On June 18, 2026 Mabwell (688062.SH, 02493.HK), an innovation-driven biopharmaceutical company with a fully integrated industry chain, reported two latest clinical study results of its independently developed Nectin-4-targeting ADC 9MW2821 (Bulumtatug Fuvedotin, BFv) in cervical cancer at the European Society for Medical Oncology Gynaecological Cancers Congress 2026 (ESMO Gynae 2026) in Copenhagen, Denmark, held June 17–19, 2026. The two studies demonstrated that 9MW2821 has a manageable safety profile and promising therapeutic effects in patients with cervical cancer, with particularly notable survival benefits observed in immunotherapy-pretreated patients. The combination of 9MW2821 with a PD-1 inhibitor showed encouraging antitumor activity in advanced cervical cancer.

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Oral Presentation: BFv in Recurrent or Metastatic Cervical Cancer

The Phase I/II cervical cancer cohort of this clinical study (NCT05216965) enrolled patients with recurrent or metastatic cervical cancer (r/m CC) who had progressed on or after platinum-based chemotherapy with or without bevacizumab and received no more than 2 previous systemic regimens for recurrent or metastatic disease. Subjects received 1.25 mg/kg of BFv by intravenous infusion on days 1, 8, and 15 each 28-day cycle.

As of March 20, 2025, 55 patients were enrolled. Of these, 49.09% patients had received prior platinum-based doublet chemotherapy plus bevacizumab, and 58.18% had received prior platinum-based doublet chemotherapy plus immune checkpoint inhibitors.

Among the 53 patients evaluable for efficacy, the confirmed objective response rate (cORR) and disease control rate (DCR) were 32.08% and 81.13%, respectively, with 1 complete response (1.87%) and 17 partial responses (30.19%). Median progression-free survival (mPFS) was 3.9 months and median duration of response (mDOR) was 5.98 months. Median overall survival (mOS) was 19.4 months, with a 12-month OS rate of 72.7% and a 24-month OS rate of 49.1%.

Among the 31 post-IO patients evaluable for efficacy, cORR and DCR were 29.00% and 77.40%, respectively. Median PFS was 4.0 months and median DoR was 9.1 months. Median OS has not yet been reached. The 12-month OS rate was 76.6% and the 24-month OS rate was 51.1%. No new safety signals were observed in this follow-up.

Poster Presentation: BFv in Combination with Toripalimab for Recurrent or Metastatic Cervical Cancer

The study consists of a phase lb safety run-in followed by a phase lI cohort expansion, enrolling patients with cervical cancer who had received ≥ 1 line therapy (Phase lb), and who had no prior systemic chemotherapy (Phase ll). Patients received BFv 1.25mg/kg on days 1, 8 and Toripalimab at 240mg on day 1 of each 21-days cycle. The primary endpoints were safety and preliminary efficacy.

As of March 19, 2026, a total of 19 patients were enrolled, including 3 previously treated patients and 16 treatment-naïve patients. The mean patient age was 57.8 years, and 89.5% had squamous cell carcinoma. 13 patients were evaluable for efficacy with at least one post-baseline tumor assessment. The ORR was 76.9% (10/13), including 1 complete response (CR) and 9 partial responses (PR), and the DCR was 100%. In treatment-naïve patients, the ORR reached 80.0% (8/10). Treatment-related adverse events (TRAEs) were primarily Grade 1–2, and no new safety signals were observed.

The preliminary findings demonstrate a synergistic effect of the Nectin-4-targeting ADC combined with a PD-1 inhibitor in the treatment of cervical cancer, and also offer the potential to establish a new first-line therapy for patients with recurrent or metastatic cervical cancer.

About 9MW2821 (BFv)

9MW2821 is a novel Nectin-4-targeting ADC independently developed by Mabwell based on its ADC development platform. It is the world’s first Nectin-4 ADC to enter Phase III clinical trials for cervical cancer (CC) and triple-negative breast cancer (TNBC). Four pivotal Phase III clinical studies are underway. 9MW2821 has obtained FDA Fast Track Designation for three indications, Orphan Drug Designation for one indication, and Breakthrough Therapy Designation from the CDE of NMPA for two indications.

Interim analysis for the Phase III clinical trials of urothelial carcinoma (UC) monotherapy, UC combination therapy and CC monotherapy are planned to be conducted in 2026, and Applications for pre-NDA meetings are expected to be submitted to the Center for Drug Evaluation under the National Medical Products Administration based on the data of interim analysis.

(Press release, Mabwell Biotech, JUN 18, 2026, View Source [SID1234668802])

On June 18, 2026 Deck Bio, a biotechnology company advancing multi-pMHC targeted T cell engagers for solid tumors, reported its participation in the 8th T-Cell Engager Therapeutics Summit and the BIO International Convention 2026, both taking place in San Diego, California. The company’s leadership team will participate in scientific presentations, panel discussions, and partnering meetings focused on the development of next-generation T cell engager therapies.

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"T cell engagers have transformed the treatment of hematologic malignancies, but extending that success to solid tumors will require new approaches to target biology and therapeutic design," said Jack Silberstein, Chief Executive Officer and Founder of Deck Bio. "These meetings provide an opportunity to discuss how multi-pMHC targeting may help address some of the longstanding challenges in the field and to share the progress we’re making with our lead program, DBXO-1."

DBXO-1 is a multi-pMHC targeted T cell engager designed to recognize multiple cancer-associated peptide–major histocompatibility complexes (pMHCs) using a single engineered T cell receptor (TCR)-based binder. By targeting multiple independent pMHCs, DBXO-1 is designed to expand patient eligibility and improve durability of response across major solid tumor indications.

Details of Deck Bio’s participation are as follows:

8th T-Cell Engager Therapeutics Summit

Date: June 23-25, 2026
Location: Westin San Diego Bayview
Workshop Leadership: Synchronizing Global Regulatory Strategies through Modelling & Translational Approaches for Next-Generation TCEs – Tuesday, June 23, 2:00 – 4:00 p.m. PT
Scientific Presentation: Expanding the Reach of T Cell Engagers in Solid Tumors through pMHC Multi-Targeting – Wednesday, June 24, 2:00 – 2:30 p.m. PT
BIO International Convention 2026

Date: June 22-25, 2026
Location: San Diego Convention Center
Start-Up Stadium: Deck Bio Pitch – Tuesday, June 23, 2:00 – 4:00 p.m. PT
Panel Discussion: The Therapeutic Modality Puzzle in Oncology: One Size Fits All or Fit to Purpose? – Wednesday, June 24, 4:15 – 5:15 p.m. PT
Deck Bio’s leadership team will be available for partnering and scientific discussions throughout both conferences.

(Press release, Deck Bio, JUN 18, 2026, View Source [SID1234668801])

On June 18, 2026 Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage siRNA biopharmaceutical company developing therapeutics using its proprietary INTASYL gene silencing technology to eliminate cancer, reported that Robert Bitterman, CEO and Chairman of the Board, will present an overview of the Company’s INTASYL siRNA platform, including its lead clinical candidate PH-762 for the treatment of cutaneous carcinomas. The presentation will conclude with a live question and answer session, providing attendees the opportunity to engage directly. In addition, Mr. Bitterman will be available for one-on-one meetings on June 24-25, 2026.

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"We look forward to participating in the Life Sciences Investor Forum, where we will discuss why we believe INTASYL represents a differentiated and promising approach in immuno-oncology," said Robert Bitterman, CEO and Chairman of Phio Pharmaceuticals.

One-on-One Meetings: Phio’s availability is June 24-25, 2026

Phio’s Presentation and live Q&A : Thursday June 25, 2026, at 3 PM EDT

REGISTER HERE: Phio Pharmaceuticals Corp. (NASDAQ: PHIO)

The event will be conducted as a live, interactive online forum, offering investors and industry professionals within the life sciences community the opportunity to submit questions to management in real time. A replay of the webcast will be available following the conclusion of the conference.

It is recommended that online investors pre-register and run the online system check to expedite participation and receive event updates.

Learn more about the event at www.virtualinvestorconferences.com.

(Press release, Phio Pharmaceuticals, JUN 18, 2026, View Source [SID1234668800])

On June 18, 2026 Allarity Therapeutics, Inc. ("Allarity" or the "Company") (NASDAQ: ALLR), a Phase 2 clinical-stage pharmaceutical company dedicated to developing stenoparib (2X-121)—a differentiated, dual PARP and WNT pathway inhibitor, reported that it will present a Trial-in-Progress poster at the ESMO (Free ESMO Whitepaper) Gynaecological Cancers Congress 2026, held June 17–19 in Copenhagen, Denmark.

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The poster outlines the scientific background, study design, and clinical rationale for the Company’s ongoing Phase 2 trial evaluating stenoparib in patients with advanced platinum-resistant or platinum-ineligible ovarian cancer. The study builds directly on Allarity’s prior Phase 2 clinical experience, including the durable clinical benefit observed in heavily pretreated ovarian cancer patients. As a Trial-in-Progress presentation, the poster describes the study design and clinical rationale but cannot include new clinical data.

The poster will be presented by the study’s Principal Investigator, Kathleen N. Moore, M.D., an internationally recognized specialist in gynecologic oncology and a leading expert in advanced platinum-resistant and platinum-refractory ovarian cancer. Dr. Moore is also a featured speaker during the congress, which brings together leading international clinical investigators focused on advancing treatment for patients with gynecological cancers.

Poster presentation

Title: 166TiP – NCT03878849: A phase II trial of stenoparib/2X-121, a novel dual inhibitor of PARP and the WNT pathway, in platinum resistant/ineligible ovarian cancer patients
Session: Poster display session
Presenter: Kathleen N. Moore, M.D. (Omaha, United States)
Date: Thursday, June 18, 2026
Location: Exhibition
"Presenting this Trial-in-Progress poster at the ESMO (Free ESMO Whitepaper) Gynaecological Cancers Congress places our ongoing Phase 2 study before the most focused and relevant audience for gynecologic oncology in the U.S. and Europe," said Thomas Jensen, Chief Executive Officer of Allarity Therapeutics. "For Allarity, this is an important opportunity to highlight the clinical rationale and design of our stenoparib study, while beginning to frame the potential role our drug-specific DRP patient selection approach may play in addressing advanced platinum-resistant or platinum-ineligible ovarian cancer for this highly specialized audience. Across both Europe and the U.S., this patient population is recognized as having an urgent need for new, more tolerable treatment options. We are particularly pleased that the poster will be presented by our Principal Investigator, Dr. Kathleen N. Moore, whose expertise in gynecologic oncology is widely recognized and highly valuable as we continue to advance stenoparib toward its next clinical milestones."

The poster will be available on the Company’s website under the Scientific Publications section following its presentation on June 18, 2026.

About Stenoparib/2X-121
Stenoparib is an orally available, small-molecule dual-targeted inhibitor of PARP1/2 and tankyrase 1/2. At present, tankyrases are attracting significant attention as emerging therapeutic targets for cancer, principally due to their role in regulating the WNT signaling pathway. Aberrant WNT/β-catenin signaling has been implicated in the development and progression of numerous cancers, especially drug-resistant cancers. By inhibiting PARP and blocking WNT pathway activation, stenoparib’s unique therapeutic action shows potential as a promising therapeutic for many cancer types, including ovarian cancer, small cell lung cancer and colorectal cancer. Allarity has secured exclusive global rights for the development and commercialization of stenoparib, which was originally developed by Eisai Co. Ltd. and was formerly known under the names E7449 and 2X-121. Allarity has completed its first Phase 2 trial for stenoparib in advanced ovarian cancer patients. That trial showed promising and durable clinical benefit ovarian cancer patients who had 2+ lines of therapy were enrolled on stenoparib and given drug twice daily. The updated data from this study were presented at the AACR (Free AACR Whitepaper) special conference on advances in ovarian cancer in September 2025. Note that, as these data are from an ongoing trial, analyses may change as the study fully matures. A new protocol was designed expressly to capitalize on this emerging clinical experience with stenoparib in platinum resistant patients and began enrolling patients in the summer of 2025. This amended protocol enrolls only platinum resistant or platinum-ineligible patients and is designed to accelerate the clinical development of stenoparib toward FDA approval. In parallel, a separate Phase 2 trial evaluating stenoparib in combination with temozolomide for relapsed small cell lung cancer (SCLC) began enrolling patients in early 2026 and is currently enrolling patients across multiple VA sites in the US.

About the Drug Response Predictor – DRP Companion Diagnostic
Allarity uses its drug-specific DRP to select those patients who, by the gene expression signature of their cancer, may have a high likelihood of benefiting from a specific drug. By screening patients before treatment, and only treating those patients with a sufficiently high, drug-specific DRP score, the therapeutic benefit rate may be enhanced. The DRP method builds on the comparison of sensitive vs. resistant human cancer cell lines, including transcriptomic information from cell lines, combined with clinical tumor biology filters and prior clinical trial outcomes. DRP is based on messenger RNA expression profiles from patient biopsies. The DRP platform has shown an ability to provide a statistically significant prediction of the clinical outcome from drug treatment in cancer patients across dozens of clinical studies (both retrospective and prospective). The DRP platform, which may be useful in all cancer types and is patented for dozens of anti-cancer drugs, has been extensively published in the peer-reviewed literature.

(Press release, Allarity Therapeutics, JUN 18, 2026, View Source [SID1234668799])

On June 18, 2026 Voro Therapeutics, a biotechnology company developing tumor-activated biologics designed to improve the therapeutic index of immune therapies and Alloy Therapeutics, a biotechnology ecosystem company dedicated to empowering the global biologics community, reported a strategic research collaboration focused on the discovery and development of next-generation masked T-cell engager (TCE) therapeutics.

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The collaboration combines Voro’s proprietary tumor-activated biologics platform and experience in T-cell engager development with Alloy’s optimized CD3 antibodies and multispecific engineering expertise to develop novel immunotherapies designed to selectively activate immune responses within the tumor microenvironment while minimizing activity in healthy tissues.

TCEs have demonstrated significant therapeutic potential across a broad range of cancers but are often limited by systemic toxicities associated with widespread immune activation. Through this collaboration, Voro and Alloy aim to advance novel approaches that may improve the therapeutic index of TCE therapies, potentially enabling broader clinical utility and expanding the reach of immune-based cancer treatments.

"T-cell engagers have shown tremendous promise, but their broader impact has been constrained by the same challenge facing many powerful immune therapies: how to deliver potency without unacceptable systemic toxicity," said Ugur Eskiocak, Ph.D., Co-Founder and CEO of Voro Therapeutics. "We believe tumor-activated T-cell engagers represent the next evolution of the field. By combining Voro’s PrimeBody platform and TCE design expertise with Alloy’s discovery and multispecific engineering capabilities, we aim to create highly potent, tumor-selective therapies that broaden access for patients."

"We are excited to collaborate with Voro as they apply their innovative tumor-activated biologics platform to address important challenges in immuno-oncology. By integrating Voro’s differentiated linker and masking technologies with Alloy’s optimized CD3 antibodies and cell engager engineering expertise, we can accelerate the development of next-generation TCE’s with potentially best-in-class safety and efficacy. Partnerships like this demonstrate how Alloy’s discovery ecosystem can help enable the next generation of therapeutic innovation," said Mike Schmidt, CSO of Alloy Therapeutics.

This collaboration reflects a shared commitment to advancing innovative biologics and generating novel therapeutic approaches that expand the applicability of T-cell engager therapies, while further strengthening Voro’s growing ecosystem of strategic partners.

(Press release, Voro Therapeutics, JUN 18, 2026, View Source [SID1234668798])