Marijuana, Inc., Completes Acquisition of Exousia AI and Enters Expanding Exosome Market

On January 6, 2025 Marijuana, Inc. (OTCPINK: MAJI), dba Exousia Pro, Inc., reported it has acquired 100% of Exousia AI in a cash and stock transaction from Ludwig Enterprises, Inc (Press release, Exousia Pro, JAN 6, 2025, View Source [SID1234656255]). Exousia Pro will issue 47,000,000 million restricted shares of its Common stock to Ludwig Enterprises.

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The 47,000,000 shares being issued are restricted shares with certain lock-up features. The legend cannot be removed until six months AFTER Exousia Pro has completed its up-listing with NASDAQ or an equivalent exchange. The Company further agreed to assume liabilities under $75,000 and issued Ludwig a Note for $100,000.

Exousia AI is a leading USA-based biotechnology company in the field of Exosomes. The Company secured a worldwide license for its Exosome technology. The technology covers growing and extracting plant-based exosomes and loading them for use as a drug delivery system. The loading process can also be applied to human-derived exosomes. The acquisition includes an ongoing study on using Exosomes to treat Glioblastoma ("GBM"). The study is well underway, with very promising initial findings. Exousia AI is involved in other studies, including one study concluding in Italy. Exousia Pro will enter two additional studies covering dermatology and the dental market that are part of the acquisition.

Exousia Pro will manufacture and sell vials of wet exosomes or jars of dried exosomes to the nutraceutical and dermatology markets. The OTC exosome market, known as cosmeceuticals, is rapidly expanding due to consumer demand for antiaging and regenerative skincare solutions. A 30-day treatment for skin and hair sells for $400 a vial. Reports suggest a compound annual growth rate of 10%, growing from $310 million in 2025 to $633 million in 2033, for the exosomes skincare market; this is a global trend, with markets in North America, Europe, and Asia Pacific showing strong growth.

Exousia is in talks to license several other patents using Exosomes, which, once secured, will allow the Company to expand its oncology studies beyond GBM.

When Exousia Pro proves its technology enhances current chemotherapy drugs on the market, it can contact the drug manufacturers and license the tech for use in their drug therapy.

"The exosome market is in its infancy, but poised for explosive growth, as evidence by a surge of promising studies," said CEO of Marijuana Inc., Michael Sheikh. "Mounting research points to the vast therapeutic potential of exosomes, highlighting their capacity to precisely target diseases while minimizing side effects. Investors may not fully appreciate the dominance of monoclonal antibodies, which now lead the pharmaceutical market in revenue. This success stems from their ability to target diseased cells, often delivering therapeutic payloads directly where needed. Every major pharmaceutical company is actively developing monoclonal antibody drugs, driven by the universal desire for treatments that alleviate symptoms without causing new ones."

"Exosomes represent the next generation of targeted therapies, surpassing monoclonal antibodies in several key aspects. They offer significant cost advantages in production, the capacity to deliver larger and more complex payloads, including sensitive molecules like DNA, and a broader range of applications. Importantly, exosomes also mitigate the risk of off-target effects and immune reactions often associated with current monoclonal antibody treatments. This would be a key selling point in the event of licensing discussions. Exosomes embody an elegant evolution in biotechnology, and Exousia Pro is committed to spearheading their commercialization and therapeutic development."

Genprex to Participate at the 43rd Annual J.P. Morgan Healthcare Conference

On January 6, 2025 Genprex, Inc. ("Genprex" or the "Company") (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, reported that members from its executive leadership team will be attending and participating in investor, industry and business development meetings at the 43rd Annual J.P. Morgan Healthcare Conference, taking place Jan. 13-16, 2025 in San Francisco, California (Press release, Genprex, JAN 6, 2025, View Source [SID1234649484]).

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In attendance will be Ryan Confer, President, Chief Executive Officer and Chief Financial Officer; Mark Berger, MD, Chief Medical Officer; and Thomas Gallagher, Senior Vice President of Intellectual Property and Licensing. Throughout the duration of the conference, Genprex executives will be available to conduct one-on-one meetings with industry and investor groups to provide an overview of the Company’s gene therapies for cancer and diabetes.

For those interested in meeting Genprex management during the conference, please request a meeting through Investor Relations at [email protected].

Akeso to Share Global Strategy for New Drug Development at the 43rd J.P. Morgan Healthcare Conference

On Jan. 6, 2025 Akeso, Inc. (9926.HK) ("Akeso" or the "Company") reported its participation in the upcoming 43rd Annual J.P. Morgan Healthcare Conference, taking place on January 13, 2025, in San Francisco, California (Press release, Akeso Biopharma, JAN 6, 2025, View Source [SID1234649483]). The company’s founder, chairwoman, president, and CEO, Dr. Michelle Xia will share the latest developments and plans for its globally leading programs, including ivonescimab (PD-1/VEGF bispecific antibody), cadonilimab (PD-1/CTLA-4 bispecific antibody), and ligufalimab (CD47 monoclonal antibody), as well as more cutting-edge multispecific antibody pipeline assets.

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Time:SF local time 2:15-2:55pm, Jan. 15, 2025

Avenzo Therapeutics and DualityBio Announce Exclusive Global License for Potential Best-In-Class EGFR/HER3 Antibody-Drug Conjugate

On January 7, 2025 Avenzo Therapeutics, Inc. ("Avenzo"), a clinical-stage biotechnology company developing next-generation oncology therapies, and Duality Biotherapeutics ("DualityBio"), a clinical-stage biotech company focusing on the discovery and development of next-generation antibody-drug conjugate (ADC) therapeutics, reported that they have entered into an exclusive license agreement, pursuant to which Avenzo will develop, manufacture and commercialize AVZO-1418/DB-1418, a potential best-in-class EGFR/HER3 bispecific ADC, globally (excluding Greater China) (Press release, Avenzo Therapeutics, JAN 6, 2025, View Source [SID1234649459]).

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"DualityBio has a strong track record of developing and advancing a pipeline of differentiated ADCs that target a broad range of indications," said Athena Countouriotis, M.D., Co-founder, President and CEO of Avenzo Therapeutics. "By targeting both EGFR and HER3 with its differentiated design, AVZO-1418/DB-1418 has the potential to provide clinical benefit across multiple solid tumor types. We are excited to add this drug candidate to our clinical pipeline and look forward to collaborating with DualityBio to quickly progress this program into clinical studies."

Under the terms of the agreement, DualityBio will receive an upfront payment of $50 million and will be eligible to receive up to approximately $1.15 billion in development, regulatory and commercial milestone payments. In addition, DualityBio is eligible to receive tiered royalties on sales in Avenzo’s territory.

"DualityBio and Avenzo share a common purpose in developing the next generation of oncology therapies that address underserved therapeutic areas," said John Zhu, Ph.D., Founder and CEO of DualityBio. "Based on preclinical studies, we believe AVZO-1418/DB-1418 has the potential to offer enhanced therapeutic benefits over other therapies. We look forward to partnering with the Avenzo team to accelerate the development of this program and provide a potential new treatment option to cancer patients."

IND-enabling studies are ongoing with plans to advance AVZO-1418/DB-1418 into a first-in-human clinical study this year.

About AVZO-1418/DB-1418
AVZO-1418/DB-1418 is an EGFR/HER3 dual targeting, topoisomerase-1 inhibitor-based ADC built from DualityBio’s proprietary Duality Innovative Bispecific Antibody Conjugate (DIBAC) platform. In preclinical studies, AVZO-1418/DB-1418 has exhibited higher binding affinity to tumor cells and has demonstrated its efficacy potential across various solid tumors, including those that are EGFR-resistant, EGFR-low or HER3-resistant.

Obsidian Therapeutics to Present at the 43rd Annual J.P. Morgan Healthcare Conference

On January 6, 2025 Obsidian Therapeutics, Inc., a clinical-stage biotechnology company pioneering engineered cell and gene therapies, reported that Chief Executive Officer, Madan Jagasia, M.D., will present at the 43rd Annual J.P. Morgan Healthcare Conference, on Wednesday, January 15, at 8:00 am PST (11:00 am EST) (Press release, Obsidian Therapeutics, JAN 6, 2025, View Source [SID1234649450]).

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