On November 25, 2025 AnaptysBio, Inc. (Nasdaq: ANAB), a clinical-stage biotechnology company focused on delivering innovative immunology therapeutics, reported that Daniel Faga, president and chief executive officer of Anaptys, and/or other members of its executive leadership team, are scheduled to participate in multiple upcoming investor conferences:

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Piper Sandler 37th Annual Healthcare Conference, New York, NY

Format – Fireside chat and 1×1 investor meetings
Date and Time – Tuesday, Dec. 2, 2025 at 1:30pm ET

Evercore 8th Annual Healthcare Conference, Coral Gables, FL

Format – Fireside chat and 1×1 investor meetings
Date and Time – Wednesday, Dec. 3, 2025 at 7:55am ET
Live webcasts of the fireside chats will be available on the investor section of the Anaptys website at View Source Replays of the webcasts will be available for at least 30 days following the events.

(Press release, AnaptysBio, NOV 25, 2025, View Source [SID1234660941])

On November 25, 2025 Zetagen Therapeutics, Inc., a privately held, clinical-stage biopharmaceutical company pioneering first-of-its-kind, intratumoral treatments for metastatic and primary breast cancer, reported the successful closure of its Series B1 financing round of $12,908,000. The round was 100% oversubscribed, reflecting strong investor confidence in the company’s proprietary Zeta Platform and its potential to transform breast cancer care.

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Proceeds from this round will support the advancement of Zetagen’s lead candidate, ZetaMet (Zeta-BC-003) towards commercialization, accelerate clinical development of ZetaMast (Zeta-MBC-005), and complete preclinical studies & GMP manufacturing of ZetaPrime (Zeta-PBC-007).

"The strong demand in our Series B1 round highlights the promise of our Phase 2a clinical data for ZetaMet in treating metastatic breast cancer to bone," said Joe C. Loy, CEO of Zetagen Therapeutics. "At the core of these encouraging results is our discovery of a novel molecular pathway—triggered by our compounds activating a conserved nuclear receptor—which enables promising predictability in dosing and outcomes from bench to bedside."

Advancing the Zeta Platform
Zetagen’s Zeta Platform is the development of first-of-its-kind therapies for metastatic and primary breast cancer. Our novel approach via proprietary carriers with a singular injection, delivers tumoricidal compounds which minimize severe off-target side effects while increasing survival rates.

The platform includes:
ZetaMet (Zeta-BC-003): Targets metastatic breast cancer in bone, ceasing lytic activity, inhibiting pain, and regenerating new bone, all via a singular intratumoral injection, without systemic limitation, minimizing skeletal related events (fractures). We have completed a Phase 2a clinical trial at the University of British Columbia demonstrated Complete Response in treated lesions, full bone regeneration, and no skeletal-related events. Preliminary results to be presented at the upcoming SABCS conference.
ZetaMast (Zeta-MBC-005): is a novel hydrogel delivering two synergistic tumoricidal agents via a single intratumoral injection for breast cancer liver metastases (BCLM). Designed to localize treatment and reduce systemic toxicity, it has shown promising preclinical results—published in PLOS ONE and co-authored by Dr. Debu Tripathy—demonstrating reduced tumor burden, prevention of soft tissue metastases, and improved survival. A Phase 1b dose-escalation study is planned for 1H-2026.
ZetaPrime (Zeta-PBC-007): a neo-adjuvant treatment engineered for intratumoral administration following diagnosis. Utilizing proprietary hydrogel-like lipid carrier, formulation enables controlled release of 2 small molecules—one being novel molecular entity and or the ability to deliver a CDK4 or CDK4/6 protein inhibitor. Designed for solubility within adipose tissue, approach targets primary breast cancer, aiming to mitigate off-target effects, potentially reducing necessity for lumpectomies and mastectomies, decrease radiation exposure, and enhance patient survival. ZetaPrime’s single-dose in-vivo study showed improved survival and tumor suppression over Tamoxifen and Verzenio in a mouse mammary fat pad model; results will be presented at the upcoming SABCS conference.
Continued Momentum
The Series B1 funding follows a series of strategic milestones for Zetagen, including:

Expansion of the company’s global IP portfolio to 70+issued patents including Composition-of-Matter patents & claims on ZetaMet, ZetaMast, and ZetaPrime
Successful completion of the Phase 2a study of ZetaMet for metastatic breast cancer to bone
Accepted abstracts by SABCS on ZetaMet preliminary clinical results and ZetaPrime in-vivo results of head-to-head comparison towards Verzenio

(Press release, Zetagen Therapeutics, NOV 25, 2025, View Source [SID1234660940])

On November 25, 2025 UroGen Pharma Ltd. (Nasdaq: URGN), a biotech company dedicated to developing and commercializing innovative solutions that treat urothelial and specialty cancers, reported that it will present at the Piper Sandler 37th Annual Healthcare Conference to take place on December 2-4, 2025.

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Piper Sandler 37th Annual Healthcare Conference

Date / Time: December 2, 2025, at 1:00 PM ET
Format: Fireside Chat
Location: New York, NY
Webcast Link: here

Webcasts from the conferences will also be available on UroGen’s Investor Relations website. A replay will be available on the site for approximately 90 days.

(Press release, UroGen Pharma, NOV 25, 2025, View Source [SID1234660939])

On November 25, 2025 Tempest Therapeutics, Inc. (Nasdaq: TPST), a clinical-stage biotechnology company with a pipeline of first-in-class1 targeted and immune-mediated therapeutics to fight cancer, reported that it has entered into a definitive agreement with a single healthcare-focused institutional investor for the purchase and sale of 1,172,414 shares of its common stock (or common stock equivalents), at an offering price of $3.625 per share of common stock (or common stock equivalent) in a registered direct offering priced at-the-market under Nasdaq rules. Additionally, in a concurrent private placement, the Company will issue and sell short-term unregistered warrants to purchase up to an aggregate of 1,172,414 shares of common stock at an exercise price of $3.50 per share. The short-term unregistered warrants will be immediately exercisable upon issuance and will expire eighteen months following the effective date of the registration statement registering the resale of the shares of common stock issuable upon exercise of the warrants. The closing of the offering is expected to occur on or about November 25, 2025, subject to the satisfaction of customary closing conditions.

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H.C. Wainwright & Co. is acting as the exclusive placement agent for the offering.

The aggregate gross proceeds to the Company from the offering are expected to be approximately $4.25 million, before deducting the placement agent’s fees and other offering expenses payable by the Company. The potential additional gross proceeds to the Company from the short-term unregistered warrants, if fully exercised on a cash basis, will be approximately $4.1 million. No assurance can be given that any of such short-term unregistered warrants will be exercised. The Company intends to use the net proceeds from this offering primarily for working capital and general corporate purposes.

The shares of common stock (or common stock equivalents) described above (but not the short-term unregistered warrants issued in the concurrent private placement and the shares issuable thereunder) are being offered and sold by the Company in a registered direct offering pursuant to a "shelf" registration statement on Form S-3 (File No. 333- 280918) that was filed with the Securities and Exchange Commission (the SEC), on July 19, 2024, as amended on January 24, 2025, which was declared effective by the SEC on January 27, 2025. The offering of the securities in the registered direct offering is being made only by means of a base prospectus and prospectus supplement that forms a part of the effective registration statement. A final prospectus supplement and the accompanying base prospectus relating to the registered direct offering will be filed with the SEC and will be available on the SEC’s website at www.sec.gov. Electronic copies of the final prospectus supplement and the accompanying base prospectus, when available, may also be obtained from H.C. Wainwright & Co., LLC at 430 Park Avenue, 3rd Floor, New York, NY 10022, by phone at (212) 856-5711 or e-mail at [email protected].

The short-term unregistered warrants issued in the concurrent private placement and the shares issuable upon exercise of such warrants were offered in a private placement under Section 4(a)(2) of the Securities Act of 1933, as amended (the "Act"), and/or Regulation D promulgated thereunder, have not been registered under the Act or applicable state securities laws and may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements.

This press release shall not constitute an offer to sell or a solicitation of an offer to buy any of the securities described herein, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

(Press release, Tempest Therapeutics, NOV 25, 2025, View Source [SID1234660938])

On November 25, 2025 Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of targeted protein degradation medicines in oncology and autoimmune diseases, reported that Arthur T. Sands, M.D., Ph.D., president and chief executive officer, and Hans van Houte, chief financial officer, will participate in a fireside chat at the Piper Sandler 37th Annual Healthcare Conference on Wednesday, December 3, 2025, at 12:30 p.m. ET in New York City.

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The fireside chat will be webcast live and can be accessed via a link in the Investors section of the Nurix website. The archived webcast will be available for 30 days after the event.

(Press release, Nurix Therapeutics, NOV 25, 2025, View Source [SID1234660937])