Labcorp to Host Investor Day on September 10, 2026

On August 17, 2026 Labcorp Holdings Inc. (NYSE: LH), a global leader of innovative and comprehensive laboratory services, reported it will host an Investor Day on Thursday, September 10, 2026, from 9 a.m. to noon ET.

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Chairman and CEO Adam Schechter, Executive Vice President and CFO Julia Wang and other members of the executive leadership team will discuss the company’s go-forward strategy, capital deployment priorities and long-term financial outlook. Presentations will be followed by a Q&A session.

A live webcast of the event will be available through the Labcorp Investor Relations website beginning at 9 a.m. ET. A replay of the webcast and supporting materials will be available after the conclusion of the event.

(Press release, LabCorp, AUG 17, 2026, View Source [SID1234670177])

Galmed Announces First Time Results in Prostate Oncology Studies: Aramchol Demonstrates 3-4 Fold Increase in Cell Death Compared to Enzalutamide (XTANDI®) Alone in Prostate Cancer Models

On August 17, 2026 Galmed Pharmaceuticals Ltd. (NASDAQ: GLMD) ("Galmed" or the "Company"), a clinical-stage biopharmaceutical company focused on liver, cardiometabolic and oncology diseases, reported significant results from a pre-clinical study of a combination of Aramchol and Xtandi (enzalutamide) for prostatic cancer.

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Prostate cancer is the second most common cancer in men worldwide and remains a significant cause of cancer-related morbidity and mortality. Androgen signaling plays a central role in the development and progression of prostate cancer. For this reason, anti-androgen therapy and related androgen axis-targeting approaches represent important modalities in the treatment of prostate cancer. Despite the availability of anti-androgen therapies, there remains a need for improved treatment regimens that may be used alone or in combination with existing anti-androgen therapies, including in patients having resistant, recurrent, advanced, metastatic, or otherwise difficult-to-treat prostate cancer.

Recent publications indicate that prostate cancer tumors can adapt to SoC treatments such as enzalutamide by altering their lipid metabolism. Both enzalutamide-sensitive and resistant cells depend on this lipid desaturation pathway. Combining enzalutamide (an androgen receptor blocker) with an SCD1 inhibitor blocks this lipid synthesis and desaturation, potentially leading to decreased cell viability, and delayed development of drug resistance.

The data we present today, demonstrate that a combination of Aramchol (an SCD1 inhibitor) with enzalutamide resulted in 3–4-fold increase in cell death (compared with enzalutamide as a single agent) and that the interaction gets stronger, the longer the drugs are on board. The VCaP prostate cancer cell line features high expression of wild-type androgen receptors, the clinically relevant AR-V7 splice variant, and the TMPRSS2-ERG gene fusion, sourced from a vertebral metastasis of a 59 year old Caucasian mCSPC patient.

Previously Galmed demonstrated that Aramchol synergistically interacts with docetaxel (Taxotere) a potent, semisynthetic chemotherapy medication, to cause greater than additive killing in a whole range of tumor types where docetaxel is approved, including prostate cancer cells. The results from those studies support the further evaluation of Aramchol in combination with approved prostate cancer therapies, including combining Aramchol with enzalutamide (with or without GnRH analogue) and as the anti-androgen interaction starts to wear off, switch to a combination of Aramchol with docetaxel.

Allen Baharaff, Galmed’s Co-founder and CEO, commented: "The data we present today is a result of our research work in prevention of drug resistance to blockbuster agents in oncology (as previously reported in our earlier press releases). Global sales for Xtandi (marketed by Astellas Pharma and Pfizer) reached approximately $8 billion and $6 billion globally in 2024 and 2025 (accounting for roughly 4% of Pfizer’s total revenue). The main composition of matter patents for enzalutamide (sold as Xtandi) expire in 2026 in Europe and 2027 in the United States (Patent US9126941 & Patent US8183274). A combination of Aramchol and enzalutamide could potentially become a lifecycle management for Xtandi in light of the U.S. price cut scheduled to begin in 2027 as well as a key differentiating factor for any generic competitor trying to capture a portion of this multibillion-dollar market. Galmed is planning to initiate discussions with potential partners based on a patent application for the combination that has been recently submitted".

(Press release, Galmed Pharmaceuticals, AUG 17, 2026, View Source [SID1234670176])

Can-Fite: Namodenoson Enhances the Anti-Cancer Effect of Chemotherapy in Pancreatic Cancer

On August 17, 2026 Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CANF), a clinical-stage biotechnology company developing a pipeline of proprietary small molecule drugs targeting oncological and inflammatory diseases, reported new preclinical findings demonstrating that namodenoson enhances the anti-cancer effect of gemcitabine chemotherapy in pancreatic cancer. The findings provide mechanistic support for the design of Can-Fite’s planned Phase IIb study evaluating namodenoson in combination with gemcitabine and additional standard-of-care therapy in patients with advanced pancreatic adenocarcinoma.

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In pre-clinical studies the combination of namodenoson and gemcitabine increased the level of a protein, cleaved caspase-3, a central mediator of cell death (apoptosis). These findings indicate that namodenoson weakens the survival mechanisms of pancreatic cancer cells, thereby increasing their susceptibility to chemotherapy and enabling a stronger tumor cell-death response.

The new findings directly support the scientific rationale underlying Can-Fite’s planned randomized Phase IIb study in advanced pancreatic adenocarcinoma. The proposed study will evaluate namodenoson in combination with gemcitabine and additional standard-of-care therapy, Nab-paclitaxel, building upon the favorable safety profile and encouraging clinical activity observed with namodenoson monotherapy in the Company’s Phase 2a pancreatic cancer study.

"These findings provide an important mechanistic explanation for the enhanced anti-cancer effect observed when namodenoson is combined with chemotherapy," stated Pnina Fishman, Ph.D., Can-Fite’s Chief Scientific Officer and Chairperson. "Namodenoson suppressed key survival pathways in pancreatic cancer cells and increased caspase-3-mediated apoptosis, thereby enhancing the activity of gemcitabine. These results strongly support the combination approach incorporated into the design of our planned Phase IIb study."

Clinical results from Can-Fite’s Phase 2a study of namodenoson in advanced pancreatic adenocarcinoma have been accepted for presentation at the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress 2026.

About Namodenoson

Namodenoson is a small orally bioavailable drug that binds with high affinity and selectivity to the A3 adenosine receptor (A3AR). Namodenoson is currently being evaluated in a pivotal Phase 3 trial for advanced liver cancer, concluded successfully a Phase 2a study in pancreatic cancer and is enrolling patients in a Phase 2b trial for the treatment of Metabolic Dysfunction-associated Steatohepatitis (MASH). A3AR is highly expressed in diseased cells whereas low expression is found in normal cells. This differential expression may be one of the important factors that accounts for the excellent safety profile of the drug.

(Press release, Can-Fite BioPharma, AUG 17, 2026, View Source [SID1234670175])

AB Science announces the successful settlement and delivery of securities issued as part of its €14.2 million private placement announced on August 10, 2026

On August 17, 2026 AB Science S.A. (the "Company" or "AB Science," Euronext – FR0010557264 – AB) reported the successful settlement and delivery of the securities issued as part of its capital increases subscribed to by a limited number of investors and announced on August 10, 2026 (the "Private Placement").

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As announced on August 10, 2026, the Private Placement, totaling EUR 14.2 million (including the issuance premium and excluding the potential exercise of BSA-1 and BSA-2 warrants), was carried out through the issuance, without preemptive subscription rights and without a priority period, of:

(i) 3,606,560 new common shares of the Company (the "New Shares") issued at a price of EUR 0.61 per share, each accompanied by a stock subscription warrant (a "BSA-1") – five BSA-1s entitle their holder to subscribe for three new common shares of the Company at a price of EUR 1.00 per common share; and

(ii) 19,672,132 New Shares issued at a price of EUR 0.61 per share, each accompanied by a stock subscription warrant (a "BSA-2") – four BSA-2s entitle their holder to subscribe for seven new common shares of the Company at a price of EUR 1.00 per common share.

If all BSA-1s and BSA-2s are exercised, a total of 36,590,166 additional common shares of the Company will be issued, representing total additional proceeds of approximately EUR 36.6 million. Thus, taking into account the issuance of the New Shares and the potential future exercise of the BSA-1 and BSA-2 warrants, the total amount of the Private Placement will amount, if applicable, to approximately EUR 50.8 million.

On this basis, the ownership interest of a shareholder holding 1.00% of the Company’s share capital prior to the completion of the Private Placement and who did not subscribe to it is now 0.7747% on an undiluted basis and 0.6072% on a diluted basis prior to the exercise of the BSA-1 and BSA-2 warrants, and 0.5721% on a non-diluted basis and 0.5332% on a diluted basis after the exercise of BSA-1 and BSA-2 warrants.

Finally, it is confirmed that Stéphane Ledermann, the Company’s Chairman and Chief Executive Officer, participated in the Private Placement in the amount of EUR 150,000.

About masitinib

Masitinib is a novel oral tyrosine kinase inhibitor that is being developed to target mast cells and macrophages, key immune cells, through inhibition of a limited number of kinases. Through its activity on mast cells and microglial cells and therefore its inhibitory effect on the activation of the inflammatory process, masitinib may have an effect on the course of central nervous system diseases.

About AB8939

AB8939 is a new synthetic microtubule-destabilizing drug candidate. Preclinical data suggests that AB8939 has broad anticancer activity, with a notable advantage over standard chemotherapies that target microtubules of being able to overcome P-glycoprotein (Pgp) and myeloperoxidase (MPO) mediated drug resistance. Development of drug resistance often restricts the clinical efficacy of microtubule-targeting chemotherapy drugs (for example, taxanes and vinca alkaloids); thus, AB8939 has the potential to be developed in numerous oncology indications.

(Press release, AB Science, AUG 17, 2026, View Source [SID1234670174])

Sandoz announces strategic collaboration with Henlius on up to 10 biosimilars, further expanding industry-leading pipeline

On August 17, 2026 Sandoz (SIX:SDZ/OTCQX:SDZNY), the global leader in affordable medicines, reported a major development, manufacturing and commercialisation collaboration agreement with Shanghai Henlius Biotech, Inc. (Henlius, HKEX:02696), marking another significant step to broaden patient access to high-quality biosimilar medicines worldwide.

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The agreement paves the way for the two companies to collaborate on up to 10 biosimilars, with an initial bundle of assets already agreed. Under its terms, Sandoz will have global commercialisation rights for agreed biosimilar assets outside China, while Henlius will be responsible for development and manufacturing. The collaboration agreement is milestones-based for a total consideration of up to USD 322 million, with near-term payments associated with the initial assets that could reach up to USD 100.5 million.

Richard Saynor, Chief Executive Officer, Sandoz, says: "Expanding access to life-enhancing medicines for patients around the world lies at the heart of everything we do. By strengthening our collaboration with Henlius through this strategic agreement, one of our largest ever in biosimilars, we are not only underlining our commitment to patients but also taking another step towards capturing a significant share of the unprecedented biosimilar market opportunity that lies ahead."

One of the initial assets under the agreement will be a proposed cetuximab biosimilar, which is in clinical development. The reference medicine, Erbitux* (cetuximab), is an epidermal growth factor receptor-targeted oncology therapy used to treat selected patients with metastatic colorectal cancer and squamous cell carcinoma of the head and neck2, 3. Colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide4. According to the latest estimates, close to one million new cases of head and neck cancer are reported annually5.

In addition, the collaboration also covers a proposed evolocumab biosimilar used in patients with hypercholesterolaemia and for reducing the risk of major cardiovascular events in adults at increased cardiovascular risk6, and a proposed belimumab biosimilar intended for the treatment of active systemic lupus erythematosus in adults and children and active lupus nephritis in eligible patients, in addition to standard therapy7.Finally, there is an option for a recombinant human hyaluronidase to be used in the development of a subcutaneously administered biosimilar, which increases the dispersion and absorption of other injected medicines. The proposed evolocumab biosimilar and recombinant human hyaluronidase are in technical development, while belimumab is in early development.

Overall, the collaboration expands the industry-leading Sandoz biosimilar pipeline to 39 assets1, with the potential to increase to up to 46, and represents another milestone in the Company’s strategy to capitalise on a significant share of the unprecedented global biosimilar loss-of-exclusivity market over the next decade. It also builds on the existing collaboration between the two companies, first established in April 2025 through a global collaboration agreement for oncology therapy ipilimumab.

Sandoz continues to expand its industry-leading pipeline of biosimilar medicines, building on its experience as the pioneer and global leader with a portfolio of 13 molecules available in nearly 100 countries.

*Erbitux is a registered trademark of ImClone LLC.

(Press release, Sandoz, AUG 17, 2026, View Source [SID1234670161])