On November 12, 2025 Nucleai, a leader in AI-powered spatial biology for precision medicine, and the University of Glasgow, a global leader in spatial proteomics and transcriptomics research, reported a collaboration to identify and validate predictive biomarkers for colorectal cancer (CRC) and advanced polyp incidence. The project leverages artificial intelligence and multimodal spatial biology data, combining tissue, molecular, and clinical data to improve patient risk stratification and early detection.

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The collaboration will analyze data from the Integrated Technologies for Improved Polyp Surveillance (INCISE) study – one of the world’s most comprehensive and unique colon precancerous polyp cohorts – to uncover how tissue architecture, cell-to-cell interactions, and molecular signaling influence cancer progression. These insights will lay the foundation to develop clinically validated precision diagnostic products, designed to predict disease risk and personalize surveillance strategies.

Harnessing AI and Multimodal Data to Predict and Prevent Colorectal Cancer

Colorectal cancer remains one of the most preventable yet deadly cancers, with outcomes heavily dependent on early detection and accurate risk assessment. Current surveillance programs often suffer from overuse and limited precision, leading to unnecessary procedures and missed opportunities for cancer detection and prevention.

The collaboration combines the University of Glasgow’s clinical and pathology excellence with Nucleai’s scalable multimodal spatial pipeline, the most advanced in the world for spatial proteomics and tissue-level AI analysis. This pipeline integrates multiplex immunofluorescence (mIF), IHC, H&E, and clinical data in an automated, AI-driven workflow, enabling biomarker discovery and validation at unprecedented scale and accuracy.

"This collaboration is a significant step toward realizing the promise of multimodal spatial precision medicine," said Avi Veidman, CEO of Nucleai. "By combining Glasgow’s leadership in spatial biology with our AI-powered platform, we’re moving from discovery to deployable diagnostics – translating complex biological data into actionable clinical insights."

Nigel Jamieson, Professor of Hepatobiliary and Pancreatic surgery, University of Glasgow, added: "Deep phenotyping of pathology specimens using spatial omics technologies has the potential to revolutionize our understanding of disease mechanisms and progression, and to drive the discovery of novel spatial biomarkers. Through SPARC (Spatial Pathology Analytic for Research and Clinical Integration), we have established substantial spatial-omics capability at the University of Glasgow, empowering us to better characterize a wide range of immune conditions and cancers, including colorectal and pancreatic cancer. SPARC and the University of Glasgow are at the forefront of this spatial biology revolution, but a key challenge remains — the integration of multimodal data encompassing clinical information, tissue imaging, and computational pathology. Our partnership with Nucleai will help us address this challenge and accelerate the translation of spatial biology insights into clinical practice, ultimately improving patient care."

Joanne Edwards, Professor of Translational Cancer Pathology, University of Glasgow, added: "The INCISE study represents a transformative opportunity to understand colorectal cancer at a systems level. By integrating spatial biology with clinical data, we’re uncovering the hidden architecture of disease progression. This partnership with Nucleai allows us to translate these insights into predictive tools that can truly personalize surveillance and prevention strategies — bringing precision medicine into routine care."

A New Approach for Deployable Diagnostics

Nucleai’s approach uniquely integrates high dimensionality multimodal data for biomarker discovery and applies complexity reduction techniques to translate those discoveries into scalable diagnostic tests. This strategy bridges the gap between advanced discovery science and real-world clinical deployment – enabling broad accessibility without compromising biological depth. Unlike approaches based solely on low-complexity or H&E data, Nucleai’s platform captures a greater biological context of disease, yielding more predictive and clinically actionable tests.

Building the Future of Precision Medicine

This project marks the first step in Nucleai’s broader initiative to build a global precision medicine network – connecting academia, life science tools, and clinical institutions. By extending its platform beyond drug development into diagnostics, Nucleai is positioning itself as the operating system for next-generation precision medicine, capable of translating biological complexity into clinical action.

"And this is just the beginning," Veidman added. "We’re preparing additional announcements that will expand our multimodal collaborations and further solidify our role in shaping the future of precision medicine."

(Press release, University of Glasgow, NOV 12, 2025, View Source [SID1234659863])

On November 12, 2025 City of Hope, one of the largest and most advanced cancer research and treatment organizations in the United States with its National Medical Center ranked among the nation’s top cancer centers by U.S. News & World Report, reported it will present leading-edge findings at the 2025 American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting and Exposition happening Dec. 6-9 in Orlando and online.

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Across 105 sessions, City of Hope experts will highlight advances in blood cancer research, cellular therapies and precision medicine.

The ASH (Free ASH Whitepaper) meeting is the world’s largest hematology gathering, attracting more than 30,000 hematology professionals globally.

"ASH is where the future of hematology takes shape," said Marcel van den Brink, M.D., Ph.D., City of Hope chief physician executive and president of City of Hope National Medical Center. "Our teams are proud to share discoveries that deepen scientific understanding and accelerate progress toward more effective, safer treatments for patients worldwide."

From innovative immunotherapies to strategies that improve transplant outcomes, City of Hope is leading progress in areas that matter most to patients.

ORAL ABSTRACT SESSIONS

Leukemia

Plenary 6: Results from paradigm – a phase 2 randomized multi-center study comparing azacitidine and venetoclax to conventional induction chemotherapy for newly diagnosed fit adults with acute myeloid leukemia
Time: Sunday, Dec. 7, 3:45 p.m. EST
Senior Author: Ibrahim Aldoss, M.D., City of Hope associate professor, Division of Leukemia, Department of Hematology & Hematopoietic Cell Transplantation

443: CD19-CAR T cell therapy as a definitive consolidation in older adults with b-ALL in CR1 is safe and induces durable MRD-remission
Time: Sunday, Dec. 7, 10:30 a.m. EST
Presenter: Ibrahim Aldoss, M.D., City of Hope associate professor, Division of Leukemia, Department of Hematology & Hematopoietic Cell Transplantation

Lymphoma

151: 3-year follow-up of the S1826 study confirms improved progression-free survival with nivolumab-AVD compared to brentuximab vedotin-AVD in advanced stage classic Hodgkin lymphoma
Time: Saturday, Dec. 6, noon EST
Presenter: Alex Herrera, M.D., City of Hope professor, Division of Lymphoma, Department of Hematology & Hematopoietic Cell Transplantation

268: BAFFR-CAR T cells (PMB-CT01) demonstrate durable responses and manageable toxicities in relapsed/refractory B-cell lymphomas with prior CD19-directed therapy failure or CD19-negative disease
Time: Saturday, Dec. 6, 2:45 p.m. EST
Presenter: Elizabeth Budde, M.D., Ph.D., City of Hope associate professor, Division of Lymphoma, Department of Hematology & Hematopoietic Cell Transplantation

883: Interim analysis of the phase II study of glofitamab, lenalidomide and venetoclax (GLOVe) in untreated patients w/ high-risk mantle cell lymphoma. Response and safety outcomes after the completion of stage 1 of 2 enrollment.
Time: Monday, Dec. 8 at 2:45 p.m. EST
Presenter: Tycel Phillips, M.D., associate professor, Division of Lymphoma, Department of Hematology & Hematopoietic Cell Transplantation

1013: CAR T cell therapy outcomes in adolescent and young adult patients with non-Hodgkin lymphoma
Time: Monday, Dec. 8, 5:30 p.m. EST
Presenter: Lindsey Murphy, M.D., M.S., City of Hope assistant professor, Department of Pediatrics

Myeloma

405: Safety and efficacy of out-of-specification ciltacabtagene autoleucel (cilta-cel) in relapsed/refractory multiple myeloma (RRMM)
Time: Saturday, Dec. 6, 4:30 p.m. EST
Presenter: Azra Borogovac, M.D., M.S., City of Hope assistant professor, Department of Hematology & Hematopoietic Cell Transplantation

Transplantation

376: Total marrow and lymphoid irradiation (TMLI) with fludarabine-melphalan (FM) conditioning for matched donor hematopoietic cell transplant (HCT) in older patients with relapsed/refractory (R/R) disease
Time: Saturday, Dec. 6, 4:45 p.m. EST
Presenter: Monzr M. Al Malki, M.D., City of Hope professor, Department of Hematology & Hematopoietic Cell Transplantation

276: First-in-human trial of allogeneic CD6-CAR tregs in patients with chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation
Time: Saturday, Dec. 6, 3:15 p.m. EST
Presenter: Amandeep Salhotra, M.D., City of Hope associate professor, Division of Leukemia, Department of Hematology & Hematopoietic Cell Transplantation

160: A TLR4-HSP70 efferocytic program in thymic macrophages sustains thymic homeostasis and T cell output
Time: Saturday, Dec. 6, 12:45 p.m. EST
Presenter: Andri Lemarquis, M.D., Ph.D., City of Hope staff scientist

CITY OF HOPE-LED EDUCATIONAL SESSIONS

14th Annual BMT & Cell Therapy Winter Workshop, co-chaired by Dr. Marcel van den Brink
Time: Friday, Dec. 5, 1:30 – 8 p.m. EST
Register for virtual attendance here.

Satellite Symposia fss25-93: Moving Forward in B-ALL: Insights on Modern and Emerging Standards With Off-the-Shelf Bispecific Antibodies
Time: Friday, Dec. 5, 7 a.m. EST
Presenter: Ibrahim Aldoss, M.D., City of Hope associate professor, Division of Leukemia, Department of Hematology & Hematopoietic Cell Transplantation

Scientific Workshop on State of the Art (ws25-58): Integrating Functional and Genomic Precision Medicine for Hematologic Malignancies
Time: Friday, Dec. 5, 3 p.m. EST
Chair: Pamela Becker, M.D., Ph.D., professor, Division of Leukemia, Department of Hematology & Hematopoietic Cell Transplantation

Scientific Workshop: Microbiome and Diet and Cancer Immunotherapy
Time: Friday, Dec. 5, 3:06 p.m. EST
Presenter: Marcel van den Brink, M.D., Ph.D., City of Hope chief physician executive

How I Treat: How I Incorporate Novel Therapies into Hodgkin Lymphoma Treatment: Frontline vs. Relapse
Time: Sunday, Dec. 7 at 8 a.m. EST
Presenter: Alex Herrera, M.D., City of Hope professor, Division of Lymphoma, Department of Hematology & Hematopoietic Cell Transplantation

Educational Spotlight: Measures to Minimize Infection Risk in Immunocompromised Patients after Cellular Therapies — How, for Whom, for How Long?
Time: Monday, Dec. 8, 4:30 p.m. EST
Presenter: Randy Taplitz, M.D., City of Hope professor, Department of Medicine

(Press release, City of Hope, NOV 12, 2025, View Source [SID1234659862])

On November 12, 2025 Leukogene Therapeutics Inc., a biopharmaceutical company developing next-generation therapies for hematologic and other immunologically "cold" malignancies, reported that it has received funding from the South Carolina Research Authority (SCRA) and its investment affiliate, SC Launch Inc.

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"We are honored to receive this strategic funding from SCRA and SC Launch Inc. It will allow us to advance our programs toward the clinic, strengthen our position as a leader in developing next-generation cancer therapeutics and continue building a world-class biotech company right here in South Carolina," said Dr. Sandeep Gupta, Chief Executive Officer of Leukogene. Nathan Dolloff, PhD, Founder and Chief Scientific Officer added, "This investment represents a strong validation of our vision and science and enables us to accelerate our mission of bringing transformative therapies to patients with hard-to-treat cancers."

"Leukogene Therapeutics exemplifies the kind of innovative, high-growth company that SCRA and SC Launch Inc. were designed to support," said Matt Bell, Executive Director of SC Launch. "Their groundbreaking immunotherapy platform and strong leadership team are well-positioned to make a lasting impact in oncology and the broader biotech sector. We are proud to partner with them as they advance toward clinical development."

(Press release, Leukogene Therapeutics, NOV 12, 2025, View Source [SID1234659861])

On November 12, 2025 Novocure (NASDAQ: NVCR) reported that management will participate in the Jefferies Global Healthcare Conference in London on Wednesday, November 19, 2025. Ashley Cordova, Chief Executive Officer, will present on behalf of the company at 2:00 p.m. GMT (9:00 a.m. ET). Ms. Cordova will be joined by Christoph Brackmann, Chief Financial Officer, for one-on-one meetings with investors throughout the event.

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A live audio webcast of this presentation can be accessed from the Investor Relations page of Novocure’s website, www.novocure.com/investor-relations, and will be available for replay for at least 14 days following the event.

(Press release, NovoCure, NOV 12, 2025, View Source [SID1234659860])

On November 12, 2025 Parabilis Medicines, a clinical-stage biopharmaceutical company committed to creating extraordinary medicines for people living with cancer, reported that the U.S. Food and Drug Administration (FDA) has granted Fast Track product designation to FOG-001 for the treatment of desmoid tumors, reflecting significant unmet need and the potential of this first-in-class therapy to transform patient care. FOG-001, Parabilis’s lead investigational Helicon peptide, is the first and only direct inhibitor of the "undruggable" β-catenin:TCF interaction.

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The FDA’s Fast Track designation is intended to help facilitate the development and expedite the review of new therapies for serious conditions that address an unmet medical need. A therapy may qualify if it targets a disease with no existing treatments, or if it offers a meaningful advantage over available options – such as showing superior effectiveness, avoiding serious side effects, or decreasing toxicities that frequently cause discontinuation of treatment. Fast Track designation enables more frequent interactions with the FDA throughout development and provides eligibility for features like Rolling Review and potential Priority Review, helping promising medicines reach patients sooner.

"Obtaining Fast Track designation for FOG-001 reinforces our confidence in its potential to offer meaningful clinical benefit to patients with desmoid tumors, who today have no therapies that directly address the underlying disease biology," said Fawzi Benzaghou, M.D., Chief Medical Officer of Parabilis Medicines. "More than half of patients do not respond to current treatment options, which are also associated with high toxicities. By inhibiting the β-catenin:TCF interaction, FOG-001 has the potential to intervene at the source of disease and marks an important step forward in advancing our mission to drug the undruggable."

This designation follows preliminary data, first released at ESMO (Free ESMO Whitepaper) and to be presented this week at the Connective Tissue Oncology Society (CTOS) 2025 Annual Meeting, demonstrating that FOG-001 has shown evidence of clinically meaningful antitumor activity in desmoid tumors. Desmoid tumors are rare, locally invasive soft-tissue tumors that form in the connective tissues of the body, often causing pain, limited mobility, disfigurement, and organ dysfunction. Despite its impact on quality of life, there are no FDA-approved therapies that directly target the underlying biology of the disease.

In the company’s ongoing Phase 1/2 trial, as of the mid-August 2025 data cutoff, 12 patients with desmoid tumors had been treated with FOG-001. Tumor reductions were seen in all response-evaluable patients (n=10), and an 80% objective response rate (ORR) was seen in patients with more than one post-baseline scan (n=5), per RECIST 1.1. These responses were irrespective of prior exposure to gamma secretase inhibitors, progression on gamma-secretase inhibitors, tumor location, or mutations in CTNNB1 or APC. FOG-001 also demonstrated an acceptable safety and tolerability profile, with no Grade 4/5 treatment-related adverse events or discontinuations. No high-grade gastrointestinal (GI) or skin toxicities were observed.

"The Wnt/β-catenin pathway is implicated in millions of cancer cases each year, yet remains unaddressed by any approved therapies despite decades of effort," said Mathai Mammen, M.D., Ph.D., Chairman and CEO of Parabilis Medicines. "FOG-001 demonstrates that our Helicon peptides can unlock disease biology once considered completely inaccessible – opening a new path to drug targets long thought out of reach and medicines with the potential to fundamentally transform outcomes for patients."

Beyond desmoid tumors, FOG-001 is being evaluated across a broad range of rare and common Wnt/β-catenin-driven tumor types. Clinical data presented recently at the AACR (Free AACR Whitepaper)-NCI-EORTC 2025 meeting showed FOG-001 had single-agent activity in five low-complexity tumor types where Wnt/β-catenin mutations are the primary drivers of disease – including desmoid, adamantinomatous craniopharyngioma (ACP), ameloblastoma, salivary gland cancer, and solid pseudopapillary neoplasm (SPN) – with strong scientific rationale for combination therapy in more complex cancers such as microsatellite-stable colorectal cancer (MSS CRC).

Parabilis plans to share additional FOG-001 data in 2026.

About FOG-001

FOG-001 is an investigational first-in-class competitive inhibitor of β-catenin interactions with the T-cell factor (TCF) family of transcription factors and is currently in clinical development. By directly targeting the β-catenin:TCF protein-protein interaction, FOG-001 is intended to block the Wnt signaling pathway irrespective of the various APC and β-catenin mutations that typically drive disease.

FOG-001 combines key features that distinguish it from previously reported Wnt/β-catenin pathway modulators: FOG-001 acts inside the cell where it binds directly to the key oncogenic driver β-catenin; and FOG-001 blocks the Wnt pathway at the key downstream node, disrupting the interaction between β-catenin and the TCF transcription factors, thereby abrogating the signal transmission by which Wnt pathway mutations are believed to drive oncogenesis.

FOG-001 is currently being evaluated in a first-in-human Phase 1/2 clinical trial in patients with locally advanced or metastatic solid tumors.

About the Phase 1/2 trial of FOG-001

FOG-001 is being evaluated in a first-in-human Phase 1/2 multicenter, open-label study (NCT05919264) assessing its safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity. The trial includes dose-escalation and dose-expansion phases and is testing FOG-001 both as a monotherapy and in combination with other anticancer agents in patients with advanced or metastatic solid tumors likely or known to harbor a Wnt pathway–activating mutation (WPAM).

(Press release, Parabilis Medicines, NOV 12, 2025, View Source;cateninTCF-Interaction-for-the-Treatment-of-Desmoid-Tumors [SID1234659859])