Celyad Oncology Announces the Sale of C-CATHez ® Catheter

On February 11, 2026 Celyad Oncology (Euronext: CYAD) ("Celyad" or the "Company"), reported the acquisition by CellProthera of C-Cathez, the transendocardial catheter originally developed by Celyad Oncology. The acquisition is a decisive step for CellProthera as it prepares to enter Phase 3 clinical trial, with the transendocardial catheter as a cornerstone of its therapeutic approach, enabling targeted delivery of stem cells directly into damaged cardiac tissue. The transaction relates to all intellectual property rights and associated technical documentation.

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Under the terms of the agreement, the consideration consists of (i) a purchase price of up to €5 million payable in instalments tied to milestones, and (ii) future royalties on net sales.

The consideration being entirely deferred, the transaction will not impact Celyad Oncology’s current cash runway, which is currently anticipated to extend into Q3-2026

(Press release, Celyad, FEB 11, 2026, View Source [SID1234662611])

Nektar Therapeutics Announces Pricing of Upsized $400 Million Public Offering

On February 11, 2026 Nektar Therapeutics (Nasdaq: NKTR), a clinical-stage biotechnology company focused on the development of innovative medicines in the field of immunotherapy, reported the pricing of its upsized underwritten public offering of $400 million of shares of its common stock and, in lieu of common stock to certain investors, pre-funded warrants. Nektar is selling 6,603,449 shares of common stock and 293,103 pre-funded warrants in the offering. The shares of common stock are being sold at a public offering price of $58.00 per share and the pre-funded warrants to purchase are being sold at a public offering price of $57.9999 per pre-funded warrant, which represents the per share public offering price of each share of common stock less the $0.0001 per share exercise price of each pre-funded warrant. The gross proceeds to Nektar from the offering are expected to be approximately $400 million, before deducting underwriting discounts and commissions and estimated offering expenses. In addition, Nektar has granted the underwriters a 30-day option to purchase up to an additional 1,034,482 shares of its common stock at the public offering price per share, less underwriting discounts and commissions. All of the securities being sold in this offering are being offered by Nektar. The offering is expected to close on February 13, 2026, subject to the satisfaction of customary conditions.

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Nektar intends to use the net proceeds from the offering for general corporate purposes, which may include research and development, clinical development (including Phase 3 trials for rezpegaldesleukin) and manufacturing costs to support the advancement of its drug candidates, as well as other general corporate purposes.

Jefferies, TD Cowen, and Piper Sandler are acting as joint bookrunning managers for the offering. Oppenheimer & Co. and H.C. Wainwright & Co. are acting as lead managers and B. Riley Securities is acting as manager for the offering.

The securities described above are being offered pursuant to a shelf registration statement on Form S-3ASR (No. 333-291466) that was filed with the U.S. Securities and Exchange Commission (the "SEC") on November 12, 2025 and automatically became effective upon filing. This offering is being made only by means of a prospectus supplement and an accompanying prospectus that form a part of the registration statement.

A final prospectus supplement related to and describing the terms of the offering will be filed with the SEC and will be available on the SEC’s website located at www.sec.gov. Copies of the final prospectus supplement and an accompanying prospectus related to the offering may also be obtained, when available, from Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, New York, NY 10022, by telephone at (877) 821-7388, or by email at [email protected]; TD Securities (USA) LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717 or by email at [email protected]; or Piper Sandler & Co., 350 North 5th Street, Suite 1000, Minneapolis, MN 55401, Attention: Prospectus Department, by telephone at (800) 747-3924, or by email at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of that state or jurisdiction.

(Press release, Nektar Therapeutics, FEB 11, 2026, View Source [SID1234662610])

Niowave and Novartis Enter Global Actinium-225 Supply Agreement to Advance Next-Generation Cancer Therapies

On February 11, 2026 Niowave Inc., a U.S.-based global leader in medical radioisotope production, reported a new long-term supply agreement with Novartis to deliver Actinium-225 (Ac-225). The agreement provides Novartis with a scalable supply of this critical isotope to support its growing portfolio of radioligand therapies (RLT). RLTs use a targeting component with a radioisotope to selectively target and destroy cancer cells. Financial terms of the agreement are not being disclosed.

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The long-term agreement supports Novartis’s growing portfolio of RLT programs for difficult-to-treat cancers. In turn, Niowave expects to expand production capacity, and to support that growth, intends to begin construction of a new manufacturing facility in Lansing, Michigan, in early 2026.

"Our new agreement with Novartis underscores Niowave’s leading position as a trusted global supplier of medical radioisotopes," said Mike Zamiara, Chief Executive Officer of Niowave. "Niowave’s ability to provide dependable, scalable supply of Actinium-225 will contribute to the advancement of Novartis’s targeted cancer therapies and has the potential to meaningfully transform cancer care on a global scale."

Actinium-225 is among the most promising isotopes in oncology. Its alpha particles deliver highly potent energy, enabling the precise destruction of cancer cells while minimizing damage to surrounding healthy tissue. Despite its significant potential, global supply of Ac-225 remains limited. Niowave’s proprietary superconducting linear accelerator technology and advanced radiochemistry capabilities enable the company to provide sustainable production to address this critical supply challenge.

This new supply agreement highlights both the transformative promise of radiopharmaceuticals and the importance of securing a reliable isotope supply.

Solomon Partners and PMCF acted as advisors to Niowave.

(Press release, Novartis, FEB 11, 2026, View Source [SID1234662609])

SOFIE Biosciences Announces First Patient Dosed in [18F]FAPI-74 Phase 3 Study for Pancreatic Cancer

On February 11, 2026 SOFIE Biosciences, an established U.S. manufacturer and developer of radiopharmaceuticals, reported that the first patient has been dosed in the second of its two Phase 3 clinical trials evaluating [18F]FAPI-74, a fluorine-18 labeled radiopharmaceutical targeting Fibroblast Activation Protein (FAP), as a novel diagnostic for patients with Pancreatic Ductal Adenocarcinoma.

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"Dosing the first patient in our FAPI-PRO trial is a major step forward in the evaluation of FAPI as an oncological diagnostic tool," said Philipp Czernin, Chief Business Officer, SOFIE Biosciences. "We undergo this trial encouraged by the results of our Phase 2 and independent academic investigator-initiated studies supporting [18F]FAPI-74’s potential role in staging accuracy, which is especially needed for pancreatic cancer."

"The potential sensitivity of [18F]FAPI-74 PET makes its availability to stage patients with newly diagnosed pancreatic ductal adenocarcinoma attractive to patients and clinicians alike. The whole team, including surgeons and oncologists, are enthusiastic about using [18F]FAPI-74 PET to help select the best initial treatments," said Dr. Gary Ulaner, James & Pamela Muzzy Endowed Chair in Molecular Imaging and Therapy, Hoag Family Cancer Institute, and Professor of Radiology and Cancer Biology, University of Southern California.

The FAPI-PRO (FAPI in Precision Imaging of Pancreatic Cancer) trial is a multi-site, open-label, non-randomized, single dose study to assess the clinical utility of [¹⁸F]FAPI-74 PET/CT in the detection of metastatic disease in adults with Pancreatic Ductal Adenocarcinoma. The study is planned for 18 sites with an estimated enrollment of 200 subjects over a 24-month period.

The primary study endpoints are sensitivity and specificity for detection of distant metastatic disease (M1). For additional trial details, visit the study page on ClinicalTrials.gov NCT07217717).

The partner Phase 3 study, FAPI-GO (FAPI in Gastroesophageal Oncology), which began November 2025, is a multi-site, open-label, non-randomized, single dose study to assess the clinical utility of [¹⁸F]FAPI-74 PET/CT in the detection of metastatic disease in adults with gastroesophageal cancers. The first patient in FAPI-GO was dosed on December 26, 2025. For additional trial details, visit the study page on ClinicalTrials.gov (NCT07217704).

ABOUT [18F]FAPI-74

[18F]FAPI-74 is the lead fluorine-18 radiolabeled PET tracer in the FAPI family of compounds. It has demonstrated favorable dosimetry, avidity, safety, and a biodistribution profile amenable to detection of FAP-expressing cells in patients with various cancers. This radioligand for imaging is currently optimized for production within SOFIE and its clinical trial partners.

(Press release, Sofie Biosciences, FEB 11, 2026, View Source [SID1234662608])

Candel Therapeutics to Present at the 7th Annual Glioblastoma Drug Development Summit

On February 11, 2026 Candel Therapeutics, Inc. (Candel or the Company) (Nasdaq: CADL), a clinical-stage biopharmaceutical company focused on developing multimodal biological immunotherapies to help patients fight cancer, reported that Francesca Barone, M.D., Ph.D., Candel’s Chief Scientific Officer, will present data and participate in multiple sessions at the 7th Annual Glioblastoma Drug Development Summit, taking place February 17-19, 2026 in Boston, Massachusetts.

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Dr. Barone will share insights from Candel’s HSV-based platform and the linoserpaturev (CAN-3110) program in recurrent high-grade glioma (rHGG) through workshop presentations and panel discussions focused on advancing biomarker-driven clinical development in glioblastoma.

Details are as follows:

Workshop Panel

Title: Harnessing Omics Data & Molecular Subtyping to Inform Patient Stratification in Clinical & Translational Strategies in Glioblastoma Drug Development
Date/Time: Tuesday, Feb. 17, 2026, 8:00 a.m. ET

Conference Presentation

Title: Integration of Biomarkers & Imaging to Define Patient Response in a Phase I/II Clinical Trial
Date/Time: Wednesday, Feb. 18, 2026, 9:30 a.m. ET

Panel Discussion

Title: Driving the Use of Biomarker-Based Enrollment in GBM Trials to Accelerate Clinical Success & Improve Patient Outcomes
Date/Time: Wednesday, Feb. 18, 2026, 12:00 p.m. ET

About linoserpaturev (CAN-3110)

CAN-3110 is a first-in-class, replication-competent, next-generation oncolytic herpes simplex virus-1 (HSV-1) immunotherapy candidate designed for dual activity for oncolysis and immune activation in a single therapeutic. In October 2023, the Company announced that Nature published results from the ongoing clinical trial where linoserpaturev was reported to be generally well tolerated with no dose-limiting toxicity. In the clinical trial, the investigators observed improved median overall survival compared to historical controls after a single linoserpaturev injection in this therapy-resistant condition.1 The Company and academic collaborators are currently supported by the Break Through Cancer foundation to evaluate the effects of repeated linoserpaturev injections in patients with recurrent glioblastoma in an expansion cohort from the phase 1b clinical trial. In October 2025, Science Translational Medicine presented findings from the comprehensive analysis of 97 serial tumor biopsies collected from two patients treated with repeated administrations of linoserpaturev in arm C. Linoserpaturev previously received Fast Track Designation and Orphan Drug Designation for the treatment of recurrent HGG from the U.S. Food and Drug Administration (FDA).

(Press release, Candel Therapeutics, FEB 11, 2026, View Source [SID1234662607])