On September 29, 2026 Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of targeted protein degradation medicines, reported the achievement of a $7 million research milestone under its strategic collaboration with Pfizer for the discovery and development of degrader antibody conjugates (DACs).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Nurix entered into the collaboration with Seagen Inc., now part of Pfizer, in September 2023. Under the terms of the agreement, Nurix received an upfront payment of $60 million and became eligible to receive up to $3.4 billion in potential research, development, regulatory and commercial milestone payments across multiple programs, as well as mid-single-digit to low-double-digit percentage tiered royalties on future product sales. Nurix also retains an option for U.S. profit sharing and co-promotion on up to two products arising from the collaboration. In connection with today’s announcement, Nurix will receive a $7 million milestone payment from Pfizer, which will bring the total amount received under this agreement to $82 million.

About Degrader Antibody Conjugates (DACs)
DACs are an emerging therapeutic modality designed to combine the cell and tissue selectivity of antibodies with the catalytic mechanism of targeted protein degraders. Unlike traditional antibody-drug conjugates (ADCs), which typically deliver cytotoxic payloads to antigen-expressing cells, DACs deliver targeted protein degraders designed to eliminate specific disease-driving proteins. This approach has the potential to provide multiple layers of selectivity based on cell-surface antigen expression, the intracellular protein target and E3 ligase expression.

(Press release, Nurix Therapeutics, SEP 29, 2026, View Source [SID1234671174])

On September 29, 2026 Veracyte, Inc. (Nasdaq: VCYT), a leading cancer diagnostics company, reported that new findings from a retrospective ancillary analysis of the randomized phase III NRG/RTOG 0815 trial will be presented at the 2026 American Society for Radiation Oncology (ASTRO) Annual Meeting. The trial evaluated dose-escalated radiation with or without short-term androgen deprivation therapy (ADT) in men with intermediate-risk prostate cancer. The analysis showed that the Decipher Prostate Genomic Classifier can predict which patients are more likely to benefit from adding short-term ADT to dose-escalated radiation, providing both Level 1B1 prognostic and predictive evidence.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

In the study, patients with higher Decipher scores had substantially improved outcomes with the addition of short-term ADT to radiation, while patients with low Decipher scores derived minimal treatment benefit. These findings extend Decipher’s long-established role in assessing the risk of prostate cancer progression to informing treatment selection for patients with intermediate-risk disease. The results will be presented today at 3:55 p.m. ET in an oral session at the 2026 ASTRO Annual Meeting by Angela Jia, M.D., Ph.D., University Hospitals Seidman Cancer Center, Case Western Reserve University.

"For men with intermediate-risk prostate cancer, the question is not simply whether hormone therapy works — it is who truly needs it," said Angela Jia, M.D., Ph.D. "This analysis suggests tumor biology can distinguish patients who may achieve a substantial reduction in the risk of distant metastasis from those who may see little added benefit. That could help clinicians and patients make a more individualized decision about intensifying treatment."

While ADT can reduce the risk of recurrence and distant spread, it can also have metabolic and quality-of-life effects. Because intermediate-risk disease is biologically diverse, clinical variables such as Gleason grade, PSA or clinical stage may not reveal which patients are most likely to benefit from adding the therapy.

Key study findings:

Decipher predicted differential benefit from hormone therapy: The treatment-by-Decipher interaction for distant metastasis was statistically significant (p<0.001).
Patients with higher scores experienced substantially greater benefit: Among patients with intermediate/high Decipher scores, adding short-term ADT was associated with an 8% absolute reduction in distant metastasis at 10 years.
Patients with low scores did not have substantial benefit from short-term ADT: Among the 44% of patients with low Decipher scores, the absolute difference in 10-year distant metastasis was 1 percentage point and was not statistically significant.

Decipher also refined prognosis: Higher scores were independently associated with greater risk of biochemical failure, distant metastasis and prostate-specific mortality. Researchers analyzed tumor samples from 395 patients enrolled in NRG/RTOG 0815, with a median follow up of 10.2 years. The biomarker cohort was representative of the overall trial enrollment of 1,492 patients and was balanced between treatment arms. The Decipher score was both prognostic for disease outcomes and predictive of ADT benefit for both distant metastasis as well as prostate cancer specific mortality endpoints.

"For men with intermediate-risk prostate cancer, these findings provide predictive evidence that treatment decisions can be guided by the biology of each patient’s tumor, not simply a broad clinical risk category," said Daniel E. Spratt, M.D., chair of the Department of Radiation Oncology at University Hospitals Cleveland Medical Center, professor at Case Western Reserve University School of Medicine, and a study author. "Decipher may help identify who is likely to gain meaningful protection from metastasis by adding hormone therapy and who may face its health and quality-of-life effects with little added benefit. That is the kind of precision that patients and physicians need when deciding how aggressively to treat the cancer."

"These findings provide the first evidence that Decipher can predict which men with intermediate-risk prostate cancer are most likely to benefit from adding hormone therapy to radiation," said Elai Davicioni, Ph.D., Veracyte’s medical director, Urology. "This extends the Decipher test’s prognostic use toward answering a more consequential question: Will this treatment make a meaningful difference for this patient? By revealing the biology beneath a broad clinical risk category, Decipher may help physicians intensify treatment for patients most likely to benefit while potentially sparing others from side effects with little added benefit. With the addition of these findings, we believe that all men diagnosed with intermediate-risk prostate cancer may benefit from the use of Decipher in their care pathway."

ASTRO 2026 presentation details

Abstract #312: Genomic Stratification of Benefit from Short-Term Androgen Deprivation with Dose-Escalated Radiotherapy in Intermediate-Risk Prostate Cancer: An Ancillary Study of NRG/RTOG 0815

Session: SS 36 – Predicting Benefit and Toxicity: Biomarkers in Prostate Radiotherapy
Presenter: Angela Jia, M.D., Ph.D.
Date and time: Tuesday, September 29, 2026, 3:55–4:05 p.m. ET
Location: Room 210, Thomas M. Menino Convention & Exhibition Center, Boston

Another trial prospectively evaluating the use of the Decipher prostate test to guide treatment intensification or de-intensification is the phase III biomarker-driven NRG-GU010 (GUIDANCE) study, which completed enrollment earlier this year. This trial will build on the findings from the NRG/RTOG 0815 trial, further expanding the predictive evidence around the Decipher test in intermediate-risk disease.

About the NRG/RTOG 0815 analysis

NRG/RTOG 0815 was a randomized phase III trial evaluating the addition of short-term ADT to dose-escalated radiation in patients with intermediate-risk prostate cancer. In this NCI-approved ancillary analysis, archived diagnostic biopsy specimens were evaluated using the locked, clinical-grade 22-gene Decipher Genomic Classifier. The analysis included 395 patients with a median follow-up of 10.2 years. The primary endpoint was distant metastasis; secondary endpoints included biochemical failure, metastasis-free survival, prostate cancer-specific mortality and overall survival.

(Press release, Veracyte, SEP 29, 2026, View Source [SID1234671173])

On September 29, 2026 Ernexa Therapeutics (Nasdaq: ERNA), an industry innovator developing novel cell therapies for the treatment of advanced cancers, reported that the Company has been selected for the Emerging Track at the 2026 Cell & Gene Meeting on the Mesa, taking place October 5–7, 2026, in Mesa, Arizona. As part of this recognition, Chief Executive Officer Sanjeev Luther will deliver an Innovation Spotlight presentation on October 6, 2026, at 1:30 PM.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

During the presentation, Mr. Luther will showcase Ernexa’s differentiated off-the-shelf induced mesenchymal stem cell, or iMSC, platform and the Company’s progress toward becoming a clinical-stage oncology company. The presentation will focus on ERNA-101, Ernexa’s lead oncology cell therapy candidate, and the Company’s focused strategy to establish clinical proof of concept initially in platinum-resistant ovarian cancer, with the potential to expand ERNA-101 across the ovarian cancer treatment continuum and into additional solid tumor indications.

Mr. Luther will also highlight the differentiated characteristics of Ernexa’s synthetic iMSC platform, which is designed to provide a scalable, off-the-shelf treatment solution without the need for patient-specific cell harvesting, as well as recently announced preclinical findings supporting the therapeutic potential of ERNA-101, including:

Independent validation of ERNA-101 combination therapy: In a larger, statistically robust study conducted by an independent contract research organization, ERNA-101 in combination with anti-PD-1 therapy achieved complete tumor clearance and long-term survival in two-thirds of treated animals. No complete responses were observed in either monotherapy group or the untreated control group.
Complete tumor elimination and 100% long-term survival in an earlier ovarian cancer study: ERNA-101 in combination with PD-1 blockade achieved complete tumor clearance and 100% survival through the end of the study follow-up period, demonstrating the potential of ERNA-101 to enhance the activity of checkpoint inhibition in an immunologically cold tumor model.
Focused path toward clinical validation: Ernexa remains on track for a planned Investigational New Drug application submission for ERNA-101 in 2026. The Company believes establishing clinical proof of concept in ovarian cancer could provide a foundation for evaluating ERNA-101 across broader oncology indications.

Emerging Track Innovation Spotlight Presentation Details

Presenter: Sanjeev Luther, President & CEO
Company: Ernexa Therapeutics
Date: October 6, 2026
Time: 1:30 PM
Room: FLW Ballroom G

"We are honored that Ernexa has been selected for the Emerging Track at the 2026 Cell & Gene Meeting on the Mesa, and we look forward to sharing the progress we are making with ERNA-101," said Mr. Luther. "We believe this recognition reflects the potential of our differentiated approach to cell therapy as we prepare to transition ERNA-101 toward the clinic. Our strategy is focused on advancing one differentiated oncology candidate through a clear initial clinical pathway in platinum-resistant ovarian cancer, supported by a growing body of compelling preclinical evidence and independent validation of ERNA-101’s anti-tumor activity. As we advance toward planned clinical entry, we believe our synthetic, off-the-shelf iMSC platform provides a differentiated foundation to establish clinical proof of concept in ovarian cancer and potentially expand ERNA-101 into broader oncology indications. Most importantly, our focus remains on translating this strong preclinical foundation into a potential new treatment for patients who need better options."

Presented by the Alliance for Regenerative Medicine, the Cell & Gene Meeting on the Mesa brings together senior executives, investors, strategic partners and other decision-makers from across the cell and gene therapy industry. The 2026 program is expected to feature more than 100 company presentations and more than 5,000 partnering meetings focused on advancing scientific, clinical and commercial innovation across the sector.

For more information about ERNA-101 and the Company’s development plans, visit www.ernexatx.com

(Press release, Ernexa Therapeutics, SEP 29, 2026, View Source [SID1234671172])

On September 29, 2026 Pyxis Oncology, Inc. (Nasdaq: PYXS), a clinical-stage company developing next-generation therapeutics for difficult-to-treat cancers, reported that it has commenced a registered public offering (the "Offering") of (i) shares of its common stock, or in lieu of common stock to certain investors, pre-funded warrants to purchase shares of common stock, and (ii) accompanying common warrants to purchase shares of common stock. Each share of common stock and each pre-funded warrant will be sold together with a common warrant to purchase one share of common stock.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The common warrants will become exercisable only upon approval by the Company’s stockholders of an amendment to the Company’s certificate of incorporation to increase the number of authorized shares of common stock and the effectiveness of that amendment (the date of such effectiveness, the "Charter Amendment Effective Date"), and will expire upon the earlier of (i) the fifth anniversary of the Charter Amendment Effective Date and (ii) the 30th calendar day following the later (x) of the Charter Amendment Effective Date and (y) the Company’s public disclosure of overall survival data (the "OS Data Release Date") from its ongoing Phase 1 monotherapy study of micvotabart pelidotin (MICVO) in second-line and beyond (2L+) recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), expected in the first half of 2027. All of the securities in the Offering are to be sold by Pyxis Oncology.

Leerink Partners, Guggenheim Securities and Wells Fargo Securities are acting as joint bookrunning managers for the proposed Offering. The proposed Offering is subject to market and other conditions, and there can be no assurance as to whether or when the Offering may be completed or as to the actual size or terms of the Offering.

Pyxis Oncology intends to use the net proceeds from the Offering to advance its lead clinical program, MICVO, through key clinical milestones, including Headliner, its planned Phase 3 trial in 2L+ R/M HNSCC, and for working capital and general corporate purposes.

The common stock, common warrants and pre-funded warrants are being offered pursuant to a registration statement on Form S-3 (File No. 333-291801), which was previously filed with and subsequently declared effective by the Securities and Exchange Commission (the "SEC"). The Offering will be made only by means of a prospectus supplement and accompanying prospectus that form a part of the registration statement. A copy of the preliminary prospectus supplement relating to and describing the terms of the Offering will be filed with the SEC and will be available for free on the SEC’s website at www.sec.gov. Copies of the preliminary prospectus supplement and the accompanying prospectus may also be obtained, when available, from Leerink Partners LLC, Attention: Syndicate Department, 53 State Street, 40th Floor, Boston, MA 02109, by telephone at 1-800-808-7525 ext. 6105, or by email at [email protected]; Guggenheim Securities, LLC, Attention: Equity Syndicate Department, 330 Madison Avenue, 8th Floor, New York, NY 10017, by telephone at (212) 518-9544, or by email at [email protected]; or from Wells Fargo Securities, LLC, Attention: Equity Syndicate Department, 90 South 7th Street, 5th Floor, Minneapolis, Minnesota 55402, at (800) 645-3751 (option #5) or email a request to [email protected].

This press release does not constitute an offer to sell or a solicitation of an offer to buy the securities in the Offering, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

(Press release, Pyxis Oncology, SEP 29, 2026, View Source [SID1234671171])

On September 29, 2026 NorthStar Medical Technologies, LLC (NorthStar), the first commercial-scale producer of no-carrier-added actinium-225 (n.c.a. Ac-225) using electron-accelerator technology, reported a multi-year growth capital facility of up to $185 million with Hercules Capital, Inc. (NYSE: HTGC) to support NorthStar’s continued growth and expansion. The financing, including $100 million upfront, will accelerate investment in isotope production and in clinical and commercial drug manufacturing capabilities, enabling NorthStar’s pharmaceutical and biotechnology partners to advance next-generation precision cancer therapies to patients worldwide.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The agreement supports NorthStar’s continued commercial scale-up investment leveraging its industry-leading scientific talent and vertically integrated radiopharmaceutical campus, where it provides clinical and commercial isotope production and radiopharmaceutical manufacturing, including comprehensive cGMP services through its state-of-the-art CDMO.

"NorthStar is executing on our vision to become the radiopharmaceutical industry’s most comprehensive strategic supply-chain partner," said Dr. Frank Scholz, President & CEO of NorthStar. "This commitment from Hercules provides the necessary capital to expand our capacity, accelerate our growth, and support our partners as they advance innovative therapies to patients across the world."

The financing follows a period of significant expansion for NorthStar and several milestones. In January 2026, the company became the first in the industry to produce commercial-scale no-carrier-added (n.c.a.) Actinium-225 (Ac-225) using electron-accelerator technology and announced an expanded partnership with Convergent to support late-stage clinical studies and commercial demand. More recently, the U.S. Food & Drug Administration accepted NorthStar’s Drug Master File (DMF) for n.c.a. Ac-225, providing pharmaceutical and biotech companies with a validated pathway to incorporate the isotope into clinical and commercial radiopharmaceutical programs. Later this year, NorthStar plans to transition to its high-capacity production line of n.c.a. Ac-225 at its integrated campus.

"NorthStar has demonstrated the ability to produce a critical isotope at scale at an important time for the industry," said Lake McGuire, Managing Director of Hercules Capital. "We are pleased to provide capital to help NorthStar expand its production and meet growing demand, while supporting its role as a partner to companies advancing these therapies."

NorthStar has supply and manufacturing agreements in place with more than 30 pharmaceutical and biotechnology customers, including several of the largest companies developing Ac-225 therapies.

(Press release, NorthStar Medical Radiostopes, SEP 29, 2026, View Source [SID1234671170])