On August 21, 2026 AbbVie (NYSE: ABBV) reported new data highlighting research programs across its lung cancer portfolio being presented at the 2026 World Conference on Lung Cancer (WCLC), including non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). The presentations span clinical, translational and real-world data across next-generation immunotherapies and targeted antibody-drug conjugates (ADCs), designed to generate insights into treatment burden, patient experience and biomarker identification that may help inform future research.

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"Our strategy in lung cancer is focused on building a complementary pipeline that brings together next-generation immunotherapies and targeted antibody-drug conjugates with the potential to address different aspects of tumor biology," said Daejin Abidoye, M.D., vice president and therapeutic area head of oncology, solid tumor and hematology at AbbVie. "Exploring the PD-1/VEGF approach represented by ABBV-1480 and the c-Met targeting by Temab-A are important elements of that strategy and may provide a foundation for potential novel combinations as we work to develop more tailored treatment approaches for people living with lung cancer."

Advancing Novel Therapies Across Various Modalities in NSCLC
Multiple presentations across AbbVie’s NSCLC portfolio will showcase new studies and data analyses spanning multiple treatment modalities, highlighting first-line treatment approaches, patient experience and biomarker-informed research.

ABBV-1480 (RC148): AbbVie, in partnership with RemeGen, will present Phase 1b data evaluating the investigational PD-1/VEGF bispecific antibody, ABBV-1480, in combination with platinum-based chemotherapy as a potential first-line treatment for advanced NSCLC. At the 10 mg/kg dose, identified as the recommended Phase 3 dose for further development in combination regimens in both squamous and non-squamous NSCLC, the primary endpoint of objective response rate (ORR) was 90.0% in squamous NSCLC (n=27/30) and 75.9% (n=22/29) in non-squamous NSCLC. The most common treatment-related adverse events (TRAEs) were a decrease in white blood cells, neutrophil, platelet counts and anemia. No grade ≥3 hemorrhages with the 10 mg combinations were observed. This overall manageable safety profile supports ongoing Phase 3 development for this novel investigational asset.1

Telisotuzumab adizutecan (Temab-A), an investigational c-Met-directed ADC with a topoisomerase 1 inhibitor (Top1i) payload: Building on encouraging preliminary activity2 observed in heavily pretreated patients, AbbVie initiated a Phase 1b/2 M24-536 study (NCT06772623). The study is evaluating a platinum-free combination of Temab-A and a PD-1 inhibitor, as a potential first-line treatment for advanced non-squamous NSCLC. The study includes analyses of c-Met and PD-L1 expression to identify the patients most likely to benefit from treatment.3 Temab-A is also being studied in epidermal growth factor receptor (EGFR)-mutated NSCLC as monotherapy or in combination with osimertinib (NCT07155187).
Clinical Data Showcasing the Potential of ABBV-706 in SCLC
ABBV-706 is an investigational SEZ6-targeted ADC with a Top1i payload, being evaluated in SCLC. Presentations at WCLC include research that further characterizes the program and the potential role of SEZ6 in SCLC.

As previously reported, ABBV-706 demonstrated an ORR of 82% in patients with relapsed/refractory SCLC post platinum-based chemotherapy (n=17).4 New safety analyses from 240 patients who received ABBV-706 monotherapy showed generally manageable hematologic and gastrointestinal toxicities, with the most common gastrointestinal events, including nausea (35.8%), vomiting (17.5%) and diarrhea (10.8%), being largely low grade and most requiring no dose adjustments.5 Grade ≥3 treatment-related pneumonitis or interstitial lung disease was reported in 1.7% of patients receiving ABBV-706 monotherapy.6 Hematologic toxicities, including anemia, neutropenia and thrombocytopenia, were among the most common TRAEs.5 Serious TRAEs occurred in 12.5% of patients. ABBV-706 is being evaluated as monotherapy in a Phase 3 study (NCT07365241) and in combination with atezolizumab in the Phase 2 study (NCT07155174), in SCLC.

Real-world research demonstrated that SEZ6 is broadly expressed in 91% of SCLC patients overall and in more than 96% of patients with brain or liver metastases. These findings further support SEZ6 as a potential therapeutic target in SCLC and other SEZ6-expressing tumors. 7
Additional details on key presentations are available below, and the full WCLC 2026 abstracts are available online.

For information about AbbVie’s clinical trial efforts in lung cancer, please visit clinicaltrials.gov.

Title

Date/Time

Session

Abstract Number

Radiomic Biomarkers on Baseline CT

Scans for Predicting Response to

Teliso-V in NSCLC: A Machine

Learning Approach

Monday,
September 14

10:30AM-12:00PM KST

Poster

Session: P2.077-248.

Pathology and
Biomarkers

P2.137.

Telisotuzumab Adizutecan and PD-1 Inhibitor

in Untreated Advanced Non-Squamous

Non-Small Cell Lung Cancer: A Phase

1b/2 Study

Monday,
September 14

10:30AM-12:00PM KST

Poster

Session: P2.304-390.

Clinical Trials in
Progress

P2.374.

Efficacy and Safety of ABBV-706 Versus

Standard of Care in Relapsed/Refractory

Small Cell Lung Cancer: A Phase 3 Study

Monday,
September 14

10:30AM-12:00PM KST

Poster

Session: P2.304-390.

Clinical Trials in
Progress

P2.377.

A Phase 3, Randomized, Double-Blind Trial

of RC148 (ABBV-1480) Plus Chemotherapy

in First-Line Squamous Non-Small-Cell

Lung Cancer

Monday,

September 14

10:30AM-12:00PM KST

Poster

Session: P2.304-390.

Clinical Trials in
Progress

P2.379.

Peripheral Neuropathy With Teliso-V in

c-Met- Protein Overexpressing NSCLC

in LUMINOSITY: Clinical Characteristics

and PROs

Monday,

September 14

2:17-2:25 PM KST

Poster

Session: PT2.01.

Metastatic
NSCLC –
Antibody-Drug
Conjugate and
Cytotoxic
Therapy

PT2.01.05.

Telisotuzumab vedotin Demonstrates Potent

Antitumor Efficacy in Preclinical Models of

Diffuse Pleural Mesothelioma

Monday,

September 14

2:17-2:25 PM KST

Poster

Session: PT2.05.

Mesothelioma,
Thymoma, and
Other Thoracic
Tumors

PT2.05.05.

Hematologic and Gastrointestinal Toxicity of

ABBV-706 in Advanced Solid Tumors: Safety

Profile from the First-in-Human Study

Tuesday,

September 15

9:30-11:00 AM KST

Poster

Session: P3.282-354.

Small Cell Lung
Cancer and
Neuroendocrine
Tumors

P3.316.

SEZ6 Is Expressed Across Major Clinical and

Demographic Groups of SCLC Patients:

Evidence From a US Clinicogenomic

Database

Tuesday,

September 15

9:30 AM-11:00 AM KST

Poster

Session: P3.282-354.

Small Cell Lung
Cancer and
Neuroendocrine
Tumors

P3.340.

RC148 (ABBV-1480, PD-1/VEGF Bispecific

Antibody) Plus Chemotherapy in First-Line

Locally Advanced or Metastatic Non-Small-

Cell Lung Cancer

Tuesday,

September 15

12:52-1:02 PM KST

Oral Presentation

Session: OA14.

The Breakthrough
Immunotherapy
for Advanced
NSCLC

OA14.01.03.

High Burden and Limited Evidence in Late-

Line ES-SCLC: A Structured Review of

Clinical and Humanistic Outcomes

E-Poster

EP13 Small Cell
Lung Cancer and
Neuroendocrine
Tumors

EP13.05.

Pneumonitis/Interstitial Lung Disease in the

First-in-Human ABBV-706 Study: Incidence,

Management, and Risk Factors

E-Poster

EP13 Small Cell
Lung Cancer and
Neuroendocrine
Tumors

EP13.32.

Telisotuzumab adizutecan (Temab-A) and ABBV-706 are investigational medicines and are not approved by any health authorities worldwide. The safety and efficacy of these investigational medicines are under evaluation as part of ongoing clinical studies.

AbbVie holds exclusive rights from RemeGen to develop, manufacture, and commercialize ABBV-1480 outside of the Greater China territory.

Emrelis (telisotuzumab vedotin-tllv) is an approved medicine being investigated for additional uses. Safety and efficacy have not been established for these unapproved additional uses.

(Press release, AbbVie, AUG 21, 2026, View Source [SID1234670272])

On August 21, 2026 Ipsen (Euronext: IPN; ADR: IPSEY) reported it has completed the acquisition of Kartos Therapeutics, a clinical-stage biopharmaceutical company adding late-stage MDM2 inhibitor navtemadlin in Phase III clinical development in myelofibrosis.

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About navtemadlin
Navtemadlin is an investigational oral MDM2 inhibitor being developed as an add-on therapy to ruxolitinib for patients with myelofibrosis who have a suboptimal response to ruxolitinib. The Phase III POIESIS study is evaluating whether the addition of navtemadlin could improve clinical outcomes compared with ruxolitinib alone in this patient population. Early clinical data demonstrate navtemadlin has the potential to transform suboptimal responses to standard of care ruxolitinib into clinically meaningful responses in patients with intermediate and high risk TP53wt myelofibrosis, to provide both enhanced clinical outcomes and potential disease-modifying benefit.

About myelofibrosis
Myelofibrosis is a myeloproliferative neoplasm, frequently linked to alterations in the JAK/STAT pathway, in which patients develop bone marrow fibrosis due to the abnormal proliferation of hematopoietic stem cells and secretion of fibrogenic cytokines. As marrow function declines, blood production shifts to other organs, most often the spleen, leading to splenomegaly. Myelofibrosis is characterized by bone marrow failure, fibrosis, splenomegaly and a high symptom burden that can significantly affect quality of life, including fatigue, night sweats and other progressive symptoms. It also carries a risk of transformation to acute myeloid leukemia. The median age at diagnosis is approximately 67–69 years and the condition affects around 1.5 per 100,000 people in the U.S. and Europe. Approximately 75–89% of patients are intermediate- or high-risk at diagnosis and more than 95% are TP53wt. Ruxolitinib, a JAK inhibitor, is the first-line standard of care; however, it is estimated that a significant proportion of patients have an initial suboptimal response and approximately 50%-75% discontinue treatment after three years. Median overall survival is typically one to two years after treatment discontinuation, underscoring the need for new strategies that can increase the number of patients that can achieve optimal clinical outcomes.

(Press release, Ipsen, AUG 21, 2026, View Source [SID1234670270])

On August 20, 2026 Radiopharm Theranostics (ASX: RAD, Nasdaq: RADX, "Radiopharm" or the "Company"), a clinical-stage biopharmaceutical company focused on developing innovative oncology radiopharmaceuticals for areas of high unmet medical need, reported that it has received a positive recommendation from the Data Safety and Monitoring Committee (DSMC) to advance its clinical-stage radiotherapeutic asset, 177Lu-RAD202 (RAD202), to the next dose level of 180mCi in the Phase 1 ‘HEAT’ clinical trial in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-positive advanced solid tumors1. The DSMC is a multidisciplinary committee that conducts detailed reviews of study data, discusses potential safety events and provides recommendations regarding trial continuation.

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"Advancing RAD202 into Cohort 4 marks a significant step forward in the development of one of our most promising therapeutic candidates," said Riccardo Canevari, CEO and Managing Director of Radiopharm Theranostics. "The DSMC’s recommendation supports the favorable safety profile observed to date and allows us to continue evaluating higher dose levels in patients with HER2-positive advanced solid tumors. As we execute on our clinical development strategy, we remain focused on unlocking the full potential of RAD202 and generating meaningful data that could support a differentiated radiotherapeutic option for HER2-positive patients in need of new treatment alternatives."

The Phase 1 ‘HEAT’ study is currently being conducted at clinical centers across Australia. The announcement of the previous dose level in this study of 130mCi was released on 8 April 2026.

About 177Lu-RAD202:

RAD202 is a proprietary single-domain monoclonal antibody (sdAb) that targets the Human Epidermal Growth Factor Receptor 2 (HER2)-positive expression in advanced solid tumors. HER2 is overexpressed in breast cancer and several other solid tumors and represents a validated target in oncology. In a previous diagnostic study of ten HER2-positive breast cancer patients, RAD202 demonstrated clinical proof-of-concept and had positive safety and biodistribution.

(Press release, Radiopharm Theranostics, AUG 20, 2026, View Source [SID1234670267])

On August 20, 2026 Adagene Inc. (Nasdaq: ADAG) a platform-driven, clinical-stage biotechnology company transforming the discovery and development of novel antibody-based therapies, reported that senior management will participate in three upcoming investor conferences taking place in New York, New York.

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2026 Cantor Global Healthcare Conference; New York, NY – September 9-11, 2026

Format: 1×1 Meetings
Date/Time: September 11, 2026
Morgan Stanley 24th Annual Global Healthcare Conference; New York, NY – September 14-16, 2026

Format: Fireside Chat and 1×1 Meetings
Fireside Chat Date/Time: September 15, 2026, 10:45–11:20 AM (Eastern Time)
H.C. Wainwright 28th Annual Global Investment Conference; New York, NY – September 14-16, 2026

Format: Fireside Chat and 1×1 Meetings
Fireside Chat Date/Time: September 16, 2026, 9:00–9:30 AM (Eastern Time)
If you are interested in meeting with Adagene management during the conferences, please reach out to your representative for each respective conference.

Webcasts of the fireside chats will be accessible in the Investors section of the Company’s website at View Source for at least 30 days following each of the conferences.

(Press release, Adagene, AUG 20, 2026, View Source [SID1234670266])

On August 20, 2026 Artelo Biosciences, Inc. (Nasdaq: ARTL) ("Artelo" or the "Company"), a clinical-stage pharmaceutical company focused on modulating lipid-signalling pathways to develop treatments for people living with cancer, pain, dermatologic, or neurological conditions, reported that the Japanese Patent Office has issued a notification of allowance with a Decision to Grant for the Company’s patent application covering the intended commercial formulation of ART27.13, Artelo’s peripherally selective dual cannabinoid agonist currently being evaluated in two Phase 2 clinical trials.

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The allowed claims in Japan protect compositions of ART27.13 dispersed in polyethylene glycol. These claims are consistent with those previously allowed in the United States and Europe, and all jurisdictions are expected to provide patent protection through 2041. This brings Artelo’s intellectual property estate for ART27.13 to issued or allowance status in three major pharmaceutical markets, the United States, Japan, and Europe, and further strengthens the program’s global IP position while supporting its long-term commercial potential.

"Receiving this allowance decision in Japan represents another important advancement in our global intellectual property and clinical development strategy for ART27.13," said Gregory D. Gorgas, President and Chief Executive Officer of Artelo Biosciences. "The innovator of our investigational drug, AstraZeneca, previously conducted a Phase 1 safety study with ART27.13 in Japan, with no major safety or tolerability concerns, and had concluded the plasma exposure and adverse event profiles were comparable between Japanese and Caucasian participants." ART27.13 was fully licensed to Artelo in 2019.

Currently being evaluated in the Phase 2 portion of CAReS targeting cancer-related anorexia, ART27.13 was well-tolerated in the Phase 1 stage and showed early signs of stabilizing or reversing weight loss in more than 60% of participants. Interim results from the CAReS Phase 2 demonstrated the ability of the drug to reverse cancer-related anorexia in all patients taking the highest dose of 1300 µg whereas the all the participants on placebo continued to lose weight throughout the study.

ART27.13 is also being evaluated in the DREAM study, a pilot Phase 2 in people with glaucoma or ocular hypertension. Funded by Glaucoma UK and the HSC R&D Division in the UK, the investigator-led study is evaluating ART27.13’s potential at a 600 µg orally administered daily dose to reduce intraocular pressure, alongside additional assessments of visual acuity, body weight, mood, safety and tolerability. Initial results are anticipated in the fourth quarter of this year.

"With allowances now secured in the United States, Europe and Japan for claims covering our intended commercial formulation, we believe we have established a strong foundation for ART27.13 across three of the world’s major pharmaceutical markets. This growing patent estate further enhances the strategic and commercial value of the program as ART27.13 advances in multiple potential indications," concluded Mr. Gorgas.

About ART27.13
ART27.13 is a dual cannabinoid agonist and novel benzimidazole derivative. Initially developed by AstraZeneca plc, ART27.13 has been in over seven clinical studies with nearly 300 participants. It is primarily being developed as a once-daily, orally administered agent selectively targeting peripheral CB1 and CB2 receptors, with the potential to reduce muscle degeneration while improving body weight, appetite, and quality of life in cancer patients. Importantly, the drug enables systemic metabolic effects while minimizing central nervous system-mediated toxicity. Artelo is conducting a Phase 2 named the Cancer Appetite Recovery Study (CAReS) evaluating ART27.13 as a supportive care therapy for cancer patients suffering from anorexia and weight loss. Interim Phase 2 data revealed patients who had lost at least 5% of body weight to be included in CAReS and titrated to the highest ART27.13 dose (1300 µg) achieved an average +6% weight gain over 12 weeks, while patients on placebo lost an additional ~5%. Currently, there is no FDA approved treatment for cancer anorexia cachexia syndrome. In addition to CAReS, ART27.13 is also being evaluated in a Phase 2 study in people with glaucoma, called the DREAM study. In DREAM, ART27.13 is administered orally at a daily dose of 600 µg.

(Press release, Artelo Biosciences, AUG 20, 2026, View Source [SID1234670265])