On September 2, 2026 SELLAS Life Sciences Group, Inc. (NASDAQ: SLS) ("SELLAS’’ or the "Company"), a late-stage clinical biopharmaceutical company focused on the development of novel therapies for a broad range of cancer indications, reported that three abstracts evaluating SLS009 (tambiciclib), a potent, selective CDK9 inhibitor, in preclinical models of pancreatic ductal adenocarcinoma (PDAC) have been accepted for poster presentation at the AACR (Free AACR Whitepaper) Conference on Pancreatic Cancer: New Frontiers in Biology and Therapeutic Development. The conference will be held September 25–28, 2026, at the Hilton San Diego Bayfront in San Diego, CA.

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"Pancreatic cancer remains one of the most difficult solid tumors to treat, with a significant need for new therapeutic approaches," said Angelos Stergiou, MD, ScD h.c., President and Chief Executive Officer of SELLAS. "The acceptance of three abstracts evaluating SLS009 across patient-derived organoid models reflects the breadth of our preclinical work in PDAC. We look forward to sharing these findings with the pancreatic cancer research community and discussing their potential implications for the further development of SLS009 in solid tumors."

Jeremy D. Kratz, MD, Assistant Professor of Medicine & Principal Investigator, University of Wisconsin-Madison commented: "These studies are designed to deepen our understanding of the mechanistic and translational rationale for CDK9 inhibition in pancreatic cancer. The presentations will explore the potential for SLS009 to create synthetic lethal interactions through rational combinations with BET- and KRAS-directed approaches, as well as its potential to exploit MYC-associated vulnerabilities. We look forward to sharing this work with the scientific community later this month."

Poster presentation details:
Title: Elucidating MYC allelic imbalance and therapeutic response in pancreatic ductal adenocarcinoma via patient-derived organoids
Authors: Sawyer AG, Flannagan LE, Esguerra PN, Hossan MS, Kratz JD
Poster Number: A036

Title: Synthetic Lethality Through Combined BET and CDK9 Inhibition in MYC-Amplified Pancreatic Ductal Adenocarcinoma
Authors: Esguerra PN, Cadarso M, Livingwell S, Hossan MD, Wong O, Kratz JD
Poster Number: B127

Title: Targeting dual CDK9 and KRASG12D selective inhibition as a novel combination therapy in pancreatic ductal adenocarcinoma
Authors: Cadarso M, Esguerra P, Flannagan L, Hossan MS, Kratz JD
Poster Number: B043

(Press release, Sellas Life Sciences, SEP 2, 2026, View Source [SID1234670542])

On September 2, 2026 Black Diamond Therapeutics, Inc. (Nasdaq: BDTX), a clinical-stage oncology company developing MasterKey therapies that target families of oncogenic mutations in patients with cancer, including silevertinib, a potential best-in-class brain-penetrant epidermal growth factor receptor (EGFR) inhibitor, reported that its Chief Scientific Officer, Elizabeth Buck, Ph.D., will participate in a fireside chat at the H.C. Wainwright 28th Annual Global Investment Conference on September 15, 2026, in New York, NY. In addition, the Company will host one-on-one meetings with investors on the same day.

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Presentation details are as follows:

10:00-10:30am ET on Tuesday, September 15
The Webcast will be available at the start of the presentation under "Events and Presentations" on the Investors section of the Company’s website, www.blackdiamondtherapeutics.com. A replay of the webcast will also be available and archived for 90 days following the event.

About Silevertinib

Silevertinib is an investigational oral, covalent, brain-penetrant fourth-generation tyrosine kinase inhibitor (TKI) that has demonstrated best-in-class CNS activity, selectively targeting classical and more than 50 non-classical EGFR mutations in NSCLC. It is also designed to potently inhibit key EGFR alterations seen in GBM, including EGFRvIII, while avoiding the paradoxical EGFR activation reported with reversible TKIs. To date, over 200 patients with EGFRm NSCLC or EGFR-altered GBM have been treated with silevertinib.

In addition to the ongoing Phase 2 trial of silevertinib in patients with non-classical EGFRm NSCLC, the Company also initiated a randomized Phase 2 trial of silevertinib in patients with newly diagnosed EGFRvIII-positive GBM (NCT07326566) in May 2026.

(Press release, Black Diamond Therapeutics, SEP 2, 2026, View Source [SID1234670541])

On September 2, 2026 Kyverna Therapeutics, Inc. (Nasdaq: KYTX), a late-stage clinical immunology company pioneering transformative therapies for people with neurologic autoimmune diseases, reported that company management will present at the following upcoming conferences:

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2026 Wells Fargo Healthcare Conference
Format: Fireside chat and investor meetings
Date: Wednesday, September 9th, 2026
Time: 4:30 p.m. ET

Morgan Stanley 24th Annual Global Healthcare Conference
Format: Fireside chat and investor meetings
Date: Monday, September 14th, 2026
Time: 4:05 p.m. ET

H.C. Wainwright 28th Annual Global Investment Conference
Format: Fireside chat and investor meetings
Date: Tuesday, September 15th, 2026
Time: 11:30 a.m. ET

Live webcasts of the presentations may be accessed via the Investors section of the Kyverna website at ir.kyvernatx.com. Archived replays of all events will be available on the website for approximately 90 days following the conference.

(Press release, Kyverna Therapeutics, SEP 2, 2026, View Source [SID1234670540])

On September 2, 2026 Transgene (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapies for the treatment of cancer, and NEC Corporation (NEC; TSE: 6701), a leader in IT, network and AI technologies, reported sustained 100% three-year disease-free survival (DFS) in patients treated with TG4050 in the Phase 1 part of a randomized Phase 1/2 trial evaluating TG4050, the first individualized neoantigen therapeutic vaccine (INTV) based on the myvac platform, in patients with resected, locally advanced HPV-negative head and neck squamous cell carcinoma (HNSCC).

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The companies also announced the publication of the Phase 1 comprehensive clinical and translational data from the study, for the first time in the peer-reviewed journal Nature Communications.

Three-year follow-up data from the Phase 1 trial continue to demonstrate durable clinical outcomes in the adjuvant setting, with all 16 TG4050-treated patients remaining disease-free while three of 16 patients in the control arm experienced relapse after a median follow-up of 41 months. TG4050, encoding up to 30 patient-specific neoantigens, also continues to demonstrate a favorable safety profile with no unexpected safety findings.

The peer-reviewed publication builds on the Phase 1 results first shared with the scientific community through a prepublication on medRxiv and presents comprehensive clinical and translational findings based on the study’s primary data cut-off, including detailed analyses of vaccine-induced immune responses. Together, the clinical and translational findings provide further evidence supporting TG4050 as a potential individualized immunotherapy for patients with head and neck cancer at high risk of relapse following surgery and (chemo)-radiotherapy.

"The publication of these data in Nature Communications, together with the sustained three-year disease-free survival observed with TG4050 monotherapy, represents an important milestone for Transgene," commented Alessandro Riva, MD, Chairman and Chief Executive Officer of Transgene. "Beyond the encouraging clinical outcomes, the sustained neoantigen-specific immune responses observed over time provide important evidence that our individualized therapeutic vaccine approach can generate durable anti-tumor immunity, strengthening our confidence in TG4050 as a potential new treatment option for head and neck cancer patients at high risk of relapse."

"The latest three-year follow-up data further reinforce the ability of individualized neoantigenbased immunotherapy and the capacity of TG4050 to deliver continued clinical benefit for patients with head and neck cancer," said Masaki Kondo, Corporate Executive and Managing Director, Life Science Division of NEC Corporation. "These results additionally demonstrate that NEC’s AI-powered neoantigen prediction can identify highly relevant tumor targets capable of generating clinically meaningful immune responses. We are proud of our collaboration with Transgene and remain committed to advancing innovative technologies that help bring individualized cancer treatments to patients."

The Phase 1 clinical and translational data published in Nature Communications demonstrate robust and persistent neoantigen-specific CD8+ T-cell responses consistent with the proposed vaccine’s mechanism of action. Vaccine-induced responses were detected in 73.3% of patients treated with TG4050, with a median of three responding neoantigens per responder. These responses were maintained throughout treatment and persisted for more than one year after the last vaccination, providing evidence of durable anti-tumor immunity.

"Robust and persistent CD8+ T-cell responses against patient-specific tumor neoantigens were observed following TG4050 vaccination, supporting the vaccine’s ability to generate a targeted anti-tumor immune response. These results further reinforce the potential of TG4050 as an individualized immunotherapy for patients with head and neck cancer at risk of recurrence for whom there is a major unmet need," added Prof. Christian Ottensmeier, MD, PhD, FRCP, University of Liverpool, La Jolla Institute for Immunology and Principal Investigator.

TG4050 continues to be evaluated in the ongoing randomized Phase 1/2 clinical trial (NCT04183166) in patients with resected HNSCC. Key upcoming milestones include first immunological data and two-year efficacy data (DFS) from the Phase 2 study respectively in H2 2026 and Q1 2028.

(Press release, Transgene, SEP 2, 2026, View Source [SID1234670538])

On September 2, 2026 Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP) ("Tonix" or the "Company"), a fully integrated, commercial-stage biopharmaceutical company, reported that the management team will participate in a fireside chat and 1x1s at Cantor’s 2026 Global Healthcare Conference, being held September 9-11, 2026, in New York.

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Cantor’s 2026 Global Healthcare Conference
Fireside Chat
Presenter: Seth Lederman, M.D., President and Chief Executive Officer of Tonix Pharmaceuticals
Date: September 10, 2026
Presentation Time: 3:55-4:25 p.m. ET

A live webcast and replay will be available under the News & Events tab in the Investors section of the Tonix website at View Source

(Press release, TONIX Pharmaceuticals, SEP 2, 2026, View Source [SID1234670537])