On the May 12, 2025 British techbio innovator Etcembly, reported that it has signed a collaboration agreement with DJS Antibodies, a part of AbbVie, to accelerate the discovery of novel antibody therapeutics (Press release, Etcembly, MAY 12, 2025, View Source [SID1234652900]).

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Etcembly’s flagship AI platform, EMLy, stands as the most advanced immune discovery and engineering technology. Bringing together billions of T-cell receptor (TCR) and antibody sequences with cutting-edge bioinformatics, large language models (LLMs) and structural modeling, EMLy enables the exploration of immune system interactions with targets in unprecedented detail.

This inaugural partnership will leverage EMLy’s deep immune repertoire analysis to identify novel antibodies against an undisclosed G protein-coupled receptor (GPCR) target in autoimmune disease.

Michelle Teng, CEO of Etcembly said, "We’ve already showcased EMLy’s ability to discover and optimize picomolar affinity TCRs in months rather than years. With our expanded capabilities now encompassing antibody discovery and engineering, we are thrilled to partner with DJS Antibodies to address challenging targets and drive faster, smarter development of next-generation biotherapeutics.

On May 12, 2025 Nuvation Bio Inc. (NYSE: NUVB), a global oncology company tackling some of the toughest challenges in cancer treatment, reported that David Hung, M.D., Founder, President, and Chief Executive Officer of Nuvation Bio, and Philippe Sauvage, Chief Financial Officer of Nuvation Bio, will participate in fireside chats at three upcoming investor conferences (Press release, Nuvation Bio, MAY 12, 2025, View Source [SID1234652899]):

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H.C. Wainwright 3rd Annual BioConnect Investor Conference at NASDAQ on Tuesday, May 20, 2025, at 3:00 p.m. ET in New York, NY
2025 RBC Capital Markets Global Healthcare Conference on Wednesday, May 21, 2025, at 1:35 p.m. ET in New York, NY
TD Cowen 6th Annual Oncology Innovation Summit: Insights for ASCO (Free ASCO Whitepaper) & EHA (Free EHA Whitepaper) on Wednesday, May 28, 2025, at 3:30 p.m. ET (virtual)
Live webcasts of each presentation will be available on the Nuvation Bio website at View Source An archived recording will be available for 90 days following each event.

On May 12, 2025 Tyra Biosciences, Inc. (Nasdaq: TYRA), a clinical-stage biotechnology company focused on developing next-generation precision medicines that target large opportunities in Fibroblast Growth Factor Receptor (FGFR) biology, reported that management will participate in the following investor conferences (Press release, Tyra Biosciences, MAY 12, 2025, View Source [SID1234652898]):

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Bank of America Global Healthcare Conference, May 13-15, 2025
Format: Fireside chat and one-on-one investor meetings
Presentation Date/Time: Tuesday, May 13, 2025, at 5:15 PM PT
Location: Las Vegas, NV

Jefferies Global Healthcare Conference, June 3-5, 2025
Format: One-on-one investor meetings
Location: New York, NY

UBS Biotech 1×1 Symposium, June 24, 2025
Format: One-on-one investor meetings
Location: New York, NY

A live and archived webcast of the fireside chat will be available via the For Investors page on the Investor section of the TYRA website.

On May 12, 2025 Grit Biotechnology Co., Ltd. ("Grit Bio"), a clinical-stage biotech pioneering novel immunotherapies reported that three research programs, in collaboration with Vitalgen BioPharma Co., Ltd. ("Vitalgen"), will be showcased in one oral presentation and two poster sessions at the American Society of Gene and Cell Therapy (ASGCT) (Free ASGCT Whitepaper) 28th annual meeting in New Orleans, LA from May 13th to 17th (Press release, Grit Bio, MAY 12, 2025, View Source [SID1234652897]).

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Grit Bio will provide the updates of three preclinical programs, including APC-targeted neoantigen cancer vaccine, non-viral-nanoparticle-directed in vivo CAR-T, and LNP-mediated gene editing in tumor infiltrating lymphocyte (TIL). The details of three presentations are:

Title: APC-Targeted LNP Enables Systemic Delivery of Neoantigen mRNA Vaccines and Enhanced Antigen-Specific T Cell Responses
Presentation Type: Oral
Time: 5:15-5:30 pm local time, Thursday, May 15th
Speaker: Pin Wang, Ph.D., CSO of Grit Biotechnology
Title: In Vivo CAR-T Therapy Powered by Novel CLAMP Technology for T cell-Targeted mRNA Delivery
Presentation Type: Poster
Time: 5:30-7:00 pm local time, Wednesday, May 14th
Poster #: 1282
Title: Enhancing Production and Functional Potential of Tumor-Infiltrating Lymphocytes via Lipid Nanoparticle-Mediated CRISPR/Cas9 Gene Editing
Presentation Type: Poster
Time: 5:30-7:00 pm local time, Thursday, May 15th
Poster #: 1776
"Through a strategic collaboration with Vitalgen, we are pioneering next-generation immunotherapies and precision delivery technologies. This synergy accelerates the development of advanced therapies with transformative improvements in safety and efficacy. We are now expanding those innovations toward global clinical implementation." said Dr. Yarong Liu, founder and Chief Executive Officer of Grit Biotechnology.

On May 12, 2025 Caris Life Sciences(Caris), a leading next-generation AI TechBio company and precision medicine pioneer, reported MET Immunohistochemistry (IHC) testing as standard of care for all non-squamous non-small cell lung cancer (NSQ NSCLC) patients and is poised for future drug approvals (Press release, Caris Life Sciences, MAY 12, 2025, View Source [SID1234652896]). This advanced testing protocol aims to provide deeper insights into the molecular characteristics of NSQ NSCLC, facilitating more personalized and effective treatment strategies.

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Approximately 50% of NSQ NSCLCs lack a targetable gene driver mutation, making MET protein expression an important additional personalized target. Caris is addressing these challenges by leveraging the power of MET IHC testing, which evaluates the expression of the MET protein in cancer cells. This protein is known to play a crucial role in cell proliferation, invasion, and survival, making it a vital biomarker for targeted therapies.

"To our knowledge, Caris is the only lab in the US that has historically and is currently offering the MET (SP44) RxDx assay for NSQ NSCLC," said Caris President David Spetzler, MS, PhD, MBA. "With MET IHC testing already in place, we are poised and ready to provide a detailed molecular profile to inform targeted therapies and future drug development approvals."

Key Highlights of MET IHC Testing:
Comprehensive Molecular Profiling: Caris utilizes a multi-platform approach, including immunohistochemistry (IHC) and next-generation sequencing (NGS), to provide a detailed molecular profile of NSQ NSCLC tumors.

Identification of Actionable Targets: The MET IHC testing helps identify overexpression of the MET protein, which is associated with poor prognosis and can be targeted by specific therapies.

Enhanced Treatment Personalization: By understanding the molecular makeup of NSQ NSCLC tumors, oncologists can tailor treatment plans to the individual needs of patients, potentially improving outcomes and quality of life.

Caris remains committed to advancing cancer diagnostics and treatment through innovative technologies and rigorous scientific research. Deployment of MET IHC testing for NSQ NSCLC patients underscores this commitment and highlights Caris’ dedication to improving patient care and outcomes.

Caris’ comprehensive molecular profile testing includes MI Cancer Seek and Caris Assure. Caris received FDA approval in November of 2024 for MI Cancer Seek, a tissue-based assay which is the first and only simultaneous Whole Exome Sequencing (WES) and Whole Transcriptome Sequencing (WTS)-based assay with FDA-approved CDx indications for molecular profiling of solid tumors. Caris Assure is a powerful blood-based assay that uniquely identifies somatic tumor, incidental clonal hematopoiesis and incidental germline variants by sequencing both plasma and buffy coat through a WTS and WES-based assay.