On April 30, 2025 Aveta Biomics, a clinicalstage biotechnology company developing first-in-class drugs that reprogram the immune system to fight cancer, reported acceptance of abstract for poster presentation at the 2025 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, taking place May 30 – June 3, 2025, in Chicago, Illinois (Press release, Aveta Biomics, APR 30, 2025, View Source [SID1234652377]).

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The poster will feature clinical data from the company’s Phase IIA trial evaluating its drug APG157 as a neoadjuvant monotherapy in patients with locally advanced squamous cell carcinoma of the head and neck.

"The acceptance of our Phase IIA data for presentation at ASCO (Free ASCO Whitepaper) marks an important milestone for Aveta Biomics," said Parag Mehta, Ph.D., Chief Executive Officer of Aveta Biomics. "We look forward to sharing the full dataset with the oncology community and advancing APG-157 toward a pivotal trial in head and neck cancer."

"APG-157 has the potential to become a first-in-class, practice-changing neoadjuvant therapy for patients with locally advanced head and neck cancer," said Selda Samakoglu, M.D., Ph.D., Chief Medical Officer of Aveta Biomics. "In our Phase IIA study, APG-157 demonstrated clinically meaningful activity across multiple key endpoints, including survival outcomes, with consistent benefits observed both in the overall patient population and in key subgroups. We look forward to advancing APG-157 into a pivotal trial, with the goal of confirming these promising results and establishing APG-157 as a transformative monotherapy option in this setting."

PRESENTATION DETAILS:

TITLE: Neoadjuvant APG-157 monotherapy in patients with locally advanced squamous cell carcinoma of head and neck: A phase IIA, single arm trial
ABSTRACT NUMBER: 6087
POSTER BOARD 495
SESSION TITLE: Head and Neck Cancer
SESSION DATE AND TIME: June 2, 2025, 9:00 AM – 12:00 PM CDT

PRESENTERS:
• Marilene Wang, M.D., Professor, Department of Head and Neck Surgery, UCLA David Geffen School of Medicine and VA Hospital of Greater Los Angeles
• Elizabeth Franzmann, M.D., Professor, Head and Neck Surgery, University of Miami, Sylvester Comprehensive Cancer Center

On April 30, 2025 Anixa Biosciences, Inc. ("Anixa" or the "Company") (NASDAQ: ANIX), a biotechnology company focused on the treatment and prevention of cancer, reported its participation in the H.C. Wainwright 3rd Annual BioConnect Investor Conference, to be held on May 20, 2025, at Nasdaq World Headquarters in New York City (Press release, Anixa Biosciences, APR 30, 2025, View Source [SID1234652376]).

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Mike Catelani, President and CFO of Anixa, will deliver a presentation and will be available for one-on-one meetings during the conference.

Details of the presentation are as follows:

Event: H.C. Wainwright 3rd Annual BioConnect Investor Conference
Date: May 20, 2025
Time: 11:00 AM ET
Location: Nasdaq World Headquarters in New York City
Webcast: View Source

On April 30, 2025 Akiram Therapeutics, a Swedish biotech company specializing in targeted radiotherapy, reported that the first patient has been enrolled in the Phase 1 clinical trial of its drug candidate 177Lu-AKIR001 (Press release, Akiram Therapeutics, APR 30, 2025, View Source [SID1234652375]). The trial is being conducted at Karolinska University Hospital, which also acts as the study sponsor, and marks an important milestone in Akiram’s efforts to develop a new targeted treatment for difficult-to-treat cancers.

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This is the first-in-human trial with AKIR001 and aims to evaluate the drug’s safety, tolerability, and pharmacokinetic profile. The trial follows a dose-escalation design and targets patients with advanced, difficult-to-treat tumors.

Akiram’s drug candidate 177Lu-AKIR001 is a targeted radiopharmaceutical that combines an antibody directed against CD44v6—a cancer marker associated with several aggressive tumor types—with the therapeutic radioisotope lutetium-177. Through this mechanism, radiation can be delivered directly to tumor cells while minimizing damage to surrounding healthy tissue.

The trial is enrolling patients with anaplastic and iodine-refractory thyroid cancer, head and neck squamous cell carcinoma, gynecological squamous cell carcinoma, and non-small cell lung cancer. It is expected to run for 18–24 months with patients recruited on a rolling basis. As the sponsor, Karolinska University Hospital is responsible for conducting the trial in accordance with applicable regulations and with patient safety as a top priority.

"The launch of the clinical trial with AKIR001 marks the beginning of a new chapter for Akiram. Our vision has always been to develop a treatment that can offer new opportunities for patients with difficult-to-treat cancers, where treatment options are often limited. Seeing our drug candidate now being evaluated in collaboration with Karolinska University Hospital—one of Europe’s leading cancer centers—is a major milestone and a strong motivator for our continued work," says Marika Nestor, CEO of Akiram Therapeutics.

"The enrollment of the first patient means that we have now initiated dose escalation and systematic evaluation of AKIR001’s safety and potential. This is an important first step in understanding how the drug behaves clinically and the potential role a CD44v6-targeted therapy could play in tumor types where treatment options today remain limited," says Dr. Luigi De Petris, Principal Investigator at Karolinska University Hospital.

The trial is registered at ClinicalTrials.gov: NCT06639191.

On April 30, 2025 Rein Therapeutics ("Rein") (NASDAQ: RNTX), a biopharmaceutical company advancing a novel pipeline of first-in-class medicines to address significant unmet medical needs in orphan pulmonary and fibrosis indications, reported that Brian Windsor, Ph.D., President and Chief Executive Officer, will present at The Citizens Life Sciences Conference 2025 on Thursday, May 8, 2025 at 12:00 p.m. EDT in New York, NY (Press release, Aileron Therapeutics, APR 30, 2025, View Source [SID1234652374]).

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A live webcast of the event can be accessed at View Source A replay of the webcast will be available for 90 days following the presentation.

On April 30, 2025 Cellectar Biosciences, Inc. (NASDAQ: CLRB), a late-stage clinical biopharmaceutical company focused on the discovery, development and commercialization of drugs for the treatment of cancer, reported that the company will explore a full range of strategic alternatives to advance its promising platform and radiopharmaceutical drug development pipeline to maximize stockholder value (Press release, Cellectar Biosciences, APR 30, 2025, View Source [SID1234652361]). Strategic alternatives under consideration may include, but are not limited to mergers, acquisitions, partnerships, joint ventures, licensing arrangements or other strategic transactions. The company’s board of directors has approved the engagement of Oppenheimer & Co. Inc. to serve as exclusive financial advisor to assist in the strategic evaluation process.

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"We have initiated a process to explore alternatives available to the company to maximize stockholder value that includes identifying a strategic partner with the resources to develop iopofosine I 131. In addition to iopofosine I 131, our platform provides exciting opportunities including our alpha- and Auger-emitting radioconjugates, CLR 225 and CLR 125, respectively, in multiple solid tumor indications as well as our small molecule and oligonucleotide conjugates," said James Caruso, president and chief executive officer of Cellectar.

The company has not set a timetable for completion of the strategic evaluation process and does not intend to disclose information on the progress of any such options unless and until it is determined that further disclosure is necessary. No agreement providing for any transaction has been reached and there can be no assurances that any transaction will result from the process of evaluating strategic alternatives. If the process for evaluating strategic alternatives results in an agreement regarding a transaction, there can be no assurances that any transaction will be completed.