On April 9, 2025 CiMaas reported a new grant from LIOF to further explore the recently developed and patented feeder cell technology (Press release, CiMaas, APR 9, 2025, View Source [SID1234651850]). A GMP grade feeder cells master bank has been previously generated and serves as starting material.

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Previously we have seen identical expansion rates and cytotoxicity of the expanded NK cells, and within this grant we will more extensively validate the NK cell expansion, activation and functional characteristics in comparison to the original protocol in which irradiation technology was used.

Finally with in the grant we will validate all characteristics in large-scale NK cell batches with numbers ready for clinical applications in cancer.

On April 9, 2025 Cellis reported that it will be present at the upcoming AACR (Free AACR Whitepaper) Annual Meeting, taking place April 25–30 in Chicago, where leaders in oncology research gather to shape the future of cancer treatment (Press release, Cellis, APR 9, 2025, View Source [SID1234651849]). We’re proud to contribute to this global conversation with new developments in macrophage-based therapies.

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We invite you to visit our three poster presentations:

PO.ET02.08
Harnessing macrophage-drug conjugates for allogeneic cell-based therapy of solid tumors
April 28, 9:00 AM – 12:00 PM | Section 23

PO.CL06.01
Macrophage-ferritin-drug conjugates: a novel approach to overcome glioblastoma drug resistance and induce long-term tumor immunity
April 28, 2:00 PM – 5:00 PM | Section 27

PO.IM01.16
Macrophage-based immunotherapy of platinum-resistant ovarian cancer
April 29, 2:00 PM – 5:00 PM | Section 40

We look forward to insightful discussions and potential collaborations in Chicago.

On April 9, 2025 Anixa Biosciences, Inc. ("Anixa" or the "Company") (NASDAQ: ANIX), a biotechnology company focused on the treatment and prevention of cancer, reported that the United States Patent and Trademark Office (USPTO) has issued a Notice of Allowance for a new patent related to the Company’s innovative breast cancer vaccine technology (Press release, Anixa Biosciences, APR 9, 2025, https://ir.anixa.com/news/detail/1076/anixa-biosciences-receives-notice-of-allowance-from-u-s-patent-and-trademark-office-for-patent-covering-breast-cancer-vaccine-technology [SID1234651848]). The patent along with others related to this technology, has been exclusively licensed to Anixa Biosciences, by Cleveland Clinic. The patent will expand the scope of immunogenic compositions utilized in Anixa’s breast cancer vaccine.

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This newly allowed patent covers methods of immunizing patients against breast cancer by administering an immunogenic composition containing the human α-lactalbumin protein, a protein typically found in breast tissue during lactation but also expressed in certain breast cancers, making it an attractive target for immunoprevention strategies.

Dr. Amit Kumar, Chairman and CEO of Anixa Biosciences, stated, "This patent strengthens our intellectual property portfolio and highlights the novelty of our breast cancer vaccine. Our intellectual property portfolio includes multiple issued and pending patents in the U.S. and international jurisdictions."

On April 8, 2025 GenScript reported its financial annual report (Presentation, GenScript, APR 8, 2025, View Source [SID1234654247]).

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On April 8, 2025 Xspray reported the company has re-submitted its application for market approval for Dasynoc, the company’s lead product candidate, an amorphous dasatinib for the treatment of leukemia (Press release, Xspray, APR 8, 2025, View Source [SID1234652254]). The application procedure thus runs according to the most recently communicated plan. Within 2-4 weeks, the FDA is expected to announce a new PDUFA date, i.e. the date they intend to decide on the application.

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Xspray Pharma has submitted its response to the CRL (Complete Response Letter) that the company received from the FDA in July 2024. The CRL addressed the company’s NDA application for market approval in the US of the product candidate Dasynoc, an amorphous dasatinib drug for the treatment of CML (chronic myeloid leukemia) and ALL (acute lymphoblastic leukemia). The response will now be reviewed by the FDA, which can apply two different processing times – two or six months from the re-submission date.

"Manufacturing and quality review of new tablet batches, which were required to address the FDA’s questions, have gone according to plan at Xspray’s US contract manufacturer, and live up to all the set quality requirements," says Per Andersson, CEO of Xspray Pharma. "We are well prepared to launch Dasynoc on the US market upon approval later this year," says Per Andersson.

The submission of the updated FDA application follows the plan communicated in January of this year. Xspray Pharma reiterates the assessment that the company has sufficient funding to take Dasynoc to approval, regardless of whether the FDA’s review takes two or six months from the re-submission.

For further information, please contact:

Per Andersson, CEO
Xspray Pharma AB (publ)
Tel: + 46 (0)8 730 37 00
E-mail: [email protected]