BriaCell Opens First Canadian Site – Sunnybrook – for Pivotal Phase 3 Trial in Metastatic Breast Cancer

On July 16, 2026 BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXL) (TSX: BCT) ("BriaCell" or the "Company"), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, reported that the Odette Cancer Centre at Sunnybrook Health Sciences Centre, a leading cancer center in Toronto, Ontario, Canada, has joined BriaCell’s ongoing pivotal Phase 3 study of Bria-IMT plus an immune checkpoint inhibitor in metastatic breast cancer (ClinicalTrials.gov identifier: NCT06072612).

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In the United States, BriaCell’s Phase 3 study now has over 80 active clinical sites across 15 states, including Penn Medicine’s Abramson Cancer Center, Mayo Clinic, Smilow Cancer Hospital at Yale New Haven, DHR Health Oncology Institute, Hematology Oncology Associates of Fredericksburg, Los Angeles Cancer Network, Manhattan Hematology/Oncology Associates, New York Cancer & Blood Specialists, Northwestern University, Sylvester Comprehensive Cancer Center (University of Miami), Texas Oncology-Baylor Charles A. Sammons Cancer Center, and the University of Arizona.

"There are a limited number of effective treatment options for patients with metastatic breast cancer and, unfortunately for most patients, standard treatments eventually stop working," commented Katarzyna Jerzak, MD, MSc, FRCPC, Medical Oncologist and Clinician Investigator at Sunnybrook’s Odette Cancer Centre, and Associate Professor in the Department of Medicine, University of Toronto. "We are excited to evaluate BriaCell’s innovative immunotherapy approach and to offer these patients the opportunity to access a potentially effective new treatment."

"Opening our first Canadian clinical site for BriaCell’s pivotal Phase 3 study is an important milestone," stated Dr. William V. Williams, BriaCell’s President & Chief Executive Officer. "Sunnybrook is a world-class cancer center, and its participation expands access to our Bria-IMT regimen to patients in Canada, as we work to accelerate development of this our novel immunotherapy for patients with metastatic breast cancer."

BriaCell’s pivotal Phase 3 clinical study is evaluating BriaCell’s lead clinical candidate, Bria-IMT, in combination with an immune checkpoint inhibitor (CPI), compared with physician’s treatment of physician’s choice in patients with advanced metastatic breast cancer (the Bria-ABC study). The study’s primary endpoint is overall survival (OS). An interim analysis is planned after 144 patient deaths have occurred, comparing mortality in patients treated with the Bria-IMT combination regimen versus those treated with physician’s choice.

BriaCell recently received a positive recommendation from the independent Data Safety Monitoring Board (DSMB) to continue the Phase 3 Study in metastatic breast cancer. At ASCO (Free ASCO Whitepaper) 2026, BriaCell reported positive Phase 2 survival data in a similar metastatic breast cancer patient population treated with the same Bria-IMT combination regimen. The Bria-IMT combination regimen has received FDA Fast Track designation.

For additional information on BriaCell’s pivotal Phase 3 study of Bria-IMT and an immune checkpoint inhibitor in metastatic breast cancer, please visit ClinicalTrials.gov NCT06072612.

(Press release, BriaCell Therapeutics, JUL 16, 2026, View Source [SID1234669270])

BriaCell Partners with Uneedle for Scalable Microneedle Administration of Bria-IMT(TM)

On July 16, 2026 BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXL) (TSX: BCT) ("BriaCell" or the "Company"), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, reported it has entered into a Memorandum of Understanding ("MoU"), with Uneedle, a microneedle based drug-delivery device company in the Netherlands, to support the continued use and commercial readiness of Uneedle’s proprietary microneedle technology for intradermal administration of BriaCell’s lead Phase 3 clinical candidate, Bria-IMT, for the treatment of metastatic breast cancer.

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The MoU reflects the continued commitment of BriaCell and Uneedle to collaborate on the potential regulatory and commercial development of BriaCell’s cell-based immunotherapy Bria-IMT. The non-binding MoU is intended to establish a plan that details scaling of Uneedle’s microneedle devices for use in commercial quantities. All activities and projections described herein are contingent upon successful regulatory approval of BriaCell’s lead Phase 3 clinical candidate, Bria-IMT, in the relevant jurisdictions.

Bria-IMT is currently being evaluated in BriaCell’s ongoing pivotal Phase 3 study in advanced metastatic breast cancer (ClinicalTrials.gov identifier: NCT06072612). Uneedle’s microneedle technology is being used in this pivotal study to intradermally administer Bria-IMT.

"Efficient and reliable drug administration is integral to treating cancer patients," said William V. Williams, MD, President and Chief Executive Officer of BriaCell. "Uneedle’s microneedle technology is already being used in our pivotal Phase 3 study, and we believe this approach may support faster, more convenient administration and a more patient-friendly treatment experience."

"Precision and consistency in intradermal drug delivery are important attributes for therapies administered into the skin," said Jeroen Wissink, Chief Executive Officer of Uneedle. "We are excited to work with BriaCell to support the use of our proprietary microneedle technology for Bria-IMT and to help advance delivery readiness ahead of potential commercialization."

(Press release, BriaCell Therapeutics, JUL 16, 2026, View Source [SID1234669269])

Abbott Reports Second-Quarter 2026 Results and Raises Full-Year EPS Guidance

On July 16, 2026 Abbott (NYSE: ABT) reported financial results for the second quarter ended June 30, 2026.

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Second-quarter sales increased 13.0 percent on a reported basis and 4.8 percent on a comparable basis.
Second-quarter GAAP diluted EPS of $0.53 and adjusted diluted EPS of $1.31, which excludes specified items.
Abbott reaffirms full-year 2026 comparable sales growth guidance of 6.5% to 7.5%1.
Abbott raises full-year 2026 adjusted diluted EPS guidance range to $5.45 to $5.60, compared to previous range of $5.38 to $5.58.
In April, Abbott completed enrollment in its TECTONIC U.S. pivotal trial. This trial is designed to evaluate Abbott’s investigational Coronary Intravascular Lithotripsy (IVL) System for treating severe calcification in coronary arteries prior to stent implantation.
In April, at the Heart Rhythm Society (HRS) conference, Abbott presented new late-breaking data from four clinical trials that demonstrated strong clinical outcomes across the company’s pulsed field ablation (PFA) and conduction system pacing (CSP) portfolios.
In May, Abbott announced it secured CE Mark for Libre Duo, the world’s first dual glucose-ketone biowearable sensor. By providing real-time visibility into glucose and ketone levels, this new technology helps optimize the management of diabetes by detecting rising ketone levels, which can lead to diabetic ketoacidosis, a serious health condition for people with diabetes.
In May, Abbott completed its submission to the U.S. Food and Drug Administration (FDA) seeking approval for the company’s Amulet 360 left atrial appendage (LAA) device.
In May, the American Cancer Society (ACS) issued updated colorectal cancer (CRC) screening guidelines that reaffirmed Cologuard and Cologuard Plus as preferred screening options for adults age 45 and older who are at average risk for CRC.
"Our second-quarter results reflect the momentum we are building," said Robert B. Ford, chairman and chief executive officer, Abbott. "We expect this momentum to continue and drive accelerating sales and earnings growth in the second half of the year."

SECOND-QUARTER BUSINESS OVERVIEW

Comparable sales growth:
Management believes that measuring sales growth on a comparable basis is an appropriate way for investors to best understand the underlying performance of the business. Comparable sales growth includes the prior and current year sales of Exact Sciences, a cancer diagnostics company that Abbott acquired on March 23, 2026. Comparable sales growth excludes the impact of foreign exchange and revenue in both the prior and current year related to compensation payments that Abbott’s Structural Heart business received as part of a multi-year agreement with a competitor. The final payment under this agreement was recognized in the first quarter of 2026.

Note: In order to compute results excluding the impact of exchange rates, current year U.S. dollar sales are multiplied or divided, as appropriate, by the current year average foreign exchange rates and then those amounts are multiplied or divided, as appropriate, by the prior year average foreign exchange rates.

Second Quarter 2026 Results (2Q26)

Sales 2Q26 ($ in millions)

Total Company


Nutrition


Diagnostics


Established
Pharmaceuticals


Medical Devices

U.S.

5,216


871


1,660



2,680

International

7,377


1,273


1,432


1,499


3,173

Total reported

12,593


2,144


3,092


1,499


5,853


% Change vs. 2Q25


U.S.

22.0


(9.0)


104.8


n/a


7.0

International

7.5


1.4


5.1


8.4


10.7

Total reported

13.0


(3.1)


42.3


8.4


9.0

Total reported excl. foreign exchange impact

12.2


(3.6)


41.3


8.7


7.9

Comparable sales growth

4.8


(3.6)


2.9


8.7


8.4


U.S.

3.5


(9.0)


4.0


n/a


8.0

International

5.8


0.6


1.6


8.7


8.7

First Half 2026 Results (1H26)


Sales 1H26 ($ in millions)

Total Company


Nutrition


Diagnostics


Established
Pharmaceuticals


Medical Devices

U.S.

9,490


1,715


2,565



5,203

International

14,267


2,446


2,707


2,925


6,189

Total reported

23,757


4,161


5,272


2,925


11,392


% Change vs. 1H25


U.S.

12.4


(10.3)


52.5


n/a


7.4

International

9.3



6.4


10.7


14.2

Total reported

10.5


(4.5)


24.7


10.7


11.0

Total reported excl. foreign exchange impact

8.2


(5.6)


22.4


8.9


8.0

Comparable sales growth

4.3


(5.6)


2.4


8.9


8.4


U.S.

3.0


(10.3)


3.0


n/a


8.3

International

5.3


(1.9)


1.6


8.9


8.5

Refer to table titled "Non-GAAP Revenue Reconciliation" for a reconciliation of comparable sales growth.

Nutrition

Second Quarter 2026 Results (2Q26)

Sales 2Q26 ($ in millions)

Total


Pediatric


Adult

U.S.

871


525


346

International

1,273


500


773

Total reported

2,144


1,025


1,119


% Change vs. 2Q25


U.S.

(9.0)


(10.7)


(6.4)

International

1.4


7.3


(2.0)

Total reported

(3.1)


(2.7)


(3.4)

Total reported excl. foreign exchange impact

(3.6)


(3.1)


(4.0)

Comparable sales growth

(3.6)


(3.1)


(4.0)


U.S.

(9.0)


(10.7)


(6.4)

International

0.6


6.4


(2.8)

Worldwide Nutrition sales decreased 3.1 percent on a reported basis and 3.6 percent on a comparable basis in the second quarter.

Results in the quarter reflect the impact of lower sales volumes compared to the prior year and the effect of strategic pricing actions implemented in the fourth quarter of 2025. These pricing actions, together with the launch of new products, are contributing to improving performance. Nutrition sales increased $127 million on a sequential basis compared to the first quarter of 2026.

First Half 2026 Results (1H26)

Sales 1H26 ($ in millions)

Total


Pediatric


Adult

U.S.

1,715


1,036


679

International

2,446


942


1,504

Total reported

4,161


1,978


2,183


% Change vs. 1H25


U.S.

(10.3)


(11.9)


(7.8)

International


2.4


(1.5)

Total reported

(4.5)


(5.6)


(3.5)

Total reported excl. foreign exchange impact

(5.6)


(6.4)


(4.9)

Comparable sales growth

(5.6)


(6.4)


(4.9)


U.S.

(10.3)


(11.9)


(7.8)

International

(1.9)


0.7


(3.5)

Diagnostics*

Second Quarter 2026 Results (2Q26)

Sales 2Q26 ($ in millions)

Total


Core Laboratory


Cancer Diagnostics


Rapid/Molecular
Diagnostics

U.S.

1,660


377


890


393

International

1,432


1,041


29


362

Total reported

3,092


1,418


919


755


% Change vs. 2Q25


U.S.

104.8


7.5


n/a


(14.5)

International

5.1


3.4


n/a


2.0

Total reported

42.3


4.4


n/a


(7.3)

Total reported excl. foreign exchange impact

41.3


3.2


n/a


(8.0)

Comparable sales growth

2.9


3.2


13.3


(8.0)


U.S.

4.0


7.5


13.3


(14.5)

International

1.6


1.7


13.8


0.5

Worldwide Diagnostics sales increased 42.3 percent on a reported basis and 2.9 percent on a comparable basis in the second quarter.

Worldwide Core Laboratory Diagnostics results were driven by strong growth in the U.S. and Latin America.

Rapid and Molecular Diagnostics results reflect lower sales of respiratory virus tests compared to the prior year.

Cancer Diagnostics results were driven by mid-teens growth of Cologuard, which is benefiting from a growing base of both new and repeat users. Results in the quarter also reflect contributions to growth from the precision oncology and international businesses.

First Half 2026 Results (1H26)

Sales 1H26 ($ in millions)

Total


Core Laboratory


Cancer Diagnostics


Rapid/Molecular
Diagnostics

U.S.

2,565


724


983


858

International

2,707


1,966


32


709

Total reported

5,272


2,690


1,015


1,567


% Change vs. 1H25


U.S.

52.5


6.0


n/a


(14.1)

International

6.4


6.1


n/a


2.4

Total reported

24.7


6.1


n/a


(7.4)

Total reported excl. foreign exchange impact

22.4


3.2


n/a


(8.8)

Comparable sales growth

2.4


3.2


13.3


(8.8)


U.S.

3.0


6.0


13.2


(14.1)

International

1.6


2.2


16.5


(1.1)

*Beginning in 2026, Abbott aggregated its previously reported Rapid Diagnostics, Molecular Diagnostics, and Point of Care businesses into the Rapid and Molecular Diagnostics business. On March 23, 2026, Abbott completed the acquisition of Exact Sciences. Following the acquisition, the sales of Exact Sciences are presented as Abbott’s Cancer Diagnostics business.

Refer to table titled "Non-GAAP Revenue Reconciliation" for a reconciliation of comparable sales growth.

Established Pharmaceuticals

Second Quarter 2026 Results (2Q26)

Sales 2Q26 ($ in millions)

Total


Key Emerging
Markets


Other

U.S.



International

1,499


1,164


335

Total reported

1,499


1,164


335


% Change vs. 2Q25


U.S.

n/a


n/a


n/a

International

8.4


9.8


3.7

Total reported

8.4


9.8


3.7

Total reported excl. foreign exchange impact

8.7


10.7


2.1

Comparable sales growth

8.7


10.7


2.1


U.S.

n/a


n/a


n/a

International

8.7


10.7


2.1

Established Pharmaceuticals sales increased 8.4 percent on a reported basis and 8.7 percent on a comparable basis in the second quarter.

Key Emerging Markets include several emerging countries that represent the most attractive long-term growth opportunities for Abbott’s branded generics product portfolio. Sales in these geographies increased 9.8 percent on a reported basis and 10.7 percent on a comparable basis, led by double-digit growth in several countries across the Latin America and Asia Pacific regions.

First Half 2026 Results (1H26)

Sales 1H26 ($ in millions)

Total


Key Emerging
Markets


Other

U.S.



International

2,925


2,253


672

Total reported

2,925


2,253


672


% Change vs. 1H25


U.S.

n/a


n/a


n/a

International

10.7


11.3


8.6

Total reported

10.7


11.3


8.6

Total reported excl. foreign exchange impact

8.9


10.1


4.9

Comparable sales growth

8.9


10.1


4.9


U.S.

n/a


n/a


n/a

International

8.9


10.1


4.9

Medical Devices

Second Quarter 2026 Results (2Q26)

Sales 2Q26 ($ in millions)

Total


Rhythm
Management


Electro-
physiology*


Heart
Failure


Vascular


Structural
Heart*


Neuro-
modulation


Diabetes
Care

U.S.

2,680


377


420


313


294


225


189


862

International

3,173


366


441


88


509


372


71


1,326

Total reported

5,853


743


861


401


803


597


260


2,188


% Change vs. 2Q25


U.S.

7.0


10.7


15.9


10.9


3.9


(9.8)


(2.1)


8.6

International

10.7


10.0


12.3


3.0


7.5


12.1


14.7


11.7

Total reported

9.0


10.4


14.0


9.0


6.1


2.7


2.0


10.5

Total reported excl. foreign exchange impact

7.9


9.5


13.4


8.7


5.1


1.7


1.2


9.0

Comparable sales growth

8.4


9.5


13.4


8.7


5.1


5.7


1.2


9.0


U.S.

8.0


10.7


15.9


10.9


3.9


(0.9)


(2.1)


8.6

International

8.7


8.3


11.1


1.3


5.8


10.2


11.3


9.2

Worldwide Medical Devices sales increased 9.0 percent on a reported basis and 8.4 percent on a comparable basis in the second quarter.

Sales growth in the quarter was led by low-teens growth in Electrophysiology and high-single-digit growth in Rhythm Management, Diabetes Care, and Heart Failure.

In Diabetes Care, sales of continuous glucose monitors grew 11.0 percent on a reported basis and 9.5 percent on a comparable basis.

First Half 2026 Results (1H26)

Sales 1H26 ($ in millions)

Total


Rhythm
Management


Electro-
physiology*


Heart
Failure


Vascular


Structural
Heart*


Neuro-
modulation


Diabetes
Care

U.S.

5,203


716


798


605


585


449


366


1,684

International

6,189


711


851


185


995


726


137


2,584

Total reported

11,392


1,427


1,649


790


1,580


1,175


503


4,268


% Change vs. 1H25


U.S.

7.4


11.1


14.8


11.1


6.2


(9.6)


(0.7)


9.2

International

14.2


15.9


15.7


13.5


8.7


18.1


20.4


14.0

Total reported

11.0


13.4


15.3


11.7


7.7


5.7


4.3


12.1

Total reported excl. foreign exchange impact

8.0


10.9


13.0


10.4


5.0


2.6


2.6


8.2

Comparable sales growth

8.4


10.9


13.0


10.4


5.0


6.2


2.6


8.2


U.S.

8.3


11.1


14.8


11.1


6.2


(2.2)


(0.7)


9.2

International

8.5


10.7


11.2


7.8


4.3


12.4


13.2


7.5

*Abbott’s Amplatzer Amulet Left Atrial Appendage Occluder device and related accessories were transferred from Structural Heart to Electrophysiology on January 1, 2026. As a result, $55 million of sales in the second quarter of 2025 and $101 million of sales in the first half of 2025 were moved from Structural Heart to Electrophysiology.

(Press release, Abbott, JUL 16, 2026, View Source [SID1234669268])

Second Quarter 2026

On July 15, 2026 Johnson & Johnson reported second quarter 2026 results.

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(Press release, Johnson & Johnson, JUL 15, 2026, View Source [SID1234669384])

Rakovina Therapeutics Announces $1.5 Million Private Placement

On July 15, 2026 Rakovina Therapeutics Inc. (TSX-V: RKV)( FSE: 7JO0), a biopharmaceutical company advancing innovative cancer therapies through artificial intelligence (AI)-powered drug discovery, reported a non-brokered private placement offering (the "Offering") of up to $1.5 million.

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Pursuant to the Offering, Rakovina will issue up to 15 million equity units ("Units") at an offering price of $0.10 per Unit, with each Unit consisting of one common share and one-half of one common share purchase warrant (a "Warrant"). Each whole Warrant will entitle the holder to acquire one additional common share at an exercise price of $0.20 exercisable for a period of 24 months from issuance.

Proceeds from the Offering will be used to advance Rakovina’s pipeline, with a primary focus on in vivo ADME and efficacy testing for the kt-5000AI dual ATR/mTOR inhibitor program and continued AI-driven lead optimization through the Company’s collaboration with Variational AI. Funds will also support advancement of the kt-3000 LNP formulation program through in vitro and in vivo characterization, ongoing kt-2000AI compound development, and the continued expansion of the Company’s AI-enabled drug discovery collaborations. Remaining proceeds will be used for general working capital purposes.

The Units will be sold on a non-brokered "private placement" basis in accordance with applicable Canadian securities laws and under applicable exemptions from prospectus and registration requirements and the securities will be subject to resale restrictions for a period of four months plus one day from the date of issue.

(Press release, Rakovina Therapeutics, JUL 15, 2026, View Source;utm_medium=rss&utm_campaign=rakovina-therapeutics-announces-1-5-million-private-placement [SID1234669272])