On February 26 Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN), a clinical-stage biotech company developing a novel class of custom-built protein drugs known as DARPin therapeutics ("Molecular Partners" or the "Company"), reported it has entered into an agreement with Eckert & Ziegler, leading specialist in isotope-related components for nuclear medicine and radiation therapy, to enable the development and manufacturing of Radio-DARPin therapeutics.

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"We are pleased to work with Eckert & Ziegler, a global leader in radiopharmaceutical manufacturing. This agreement will expand the potential of Radio-DARPins as vectors for precise delivery of therapeutic alpha-emitting isotopes to tumors, now including Actinium-225, in addition to Lead-212 through our long-term strategic partnership with Orano Med," said Alexander Zürcher, COO of Molecular Partners. He added: "The promise of Radio-DARPins is underlined by the progress of our lead candidate MP0712, targeting DLL3, having just opened the Phase 1/2a trial for the treatment of patients with small cell lung cancer (SCLC)".

Under the non-exclusive agreement, Eckert & Ziegler will support Molecular Partners with a comprehensive range of services covering development activities for Radio-DARPins with Actinium-225 (225Ac) and Lutetium-177 (177Lu) payloads. The development agreement will leverage Eckert & Ziegler’s state-of-the-art laboratories, including its newly established Alpha Laboratory in Berlin, Germany, dedicated exclusively to work with alpha emitters.

For its growing Radio-DARPin pipeline, Molecular Partners is evaluating various radio-nuclides to tailor Radio-DARPin candidates to patient needs – matching vector and isotope properties with target and disease biology. The Company plans to present pre-clinical data on Radio-DARPins’ suitability with multiple isotopes at the 3rd Global Radiopharmaceuticals Development Summit in March 2026 in Shanghai, China.

Eckert & Ziegler is a globally leading specialist for isotope-related components in nuclear medicine and radiation therapy, offering a broad range of services and products from early development work to contract manufacturing and distribution.

"Supporting highly innovative companies such as Molecular Partners in developing their promising technology platforms is a key objective of our group," said Dr. Harald Hasselmann, CEO of Eckert & Ziegler. "Bringing together our expertise in isotopes, radiochemistry and development infrastructure with our partners’ innovations will enable patients worldwide to benefit from new treatments in the future."

About Radio-DARPins

Molecular Partners’ Radio-DARPins are designed as ideal vectors for precise delivery of potent alpha-emitting isotopes to tumor lesions and have the potential to unlock a broad range of tumor targets for targeted radiopharmaceuticals. Building on the DARPins’ unique properties, Molecular Partners has developed a proprietary Radio-DARPin platform to address historic limitations of radioligand therapy, such as kidney accumulation and toxicity, and suboptimal tumor uptake. Molecular Partners’ Radio-DARPins addresses these limitations through half-life extension technologies and surface engineering approaches, while preserving the advantages of the small protein format.

(Press release, Molecular Partners, FEB 26, 2026, View Source [SID1234663009])

On February 26, 2026 Oncoinvent (OSE: ONCIN), a biotech company developing a receptor-independent alpha radiopharmaceutical to eradicate cancer cells in the abdominal cavity after surgery with a single, targeted dose, reported its second half 2025 results.

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Oncoinvent’s management team will give an online presentation to investors, analysts and the press at 09:30 CET today (details below).

Highlights:

Radspherin

Reported positive final data from Phase 1 Trial of Radspherin to treat ovarian cancer
Published Phase 1 trial results for Radspherin in ovarian cancer in Gynecologic Oncology
Presented final safety and efficacy results from the Phase 1/2a trial of Radspherin to treat colorectal cancer at the 15th PSOGI International Congress on Peritoneal Surface Malignancies
Corporate

Completed merger with BerGenBio and successfully uplisted to Oslo Stock Exchange
Raised NOK 130 million in equity
Appointed Dr Ramzi Amri as Chief Financial Officer
Post-period highlights

January 2026: Included four additional sites in Oncoinvent’s Phase 2 trial
February 2026: Present positive 24-month follow-up data from Phase 1 ovarian cancer trial of Radspherin at 27th Congress of the European Society of Gynecological Oncology (ESGO) 2026
Oystein Soug, CEO, commented: "The second half of 2025 marked another productive period for Oncoinvent, with solid advances across our clinical programs together with important corporate and financial milestones. During the period, we progressed the Radspherin Phase 2 trial in ovarian cancer, delivered meaningful scientific updates in two cancer indications, completed significant strategic transactions, and in the process strengthened the company’s financial foundation ahead of the planned Phase 2 interim readout."

Presentation:

We invite to a live webcast today at 09.30 CET. It will be possible to submit questions during the presentation.

Date: Thursday, 26 February 2026
Time: 9:30am CET
Webcast link: View Source
A recording of the webcast will be made available on www.oncoinvent.com after the live sending.

Reporting material:

Oncoinvent 2H 2025 report
Oncoinvent 2H25 presentation
The reporting material are also available in the Investor Relations section of the Company’s website at www.oncoinvent.com.

(Press release, Oncoinvent, FEB 26, 2026, https://www.oncoinvent.com/press-release/oncoinvent-asa-second-half-2025-results/ [SID1234663008])

On February 25, 2026 InnoCare Pharma (HKEX: 09969), a leading biopharmaceutical company focusing on the treatment of cancer and autoimmune diseases, reported key clinical development progress, including the completion of patient enrollment of multiple Phase III registrational trials.

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The Company completed patient enrollment of a Phase III registrational clinical trial of BCL2 inhibitor mesutoclax (ICP-248) in combination with BTK inhibitor orelabrutinib for treatment-naïve chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) patients.

Mesutoclax is a novel, highly selective oral BCL2 inhibitor. BCL2 is an important regulatory protein in the apoptosis pathway, and its abnormal expression is associated with the development of various hematologic malignancies. Mesutoclax exerts anti-tumor activity by selectively inhibiting BCL2 and restoring the normal apoptosis process in cancer cells. The fixed-duration treatment of mesutoclax in combination with orelabrutinib will provide deeper remission for treatment-naïve CLL/SLL patients without drug-resistant mutations, bringing hope of clinical cure to treatment-naïve CLL/SLL patients.

In addition, InnoCare also accelerated the clinical development of two novel TYK2 inhibitors. The company has completed patient enrollment in the Phase III registrational trial of soficitinib (ICP-332) for the moderate to severe atopic dermatitis (AD) and in the Phase III registrational trial of ICP-488 for the treatment of psoriasis recently.

These important milestones mark a crucial step forward in addressing the huge unmet needs in AD with soficitinib and in psoriasis with ICP-488.

Meanwhile, InnoCare has also completed patient enrollment in the Phase II clinical trial of soficitinib for the treatment of vitiligo.

Soficitinib is a potent and selective TYK2 inhibitor that is being developed for the treatment of various T-cell related autoimmune disorders. The current indications under development are strategically positioned within the vast dermatology market, including AD, vitiligo, prurigo nodularis, CSU, and psoriasis.

ICP-488 is an oral, potent, and selective TYK2 allosteric inhibitor. By binding to the JH2 domain, ICP-488 blocks the signal transduction pathways of IL-23, IL-12, type 1 IFN, and other inflammatory cytokines, thereby inhibiting the pathological processes of autoimmune and inflammatory diseases.

(Press release, InnoCare Pharma, FEB 25, 2026, View Source [SID1234663022])

On February 25, 2026 ITM Isotope Technologies Munich SE (ITM), a leading radiopharmaceutical biotech company, reported that it will provide further exploratory and post-hoc subgroup analysis data focusing on Pancreatic Neuroendocrine Tumors from its Phase 3 COMPETE trial in an oral presentation at the 23nd Annual European Neuroendocrine Tumor Society (ENETS) Conference, held from March 4 – March 6, 2026 in Kraków, Poland. The company will also host a conference booth (#6) and an interactive symposium on March 5, 2026, bringing together leading experts in radiopharmaceutical oncology to share their perspectives on key challenges and emerging clinical approaches for the treatment of neuroendocrine tumors (NETs).

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Oral Presentation Details
Title: 177Lu-edotreotide for the Treatment of Pancreatic Neuroendocrine Tumours: A Subgroup Analysis from the COMPETE Study
Presentation ID: D54
Session: Clinical science | Session 2B: Abstract session
Date and Time: Thursday, March 5, 11:50–11:57 AM (CET)
Location: Theatre Hall S2, ICE Kraków Congress Centre
Presenter: Prof. Dr. Thomas Walter, Medical Oncologist, Lyon, France

Satellite Symposium Details
Title: Vote and Learn: Radiopharmaceutical Therapy in NETs
Date and Time: Thursday, March 5, 07:45–08:45 AM (CET)
Location: Theatre Hall S2, ICE Kraków Congress Centre
Presenters: Dr. Francesca Spada, Medical Oncologist, Milano, Italy; Prof. Christophe Deroose, Nuclear Medicine Physician, Leuven, Belgium; Prof. Simron Singh, Medical Oncologist, Toronto, Canada

About the COMPETE Trial
The COMPETE trial (NCT03049189) evaluated 177Lu-edotreotide (ITM-11), a proprietary, synthetic, targeted radiotherapeutic investigational agent compared to everolimus, a targeted molecular therapy, in patients with inoperable, progressive Grade 1 or Grade 2 gastroenteropancreatic neuroendocrine tumors (GEP-NETs). This trial met its primary endpoint, with 177Lu-edotreotide demonstrating clinically and statistically significant improvement in progression-free survival (PFS) compared to everolimus. 177Lu-edotreotide is an investigational product pending review by the U.S. Food and Drug Administration (FDA) and is not approved by any regulatory authority for the safety and/or efficacy of any intended use. It is also being evaluated in COMPOSE, a Phase 3 study in patients with well-differentiated, aggressive Grade 2 or Grade 3, somatostatin receptor (SSTR)-positive GEP-NET tumors.

(Press release, ITM Isotopen Technologien Munchen, FEB 25, 2026, View Source [SID1234663021])

On February 25, 2026 Elicio Therapeutics, Inc. (Nasdaq: ELTX, "Elicio" or the "Company"), a clinical-stage biotechnology company developing a pipeline of novel immunotherapies for the treatment of cancer, reported that Robert Connelly, Chief Executive Officer, and Pete DeMuth, PhD, Chief Scientific Officer, will participate in the upcoming TD Cowen 46th Annual Health Care Conference, taking place March 2-4, 2026, in Boston, MA.

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TD Cowen 46th Annual Health Care Conference
Format: Company presentation
Date: Wednesday, March 4, 2026
Time: 1:10 PM ET

The live webcast and replay of the presentation will be available HERE and on Elicio’s Events page for 90 days following the event.

If you are interested in arranging a 1×1 meeting with management at the conference, please contact your TD Cowen representative.

(Press release, Elicio Therapeutics, FEB 25, 2026, View Source [SID1234663020])