UK, marking its debut on the international culinary stage.

At the same time, the global operations of Fosun’s overseas subsidiaries continued to grow. During the Reporting Period, Fosun Insurance Portugal’s international operations accounted for 28.2% of total consolidated business and overseas gross written premiums ("GWP") reached EUR924 million. In July 2025, S&P initiated coverage on Fosun Insurance Portugal and assigned it an "A" rating, recognizing its high-quality and well-balanced business portfolio, continuous international expansion, solid financial performance, and strong capital adequacy.

During the Reporting Period, Club Med’s global performance once again reached a record high. Its business volume amounted to RMB9.25 billion, representing a year-on-year increase of 3.8%; operating profit reached RMB1.27 billion, up 11.0% year-on-year. With strong demand continuing for the summer vacation season and the upcoming snow season, bookings are expected to witness sustainable growth in the second half of 2025 and the first half of 2026.

While strengthening its foothold in traditional markets, Fosun accelerated its expansion into global emerging markets. Fosun Pharma reached a strategic cooperation with Saudi Arabia’s comprehensive healthcare group, Fakeeh Care Group, to jointly promote the local introduction of innovative therapeutic products in Saudi Arabia. Easun Technology formed a joint venture with Saudi enterprise, Khaled Juffali Company, to provide production line solutions for Saudi Arabia’s electric vehicle industry and has already received its first order. The German asset servicing entity, HAFS, will leverage Fosun’s global network to expand into emerging markets in the Middle East and Asia, strengthening its asset-light operating model.

Fully embracing AI to develop new growth points

Amid the rapid rise of AI, Fosun has proactively embraced the trend, deeply integrating AI technologies into its diverse business scenarios to accelerate innovation and enhance operational efficiency.

In the field of biopharmaceuticals, Fosun Pharma tapped into AI productivity across all business scenarios by adopting a dual-engine approach that combines "biopharmaceutical models + large language models", building a knowledge platform to support high-quality AI applications. On the decision support front, Fosun Pharma launched the industry’s first decision intelligence platform, PharmAID. It integrates multiple global clinical information and pipeline databases, with data updated as frequently as T+1. The platform delivers higher content generation accuracy in the healthcare domain compared to general-purpose large models, and improves information extraction efficiency by 50% in areas such as R&D decision and evaluation, and pipeline optimization.

In the field of cultural tourism and consumption, Club Med continued to advance AI-driven digital transformation. The G.M Copilot conversational AI assistant, which provides 24/7 instant and personalized service, has already expanded to 12 markets worldwide, including Brazil, France, Belgium, Singapore, and Malaysia. In August 2025, FTG entered into a full-stack AI collaboration with Alibaba Cloud to jointly develop the cultural tourism intelligent system, "AI G.O", based on the Qwen3 model series. "AI G.O" is designed to optimize the entire vacation experience and enhance operational efficiency. It is scheduled for official launch at the end of September, with the first pilot program to be carried out at Atlantis Sanya.

In the field of finance services, Fosun Insurance Portugal leveraged its AI application system to comprehensively improve the efficiency of its entire business process and enhance data accuracy, driving rapid growth of its insurance business. During the Reporting Period, the total number of internet users of Fidelidade exceeded 2 million, representing nearly 20% of Portugal’s total population. By adopting AI technologies, the rate of fully automated processing for motor claims rose from 48% as at the end of 2023 to 66% as at the end of the Reporting Period.

In pursuit of new opportunities in fintech, Fosun Wealth accelerated its Web3 strategy. In July 2025, Finloop, independently incubated by Fosun Wealth, launched the FinRWA Platform (FRP). FRP is a globally leading one-stop solution for Real World Assets (RWA) technology, issuance and distribution, and Finloop is actively advancing multiple asset tokenization technology projects.

Committed to business for good, maintaining a leading ESG performance

During the Reporting Period, relying on Fosun’s continuous efforts in environmental, social, and governance (ESG) over the years, it was once again successfully included in S&P Global’s "Sustainability Yearbook 2025" and was selected as the top 1% in S&P Global’s "Sustainability Yearbook 2025 (China Edition)". In addition, Fosun’s FTSE ESG score continued to outperform the global industry average and the national average, and it has been included in the constituent stocks of the FTSE4Good Index Series for four consecutive years.

In terms of social welfare, Fosun Pharma has consistently contributed the "China Solution" to the fight against malaria in Africa. As at the end of June 2025, its independently developed artesunate for injection had been used to treat more than 84 million patients with severe malaria worldwide. Additionally, Fosun Pharma had supplied over 420 million doses of artesunate for injection globally.

In terms of rural revitalization, as at the end of June 2025, the Rural Doctors Program had covered 78 counties in 16 provinces, cities and autonomous regions (including 21 key counties for national rural revitalization), supported 25,000 rural doctors, and benefited 16.34 million rural residents and 3 million rural families.

Looking ahead, Guo Guangchang stated: "In the face of both opportunities and challenges, we will remain focused on our core businesses, step up innovation efforts, and firmly advance our globalization strategy. Building on our long-established core capabilities, we are committed to driving Fosun’s sustainable growth, scaling new heights in our areas of strength, expanding our leadership across more business areas, and creating greater value for our shareholders and society."