On August 11, 2026 Gibson Oncology, a clinical-stage oncology company developing blood-brain-barrier-penetrant therapies for brain tumors and other difficult-to-treat cancers, reported that the first patient in the Phase II clinical trial of LMP744 has been enrolled and has completed the initial treatment cycle without complication. The trial is being conducted by investigators at the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, and is evaluating LMP744 as a single agent in patients with recurrent glioblastoma (GBM). Gibson Oncology is providing partial funding and LMP744 to the trial under a Clinical Cooperative Research and Development Agreement (CRADA) with NINDS.

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LMP744 is a novel, dual-acting anticancer agent that works by reducing overexpression of the cMyc oncogene and by inhibiting topoisomerase 1 (TOPO1), two validated targets across a range of solid and hematological cancers.

Glioblastoma is the most common and aggressive primary brain tumor in adults. Approximately 13,000 new cases are diagnosed in the United States each year, median survival is generally 15 to 18 months, and the five-year survival rate is under 10 percent. Recurrent glioblastoma, for which there is no established standard of care, carries an especially poor prognosis.

In preclinical studies, LMP744 crossed the blood-brain barrier and achieved brain concentrations approximately 10 times the level needed to kill cancer cells, with a half-life in the brain exceeding 24 hours for each dose. Blood-brain-barrier penetration has long been one of the central obstacles in the treatment of brain tumors.

The Phase II trial is designed to enroll a total of 40 first-time recurrent GBM patients with a Karnofsky Performance Status (KPS) of 60 or better, with a primary endpoint of progression-free survival and a secondary endpoint of overall survival. LMP744 is being studied as a single therapeutic agent based on the strong anticancer effects observed in GBM patient-derived xenograft (PDX) animal models.

LMP744 has previously completed one Phase I clinical trial with 36 patients in heavily pretreated cancer patients, many of whom had failed as many as eight prior individual or combination treatments. Over 30% of the patients on single agent treatment with LMP744 experienced stable disease for up to 30 months and 2 patients were partial responders, even as many patients were sub-optimally dosed to establish the drug’s safety and tolerability before reaching the therapeutic dose level of 190 mg/m2.

"Completing the first treatment cycle in this trial is an important early milestone for LMP744 and, most of all, for the patients who face recurrent glioblastoma with limited therapeutic options, and one of the most difficult cancers in medicine," said Randall Riggs, President and Chief Executive Officer of Gibson Oncology. "We are grateful to the clinical team at NINDS and to the patients and families taking part in this study, and we look forward to advancing LMP744 as a potential breakthrough treatment in an area that has experienced little improvement in treatment options for decades."

Mr. Riggs continued, "The renewed excitement about LMP744 is two-fold. First, LMP744 was found to migrate rapidly into the brain at high concentrations, well beyond the levels needed to kill cancer, with each dose having a half-life of over 24 hours. Second, in PDX animal models implanted with patient-derived recurrent gliomas, just five doses of LMP744 produced tumor eradication. Together, these findings made a compelling case for initiating this Phase II study at the NINDS."

About LMP744

LMP744 is a novel, dual-acting indenoisoquinoline that reduces cMyc overexpression and inhibits topoisomerase 1 (TOPO1). In preclinical studies, it has demonstrated blood-brain-barrier penetration and sustained brain exposure. LMP744 has been granted Orphan Drug Designation by the U.S. Food and Drug Administration for all gliomas, including DIPG.

(Press release, Gibson Oncology, AUG 11, 2026, https://www.globenewswire.com/news-release/2026/08/11/3342662/0/en/gibson-oncology-announces-first-patient-completes-initial-treatment-cycle-in-phase-ii-trial-of-lmp744-for-recurrent-glioblastoma.html [SID1234669976])

On August 11, 2026 SL Science Holding Limited ("SL Science" or the "Company") (Nasdaq: SLBT), a Taiwan-headquartered biomedical company specializing in developing innovative cellular and gene therapies, reported the publication of a peer-reviewed article in Biomedicines. Co-authored by SL Science leadership and clinical researchers from Taipei Medical University, the article outlines a rigorous development framework for γδ T cell therapy in glioblastoma –a common and aggressive primary brain cancer in adults. Beyond reviewing existing literature, the paper outlines the specific clinical trial designs, biological measurements, and testing conditions required to rigorously evaluate γδ T cell therapies in future human trials.

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Strategic Impact on SL Science’s Business and Research

The publication serves as an industry roadmap while validating SL Science’s overarching business strategy and research direction. Glioblastoma remains notoriously difficult to treat because tumors rapidly mutate and evade traditional therapies aimed at a single target. In contrast, γδ T cells recognize cancer through universal stress signals rather than single antigens, target the stem-like cells responsible for tumor recurrence, and carry a low risk of graft-versus-host disease. This unique biology makes them suited for allogeneic, "off-the-shelf" manufacturing from healthy donors and repeated localized delivery directly to the brain, which is a model that directly mirrors SL Science’s FDA Drug Master File-backed platform. By publishing this framework alongside clinical researchers, SL Science establishes a clear standard of evidence for its own pipeline, supporting the design of future clinical programs to evaluate whether cells successfully reach, persist, and function within the tumor.

Translating Lab Science into Clinical Reality

To bridge the gap between promising laboratory data and actual patient outcomes, the framework outlines key operational shifts for clinical research. The authors stress that early-phase trials must embed quantitative cell-tracking and serial pharmacodynamic sampling to determine whether a treatment outcome is driven by cellular delivery, persistence, or functional exhaustion. Furthermore, cellular potency must be tested under realistic, low-oxygen and low-glucose tumor conditions rather than ideal laboratory environments. The article also supports direct, repeated delivery to the tumor cavity as a practical method to overcome the blood-brain barrier, while cautioning that trial endpoints should focus on verifiable biological activity before attempting to prove overall survival benefits in small, early-stage cohorts.

Management Commentary

"Glioblastoma has repeatedly defeated therapies that looked convincing in preclinical models. The clear lesson is that progress depends on rigorous evidence generation in humans, not further laboratory speculation," said Mr. William Wang, Chairman and Chief Executive Officer of SL Science. "This publication defines what we believe the next phase of development must look like: clinical trials designed from day one to show whether these cells reach the tumor, remain viable, and execute their therapeutic function. Translating this science into actionable clinical proof is our core focus, and our technology is advancing and evolving alongside new clinical discoveries. We intend our own programs to meet the exact standard we have set out here."

Clinical Context and Regulatory Disclosures

The article maintains a transparent assessment of current clinical evidence, noting that γδ T cell therapy in glioblastoma remains investigational. The publication represents an independent narrative review co-authored by company leadership in their personal scientific capacities; it received no external funding, was conducted independently of any commercial product, and does not evaluate or endorse any specific proprietary SL Science candidate.

(Press release, SL Science, AUG 11, 2026, View Source [SID1234669975])

On August 11, 2026 RenovoRx, Inc. ("RenovoRx" or "the Company") (Nasdaq: RNXT), a life-sciences company developing innovative targeted oncology therapies and commercializing RenovoCath, a patented, FDA-cleared drug-delivery device, reported completion of enrollment in the Company’s Phase III TIGeR-PaC trial in locally advanced pancreatic cancer (LAPC).

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As of August 7, 2026, TIGeR-PaC trial investigators have been notified by RenovoRx that patient enrollment is closing. Completion of the trial is expected during the first half of 2027, after 86 events (i.e., patient deaths) have been observed. As of August 11, 2026, 78 events have occurred. Following completion of the trial, initial top line trial data is expected to be available during the second half of 2027.

This significant milestone reflects successful patient recruitment, clinical execution, and collaboration among investigators and study teams evaluating intra-arterial gemcitabine (IAG) via RenovoCath delivered through RenovoRx’s Trans-Arterial Micro-Perfusion (TAMP) platform as a novel drug-device product candidate for difficult-to-treat LAPC. The primary endpoint of the study is overall survival. TIGeR-PaC is designed to evaluate whether RenovoRx’s patented method of targeted delivery of the chemotherapy gemcitabine improves patient survival, safety, and tolerability compared to the standard of care (systemic (intravenous) chemotherapy gemcitabine + Abraxane).

Pancreatic cancer continues to represent a major unmet medical need, with limited treatment options and current standards of care centered largely on systemic chemotherapy, which can cause significant toxicity and related side effects for patients. TAMP is designed to deliver chemotherapy directly near the tumor site while potentially reducing systemic exposure.

"The TIGeR-PaC Phase III study represents an exciting step forward in the treatment of LAPC," said Hassan Hatoum, MD Associate Professor of Medicine Medical Director, GI Oncology Disease Site Chair, GI Oncology Disease Site Group Stephenson Cancer Center University of Oklahoma Health Sciences Center and principal investigator at the University of Oklahoma Health for the TIGeR-PaC trial. "For far too long, patients with LAPC have had limited options beyond systemic chemotherapy. This novel treatment approach offers hope by adding an innovative, locoregional and targeted intervention that has the potential to improve outcomes beyond the current standard of care. The preliminary results of this study have been encouraging and reinforce the importance of continuing to explore new strategies for this challenging disease."

Dr. Hatoum continued, "What makes this approach particularly promising is its adaptability. Because the FDA-approved RenovoCath device administers chemotherapy directly near the tumor, it can continue to be integrated with a systemic therapy protocol regardless of how standard systemic treatment evolves in the future, this provides a versatile platform that can remain relevant as new chemotherapy regimens and targeted therapies emerge."

"I am proud to be part of the Phase III trial evaluating IAG, working alongside an exceptional multidisciplinary team committed to advancing care for patients with LAPC. Together, we are developing innovative treatment strategies that have the potential to improve outcomes and quality of life for our patients. Beyond pancreatic cancer, this novel platform also offers hope for expanding targeted regional chemotherapy delivery to other cancers, potentially opening new therapeutic opportunities across multiple solid tumors," concluded Dr. Hatoum.

"Completing enrollment in the Phase III TIGeR-PaC trial marks a major milestone for RenovoRx," said Ramtin Agah, M.D., Executive Chairman, Chief Medical Officer, and Founder of RenovoRx. "TIGeR-PaC is the cornerstone of our clinical development program, and we are now closer than ever in our efforts to validate IAG and its efficacy through rigorous, long-term evaluation. We thank the participating clinical sites, the patients and their families for their dedication, support, and trust in this important study. With enrollment complete, we are now focused on advancing toward completion and data analysis. We believe TIGeR-PaC will provide meaningful additional validation of our TAMP therapy platform in an area with significant unmet need and limited therapeutic progress. The validation of this approach both in terms of tolerability and efficacy should provide additional tools for clinicians to offer patients in this challenging disease."

The study’s enrollment was supported by participation from nationally recognized cancer centers and academic medical institutions across the United States, including Johns Hopkins Medicine, University of Pittsburgh Medical Center, UT Southwestern Medical Center, University of Nebraska Medical Center, Baptist Health South Florida, Stephenson Cancer Center at the University of Oklahoma, and more.

The study has also progressed through two independent interim analyses triggered following the 26th event in 2023 and the 52nd event in 2025, with the study’s independent Data Monitoring Committee (DMC) recommending continuation of the trial on both occasions. Together, these accomplishments reflect the successful execution of RenovoRx’s lead clinical program and support continued evaluation of its proprietary TAMP therapy platform.

About RenovoCath
Based on its FDA clearance, RenovoCath is intended for the isolation of blood flow and delivery of fluids, including diagnostic and/or therapeutic agents, to selected sites in the peripheral vascular system. RenovoCath is also indicated for temporary vessel occlusion in applications including arteriography, preoperative occlusion, and chemotherapeutic drug infusion. For further information regarding our RenovoCath Instructions for Use ("IFU"), please see: IFU-10004-Rev.-G-Universal-IFU.pdf.

About the TIGeR-PaC Clinical Trial
TIGeR-PaC is an ongoing Phase III randomized multi-center trial evaluating the proprietary TAMP (Trans-Arterial Micro-Perfusion) therapy platform for the treatment of locally advanced pancreatic cancer (LAPC). RenovoRx’s first investigational drug-device combination product candidate, using the TAMP therapy platform enabled with the Company’s FDA-cleared RenovoCath device, is designed for the intra-arterial administration of chemotherapy, gemcitabine (IAG).

(Press release, Renovorx, AUG 11, 2026, View Source [SID1234669974])

On August 11, 2026 BridgeBio Oncology Therapeutics, Inc. ("BBOT") (Nasdaq: BBOT), a clinical-stage biopharmaceutical company focused on RAS-pathway malignancies, reported financial results for the second quarter ended June 30, 2026, and provided a business update.

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BBOT’s portfolio of RAS-pathway inhibitors is designed to enable direct dual inhibition of KRASG12C (BBO-8520), or KRASG12D/V (BBO-11818) in both its ON and OFF states as well as disruption of RAS-driven PI3Kα activation (BBO-10203) to achieve optimal target coverage of the most mutated driver oncogene in human cancer. Together, these assets uniquely position BBOT to achieve concurrent, high-level suppression of both the MAPK and PI3Kα pathways through a wholly-owned internal combination strategy.

"During the second quarter, we made meaningful progress in patient enrollment in our monotherapy and combination cohorts across each of our three clinical programs. Differentiated patient benefit in oncology is driven by optimal target coverage and the ability to combine with standard-of-care regimens. Therefore, we continue to focus heavily on advancing our combination development strategies," said Pedro J. Beltran, Ph.D., Chief Executive Officer of BBOT. "In addition, our wholly-owned portfolio is uniquely positioned to enable concurrent suppression of the MAPK and PI3Kα pathways through internal combination strategies of each of our KRAS inhibitors with BBO-10203. We are excited to have both combinations already underway in patients. With multiple near-term clinical milestones across all programs expected in the second half of 2026 and cash runway into 2028, we believe we are well positioned to execute our strategy and expand treatment options for patients with mutant KRAS-driven cancers."

Key Program Highlights and Updates

BBO-8520: An orally bioavailable small molecule direct inhibitor targeting both the ON and OFF states of KRASG12C.

Continued to enroll BBO-8520 plus pembrolizumab combination in patients with NSCLC carrying KRASG12C mutation.
Initiated BBO-8520 plus BBO-10203 combination in patients with G12C NSCLC.

BBO-11818: An orally bioavailable small molecule pan-KRAS inhibitor that targets mutant KRAS in both the ON and OFF states.

Continued to enroll BBO-11818 monotherapy across multiple dose levels.
Initiated dosing of BBO-11818 in combination with cetuximab.
Subsequent to the end of the quarter, initiated dosing of BBO-11818 in combination with BBO-10203.
Presented preclinical data at AACR (Free AACR Whitepaper) highlighting the potency of BBO-11818 in KRASG12D and KRASG12V CDX models, potent combination effect with cetuximab or BBO-10203, and complete tumor regressions through adaptive immunity in combination with anti PD-1 antibodies.

BBO-10203: An orally bioavailable small molecule with a novel mechanism of action designed to block the physical interaction between RAS and PI3Kα, inhibiting RAS-driven PI3Kα-AKT signaling in tumors.

Continued to enroll HR+ BC, HER2+/HR- BC, and colorectal (CRC) combination cohorts.
Presented preclinical data at AACR (Free AACR Whitepaper) showing that BBO-10203 demonstrated strong in vivo combination effect with HER2 inhibitors tucatinib or trastuzumab in HER2amp tumor models.

Second Quarter 2026 Financial Results

Cash Position: As of June 30, 2026, BBOT had cash, cash equivalents and marketable securities totaling $344.1 million, which is expected to provide cash runway into 2028.
Research and development (R&D) expenses: R&D expenses were $49.2 million for the second quarter of 2026 compared to $27.4 million for the second quarter of 2025. The increase in expenses was primarily due to increases in clinical trial expenses and manufacturing expenses for BBO-8520, BBO-11818, and BBO-10203.
General and administrative (G&A) expenses: G&A expenses were $11.0 million for the second quarter of 2026 compared to $2.7 million for the second quarter of 2025. The increase in G&A expenses reflects the initiation of BBOT’s standalone operations, de-SPAC transaction, and one-time severance costs for former executives.
Net Loss: Net loss was $56.5 million for the second quarter of 2026 compared to $28.4 million for the second quarter of 2025.

(Press release, BridgeBio Oncology Therapeutics, AUG 11, 2026, View Source [SID1234669973])

On August 11, 2026 Apollomics Inc. (Nasdaq: APLM) ("Apollomics" or the "Company"), a late-stage clinical biopharmaceutical company developing multiple oncology drug candidates to address difficult-to-treat and treatment-resistant cancers, reported that it has entered into definitive subscription agreements (the "Subscription Agreements") for a private placement transaction (the "Private Placement") with certain accredited investors (the "Investors"), for an aggregate gross consideration of approximately $10.0 million. The Private Placement is expected to close on or about August 14, 2026, subject to the satisfaction of customary closing conditions.

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The Private Placement comprises the issuance of an aggregate of up to 700,001 Class A ordinary shares, par value $0.01 per share, of the Company (the "Class A Shares") under the following tranches:

Cash Investment: Cash subscriptions for an aggregate of 533,334 Class A Shares at a purchase price of $15.00 per share, generating aggregate gross cash proceeds of approximately $8.0 million before fees and expenses.

Note Conversion: The automatic conversion of the outstanding $2.0 million principal amount of that certain unsecured Convertible Promissory Note, dated March 30, 2026, held by Mr. Hung-Wen (Howard) Chen, the Company’s Chairman and Chief Executive Officer. Pursuant to the terms of the Note, the conversion price is set at $12.00 per share, representing 80% of the purchase price paid by cash investors in the PIPE Transaction, resulting in the issuance of 166,667 Class A Shares at closing.

The cash portion of the Private Placement includes participation from certain unaffiliated accredited investors, as well as several of the Company’s executive officers and directors (or their affiliates), including Chief Executive Officer Hung-Wen (Howard) Chen, Chief Financial Officer Peter Kuan-How Lin, and Maxpro Investment Co., Ltd. (an affiliate of Chief Operating Officer Yi-Kuei (Alex) Chen).

No placement agents or underwriters were utilized in connection with the Private Placement, and no finder’s fees or commissions are payable.

The Class A Shares to be issued in the Private Placement have not been registered under the Securities Act of 1933, as amended (the "Securities Act"), or any state or other applicable jurisdiction’s securities laws, in reliance on the exemption from registration provided by Section 4(a)(2) of the Securities Act and/or Rule 506 of Regulation D promulgated thereunder, or under any state securities laws. The Company relied on this exemption from registration based in part on representations made by the Investors. The securities may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements. The Investors have agreed that all Class A Shares issued at closing will be restricted securities subject to customary holding periods under Rule 144.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy any securities of Apollomics Inc., nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

(Press release, Apollomics, AUG 11, 2026, View Source [SID1234669972])