Corporate overview

On July 2, 2026 Iovance Biotherapeutics presented its corporate presentation.

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(Presentation, Iovance Biotherapeutics, JUL 3, 2026, View Source [SID1234669061])

Nona Biosciences Appoints Dr. Peng Wang as Chief Operating Officer to Advance Platform Capabilities and Drive Operational Excellence

On July 2, 2026 Nona Biosciences ("Nona"), a global biotechnology company advancing biotherapeutic discovery through innovative technology platforms, reported the appointment of Dr. Peng Wang as Chief Operating Officer (COO). Dr. Wang will be based in Suzhou and report directly to Dr. Di Hong, Chief Executive Officer of Nona Biosciences.

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In this role, Dr. Wang will be responsible for establishing an efficient and integrated scientific research platform, rapidly building core technical capabilities, and upgrading the Company’s comprehensive and standardized scientific research service system. He will lead efforts to realize lean and efficient resource management, with a focus on elevating overall project management efficiency to support Nona’s growing portfolio of partner programs.

Dr. Wang brings over 15 years of extensive experience in biomedical research and drug development. Prior to joining Nona, he served as Head of Biologics and in vitro APAC at Crown Bioscience. Before that, he held the position of Head of Antibody Group at WuXi AppTec and served as a Senior Scientist at Roche. Dr. Wang began his career with several years of postdoctoral research experience at the University of Pennsylvania.

"We are very pleased to welcome Dr. Peng Wang to Nona Biosciences at a pivotal time as we continue to strengthen our platform capabilities and enhance our operational infrastructure," said Dr. Di Hong, Chief Executive Officer of Nona Biosciences. "Peng’s deep expertise across biologics development, antibody discovery, and research operations will be instrumental in formulating our long-term platform strategy and ensuring the efficient execution of our project portfolio. I am confident that he will fulfill his role to the best of his ability and maintain Nona’s high standard of performance and delivery."

"Nona Biosciences has established itself as a leader in antibody discovery and engineering, with its proprietary technology platforms and integrated I to I framework from idea to IND," said Dr. Peng Wang, Chief Operating Officer of Nona Biosciences. "I am excited to join the team and look forward to further enhancing our scientific capabilities, streamlining operations, and delivering greater value to our partners."

Dr. Wang holds a Ph.D. in Molecular Biology from the University of Delaware.

(Press release, Nona Biosciences, JUL 2, 2026, View Source [SID1234669062])

Elicio Therapeutics Announces Pricing of $15 Million Registered Direct Offering

On July 2, 2026 Elicio Therapeutics, Inc. (Nasdaq: ELTX) ("Elicio" or the "Company"), a clinical-stage biotechnology company developing next-generation immunotherapies for KRAS-driven cancers, reported that it has entered into a definitive securities purchase agreement led by two new fundamental institutional investors with participation from a large existing shareholder for the purchase of an aggregate of 4,380,313 shares of its common stock pursuant to a registered direct offering (the "Offering"). The Offering is expected to result in gross proceeds of approximately $15 million, before deducting placement agents’ fees and other Offering expenses. The closing of the Offering is expected to occur on or about July 6, 2026, subject to the satisfaction of customary closing conditions. Elicio intends to use the net proceeds from the Offering, together with its existing cash, cash equivalents and marketable securities, to primarily fund the planned Phase 1 clinical development of ELI-002 7P in metastatic PDAC and Elicio’s pipeline and platform, as well as for working capital and general corporate purposes.

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Titan Partners, a division of American Capital Partners, is acting as lead placement agent for the Offering. B. Riley Securities, Inc. is acting as co-placement agent for the Offering.

The Offering is being made pursuant to a shelf registration statement on Form S-3 (File No. 333-293861) initially filed with the Securities and Exchange Commission ("SEC") on February 27, 2026, as amended on March 12, 2026, and declared effective by the SEC on March 16, 2026 (the "Registration Statement"). The shares of common stock are being offered only by means of a prospectus, including a prospectus supplement, forming a part of the effective registration statement. The prospectus supplement and the accompanying prospectus relating to, and describing the terms of, the Offering will be filed with the SEC and will be available for free on the SEC’s website at www.sec.gov. Electronic copies of the prospectus supplement and accompanying prospectus may also be obtained, when available, by contacting Titan Partners Group LLC, a division of American Capital Partners, LLC, 4 World Trade Center, 49th Floor, New York, NY 10007, by phone at (929) 833-1246 or by email at [email protected], or B. Riley Securities, Inc. at 1655 Fort Myer Drive, Suite 1200, Arlington, Virginia 22209, Attention: Syndicate Prospectus Department, by telephone at 703-312-9580 or by email at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy any of the securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

About ELI-002

Elicio’s lead product candidate, ELI-002, is a structurally novel investigational AMP cancer immunotherapy that targets cancers that are driven by mutations in the KRAS-gene—a prevalent driver of many human cancers. ELI-002 is comprised of two powerful components that are built with Elicio’s proprietary AMP technology consisting of AMP-modified mutant KRAS peptide antigens and ELI-004, an AMP-modified CpG oligodeoxynucleotide adjuvant that is available as an off-the-shelf subcutaneous administration.

ELI-002 7P (7-peptide formulation) was evaluated in the randomized Phase 2 AMPLIFY-7P trial in patients with mKRAS-driven pancreatic cancer (NCT05726864). The Phase 2 AMPLIFY-7P trial included patients with mKRAS-positive pancreatic cancer who completed standard therapy but remain at high risk of relapse. Based on topline results and post-hoc analyses, Elicio has refined its Phase 3 development strategy to focus on patients with lower residual disease burden and extended treatment duration. Elicio intends to initiate a Phase 1 study in metastatic PDAC designed to provide a rapid assessment of clinical activity through a focused, confirmatory study, subject to funding. Elicio plans to use the study findings to further evaluate checkpoint inhibitor combinations and help inform future development strategies in metastatic PDAC and the adjuvant PDAC Phase 3 trial. At the time of the Phase 2 AMPLIFY-7P analysis, data for overall survival remained immature. The ELI-002 7P formulation is designed to provide immune response coverage against seven of the most common KRAS mutations present in 25% of all solid tumors, thereby increasing the potential patient population for ELI-002.

(Press release, Elicio Therapeutics, JUL 2, 2026, View Source [SID1234669060])

Treos Bio Presents New Translational Data Showing PolyPEPI1018 Plus Anti-PD-L1 Immunotherapy Remodels the Tumor Immune Microenvironment in MSS Colorectal Cancer

On July 2, 2026 Treos Bio, a clinical-stage biotechnology company developing off-the-shelf and personalized active cancer immunotherapies based on its proprietary PEPI Technology, reported new translational data from the Phase Ib/II OBERTO-301 study (NCT05243862), presented at the ESMO (Free ESMO Whitepaper) Gastrointestinal Cancers Congress 2026.

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Conducted in collaboration with Mayo Clinic, the retrospective translational analysis demonstrates that PolyPEPI1018 treatment in combination with anti-PD-L1 immunotherapy induced measurable immune remodeling in patients with microsatellite-stable metastatic colorectal cancer (MSS mCRC), a tumor type generally considered resistant to checkpoint inhibition.

The retrospective analysis evaluated paired baseline and on-treatment tumor biopsies and peripheral blood samples from OBERTO-301 patients treated with PolyPEPI1018 plus atezolizumab. Post-treatment tumor samples showed increased CD8+ T-cell density and PD-L1 expression, indicating conversion toward a more inflamed tumor microenvironment.
T-cell receptor (TCR) sequencing demonstrated selective expansion of tumor-reactive T-cell clonotypes, including TCRs directed against PolyPEPI1018 antigens, additional tumor-associated antigens and neoantigens. The analysis also suggested treatment-induced antigen spreading beyond the PolyPEPI1018-targeted epitopes.

Importantly, higher numbers of tumor-reactive TCR clonotypes and higher post-treatment CD8+ TIL density were associated with improved clinical outcomes, including longer overall survival and progression-free survival. Together, these findings provide mechanistic evidence that therapeutic vaccination targeting shared tumor-associated antigens can remodel the immune microenvironment of MSS colorectal cancer converting immunologically "cold" tumors into a more immunologically active, potentially checkpoint-responsive tumor microenvironment.

"MSS colorectal cancer has long been one of the most difficult settings for immunotherapy because these tumors typically lack the immune activity needed for checkpoint inhibitors to work," said Dr. Eniko Toke, Co-founder and Chief Scientific Officer of Treos Bio. "What is encouraging in this analysis is not only that we observed immune activation in the tumor microenvironment, but that the depth of that response was associated with patient outcomes. Together with our recent clinical and platform data, these findings strengthen the rationale for advancing PolyPEPI1018 combinations in MSS colorectal cancer and applying PEPI Technology across other difficult-to-treat tumors."

Poster number: 115P
Presentation: 02 July 2026
Congress: ESMO (Free ESMO Whitepaper) Gastrointestinal Cancers Congress 2026

(Press release, Treos Bio, JUL 2, 2026, View Source [SID1234669059])

VERAXA Biotech Initiates Cell Line Development with ATUM to Advance its Lead BiTAC®-TCE Program

On July 2, 2026 VERAXA Biotech AG (NASDAQ: VRXA; "VERAXA"), an emerging leader in designing novel cancer therapies, reported the initiation of cell line development for its lead BiTAC T-cell engager (BiTAC-TCE) program. VERAXA has engaged ATUM, a global leader in bioengineering and cell line development, to apply the proprietary Leap-In Transposase technology to support stable clonal cell line generation. The collaboration marks a key step in progressing VERAXA’s most advanced T-cell engager candidate toward IND/CTA-enabling activities and supports future clinical development.

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"Today’s news underscores our commitment to accelerate the development path of our growing BiTAC-TCE portfolio. Initiating cell line development with ATUM is an important next step for our lead BiTAC-TCE program following the encouraging preclinical data we presented at AACR (Free AACR Whitepaper)," said Christoph Erkel, Ph.D., Vice President Research & Development of VERAXA. "Working with a recognized cell line development partner like ATUM allows us to pair our differentiated molecular design with expertise and workflows built for exactly this kind of advanced multi-chain formats."

Cell line development is an important milestone in translating a therapeutic candidate into a manufacturable product. The collaboration with ATUM is intended to support the generation of stable and high-producing clonal cell lines that will be used throughout CMC development, including early process, analytical, and formulation development, as well as the supply of material for nonclinical studies. ATUM’s Leap-In Transposase technology is designed to support efficient stable cell line generation and is particularly relevant for multi-chain antibody formats where balanced expression of multiple components is important, such as VERAXA’s BiTAC-TCEs. ATUM‘s Leap-In Transposase technology has supported the generation of stable cell lines used in over 50 IND submissions, providing VERAXA with an established cell line development approach for advanced biologic formats.

A new generation of T-cell engagers

T-cell-engaging bispecific molecules redirect cytotoxic T-cells to eliminate cancer cells, typically by binding the CD3 receptor on T-cells while simultaneously engaging a target protein on the tumor. While effective in select indications, conventional TCEs remain limited by toxicity; because their tumor target is often also present on healthy tissue, on-target but off-tumor T-cell activation can drive serious side effects and narrow the therapeutic window. A large proportion of conventional bispecific TCEs fail in development for this reason.

VERAXA’s BiTAC-TCE approach is designed to address this challenge at its source. Rather than delivering a single, fully active molecule, the BiTAC strategy splits the T-cell engager into two complementary precursors. In their isolated form, each precursor retains its tumor-binding capability while the CD3-binding function remains inactivated. Only when both precursors bind their respective targets on the same cell is the CD3-binding domain reconstituted and activated. This "AND"-gated mechanism restricts T-cell activity to cells displaying both tumor markers, sparing healthy cells that carry only one.

A dual-target, conditional-activation design distinguishes BiTAC-TCEs from both traditional TCEs and from masked-TCE approaches that rely on a single antibody whose effector function is shielded until cleaved in the tumor microenvironment. By requiring the simultaneous engagement of two distinct antigens to assemble the active engager, BiTAC-TCEs are engineered for greater tumor selectivity, with the goal of enabling higher dosing and a meaningfully wider therapeutic window.

Initial data from VERAXA’s most advanced BiTAC-TCE program were presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2026, in April. In those studies, VERAXA’s BiTAC-TCE candidate performed as intended in vitro and in vivo, attacking cancer cells displaying both target molecules while sparing cells expressing only one of the two targets. The data demonstrated a superior safety profile with matching efficacy compared with a more traditional TCE, pointing to the possibility of a meaningfully improved therapeutic index. The related posters are available on the VERAXA website at www.veraxa.com.

(Press release, Veraxa Biotech, JUL 2, 2026, View Source [SID1234669058])